JP2016515120A5 - - Google Patents
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- JP2016515120A5 JP2016515120A5 JP2016502082A JP2016502082A JP2016515120A5 JP 2016515120 A5 JP2016515120 A5 JP 2016515120A5 JP 2016502082 A JP2016502082 A JP 2016502082A JP 2016502082 A JP2016502082 A JP 2016502082A JP 2016515120 A5 JP2016515120 A5 JP 2016515120A5
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- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 16
- 208000033626 Renal failure acute Diseases 0.000 claims description 16
- 201000011040 acute kidney failure Diseases 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 14
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 239000012634 fragment Substances 0.000 claims description 11
- 230000002485 urinary effect Effects 0.000 claims description 10
- 210000004408 hybridoma Anatomy 0.000 claims description 8
- 210000002966 serum Anatomy 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 229940109239 creatinine Drugs 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- 231100000637 nephrotoxin Toxicity 0.000 claims description 6
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 4
- 206010016654 Fibrosis Diseases 0.000 claims description 4
- 102000013382 Gelatinases Human genes 0.000 claims description 4
- 108010026132 Gelatinases Proteins 0.000 claims description 4
- 102000019298 Lipocalin Human genes 0.000 claims description 4
- 108050006654 Lipocalin Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 206010040047 Sepsis Diseases 0.000 claims description 4
- 206010047139 Vasoconstriction Diseases 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000000747 cardiac effect Effects 0.000 claims description 4
- 230000007882 cirrhosis Effects 0.000 claims description 4
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 4
- 239000002872 contrast media Substances 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 4
- 230000003589 nefrotoxic effect Effects 0.000 claims description 4
- 231100000381 nephrotoxic Toxicity 0.000 claims description 4
- 210000000440 neutrophil Anatomy 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 4
- 238000001356 surgical procedure Methods 0.000 claims description 4
- 230000009885 systemic effect Effects 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- 230000025033 vasoconstriction Effects 0.000 claims description 4
- 230000024883 vasodilation Effects 0.000 claims description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 claims description 2
- 102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 claims description 2
- 108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 claims description 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 2
- 102100031092 C-C motif chemokine 3 Human genes 0.000 claims description 2
- 101710155856 C-C motif chemokine 3 Proteins 0.000 claims description 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000025962 Crush injury Diseases 0.000 claims description 2
- 102000012192 Cystatin C Human genes 0.000 claims description 2
- 108010061642 Cystatin C Proteins 0.000 claims description 2
- 229940123457 Free radical scavenger Drugs 0.000 claims description 2
- 206010019280 Heart failures Diseases 0.000 claims description 2
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims description 2
- 101710185991 Hepatitis A virus cellular receptor 1 homolog Proteins 0.000 claims description 2
- 208000037147 Hypercalcaemia Diseases 0.000 claims description 2
- 206010058558 Hypoperfusion Diseases 0.000 claims description 2
- 229940124790 IL-6 inhibitor Drugs 0.000 claims description 2
- 102000003810 Interleukin-18 Human genes 0.000 claims description 2
- 108090000171 Interleukin-18 Proteins 0.000 claims description 2
- 208000000913 Kidney Calculi Diseases 0.000 claims description 2
- 208000019693 Lung disease Diseases 0.000 claims description 2
- 239000000637 Melanocyte-Stimulating Hormone Substances 0.000 claims description 2
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims description 2
- 206010028629 Myoglobinuria Diseases 0.000 claims description 2
- 206010028851 Necrosis Diseases 0.000 claims description 2
- 206010029148 Nephrolithiasis Diseases 0.000 claims description 2
- 206010029164 Nephrotic syndrome Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 208000025584 Pericardial disease Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010051739 Pulmonary sepsis Diseases 0.000 claims description 2
- 108091000182 THR-184 Proteins 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 2
- 229960003942 amphotericin b Drugs 0.000 claims description 2
- 230000036783 anaphylactic response Effects 0.000 claims description 2
- 208000003455 anaphylaxis Diseases 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000002424 anti-apoptotic effect Effects 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 230000000740 bleeding effect Effects 0.000 claims description 2
- 229940046731 calcineurin inhibitors Drugs 0.000 claims description 2
- 206010007625 cardiogenic shock Diseases 0.000 claims description 2
- 238000013132 cardiothoracic surgery Methods 0.000 claims description 2
- 239000002576 chemokine receptor CXCR4 antagonist Substances 0.000 claims description 2
- 229940044683 chemotherapy drug Drugs 0.000 claims description 2
- 239000000812 cholinergic antagonist Substances 0.000 claims description 2
- 208000020832 chronic kidney disease Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 229940121384 cxc chemokine receptor type 4 (cxcr4) antagonist Drugs 0.000 claims description 2
- 201000003146 cystitis Diseases 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 230000004064 dysfunction Effects 0.000 claims description 2
- 208000028208 end stage renal disease Diseases 0.000 claims description 2
- 201000000523 end stage renal failure Diseases 0.000 claims description 2
- 230000006870 function Effects 0.000 claims description 2
- 230000007661 gastrointestinal function Effects 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 229910001385 heavy metal Inorganic materials 0.000 claims description 2
- 201000011200 hepatorenal syndrome Diseases 0.000 claims description 2
- 230000000148 hypercalcaemia Effects 0.000 claims description 2
- 208000030915 hypercalcemia disease Diseases 0.000 claims description 2
- 239000002117 illicit drug Substances 0.000 claims description 2
- 102000006495 integrins Human genes 0.000 claims description 2
- 108010044426 integrins Proteins 0.000 claims description 2
- 230000000302 ischemic effect Effects 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 230000003907 kidney function Effects 0.000 claims description 2
- 230000027939 micturition Effects 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 239000002516 radical scavenger Substances 0.000 claims description 2
- 229940044551 receptor antagonist Drugs 0.000 claims description 2
- 239000002464 receptor antagonist Substances 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 230000008736 traumatic injury Effects 0.000 claims description 2
- 238000007631 vascular surgery Methods 0.000 claims description 2
- 229940124549 vasodilator Drugs 0.000 claims description 2
- 239000003071 vasodilator agent Substances 0.000 claims description 2
- 229940125799 αvβ5 integrin inhibitor Drugs 0.000 claims description 2
- 229940126135 αvβ6 integrin inhibitor Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 41
- 230000003247 decreasing effect Effects 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 38
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792681P | 2013-03-15 | 2013-03-15 | |
| US61/792,681 | 2013-03-15 | ||
| US201361898811P | 2013-11-01 | 2013-11-01 | |
| US61/898,811 | 2013-11-01 | ||
| PCT/US2014/026234 WO2014151680A1 (en) | 2013-03-15 | 2014-03-13 | Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016515120A JP2016515120A (ja) | 2016-05-26 |
| JP2016515120A5 true JP2016515120A5 (https=) | 2017-03-23 |
Family
ID=50483565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502082A Pending JP2016515120A (ja) | 2013-03-15 | 2014-03-13 | 抗アルファｖベータ５抗体を用いた急性腎損傷の治療及び予防 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20160017041A1 (https=) |
| EP (1) | EP2970475A1 (https=) |
| JP (1) | JP2016515120A (https=) |
| KR (1) | KR20150128796A (https=) |
| CN (1) | CN105392801A (https=) |
| AU (1) | AU2014236986A1 (https=) |
| CA (1) | CA2903546A1 (https=) |
| EA (1) | EA201591806A1 (https=) |
| HK (1) | HK1219740A1 (https=) |
| IL (1) | IL240692A0 (https=) |
| MX (1) | MX2015011670A (https=) |
| WO (1) | WO2014151680A1 (https=) |
| ZA (1) | ZA201506085B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2456460A4 (en) * | 2009-07-24 | 2013-02-20 | Univ California | METHOD AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASES ASSOCIATED WITH AVB5 INTEGRIN |
| US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
| ES2836849T3 (es) | 2014-11-21 | 2021-06-28 | Nokia Technologies Oy | Un aparato, procedimiento y programa de ordenador para identificar rasgos biométricos |
| FI3380522T3 (fi) | 2015-11-25 | 2024-01-16 | Visterra Inc | Vasta-ainemolekyylejä april-proteiinille ja niiden käyttöjä |
| WO2017181152A2 (en) | 2016-04-15 | 2017-10-19 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| MX2018012472A (es) | 2016-04-15 | 2019-08-12 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras variantes de ligando icos y sus usos. |
| WO2018022946A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd155 variant immunomodulatory proteins and uses thereof |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
| SG11201907769XA (en) | 2017-03-16 | 2019-09-27 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
| EP3596116B1 (en) | 2017-03-16 | 2023-09-06 | Alpine Immune Sciences, Inc. | Pd-l1 variant immunomodulatory proteins and uses thereof |
| KR20190141146A (ko) | 2017-03-16 | 2019-12-23 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Pd-l2 변이체 면역조절 단백질 및 그의 용도 |
| JP7749319B2 (ja) | 2017-10-10 | 2025-10-06 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用 |
| BR112020007542A2 (pt) | 2017-10-18 | 2020-12-01 | Alpine Immune Sciences, Inc. | proteínas imunomoduladoras ligantes de icos variantes e composições e métodos relacionados |
| AU2019205273B2 (en) | 2018-01-03 | 2024-04-04 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| AU2019247511B2 (en) | 2018-04-06 | 2025-10-16 | Atyr Pharma, Inc. | Compositions and methods comprising anti-NRP2 antibodies |
| WO2019241758A1 (en) | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
| EP3853247A2 (en) | 2018-09-19 | 2021-07-28 | Alpine Immune Sciences, Inc. | Methods and uses of variant cd80 fusion proteins and related constructs |
| WO2020071518A1 (ja) * | 2018-10-04 | 2020-04-09 | 学校法人自治医科大学 | 急性腎障害特異的バイオマーカー、急性腎障害の診断方法、急性腎障害の検査用キット、動物治療方法、及び急性腎障害用医薬 |
| CA3120868A1 (en) | 2018-11-30 | 2020-06-04 | Alpine Immune Sciences, Inc. | Cd86 variant immunomodulatory proteins and uses thereof |
| MX2021012607A (es) | 2019-04-17 | 2022-03-11 | Alpine Immune Sciences Inc | Metodos y usos de proteinas de fusion de ligando icos (icosl) variante. |
| EP4021497B1 (en) * | 2019-08-30 | 2026-02-25 | Kashiv Biosciences, LLC | Novel formulation of highly concentrated pharmacologically active antibody |
| CA3156803A1 (en) * | 2019-10-03 | 2021-04-08 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| EP4146684A2 (en) | 2020-05-08 | 2023-03-15 | Alpine Immune Sciences, Inc. | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
| WO2022047316A1 (en) | 2020-08-28 | 2022-03-03 | Sana Biotechnology, Inc. | Modified anti-viral binding agents |
| US20240279310A1 (en) | 2021-05-07 | 2024-08-22 | Alpine Immune Sciences, Inc. | Methods of dosing and treatment with a taci-fc fusion immunomodulatory protein |
| WO2023172883A1 (en) | 2022-03-07 | 2023-09-14 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins of variant cd80 polypeptides, cell therapies thereof and related methods and uses |
| KR20250099778A (ko) | 2022-10-04 | 2025-07-02 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 자가항체-매개 질환의 치료에 사용하기 위한 돌연변이된 taci-fc 융합 단백질 |
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-
2014
- 2014-03-13 JP JP2016502082A patent/JP2016515120A/ja active Pending
- 2014-03-13 MX MX2015011670A patent/MX2015011670A/es unknown
- 2014-03-13 CN CN201480022904.2A patent/CN105392801A/zh active Pending
- 2014-03-13 HK HK16107624.1A patent/HK1219740A1/zh unknown
- 2014-03-13 EP EP14717335.5A patent/EP2970475A1/en not_active Withdrawn
- 2014-03-13 AU AU2014236986A patent/AU2014236986A1/en not_active Abandoned
- 2014-03-13 US US14/770,522 patent/US20160017041A1/en not_active Abandoned
- 2014-03-13 CA CA2903546A patent/CA2903546A1/en not_active Abandoned
- 2014-03-13 EA EA201591806A patent/EA201591806A1/ru unknown
- 2014-03-13 WO PCT/US2014/026234 patent/WO2014151680A1/en not_active Ceased
- 2014-03-13 KR KR1020157027340A patent/KR20150128796A/ko not_active Withdrawn
-
2015
- 2015-08-20 IL IL240692A patent/IL240692A0/en unknown
- 2015-08-21 ZA ZA2015/06085A patent/ZA201506085B/en unknown
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