JP2016513696A5 - - Google Patents
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- JP2016513696A5 JP2016513696A5 JP2016502433A JP2016502433A JP2016513696A5 JP 2016513696 A5 JP2016513696 A5 JP 2016513696A5 JP 2016502433 A JP2016502433 A JP 2016502433A JP 2016502433 A JP2016502433 A JP 2016502433A JP 2016513696 A5 JP2016513696 A5 JP 2016513696A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- substituted
- optionally
- compound
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 28
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 9
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000004450 alkenylene group Chemical group 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 125000004419 alkynylene group Chemical group 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010003816 Autoimmune disease Diseases 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 102000004157 Hydrolases Human genes 0.000 claims 1
- 108090000604 Hydrolases Proteins 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 230000001668 ameliorated Effects 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 200000000018 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrugs Drugs 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- -1 substituted Chemical class 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 0 *c1c2ncc(C(c3ccccc3)=O)c[n]2nc1N(*)*c1ccccc1 Chemical compound *c1c2ncc(C(c3ccccc3)=O)c[n]2nc1N(*)*c1ccccc1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361781193P | 2013-03-14 | 2013-03-14 | |
| US61/781,193 | 2013-03-14 | ||
| PCT/US2014/027428 WO2014152518A2 (en) | 2013-03-14 | 2014-03-14 | Inhibitors of leukotriene a4 hydrolase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513696A JP2016513696A (ja) | 2016-05-16 |
| JP2016513696A5 true JP2016513696A5 (US20080131398A1-20080605-C00009.png) | 2017-04-13 |
| JP6534650B2 JP6534650B2 (ja) | 2019-06-26 |
Family
ID=51581716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502433A Active JP6534650B2 (ja) | 2013-03-14 | 2014-03-14 | ロイコトリエンａ４加水分解酵素の阻害剤 |
Country Status (10)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2905340C (en) | 2013-03-12 | 2022-05-31 | Celtaxsys, Inc. | Low dose oral formulations of acebilustat |
| AU2014240042C1 (en) | 2013-03-14 | 2019-09-05 | Celltaxis, Llc | Inhibitors of leukotriene A4 hydrolase |
| WO2014152536A2 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| CN104530153A (zh) * | 2015-01-15 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类苯基s-葡萄糖苷衍生物、其制备方法和在医药上的用途 |
| CN104530152A (zh) * | 2015-01-15 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一种含丙烯腈基和三氟甲氧苯基o-葡萄糖苷结构化合物及用途 |
| CN104530151A (zh) * | 2015-01-15 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一种含硝基苯s-葡萄糖苷结构的化合物及其用途 |
| AU2017371353B2 (en) | 2016-12-09 | 2022-02-03 | Celltaxis, Llc | Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase |
| US11498903B2 (en) | 2017-08-17 | 2022-11-15 | Bristol-Myers Squibb Company | 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases |
| WO2019222265A1 (en) * | 2018-05-15 | 2019-11-21 | Alkahest, Inc. | Treatment of aging-associated disease with modulators of leukotriene a4 hydrolase |
| EP3801559A4 (en) | 2018-05-31 | 2022-03-02 | Celltaxis, LLC | METHOD FOR REDUCING LUNG EXACERBATIONS IN PATIENTS SUFFERING FROM RESPIRATORY DISEASE |
| US11155560B2 (en) | 2018-10-30 | 2021-10-26 | Kronos Bio, Inc. | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity |
| US11708366B2 (en) | 2020-08-14 | 2023-07-25 | Novartis Ag | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof |
| US11957671B2 (en) | 2021-11-01 | 2024-04-16 | Alkahest, Inc. | Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases |
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| JP2014515370A (ja) | 2011-05-23 | 2014-06-30 | ヤンセン ファーマシューティカ エヌ．ベー． | グルカゴン受容体拮抗薬として有用なピコリンアミド−プロパン酸誘導体 |
| CN103159742B (zh) | 2011-12-16 | 2015-08-12 | 北京韩美药品有限公司 | 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用 |
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| CA2905340C (en) | 2013-03-12 | 2022-05-31 | Celtaxsys, Inc. | Low dose oral formulations of acebilustat |
| AU2014240042C1 (en) | 2013-03-14 | 2019-09-05 | Celltaxis, Llc | Inhibitors of leukotriene A4 hydrolase |
| WO2014152536A2 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
-
2014
- 2014-03-14 WO PCT/US2014/027428 patent/WO2014152518A2/en active Application Filing
- 2014-03-14 JP JP2016502433A patent/JP6534650B2/ja active Active
- 2014-03-14 CA CA2906084A patent/CA2906084A1/en not_active Abandoned
- 2014-03-14 RU RU2015137975A patent/RU2678196C2/ru not_active IP Right Cessation
- 2014-03-14 AU AU2014239567A patent/AU2014239567B2/en not_active Ceased
- 2014-03-14 MX MX2015011678A patent/MX2015011678A/es unknown
- 2014-03-14 EP EP14769747.8A patent/EP2970309A4/en not_active Withdrawn
- 2014-03-14 KR KR1020157028772A patent/KR20150127246A/ko not_active Application Discontinuation
- 2014-03-14 BR BR112015022864A patent/BR112015022864A8/pt not_active Application Discontinuation
-
2015
- 2015-09-10 US US14/849,825 patent/US9777006B2/en active Active
-
2017
- 2017-09-14 US US15/704,199 patent/US10399986B2/en not_active Expired - Fee Related
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