JP2016513723A5 - - Google Patents
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- Publication number
- JP2016513723A5 JP2016513723A5 JP2016502690A JP2016502690A JP2016513723A5 JP 2016513723 A5 JP2016513723 A5 JP 2016513723A5 JP 2016502690 A JP2016502690 A JP 2016502690A JP 2016502690 A JP2016502690 A JP 2016502690A JP 2016513723 A5 JP2016513723 A5 JP 2016513723A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- item
- formulated
- thiosemicarbazone
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 21
- -1 thiosemicarbazone compound Chemical class 0.000 claims description 7
- XMYKNCNAZKMVQN-NYYWCZLTSA-N [(e)-(3-aminopyridin-2-yl)methylideneamino]thiourea Chemical compound NC(=S)N\N=C\C1=NC=CC=C1N XMYKNCNAZKMVQN-NYYWCZLTSA-N 0.000 claims description 4
- 238000007918 intramuscular administration Methods 0.000 claims description 4
- 238000007912 intraperitoneal administration Methods 0.000 claims description 4
- 239000002502 liposome Substances 0.000 claims description 4
- 238000007920 subcutaneous administration Methods 0.000 claims description 4
- 230000000699 topical effect Effects 0.000 claims description 4
- 208000027104 Chemotherapy-Related Cognitive Impairment Diseases 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 229960005526 triapine Drugs 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims 2
- 230000001149 cognitive effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 150000003584 thiosemicarbazones Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 13
- 229940102223 injectable solution Drugs 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 239000004530 micro-emulsion Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000010877 cognitive disease Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/803,482 | 2013-03-14 | ||
| US13/803,482 US20140271812A1 (en) | 2013-03-14 | 2013-03-14 | Treatment for chemotherapy-induced cognitive impairment |
| PCT/US2014/028039 WO2014152864A1 (en) | 2013-03-14 | 2014-03-14 | Treatment for chemotherapy-induced cognitive impairment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018013721A Division JP2018062537A (ja) | 2013-03-14 | 2018-01-30 | 化学療法誘発認知障害の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513723A JP2016513723A (ja) | 2016-05-16 |
| JP2016513723A5 true JP2016513723A5 (https=) | 2017-04-13 |
| JP6293258B2 JP6293258B2 (ja) | 2018-03-14 |
Family
ID=51528048
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502690A Expired - Fee Related JP6293258B2 (ja) | 2013-03-14 | 2014-03-14 | 化学療法誘発認知障害の処置 |
| JP2018013721A Withdrawn JP2018062537A (ja) | 2013-03-14 | 2018-01-30 | 化学療法誘発認知障害の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018013721A Withdrawn JP2018062537A (ja) | 2013-03-14 | 2018-01-30 | 化学療法誘発認知障害の処置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140271812A1 (https=) |
| EP (1) | EP2968319B1 (https=) |
| JP (2) | JP6293258B2 (https=) |
| CA (1) | CA2905403A1 (https=) |
| WO (1) | WO2014152864A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2984379C (en) * | 2015-04-28 | 2024-06-11 | Newsouth Innovations Pty Limited | Targeting nad+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies, and inactivity |
| WO2019147839A1 (en) * | 2018-01-24 | 2019-08-01 | Sensei Biotherapeutics, Inc. | Methods and compositions for preserving neurogenesis |
| WO2022138842A1 (ja) * | 2020-12-24 | 2022-06-30 | 参天製薬株式会社 | エピナスチン又はその塩と硫黄系抗酸化剤を含有する経皮投与用医薬組成物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447427A (en) | 1979-01-04 | 1984-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method for treating bacterial infections with 2-acetyl- and 2-propionylpyridine thiosemicarbazones |
| US5180831A (en) * | 1990-08-10 | 1993-01-19 | Georgia Tech Research Corporation | Quaternary pyridinium compounds |
| US5281715A (en) | 1992-05-13 | 1994-01-25 | Yale University | 2-formylpyridine thiosemicarbazone compounds |
| US6114376A (en) * | 1997-04-30 | 2000-09-05 | Mcgill University | Methods for using macrocyclic lactone compounds as multidrug resistance reversing agents in tumor and other cells |
| US5869676A (en) | 1997-05-15 | 1999-02-09 | Vion Pharmaceuticals, Inc. | Process for the synthesis of ribonucleotide reductase inhibitors 3-AP and 3-AMP |
| US5767134A (en) | 1997-05-15 | 1998-06-16 | Vion Pharmaceuticals, Inc. | Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-AMP |
| EP1626718A4 (en) | 2003-05-01 | 2010-05-05 | Panacea Pharmaceuticals Inc | METHOD FOR THE TREATMENT OF ISCHEMIC ILLNESSES |
| US20060194810A1 (en) | 2004-04-30 | 2006-08-31 | Bijan Almassian | Methods of treating ischemic related conditions |
| US20070243132A1 (en) * | 2005-12-22 | 2007-10-18 | Apollo Life Sciences Limited | Transdermal delivery of pharmaceutical agents |
| US20080039471A1 (en) * | 2006-08-14 | 2008-02-14 | Ghanbari Hossein A | Composition and method to inhibit tissue plasminogen activator (tPA) - potentiated neurotoxicity |
| EP2121681B1 (en) * | 2007-01-11 | 2015-04-15 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
| US20090286799A1 (en) * | 2008-05-16 | 2009-11-19 | Zhi-Gang Jiang | Methods for the treatment of brain edema |
| WO2010054260A1 (en) * | 2008-11-07 | 2010-05-14 | Biotie Therapies Gmbh | Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases |
| EP2379493B1 (en) * | 2008-12-12 | 2015-10-14 | The University of Melbourne | Process for the preparation of asymmetrical bis(thiosemicarbazones) |
| CN111789956B (zh) * | 2011-04-27 | 2023-02-17 | 耶鲁大学 | 用于抑制化疗引起副作用的药物治疗、筛选技术和试剂盒 |
-
2013
- 2013-03-14 US US13/803,482 patent/US20140271812A1/en not_active Abandoned
-
2014
- 2014-03-14 EP EP14770876.2A patent/EP2968319B1/en active Active
- 2014-03-14 CA CA2905403A patent/CA2905403A1/en not_active Abandoned
- 2014-03-14 JP JP2016502690A patent/JP6293258B2/ja not_active Expired - Fee Related
- 2014-03-14 WO PCT/US2014/028039 patent/WO2014152864A1/en not_active Ceased
-
2018
- 2018-01-30 JP JP2018013721A patent/JP2018062537A/ja not_active Withdrawn
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