JP2016513128A5 - - Google Patents
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- JP2016513128A5 JP2016513128A5 JP2015559275A JP2015559275A JP2016513128A5 JP 2016513128 A5 JP2016513128 A5 JP 2016513128A5 JP 2015559275 A JP2015559275 A JP 2015559275A JP 2015559275 A JP2015559275 A JP 2015559275A JP 2016513128 A5 JP2016513128 A5 JP 2016513128A5
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- JP
- Japan
- Prior art keywords
- compound according
- group
- atoms
- ring
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 18
- 125000004429 atom Chemical group 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 239000011593 sulfur Substances 0.000 claims 4
- 238000002255 vaccination Methods 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000006413 ring segment Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000004678 hydrides Chemical class 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768712P | 2013-02-25 | 2013-02-25 | |
| US61/768,712 | 2013-02-25 | ||
| PCT/US2014/018380 WO2014131023A1 (en) | 2013-02-25 | 2014-02-25 | Neoseptins: small molecule adjuvants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513128A JP2016513128A (ja) | 2016-05-12 |
| JP2016513128A5 true JP2016513128A5 (https=) | 2017-04-06 |
| JP6356160B2 JP6356160B2 (ja) | 2018-07-11 |
Family
ID=51391916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015559275A Expired - Fee Related JP6356160B2 (ja) | 2013-02-25 | 2014-02-25 | ネオセプチン：低分子アジュバント |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9649373B2 (https=) |
| EP (1) | EP2958889B1 (https=) |
| JP (1) | JP6356160B2 (https=) |
| CN (1) | CN105339346B (https=) |
| AU (1) | AU2014218598B2 (https=) |
| CA (1) | CA2902342C (https=) |
| WO (1) | WO2014131023A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10037382B2 (en) | 2012-10-29 | 2018-07-31 | Kyocera Corporation | Surface acoustic wave sensor |
| WO2016011195A1 (en) | 2014-07-17 | 2016-01-21 | Threshold Pharmaceuticals, Inc. | Th-302 solid forms and methods related thereto |
| BR112017019287B1 (pt) | 2015-03-10 | 2024-01-02 | Obi Pharma, Inc | Composto, e composição farmaceuticamente aceitável |
| US10829437B2 (en) * | 2015-04-02 | 2020-11-10 | Obi Pharma, Inc. | Nitrobenzyl derivatives of anti-cancer agents |
| WO2016210175A1 (en) | 2015-06-24 | 2016-12-29 | Threshold Pharmaceuticals, Inc. | Aziridine containing dna alkylating agents |
| US20180327364A1 (en) * | 2015-11-13 | 2018-11-15 | Brandeis University | Mtor inhibitors and methods of use thereof |
| KR102522730B1 (ko) * | 2016-06-29 | 2023-04-19 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 디프로보심: 새로운 강력한 부류의 tlr 작용제 |
| JP7304855B2 (ja) | 2017-11-14 | 2023-07-07 | ザ チルドレンズ メディカル センター コーポレーション | 新規イミダゾピリミジン化合物およびそれらの使用 |
| CN111587114A (zh) | 2017-11-14 | 2020-08-25 | 儿童医学中心公司 | 用于调节人免疫应答的咪唑并嘧啶的用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4031083A (en) | 1975-10-24 | 1977-06-21 | Yeda Research And Development Co., Ltd. | Cephalosporin antibiotics |
| US4045438A (en) | 1975-10-24 | 1977-08-30 | Yeda Research And Development Co. Ltd. | Cephalosporin antibiotics |
| WO2005016235A2 (en) * | 2003-04-14 | 2005-02-24 | The Regents Of The University Of California | Combined use of impdh inhibitors with toll-like receptor agonists |
| CA2611721C (en) | 2005-06-30 | 2014-04-22 | Eisai Co., Ltd. | Compounds for preparing immunological adjuvant |
| ES2577514T3 (es) | 2005-08-22 | 2016-07-15 | The Regents Of The University Of California | Antagonistas de TLR |
| EP2043672A4 (en) * | 2006-07-07 | 2009-10-21 | Univ Leland Stanford Junior | SELECTIVE INHIBITORS OF CASPASES |
| ES2552471T3 (es) * | 2007-02-07 | 2015-11-30 | The Regents Of The University Of California | Conjugados de agonistas de TLR sintéticos y usos de los mismos |
| PT2268618E (pt) * | 2008-03-03 | 2015-10-12 | Novartis Ag | Compostos e composições moduladores da actividade tlr |
| WO2010037402A1 (en) * | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US20110293565A1 (en) * | 2009-01-30 | 2011-12-01 | Idera Pharmaceuticals, Inc. | Novel synthetic agonists of tlr9 |
-
2014
- 2014-02-25 EP EP14754704.6A patent/EP2958889B1/en not_active Not-in-force
- 2014-02-25 AU AU2014218598A patent/AU2014218598B2/en not_active Ceased
- 2014-02-25 JP JP2015559275A patent/JP6356160B2/ja not_active Expired - Fee Related
- 2014-02-25 WO PCT/US2014/018380 patent/WO2014131023A1/en not_active Ceased
- 2014-02-25 CA CA2902342A patent/CA2902342C/en not_active Expired - Fee Related
- 2014-02-25 CN CN201480023040.6A patent/CN105339346B/zh not_active Expired - Fee Related
- 2014-02-25 US US14/770,002 patent/US9649373B2/en not_active Expired - Fee Related
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