JP2016515123A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016515123A5 JP2016515123A5 JP2016502230A JP2016502230A JP2016515123A5 JP 2016515123 A5 JP2016515123 A5 JP 2016515123A5 JP 2016502230 A JP2016502230 A JP 2016502230A JP 2016502230 A JP2016502230 A JP 2016502230A JP 2016515123 A5 JP2016515123 A5 JP 2016515123A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- amino acid
- composition according
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 102100013403 PLA2G12A Human genes 0.000 claims 7
- 101710045216 PLA2G12A Proteins 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 208000008466 Metabolic Disease Diseases 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 210000004369 Blood Anatomy 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 206010058108 Dyslipidaemia Diseases 0.000 claims 1
- 206010061227 Lipid metabolism disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000001072 Type 2 Diabetes Mellitus Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000000875 corresponding Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000020828 fasting Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
Claims (13)
- 配列番号1に記載のアミノ酸配列と少なくとも90%の配列同一性を有し、位置110におけるアミノ酸置換を含むアミノ酸配列を含む単離ヒトPLA2G12A変異ポリペプチドの治療有効量を含む、被検体における代謝障害を治療するための医薬組成物。
- 前記PLA2G12A変異ポリペプチドが配列番号9、13、17、21又は25のアミノ酸配列と少なくとも90%の配列同一性を有するアミノ酸配列を含む、請求項1に記載の医薬組成物。
- 前記PLA2G12A変異ポリペプチドが配列番号9、13、17、21又は25に記載のアミノ酸配列を含む、請求項2に記載の医薬組成物。
- 前記PLA2G12A変異ポリペプチドが、配列番号3のアミノ酸配列と少なくとも90%の配列同一性を有し、前記アミノ酸置換が、配列番号1に記載のアミノ酸配列の位置110に該当する位置88における置換である、請求項1に記載の医薬組成物。
- 前記PLA2G12A変異ポリペプチドが、配列番号11、15、19、23又は27に記載のアミノ酸配列と少なくとも90%の配列同一性を有するアミノ酸配列を含む、請求項2に記載の医薬組成物。
- 前記PLA2G12A変異ポリペプチドが、配列番号11、15、19、23又は27のアミノ酸配列を含む、請求項5に記載の医薬組成物。
- 前記代謝障害が2型糖尿病である請求項1〜6のいずれか一項に記載の医薬組成物。
- 前記代謝障害が脂質異常症である請求項1〜6のいずれか一項に記載の医薬組成物。
- 前記代謝障害が肥満である請求項1〜6のいずれか一項に記載の医薬組成物。
- 前記代謝障害が、前記被験体が100mg/dL以上の空腹時血糖値を有する状態を含む、請求項1〜6のいずれか一項に記載の医薬組成物。
- 前記被験体が哺乳類である、請求項1〜6のいずれか一項に記載の医薬組成物。
- 前記哺乳類がヒトである、請求項1〜6のいずれか一項に記載の医薬組成物。
- 前記PLA2G12A変異ポリペプチドが、薬学的に許容される担体と混合されている、請求項1〜6のいずれか一項に記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361793503P | 2013-03-15 | 2013-03-15 | |
US61/793,503 | 2013-03-15 | ||
PCT/US2014/026736 WO2014151962A1 (en) | 2013-03-15 | 2014-03-13 | Method of treating metabolic disorders using pla2g12a polypeptides and pla2g12a mutant polypeptides |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016515123A JP2016515123A (ja) | 2016-05-26 |
JP2016515123A5 true JP2016515123A5 (ja) | 2017-03-23 |
JP6434485B2 JP6434485B2 (ja) | 2018-12-05 |
Family
ID=50483573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016502230A Active JP6434485B2 (ja) | 2013-03-15 | 2014-03-13 | Pla2g12aポリペプチド及びpla2g12a変異ポリペプチドを使用して代謝障害を治療する方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US9474792B2 (ja) |
EP (1) | EP2968480B1 (ja) |
JP (1) | JP6434485B2 (ja) |
AU (1) | AU2014236728B2 (ja) |
CA (1) | CA2906540C (ja) |
WO (1) | WO2014151962A1 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9474792B2 (en) | 2013-03-15 | 2016-10-25 | Amgen Inc. | Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides |
WO2016040748A1 (en) | 2014-09-12 | 2016-03-17 | Ionis Pharmaceuticals, Inc. | Compositions and methods for detection of smn protein in a subject and treatment of a subject |
EP3263600A1 (en) | 2016-07-01 | 2018-01-03 | Universite Claude Bernard Lyon 1 | Inhibition of pla2r1 for the prevention and/or the treatment of type 2-diabetes |
EP3964228A4 (en) * | 2019-05-08 | 2023-01-04 | Twinpig Biolab, Inc. | COMPOSITION FOR THE PREVENTION OR TREATMENT OF OBESITY WITH PHOSPHOLIPASE A2 AS THE ACTIVE SUBSTANCE |
JP7446443B2 (ja) * | 2020-02-28 | 2024-03-08 | アイオーニス ファーマシューティカルズ, インコーポレーテッド | Smn2を調節するための化合物及び方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
EP0143949B1 (en) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
US5470582A (en) | 1992-02-07 | 1995-11-28 | Syntex (U.S.A.) Inc. | Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles |
DE69939707D1 (de) * | 1998-12-24 | 2008-11-20 | Sylus Pharmaceuticals Ltd | Varianten der humanen glycosylphosphatidylinositol-spezifischen phospholipase d und ihre verwendungen |
US20140099295A1 (en) * | 2011-05-02 | 2014-04-10 | Ngm Biopharmaceuticals, Inc. | Methods of Treating Glucose Metabolism Disorders |
WO2012151159A1 (en) * | 2011-05-02 | 2012-11-08 | Ngm Biopharmaceuticals, Inc. | Methods of modulating pla2g12a levels and treating disorders associated therewith |
US9474792B2 (en) | 2013-03-15 | 2016-10-25 | Amgen Inc. | Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides |
-
2014
- 2014-03-13 US US14/772,910 patent/US9474792B2/en active Active
- 2014-03-13 JP JP2016502230A patent/JP6434485B2/ja active Active
- 2014-03-13 EP EP14717343.9A patent/EP2968480B1/en active Active
- 2014-03-13 CA CA2906540A patent/CA2906540C/en active Active
- 2014-03-13 AU AU2014236728A patent/AU2014236728B2/en active Active
- 2014-03-13 WO PCT/US2014/026736 patent/WO2014151962A1/en active Application Filing
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2014511863A5 (ja) | ||
MX2016013243A (es) | Agonistas peptídicos duales de los receptores de glp-1/glucagón derivados de la exendina-4. | |
JP2017532343A5 (ja) | ||
PH12019501216A1 (en) | New compounds as peptidic trigonal glp1/glucagon/gip receptor agonists | |
JP2014526441A5 (ja) | ||
WO2017009236A3 (en) | New exendin-4 derivatives as selective peptidic dual glp-1 / glucagon receptor agonists | |
JP2016222689A5 (ja) | 合成ペプチド及び乾燥粉末薬剤輸送システム | |
JP2016515123A5 (ja) | ||
JP2015517488A5 (ja) | ||
JP2016509011A5 (ja) | ||
JP2015518818A5 (ja) | ||
MX2016013244A (es) | Derivados de exendina-4 como agonistas peptidicos duales del receptor de glp-1/glucagon. | |
MY187047A (en) | Selective pyy compounds and uses thereof | |
JP2016532690A5 (ja) | ||
EA201290964A1 (ru) | Пептидные конъюгаты агонистов рецептора glp-1 и их применение | |
NZ726623A (en) | Improved peptide pharmaceuticals for insulin resistance | |
JP2012041342A5 (ja) | ||
MX360208B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
MX360211B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
CL2014000458A1 (es) | Compuestos derivados de 2-amino-4-(piridin-2-il)-5,6-dihidro-4h-1,3-oxazina; composicion y combinacion farmaceutica; y uso en el tratamiento o en la prevencion del alzheimer, diabetes tipo 2, obesidad, entre otras enfermedades. | |
NZ608502A (en) | Polypeptides that bind to human complement component c5 | |
JP2015110588A5 (ja) | ||
MX2019006427A (es) | Nuevos compuestos como agonistas peptidicos de receptores de glp1/glucagon/gip. | |
EA201691789A1 (ru) | Фармацевтические композиции и соли 1,2,4-оксадиазолбензойной кислоты | |
WO2011112867A8 (en) | The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas |