JP2016508995A - 化合物 - Google Patents

化合物 Download PDF

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Publication number
JP2016508995A
JP2016508995A JP2015554038A JP2015554038A JP2016508995A JP 2016508995 A JP2016508995 A JP 2016508995A JP 2015554038 A JP2015554038 A JP 2015554038A JP 2015554038 A JP2015554038 A JP 2015554038A JP 2016508995 A JP2016508995 A JP 2016508995A
Authority
JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
disease
formula
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015554038A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016508995A5 (enExample
Inventor
ツェホン、ワン
チャン、シャオミン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property Development Ltd
Original Assignee
GlaxoSmithKline Intellectual Property Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Intellectual Property Development Ltd filed Critical GlaxoSmithKline Intellectual Property Development Ltd
Publication of JP2016508995A publication Critical patent/JP2016508995A/ja
Publication of JP2016508995A5 publication Critical patent/JP2016508995A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015554038A 2013-01-25 2014-01-23 化合物 Pending JP2016508995A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2013070970 2013-01-25
CNPCT/CN2013/070970 2013-01-25
PCT/CN2014/071205 WO2014114248A1 (en) 2013-01-25 2014-01-23 Compounds

Publications (2)

Publication Number Publication Date
JP2016508995A true JP2016508995A (ja) 2016-03-24
JP2016508995A5 JP2016508995A5 (enExample) 2016-12-28

Family

ID=51226938

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015554038A Pending JP2016508995A (ja) 2013-01-25 2014-01-23 化合物

Country Status (10)

Country Link
US (1) US9296755B2 (enExample)
EP (1) EP2948457A4 (enExample)
JP (1) JP2016508995A (enExample)
KR (1) KR20150111356A (enExample)
CN (1) CN105008365B (enExample)
AU (1) AU2014210259B2 (enExample)
BR (1) BR112015017768A2 (enExample)
CA (1) CA2899124A1 (enExample)
RU (1) RU2015135806A (enExample)
WO (1) WO2014114248A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022551093A (ja) * 2019-09-30 2022-12-07 上海紐思克生物科技有限公司 四環系ピリミジノン類化合物、その製造方法、その組成物及び使用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3156783A1 (en) 2019-11-09 2021-05-14 Yun Jin Tricycle dihydroimidazopyrimidone derivative, preparation method thereof, pharmaceutical composition and use thereof
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

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US20080279846A1 (en) * 2007-05-11 2008-11-13 Thomas Jefferson University Methods of treatment and prevention of neurodegenerative diseases and disorders
JP2010506852A (ja) * 2006-10-13 2010-03-04 グラクソ グループ リミテッド 二環式ヘテロ芳香族化合物
WO2013014185A1 (en) * 2011-07-27 2013-01-31 Glaxo Group Limited Bicyclic pyrimidone compounds

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CH690264A5 (fr) 1995-06-30 2000-06-30 Symphar Sa Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques.
CA2225627A1 (en) 1995-07-01 1997-01-23 Deirdre Mary Bernadette Hickey Azetidinone derivatives for the treatment of atherosclerosis
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GB0127141D0 (en) 2001-11-10 2002-01-02 Smithkline Beecham Plc Novel compounds
GB0208279D0 (en) * 2002-04-10 2002-05-22 Glaxo Group Ltd Novel compounds
GB0208280D0 (en) 2002-04-10 2002-05-22 Glaxo Group Ltd Novel compounds
WO2004031145A2 (en) 2002-10-02 2004-04-15 Bristol-Myers Squibb Company Lactam-containing diaminoalkyl, beta-aminoacids, alpha-aminoacids and derivatives thereof as factor xa inhibitors
KR101122782B1 (ko) 2002-10-04 2012-04-12 프라나 바이오테크놀로지 리미티드 신경 활성 화합물
EP1644353A1 (de) 2003-07-02 2006-04-12 Bayer HealthCare AG Amid-substituierte 1, 2, 4-triazin-5 (2h) - one zur behandlung von chronisch inflammatorischen krankheiten
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010506852A (ja) * 2006-10-13 2010-03-04 グラクソ グループ リミテッド 二環式ヘテロ芳香族化合物
US20080279846A1 (en) * 2007-05-11 2008-11-13 Thomas Jefferson University Methods of treatment and prevention of neurodegenerative diseases and disorders
WO2013014185A1 (en) * 2011-07-27 2013-01-31 Glaxo Group Limited Bicyclic pyrimidone compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022551093A (ja) * 2019-09-30 2022-12-07 上海紐思克生物科技有限公司 四環系ピリミジノン類化合物、その製造方法、その組成物及び使用
JP7576342B2 (ja) 2019-09-30 2024-10-31 上海紐思克生物科技有限公司 四環系ピリミジノン類化合物、その製造方法、その組成物及び使用

Also Published As

Publication number Publication date
BR112015017768A2 (pt) 2017-07-11
WO2014114248A1 (en) 2014-07-31
CN105008365A (zh) 2015-10-28
AU2014210259A1 (en) 2015-07-30
US9296755B2 (en) 2016-03-29
AU2014210259B2 (en) 2016-11-03
RU2015135806A (ru) 2017-03-03
CA2899124A1 (en) 2014-07-31
EP2948457A4 (en) 2016-09-07
KR20150111356A (ko) 2015-10-05
CN105008365B (zh) 2017-03-15
US20150322075A1 (en) 2015-11-12
EP2948457A1 (en) 2015-12-02

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