JP2016515515A - 抗プロラクチン受容体抗体製剤 - Google Patents

抗プロラクチン受容体抗体製剤 Download PDF

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Publication number
JP2016515515A
JP2016515515A JP2016502699A JP2016502699A JP2016515515A JP 2016515515 A JP2016515515 A JP 2016515515A JP 2016502699 A JP2016502699 A JP 2016502699A JP 2016502699 A JP2016502699 A JP 2016502699A JP 2016515515 A JP2016515515 A JP 2016515515A
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JP
Japan
Prior art keywords
prlr
prlr antibody
formulation
antibody formulation
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016502699A
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English (en)
Japanese (ja)
Other versions
JP2016515515A5 (enExample
Inventor
マー，シンハン
ニウ，ジエンジエ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Bayer Healthcare LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Publication of JP2016515515A publication Critical patent/JP2016515515A/ja
Publication of JP2016515515A5 publication Critical patent/JP2016515515A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2016502699A 2013-03-15 2014-03-14 抗プロラクチン受容体抗体製剤 Pending JP2016515515A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361799629P 2013-03-15 2013-03-15
US61/799,629 2013-03-15
PCT/US2014/028078 WO2014143909A1 (en) 2013-03-15 2014-03-14 Anti-prolactin receptor antibody formulations

Publications (2)

Publication Number Publication Date
JP2016515515A true JP2016515515A (ja) 2016-05-30
JP2016515515A5 JP2016515515A5 (enExample) 2017-04-13

Family

ID=50678293

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016502699A Pending JP2016515515A (ja) 2013-03-15 2014-03-14 抗プロラクチン受容体抗体製剤

Country Status (10)

Country Link
US (2) US9023357B2 (enExample)
EP (1) EP2968538A1 (enExample)
JP (1) JP2016515515A (enExample)
CN (1) CN105025925A (enExample)
AR (1) AR095496A1 (enExample)
CA (1) CA2906101A1 (enExample)
HK (1) HK1215175A1 (enExample)
TW (1) TW201513882A (enExample)
UY (1) UY35460A (enExample)
WO (1) WO2014143909A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020510079A (ja) * 2017-03-16 2020-04-02 エルジー・ケム・リミテッド 抗ＴＮＦα抗体の液状製剤
JP2021511362A (ja) * 2018-01-26 2021-05-06 ジェネンテック， インコーポレイテッド 組成物及び使用方法

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NZ631565A (en) 2012-03-14 2016-07-29 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
JP2016515515A (ja) * 2013-03-15 2016-05-30 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 抗プロラクチン受容体抗体製剤
TWI641620B (zh) 2013-08-21 2018-11-21 再生元醫藥公司 抗－ｐｒｌｒ抗體及其用途
US9545451B2 (en) 2013-08-21 2017-01-17 Regeneron Pharmaceuticals, Inc. Anti-PRLR antibodies and methods for killing PRLR-expressing cells
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
MY189159A (en) 2015-07-06 2022-01-29 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
WO2017104778A1 (ja) 2015-12-18 2017-06-22 アステラス製薬株式会社 抗ヒトｔｓｌｐ受容体抗体含有医薬組成物
IL249795B (en) 2016-02-05 2020-01-30 Grifols Worldwide Operations Ltd Intradermal administration of an immunoglobulin preparation g
WO2017190079A1 (en) 2016-04-28 2017-11-02 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
WO2018063963A1 (en) 2016-09-28 2018-04-05 Board Of Regents, The University Of Texas System Antibody and protein therapeutic formulations and uses thereof
EP3548514A1 (en) 2016-11-29 2019-10-09 Regeneron Pharmaceuticals, Inc. Methods of treating prlr positive breast cancer
TW201836647A (zh) 2017-04-06 2018-10-16 美商艾伯維有限公司 抗－ｐｒｌｒ抗體藥物軛合物（ａｄｃ）及其用途
JP7297672B2 (ja) 2017-04-13 2023-06-26 アジェナス インコーポレイテッド 抗ｃｄ１３７抗体およびその使用方法
CN112040985A (zh) 2018-02-07 2020-12-04 瑞泽恩制药公司 用于递送治疗性蛋白质的方法和组合物
SG11202108627SA (en) 2019-02-18 2021-09-29 Lilly Co Eli Therapeutic antibody formulation
KR20250120995A (ko) 2022-11-07 2025-08-11 업스트림 바이오, 인크. 항-인간 tslp 수용체 항체를 포함하는 약제학적 조성물 및 이를 사용하는 방법

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JP2010502232A (ja) * 2006-09-08 2010-01-28 メディミューン，エルエルシー ヒト化抗ｃｄ１９抗体ならびに癌、移植および自己免疫疾患の治療におけるその使用
JP2010515709A (ja) * 2007-01-11 2010-05-13 ノヴォ ノルディスク アクティーゼルスカブ 抗ｋｉｒ抗体、製剤、およびその使用
WO2011069794A1 (en) * 2009-12-10 2011-06-16 Bayer Schering Pharma Ag Neutralizing prolactin receptor antibodies and their therapeutic use
WO2012121754A1 (en) * 2011-03-09 2012-09-13 Janssen Biotech Inc. Non-aqueous high concentration reduced viscosity suspension formulations of antibodies
JP2015528465A (ja) * 2012-08-31 2015-09-28 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅＬＬＣ 抗プロラクチン受容体抗体製剤

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US20040191243A1 (en) * 2002-12-13 2004-09-30 Bei Chen System and method for stabilizing antibodies with histidine
JO3000B1 (ar) * 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
EP3018144A1 (en) * 2006-08-18 2016-05-11 XOMA Technology Ltd. Prlr-specific antibody and uses thereof
CN101553504A (zh) * 2006-12-11 2009-10-07 豪夫迈·罗氏有限公司 Aβ抗体胃肠外制剂
US8216571B2 (en) * 2007-10-22 2012-07-10 Schering Corporation Fully human anti-VEGF antibodies and methods of using
BRPI0918419A2 (pt) * 2008-09-19 2015-11-24 Hoffmann La Roche nova formulação anticorpo
EP2196476A1 (en) 2008-12-10 2010-06-16 Novartis Ag Antibody formulation
NZ595694A (en) * 2009-05-04 2013-09-27 Abbvie Biotechnology Ltd Stable high protein concentration formulations of human anti-tnf-alpha-antibodies
CN102686241A (zh) 2009-12-29 2012-09-19 霍夫曼-拉罗奇有限公司 抗体配制剂
JP2016515515A (ja) * 2013-03-15 2016-05-30 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 抗プロラクチン受容体抗体製剤

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010502232A (ja) * 2006-09-08 2010-01-28 メディミューン，エルエルシー ヒト化抗ｃｄ１９抗体ならびに癌、移植および自己免疫疾患の治療におけるその使用
JP2010515709A (ja) * 2007-01-11 2010-05-13 ノヴォ ノルディスク アクティーゼルスカブ 抗ｋｉｒ抗体、製剤、およびその使用
WO2011069794A1 (en) * 2009-12-10 2011-06-16 Bayer Schering Pharma Ag Neutralizing prolactin receptor antibodies and their therapeutic use
WO2011069798A1 (en) * 2009-12-10 2011-06-16 Bayer Schering Pharma Ag Neutralizing prolactin receptor antibodies and their therapeutic use
WO2011069795A1 (en) * 2009-12-10 2011-06-16 Bayer Schering Pharma Ag Neutralizing prolactin receptor antibodies and their therapeutic use
WO2011069797A1 (en) * 2009-12-10 2011-06-16 Bayer Schering Pharma Ag Neutralizing prolactin receptor antibodies and their therapeutic use
WO2011069796A1 (en) * 2009-12-10 2011-06-16 Bayer Schering Pharma Ag Neutralizing prolactin receptor antibodies and their therapeutic use
WO2011069799A1 (en) * 2009-12-10 2011-06-16 Bayer Schering Pharma Ag Neutralizing prolactin receptor antibodies and their therapeutic use
WO2012121754A1 (en) * 2011-03-09 2012-09-13 Janssen Biotech Inc. Non-aqueous high concentration reduced viscosity suspension formulations of antibodies
JP2015528465A (ja) * 2012-08-31 2015-09-28 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅＬＬＣ 抗プロラクチン受容体抗体製剤

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020510079A (ja) * 2017-03-16 2020-04-02 エルジー・ケム・リミテッド 抗ＴＮＦα抗体の液状製剤
JP7109849B2 (ja) 2017-03-16 2022-08-01 エルジー・ケム・リミテッド 抗ＴＮＦα抗体の液状製剤
JP2021511362A (ja) * 2018-01-26 2021-05-06 ジェネンテック， インコーポレイテッド 組成物及び使用方法
JP7345479B2 (ja) 2018-01-26 2023-09-15 ジェネンテック， インコーポレイテッド 組成物及び使用方法
US12171805B2 (en) 2018-01-26 2024-12-24 Genentech, Inc. IL-22 FC compositions

Also Published As

Publication number Publication date
US9023357B2 (en) 2015-05-05
CN105025925A (zh) 2015-11-04
US20160002342A1 (en) 2016-01-07
CA2906101A1 (en) 2014-09-18
HK1215175A1 (zh) 2016-08-19
US20140271659A1 (en) 2014-09-18
AR095496A1 (es) 2015-10-21
UY35460A (es) 2014-10-31
WO2014143909A1 (en) 2014-09-18
TW201513882A (zh) 2015-04-16
EP2968538A1 (en) 2016-01-20

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