JP2016508517A5 - - Google Patents

Info

Publication number

JP2016508517A5

JP2016508517A5 JP2015558127A JP2015558127A JP2016508517A5 JP 2016508517 A5 JP2016508517 A5 JP 2016508517A5 JP 2015558127 A JP2015558127 A JP 2015558127A JP 2015558127 A JP2015558127 A JP 2015558127A JP 2016508517 A5 JP2016508517 A5 JP 2016508517A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

amino acid

sequence shown

removals

Prior art date

2014-02-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 229920001184 polypeptide Polymers 0.000 claims description 243
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 243
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 243
• 230000006229 amino acid addition Effects 0.000 claims description 144
• 238000006467 substitution reaction Methods 0.000 claims description 144
• 125000000539 amino acid group Chemical group 0.000 claims description 36
• 230000003914 insulin secretion Effects 0.000 claims description 21
• 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims description 19
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims description 19
• 101800000224 Glucagon-like peptide 1 Proteins 0.000 claims description 19
• 108010078321 Guanylate Cyclase Proteins 0.000 claims description 19
• 102000014469 Guanylate cyclase Human genes 0.000 claims description 19
• 230000004913 activation Effects 0.000 claims description 19
• 230000000694 effects Effects 0.000 claims description 19
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 12
• 241000124008 Mammalia Species 0.000 claims description 2
• 206010012601 diabetes mellitus Diseases 0.000 claims description 2
• 230000001939 inductive effect Effects 0.000 claims description 2
• 238000000034 method Methods 0.000 description 1