AU2014236728B2 - Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides - Google Patents

Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides Download PDF

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Publication number
AU2014236728B2
AU2014236728B2 AU2014236728A AU2014236728A AU2014236728B2 AU 2014236728 B2 AU2014236728 B2 AU 2014236728B2 AU 2014236728 A AU2014236728 A AU 2014236728A AU 2014236728 A AU2014236728 A AU 2014236728A AU 2014236728 B2 AU2014236728 B2 AU 2014236728B2
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Australia
Prior art keywords
pla2g12a
amino acid
polypeptide
seq
pct
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AU2014236728A
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AU2014236728A1 (en
Inventor
Yang Li
Daniel C. H. Lin
Jinghong Wang
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Amgen Inc
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Amgen Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01004—Phospholipase A2 (3.1.1.4)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
AU2014236728A 2013-03-15 2014-03-13 Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides Active AU2014236728B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361793503P 2013-03-15 2013-03-15
US61/793,503 2013-03-15
PCT/US2014/026736 WO2014151962A1 (en) 2013-03-15 2014-03-13 Method of treating metabolic disorders using pla2g12a polypeptides and pla2g12a mutant polypeptides

Publications (2)

Publication Number Publication Date
AU2014236728A1 AU2014236728A1 (en) 2015-09-24
AU2014236728B2 true AU2014236728B2 (en) 2018-09-13

Family

ID=50483573

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AU2014236728A Active AU2014236728B2 (en) 2013-03-15 2014-03-13 Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides

Country Status (6)

Country Link
US (1) US9474792B2 (https=)
EP (1) EP2968480B1 (https=)
JP (1) JP6434485B2 (https=)
AU (1) AU2014236728B2 (https=)
CA (1) CA2906540C (https=)
WO (1) WO2014151962A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9474792B2 (en) 2013-03-15 2016-10-25 Amgen Inc. Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides
US10436802B2 (en) 2014-09-12 2019-10-08 Biogen Ma Inc. Methods for treating spinal muscular atrophy
EP3263600A1 (en) 2016-07-01 2018-01-03 Université Claude Bernard Lyon 1 Inhibition of pla2r1 for the prevention and/or the treatment of type 2-diabetes
JP2022532153A (ja) * 2019-05-08 2022-07-13 ツインピッグ バイオラブ インコーポレイテッド ホスホリパーゼａ２を有効成分として含む肥満予防または治療用組成物
JP7852185B2 (ja) * 2019-07-02 2026-04-28 フンダシオン・パラ・ラ・インベスティガシオン・メディカ・アプリカダ ｃＰＬＡ２ｅ誘導剤及びその使用
CN120505310A (zh) * 2020-02-28 2025-08-19 Ionis制药公司 用于调节smn2的化合物和方法
EP4504052A4 (en) * 2022-04-01 2026-04-01 Massachusetts Gen Hospital VECTORS AND METHODS FOR THE TREATMENT OF NEURODEGENERESCENCE, DELAYING COGNITIVE DECLINE AND IMPROVING MEMORY

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012151159A1 (en) * 2011-05-02 2012-11-08 Ngm Biopharmaceuticals, Inc. Methods of modulating pla2g12a levels and treating disorders associated therewith

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
DE3474511D1 (en) 1983-11-01 1988-11-17 Terumo Corp Pharmaceutical composition containing urokinase
US6565841B1 (en) 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5470582A (en) 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
DE69939707D1 (de) * 1998-12-24 2008-11-20 Sylus Pharmaceuticals Ltd Varianten der humanen glycosylphosphatidylinositol-spezifischen phospholipase d und ihre verwendungen
US20140099295A1 (en) * 2011-05-02 2014-04-10 Ngm Biopharmaceuticals, Inc. Methods of Treating Glucose Metabolism Disorders
US9474792B2 (en) 2013-03-15 2016-10-25 Amgen Inc. Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012151159A1 (en) * 2011-05-02 2012-11-08 Ngm Biopharmaceuticals, Inc. Methods of modulating pla2g12a levels and treating disorders associated therewith

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MORGANE ROUAULT ET AL, "Novel Mammalian Group XII Secreted Phospholipase A 2 Lacking Enzymatic Activity + , +", BIOCHEMISTRY, (2003-10), vol. 42, no. 39, doi:10.1021/bi0349930, ISSN 0006-2960, pages 11494 - 11503 *

Also Published As

Publication number Publication date
WO2014151962A1 (en) 2014-09-25
AU2014236728A1 (en) 2015-09-24
EP2968480A1 (en) 2016-01-20
US20160008439A1 (en) 2016-01-14
JP2016515123A (ja) 2016-05-26
EP2968480B1 (en) 2020-10-14
JP6434485B2 (ja) 2018-12-05
CA2906540A1 (en) 2014-09-25
CA2906540C (en) 2021-01-12
US9474792B2 (en) 2016-10-25

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