JP2016515123A5 - - Google Patents
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- Publication number
- JP2016515123A5 JP2016515123A5 JP2016502230A JP2016502230A JP2016515123A5 JP 2016515123 A5 JP2016515123 A5 JP 2016515123A5 JP 2016502230 A JP2016502230 A JP 2016502230A JP 2016502230 A JP2016502230 A JP 2016502230A JP 2016515123 A5 JP2016515123 A5 JP 2016515123A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- amino acid
- composition according
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 102100030430 Group XIIA secretory phospholipase A2 Human genes 0.000 claims 7
- 101001126622 Homo sapiens Group XIIA secretory phospholipase A2 Proteins 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 208000030159 metabolic disease Diseases 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361793503P | 2013-03-15 | 2013-03-15 | |
| US61/793,503 | 2013-03-15 | ||
| PCT/US2014/026736 WO2014151962A1 (en) | 2013-03-15 | 2014-03-13 | Method of treating metabolic disorders using pla2g12a polypeptides and pla2g12a mutant polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515123A JP2016515123A (ja) | 2016-05-26 |
| JP2016515123A5 true JP2016515123A5 (https=) | 2017-03-23 |
| JP6434485B2 JP6434485B2 (ja) | 2018-12-05 |
Family
ID=50483573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502230A Active JP6434485B2 (ja) | 2013-03-15 | 2014-03-13 | Ｐｌａ２ｇ１２ａポリペプチド及びｐｌａ２ｇ１２ａ変異ポリペプチドを使用して代謝障害を治療する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9474792B2 (https=) |
| EP (1) | EP2968480B1 (https=) |
| JP (1) | JP6434485B2 (https=) |
| AU (1) | AU2014236728B2 (https=) |
| CA (1) | CA2906540C (https=) |
| WO (1) | WO2014151962A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9474792B2 (en) | 2013-03-15 | 2016-10-25 | Amgen Inc. | Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides |
| US10436802B2 (en) | 2014-09-12 | 2019-10-08 | Biogen Ma Inc. | Methods for treating spinal muscular atrophy |
| EP3263600A1 (en) | 2016-07-01 | 2018-01-03 | Université Claude Bernard Lyon 1 | Inhibition of pla2r1 for the prevention and/or the treatment of type 2-diabetes |
| JP2022532153A (ja) * | 2019-05-08 | 2022-07-13 | ツインピッグ バイオラブ インコーポレイテッド | ホスホリパーゼａ２を有効成分として含む肥満予防または治療用組成物 |
| JP7852185B2 (ja) * | 2019-07-02 | 2026-04-28 | フンダシオン・パラ・ラ・インベスティガシオン・メディカ・アプリカダ | ｃＰＬＡ２ｅ誘導剤及びその使用 |
| CN120505310A (zh) * | 2020-02-28 | 2025-08-19 | Ionis制药公司 | 用于调节smn2的化合物和方法 |
| EP4504052A4 (en) * | 2022-04-01 | 2026-04-01 | Massachusetts Gen Hospital | VECTORS AND METHODS FOR THE TREATMENT OF NEURODEGENERESCENCE, DELAYING COGNITIVE DECLINE AND IMPROVING MEMORY |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5470582A (en) | 1992-02-07 | 1995-11-28 | Syntex (U.S.A.) Inc. | Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles |
| DE69939707D1 (de) * | 1998-12-24 | 2008-11-20 | Sylus Pharmaceuticals Ltd | Varianten der humanen glycosylphosphatidylinositol-spezifischen phospholipase d und ihre verwendungen |
| WO2012151159A1 (en) * | 2011-05-02 | 2012-11-08 | Ngm Biopharmaceuticals, Inc. | Methods of modulating pla2g12a levels and treating disorders associated therewith |
| US20140099295A1 (en) * | 2011-05-02 | 2014-04-10 | Ngm Biopharmaceuticals, Inc. | Methods of Treating Glucose Metabolism Disorders |
| US9474792B2 (en) | 2013-03-15 | 2016-10-25 | Amgen Inc. | Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides |
-
2014
- 2014-03-13 US US14/772,910 patent/US9474792B2/en active Active
- 2014-03-13 CA CA2906540A patent/CA2906540C/en active Active
- 2014-03-13 JP JP2016502230A patent/JP6434485B2/ja active Active
- 2014-03-13 WO PCT/US2014/026736 patent/WO2014151962A1/en not_active Ceased
- 2014-03-13 EP EP14717343.9A patent/EP2968480B1/en active Active
- 2014-03-13 AU AU2014236728A patent/AU2014236728B2/en active Active
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