JP2016509475A - 試料から標的分画を抽出するための、摺動可能な蓋を組み込む装置および方法 - Google Patents
試料から標的分画を抽出するための、摺動可能な蓋を組み込む装置および方法 Download PDFInfo
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Abstract
Description
Claims (23)
- 生体試料から標的物質を分離するための装置であって、前記標的物質が、固相基質に結合されて標的結合された固相基質を形成し、前記装置が、
複数の領域を有する上側表面を有し、前記生体試料が前記領域の第1の部分上に受け入れられる下側プレートと、
該下側プレートの前記上側表面に向けられた下側表面を有する上側プレートと、
前記標的結合された固相基質を前記上側プレートの前記下側表面に向かって引き付ける、該上側プレートに隣接する力と、
を備え、
前記上側プレートおよび前記下側プレートの少なくとも1つが、前記生体試料内の前記標的結合された固相基質が前記上側プレートの前記下側表面に引き寄せられる第1の位置から、また、前記標的結合された固相基質が前記生体試料から分離される第2の位置から移動可能である、生体試料から標的物質を分離するための装置。 - 前記下側プレートの前記領域が親水性である、請求項1に記載の装置。
- 前記下側プレートの前記領域の外側の前記上側表面の部分が疎水性である、請求項1に記載の装置。
- 前記上側プレートの前記下側表面が疎水性である、請求項1に記載の装置。
- 前記上側プレートが、前記第1の位置と第2の位置との間で軸方向に移動可能である、請求項1に記載の装置。
- 前記上側プレートが、前記第1の位置と第2の位置の間で回転可能である、請求項1に記載の装置。
- 前記下側プレートの前記上側表面および前記上側表面の下側表面が、所定の距離だけ離間される、請求項1に記載の装置。
- 生体試料から標的物質を分離するための方法であって、前記標的物質が、固相基質に結合されて標的結合された固相基質を形成し、前記方法が、
前記生体試料を下側プレートの表面の領域に提供するステップと、
前記下側プレートの前記上側表面に向けられた下側表面を有する上側プレートを前記下側プレートに対して離間させて配置するステップと、
前記標的結合された固相基質を前記上側プレートの前記下側表面に向かって力によって引き寄せるステップと、
前記下側プレートおよび前記上側プレートの少なくとも1つを、前記生体試料内の前記標的結合された固相基質が前記上側プレートの前記下側表面に向かって引き寄せられる第1の位置から、前記標的結合された固相基質が前記生体試料から分離される第2の位置まで移動させるステップと、を含む、生体試料から標的物質を分離するための方法。 - 前記下側プレートの前記上側表面の前記領域が親水性である、請求項8に記載の方法。
- 前記下側プレートの前記上側表面の前記領域が第1の領域であり、前記下側プレートの前記上側表面が親水性である複数の領域を含む、請求項8に記載の方法。
- 前記領域の外側の前記下側プレートの前記上側表面の部分が疎水性である、請求項10に記載の方法。
- 前記上側プレートの前記下側表面が疎水性である、請求項8に記載の方法。
- 前記上側プレートが、長手方向軸に沿って前記第1の位置と第2の位置との間を移動する、請求項9に記載の方法。
- 前記上側プレートが、前記第1の位置と第2の位置の間で回転可能である、請求項9に記載の方法。
- 前記下側プレートの前記上側表面および前記上側プレートの下側表面を所定の距離だけ離間させる追加のステップを含む、請求項9に記載の方法。
- 生体試料から標的物質を分離するための方法であって、前記標的物質が、固相基質に結合されて標的結合された固相基質を形成し、前記方法が、
前記生体試料を第1のプレートの表面の第1の領域に提供するステップと、
流体を前記第1のプレートの前記表面の第2の領域上に載せるステップと、
前記第1のプレートの前記表面に向けられた疎水性表面を有する第2のプレートを、前記第1のプレートに対して離間させて配置するステップと、
前記標的結合された固相基質を前記第2のプレートの前記表面に向かって力によって引き寄せるステップと、
前記第1のプレートおよび前記第2のプレートの少なくとも1つを、前記生体試料内の前記標的結合された固相基質が前記第2のプレートの前記表面に向かって引き寄せられる第1の位置から、前記標的結合された固相基質が前記生体試料から分離される第2の位置まで移動させるステップと、を含む、生体試料から標的物質を分離するための方法。 - 前記第1の領域および第2の領域の外側の前記第1のプレートの前記表面の部分が疎水性である、請求項16に記載の方法。
- 前記第2のプレートが、長手方向軸に沿って前記第1の位置と第2の位置との間を移動する、請求項16に記載の方法。
- 前記第2のプレートが、前記第1の位置と第2の位置との間で回転可能である、請求項16に記載の方法。
- 前記第2のプレートの前記表面を前記第1のプレートの前記表面から所定の距離だけ離間させる追加のステップを含む、請求項16に記載の方法。
- 前記力が磁気である、請求項16に記載の方法。
- 前記標的結合された固相基質が、前記第1のプレートおよび前記第2のプレートの少なくとも1つが前記第2の位置にある状態で、前記流体内に受け入れられる、請求項16に記載の方法。
- 前記標的結合された固相基質を前記力から分離する追加のステップを含む、請求項22に記載の方法。
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US13/737,448 US9766166B2 (en) | 2013-01-09 | 2013-01-09 | Device and method incorporating a slideable lid for extracting a targeted fraction from a sample |
US13/737,448 | 2013-01-09 | ||
PCT/US2013/063190 WO2014109804A1 (en) | 2013-01-09 | 2013-10-03 | Device and method incorporating a slideable lid for extracting a targeted fraction from a sample |
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JP2016211893A (ja) * | 2015-04-30 | 2016-12-15 | シスメックス株式会社 | 検体分析カートリッジを用いた検体分析方法、検体分析カートリッジ、および、検体分析装置 |
JP2018508187A (ja) * | 2015-01-13 | 2018-03-29 | ギルソン インコーポレイテッド | 摺動式磁性粒子分離のためのアダプタ |
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EP2943791A4 (en) | 2016-08-03 |
US20180095018A1 (en) | 2018-04-05 |
US20140190894A1 (en) | 2014-07-10 |
JP6385956B2 (ja) | 2018-09-05 |
EP2943791A1 (en) | 2015-11-18 |
US9766166B2 (en) | 2017-09-19 |
US20210255071A1 (en) | 2021-08-19 |
WO2014109804A1 (en) | 2014-07-17 |
US10996149B2 (en) | 2021-05-04 |
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