JP2016512830A - 終末糖化産物（ａｇｅ）前駆体の捕捉剤 - Google Patents

終末糖化産物（ａｇｅ）前駆体の捕捉剤 Download PDF

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Publication number
JP2016512830A
JP2016512830A JP2016501535A JP2016501535A JP2016512830A JP 2016512830 A JP2016512830 A JP 2016512830A JP 2016501535 A JP2016501535 A JP 2016501535A JP 2016501535 A JP2016501535 A JP 2016501535A JP 2016512830 A JP2016512830 A JP 2016512830A
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pharmaceutical composition
alkyl
composition according
cycloalkyl
cooh
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JP2016512830A5 (https=
Inventor
スティーブン・ランドール・ホルムズ−ファーリー
プラディープ・ダル
マグナス・ベセヴ
ロバート・ジェイ・ミラー
アンドリュー・ティー・パプーリス
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Genzyme Corp
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Genzyme Corp
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Publication of JP2016512830A5 publication Critical patent/JP2016512830A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F126/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F126/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
JP2016501535A 2013-03-15 2014-03-12 終末糖化産物（ａｇｅ）前駆体の捕捉剤 Pending JP2016512830A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792719P 2013-03-15 2013-03-15
US61/792,719 2013-03-15
PCT/US2014/024436 WO2014150873A1 (en) 2013-03-15 2014-03-12 Sequestrants of advanced glycation end product (age) precursors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018083623A Division JP2018135365A (ja) 2013-03-15 2018-04-25 終末糖化産物（ａｇｅ）前駆体の捕捉剤

Publications (2)

Publication Number Publication Date
JP2016512830A true JP2016512830A (ja) 2016-05-09
JP2016512830A5 JP2016512830A5 (https=) 2017-03-30

Family

ID=50439508

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016501535A Pending JP2016512830A (ja) 2013-03-15 2014-03-12 終末糖化産物（ａｇｅ）前駆体の捕捉剤
JP2018083623A Pending JP2018135365A (ja) 2013-03-15 2018-04-25 終末糖化産物（ａｇｅ）前駆体の捕捉剤
JP2019220818A Pending JP2020055850A (ja) 2013-03-15 2019-12-06 終末糖化産物（ａｇｅ）前駆体の捕捉剤
JP2021204770A Pending JP2022037143A (ja) 2013-03-15 2021-12-17 終末糖化産物（ａｇｅ）前駆体の捕捉剤

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2018083623A Pending JP2018135365A (ja) 2013-03-15 2018-04-25 終末糖化産物（ａｇｅ）前駆体の捕捉剤
JP2019220818A Pending JP2020055850A (ja) 2013-03-15 2019-12-06 終末糖化産物（ａｇｅ）前駆体の捕捉剤
JP2021204770A Pending JP2022037143A (ja) 2013-03-15 2021-12-17 終末糖化産物（ａｇｅ）前駆体の捕捉剤

Country Status (24)

Country Link
US (2) US20160024233A1 (https=)
EP (1) EP2968403A1 (https=)
JP (4) JP2016512830A (https=)
KR (1) KR20150130492A (https=)
CN (1) CN105188718A (https=)
AR (1) AR095593A1 (https=)
AU (2) AU2014235500A1 (https=)
BR (1) BR112015023404A8 (https=)
CA (1) CA2906501A1 (https=)
CL (1) CL2015002624A1 (https=)
CR (1) CR20150545A (https=)
DO (1) DOP2015000221A (https=)
EA (1) EA201591733A1 (https=)
HK (1) HK1220607A1 (https=)
IL (1) IL241406A0 (https=)
MA (1) MA38487A1 (https=)
MX (1) MX2015012843A (https=)
PE (1) PE20151766A1 (https=)
PH (1) PH12015502019A1 (https=)
SG (2) SG10201707590XA (https=)
TN (1) TN2015000390A1 (https=)
TW (1) TW201521744A (https=)
UY (1) UY35441A (https=)
WO (1) WO2014150873A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41202A (fr) * 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
CN111405870A (zh) * 2017-08-31 2020-07-10 西托索尔本茨公司 从体液中降低晚期糖基化终末产物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985938A (en) * 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
JP2004535384A (ja) * 2001-04-18 2004-11-25 ジェンザイム コーポレーション 血清グルコースの減少方法
WO2005032563A1 (en) * 2003-09-02 2005-04-14 Genzyme Corporation Method for reducing vascular inflammation
US20050165190A1 (en) * 2003-11-03 2005-07-28 Symyx Therapeutics, Inc. Polyamine polymers
WO2011106542A2 (en) * 2010-02-24 2011-09-01 Relypsa, Inc. Crosslinked polyvrnylamine, poly all ylamine, and polyethyleneimine for use as bile acid sequestrants

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
AU2005214971A1 (en) * 2004-02-17 2005-09-01 Dynamis Therapeutics, Inc. Fructoseamine 3 kinase and the formation of collagen and elastin
FR2883873B1 (fr) * 2005-03-31 2009-07-10 Pharmamens Sarl Inhibiteurs d'age

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985938A (en) * 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
JP2004535384A (ja) * 2001-04-18 2004-11-25 ジェンザイム コーポレーション 血清グルコースの減少方法
WO2005032563A1 (en) * 2003-09-02 2005-04-14 Genzyme Corporation Method for reducing vascular inflammation
US20050165190A1 (en) * 2003-11-03 2005-07-28 Symyx Therapeutics, Inc. Polyamine polymers
WO2011106542A2 (en) * 2010-02-24 2011-09-01 Relypsa, Inc. Crosslinked polyvrnylamine, poly all ylamine, and polyethyleneimine for use as bile acid sequestrants

Also Published As

Publication number Publication date
IL241406A0 (en) 2015-11-30
KR20150130492A (ko) 2015-11-23
EP2968403A1 (en) 2016-01-20
WO2014150873A1 (en) 2014-09-25
CA2906501A1 (en) 2014-09-25
SG10201707590XA (en) 2017-11-29
US20180265613A1 (en) 2018-09-20
PE20151766A1 (es) 2015-12-11
PH12015502019A1 (en) 2016-01-11
EA201591733A1 (ru) 2016-01-29
US20160024233A1 (en) 2016-01-28
JP2018135365A (ja) 2018-08-30
MA38487A1 (fr) 2017-12-29
BR112015023404A8 (pt) 2019-12-03
TW201521744A (zh) 2015-06-16
JP2022037143A (ja) 2022-03-08
DOP2015000221A (es) 2015-12-15
MX2015012843A (es) 2016-08-08
UY35441A (es) 2014-10-31
CR20150545A (es) 2015-12-01
BR112015023404A2 (pt) 2017-07-18
HK1220607A1 (zh) 2017-05-12
AR095593A1 (es) 2015-10-28
TN2015000390A1 (en) 2017-01-03
CL2015002624A1 (es) 2016-03-11
JP2020055850A (ja) 2020-04-09
CN105188718A (zh) 2015-12-23
AU2019201259A1 (en) 2019-03-14
SG11201506413PA (en) 2015-09-29
AU2014235500A1 (en) 2015-11-05

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