JP2016511755A5 - - Google Patents
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- Publication number
- JP2016511755A5 JP2016511755A5 JP2015555829A JP2015555829A JP2016511755A5 JP 2016511755 A5 JP2016511755 A5 JP 2016511755A5 JP 2015555829 A JP2015555829 A JP 2015555829A JP 2015555829 A JP2015555829 A JP 2015555829A JP 2016511755 A5 JP2016511755 A5 JP 2016511755A5
- Authority
- JP
- Japan
- Prior art keywords
- factor
- pharmaceutical composition
- variant
- seconds
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759332P | 2013-01-31 | 2013-01-31 | |
| US61/759,332 | 2013-01-31 | ||
| PCT/IB2014/058494 WO2014118677A1 (en) | 2013-01-31 | 2014-01-23 | Compositions and methods for counteracting factor xa inhibition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018190856A Division JP2019077677A (ja) | 2013-01-31 | 2018-10-09 | 第Ｘａ因子の阻害を中和するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016511755A JP2016511755A (ja) | 2016-04-21 |
| JP2016511755A5 true JP2016511755A5 (cg-RX-API-DMAC10.html) | 2017-03-30 |
| JP6437458B2 JP6437458B2 (ja) | 2018-12-12 |
Family
ID=50114451
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015555829A Expired - Fee Related JP6437458B2 (ja) | 2013-01-31 | 2014-01-23 | 第Ｘａ因子の阻害を中和するための組成物および方法 |
| JP2018190856A Withdrawn JP2019077677A (ja) | 2013-01-31 | 2018-10-09 | 第Ｘａ因子の阻害を中和するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018190856A Withdrawn JP2019077677A (ja) | 2013-01-31 | 2018-10-09 | 第Ｘａ因子の阻害を中和するための組成物および方法 |
Country Status (12)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1215196A1 (zh) | 2013-01-31 | 2016-08-19 | 辉瑞公司 | 用於抵消因子xa抑制的组合物和方法 |
| CN112195169A (zh) | 2013-09-24 | 2021-01-08 | 辉瑞大药厂 | 包含重组人凝血因子Xa蛋白的异质性群体的组合物 |
| US20160235824A1 (en) * | 2013-11-01 | 2016-08-18 | The Children's Hospital Philadelphia | Compositions and Methods for Increasing the Half-Life of Factor XA |
| CN105934250A (zh) * | 2014-01-24 | 2016-09-07 | 辉瑞公司 | 治疗脑内出血的组合物和方法 |
| NZ727444A (en) | 2014-05-26 | 2021-12-24 | Academisch Ziekenhuis Leiden | Prohemostatic proteins for the treatment of bleeding |
| JP6776221B2 (ja) | 2014-07-31 | 2020-10-28 | ヘモネティクス・コーポレーションＨａｅｍｏｎｅｔｉｃｓ Ｃｏｒｐｏｒａｔｉｏｎ | 凝固分析を使用した抗凝固剤の検出および分類 |
| WO2016028872A2 (en) | 2014-08-19 | 2016-02-25 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor ix function |
| CN105440127B (zh) * | 2015-12-30 | 2018-10-16 | 上海莱士血液制品股份有限公司 | 一种以人血浆Cohn组分III为原料的FEIBA的制备方法 |
| TW201802121A (zh) | 2016-05-25 | 2018-01-16 | 諾華公司 | 抗因子XI/XIa抗體之逆轉結合劑及其用途 |
| KR102616666B1 (ko) | 2016-12-23 | 2023-12-27 | 노파르티스 아게 | 인자 xi 항체 및 사용 방법 |
| US12703762B2 (en) | 2018-12-18 | 2026-08-11 | Novartis Ag | Reversal binding agents for anti-factor XI/XIa antibodies and uses thereof |
| WO2020163685A1 (en) * | 2019-02-07 | 2020-08-13 | Portola Pharmaceuticals, Inc. | Methods for treating intracranial hemorrhage and assessing efficacy |
| CN114681597A (zh) * | 2022-03-11 | 2022-07-01 | 兆科药业（合肥）有限公司 | 蝰蛇蛇毒血凝酶在制备用于逆转凝血因子Xa抑制剂的抗凝作用的药物中的应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5597799A (en) | 1990-09-04 | 1997-01-28 | Cor Therapeutics, Inc. | Recombinant agents affecting thrombosis |
| US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| AT405517B (de) | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-deletionsmutanten und analoge davon |
| AT405516B (de) | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-analoge mit modifizierter proteasespaltstelle |
| US6133256A (en) | 1997-04-14 | 2000-10-17 | Cor Therapeutics Inc | Selective factor Xa inhibitors |
| GB9908838D0 (en) | 1998-09-11 | 1999-06-16 | Univ London | Fibroblast inhibitor |
| AT410216B (de) | 1999-08-10 | 2003-03-25 | Baxter Ag | Faktor x-analogon mit verbesserter aktivierbarkeit |
| AU2001249389A1 (en) | 2000-03-22 | 2001-10-03 | The Children's Hospital Of Philadelphia | Modified blood clotting factors and methods of use |
| US6905683B2 (en) | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
| FR2831170B1 (fr) | 2001-10-19 | 2004-03-19 | Inst Nat Sante Rech Med | Proteines c modifiees activables directement par la thrombine |
| FR2841904B1 (fr) | 2002-07-03 | 2004-08-20 | Inst Nat Sante Rech Med | Analogues de facteurs x clivables par la thrombine |
| EP1728798A1 (en) | 2005-06-01 | 2006-12-06 | ZLB Behring GmbH | Coagulation factor X polypeptides with modified activation properties |
| DE102005028018A1 (de) * | 2005-06-16 | 2006-12-21 | Dade Behring Marburg Gmbh | Verfahren zur Standardisierung von Gerinnungstesten |
| MX336958B (es) | 2005-11-15 | 2016-02-05 | Philadelphia Children Hospital | Metodos y composiciones para modular la hemostasia. |
| EP1820508A1 (en) | 2006-02-21 | 2007-08-22 | CSL Behring GmbH | Coagulation factor X polypeptides with modified activation properties |
| EP1867660A1 (en) | 2006-06-14 | 2007-12-19 | CSL Behring GmbH | Proteolytically cleavable fusion protein comprising a blood coagulation factor |
| KR102069498B1 (ko) | 2007-09-28 | 2020-01-23 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 Ｘａ 저해제에 대한 안티도트 및 그것을 사용하는 방법 |
| WO2009061697A1 (en) | 2007-11-09 | 2009-05-14 | The Board Of Trustees Of The University Of Illinois | Anticoagulant antagonist and hemophilia procoagulant |
| CA2743496C (en) | 2008-11-14 | 2018-03-27 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents |
| JP5833448B2 (ja) | 2008-12-19 | 2015-12-16 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | セリンプロテアーゼ誘導体および血液凝固疾患の予防または処置における使用 |
| PL3604510T3 (pl) | 2009-03-30 | 2025-07-28 | Alexion Pharmaceuticals, Inc. | Antidota na inhibitory czynnika xa i sposoby ich stosowania |
| EP2453910B1 (en) * | 2009-07-15 | 2016-08-31 | Portola Pharmaceuticals, Inc. | Unit dose formulation of antidote for factor xa inhibitors for use in preventing bleeding |
| GB2485590A (en) | 2010-11-22 | 2012-05-23 | Univ Ruprecht Karis Heidelberg | Method for detecting at least one direct factor Xa inhibitors |
| FR2972114B1 (fr) | 2011-03-01 | 2013-03-15 | Univ Grenoble 1 | Un nouveau leurre moleculaire procoagulant pour le traitement des hemophiles a ou b avec ou sans inhibiteur |
| JP6514893B2 (ja) | 2011-09-30 | 2019-05-15 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ | 止血を調節するための組成物および方法 |
| WO2013123248A1 (en) | 2012-02-16 | 2013-08-22 | Portola Pharmaceuticals, Inc. | MODULATION OF FACTOR Xa INHIBITOR MEDIATED BLOOD LOSS BY PARTIAL AND TRANSIENT ADMINISTRATION OF ANTIDOTE |
| FR3000895B1 (fr) | 2013-01-11 | 2017-02-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies Sa | Utilisation d'antidotes d'inhibiteurs de la coagulation indiques dans la prevention ou le traitement de pathologies thromboemboliques |
| HK1215196A1 (zh) | 2013-01-31 | 2016-08-19 | 辉瑞公司 | 用於抵消因子xa抑制的组合物和方法 |
| CN112195169A (zh) | 2013-09-24 | 2021-01-08 | 辉瑞大药厂 | 包含重组人凝血因子Xa蛋白的异质性群体的组合物 |
| US20160235824A1 (en) * | 2013-11-01 | 2016-08-18 | The Children's Hospital Philadelphia | Compositions and Methods for Increasing the Half-Life of Factor XA |
| CN105934250A (zh) | 2014-01-24 | 2016-09-07 | 辉瑞公司 | 治疗脑内出血的组合物和方法 |
-
2014
- 2014-01-23 HK HK16103318.1A patent/HK1215196A1/zh unknown
- 2014-01-23 ES ES14704915T patent/ES2761730T3/es active Active
- 2014-01-23 US US14/759,520 patent/US20150343034A1/en not_active Abandoned
- 2014-01-23 MX MX2015008813A patent/MX2015008813A/es unknown
- 2014-01-23 CN CN201480006917.0A patent/CN104994868A/zh active Pending
- 2014-01-23 JP JP2015555829A patent/JP6437458B2/ja not_active Expired - Fee Related
- 2014-01-23 WO PCT/IB2014/058494 patent/WO2014118677A1/en not_active Ceased
- 2014-01-23 KR KR1020157020717A patent/KR20150103205A/ko not_active Withdrawn
- 2014-01-23 CA CA2897672A patent/CA2897672A1/en not_active Abandoned
- 2014-01-23 AU AU2014210830A patent/AU2014210830A1/en not_active Abandoned
- 2014-01-23 EP EP14704915.9A patent/EP2950813B1/en active Active
-
2015
- 2015-07-26 IL IL240147A patent/IL240147A0/en unknown
-
2018
- 2018-01-17 US US15/873,416 patent/US10588950B2/en active Active
- 2018-10-09 JP JP2018190856A patent/JP2019077677A/ja not_active Withdrawn
-
2020
- 2020-03-16 US US16/820,687 patent/US20210000930A1/en not_active Abandoned
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