JP2016506948A5 - - Google Patents
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- Publication number
- JP2016506948A5 JP2016506948A5 JP2015555863A JP2015555863A JP2016506948A5 JP 2016506948 A5 JP2016506948 A5 JP 2016506948A5 JP 2015555863 A JP2015555863 A JP 2015555863A JP 2015555863 A JP2015555863 A JP 2015555863A JP 2016506948 A5 JP2016506948 A5 JP 2016506948A5
- Authority
- JP
- Japan
- Prior art keywords
- methacrylic acid
- acid copolymer
- solid dispersion
- pharmaceutical composition
- cilostazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940117841 Methacrylic Acid Copolymer Drugs 0.000 claims 11
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 11
- 239000007962 solid dispersion Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- RRGUKTPIGVIEKM-UHFFFAOYSA-N Cilostazol Chemical compound C=1C=C2NC(=O)CCC2=CC=1OCCCCC1=NN=NN1C1CCCCC1 RRGUKTPIGVIEKM-UHFFFAOYSA-N 0.000 claims 4
- 229960004588 cilostazol Drugs 0.000 claims 4
- LRDIEHDJWYRVPT-UHFFFAOYSA-N 4-amino-5-hydroxynaphthalene-1-sulfonic acid Chemical compound C1=CC(O)=C2C(N)=CC=C(S(O)(=O)=O)C2=C1 LRDIEHDJWYRVPT-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Claims (10)
- （ｉ）シロスタゾールと（ii）メタクリル酸コポリマーＳおよび／またはメタクリル酸コポリマーＬを含み、その重量比が１：１〜１：３であり、熱溶融生成物または加熱混練溶融生成物である、固体分散体。
- シロスタゾールがメタクリル酸コポリマー中に非晶質状態で分散されていることを特徴とする、請求項１の固体分散体。
- 加熱混練溶融生成物である請求項１または２の固体分散体。
- （ii）メタクリル酸コポリマーＳおよび／またはメタクリル酸コポリマーＬがメタクリル酸コポリマーＳである請求項１〜３のいずれかに記載の固体分散体。
- （ii）メタクリル酸コポリマーＳおよび／またはメタクリル酸コポリマーＬがメタクリル酸コポリマーＬである請求項１〜３のいずれかに記載の固体分散体。
- 請求項１〜５のいずれかに記載の固体分散体を含む医薬組成物。
- 更にポリエチレンオキサイドを含む請求項６に記載の医薬組成物。
- 請求項６または７に記載の医薬組成物を含む経口製剤。
- 一層目に請求項７の医薬組成物を含み、二層目に粉砕されたシロスタゾールを含む医薬組成物を含む二層錠。
- （ｉ）シロスタゾールと（ii）メタクリル酸コポリマーＳおよび／またはメタクリル酸コポリマーＬを、その重量比が１：１〜１：３で熱溶融または加熱混練溶融した後、冷却及び粉砕することを特徴とする固体分散体の製造方法。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015555863A JP5980449B2 (ja) | 2013-02-06 | 2014-02-05 | 非晶質なシロスタゾールを含有する固体分散体 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013021475 | 2013-02-06 | ||
| JP2013021475 | 2013-02-06 | ||
| JP2015555863A JP5980449B2 (ja) | 2013-02-06 | 2014-02-05 | 非晶質なシロスタゾールを含有する固体分散体 |
| PCT/JP2014/053232 WO2014123244A1 (en) | 2013-02-06 | 2014-02-05 | Solid dispersion comprising amorphous cilostazol |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016102975A Division JP2016193915A (ja) | 2013-02-06 | 2016-05-24 | 非晶質なシロスタゾールを含有する固体分散体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506948A JP2016506948A (ja) | 2016-03-07 |
| JP2016506948A5 true JP2016506948A5 (ja) | 2016-04-14 |
| JP5980449B2 JP5980449B2 (ja) | 2016-08-31 |
Family
ID=50184966
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015555863A Active JP5980449B2 (ja) | 2013-02-06 | 2014-02-05 | 非晶質なシロスタゾールを含有する固体分散体 |
| JP2016102975A Pending JP2016193915A (ja) | 2013-02-06 | 2016-05-24 | 非晶質なシロスタゾールを含有する固体分散体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016102975A Pending JP2016193915A (ja) | 2013-02-06 | 2016-05-24 | 非晶質なシロスタゾールを含有する固体分散体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9555026B2 (ja) |
| EP (1) | EP2953615B1 (ja) |
| JP (2) | JP5980449B2 (ja) |
| KR (1) | KR102205192B1 (ja) |
| CN (1) | CN105050586B (ja) |
| AR (1) | AR095143A1 (ja) |
| AU (1) | AU2014215920B2 (ja) |
| CA (1) | CA2899389C (ja) |
| HK (1) | HK1218618A1 (ja) |
| PH (1) | PH12015501722B1 (ja) |
| TW (1) | TWI615157B (ja) |
| WO (1) | WO2014123244A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110381945A (zh) * | 2017-02-10 | 2019-10-25 | 阿尔图姆制药股份有限公司 | 口服给予的镓（iii）配合物的组合物 |
| KR102114550B1 (ko) * | 2018-07-10 | 2020-05-22 | 삼육대학교산학협력단 | 생리학적 체내 동태 연구 모델링을 이용한 약제학적 조성물의 제조 방법 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2266892B (en) * | 1991-10-01 | 1996-04-17 | Otsuka Pharma Co Ltd | Antithrombotic resin, antithrombotic tube, antithrombotic film and antithrombotic coat |
| JP3799093B2 (ja) * | 1995-01-10 | 2006-07-19 | 大塚製薬株式会社 | 樹脂粒状物およびこれを含有する医療製剤 |
| CN1168102A (zh) * | 1995-01-10 | 1997-12-17 | 大制药株式会社 | 树脂微粒及含该树脂微粒的药用材料和药剂 |
| ES2199289T3 (es) | 1995-07-26 | 2004-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Dispersion solida de derivados de xantina. |
| JPH11246404A (ja) | 1998-03-04 | 1999-09-14 | Taiho Yakuhin Kogyo Kk | 吸収を改善した医薬組成物 |
| US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| JP4748839B2 (ja) | 1999-03-25 | 2011-08-17 | 大塚製薬株式会社 | シロスタゾール製剤 |
| EG23951A (en) | 1999-03-25 | 2008-01-29 | Otsuka Pharma Co Ltd | Cilostazol preparation |
| CA2508840A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Products Inc. | Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor |
| CN1241566C (zh) * | 2004-03-15 | 2006-02-15 | 深圳海王药业有限公司 | 西洛他唑固体分散体及其片剂制备方法 |
| CA2589537A1 (en) | 2004-12-02 | 2006-06-08 | Stephen Craig Dyar | Pharmaceutical compositions of amorphous atorvastatin and process for preparing same |
| US20090047357A1 (en) * | 2005-12-22 | 2009-02-19 | Otsuka Pharmaceutical Co., Ltd. | Method of producing drug-containing wax matrix particles, extruder to be used in the method and sustained-release preparation containing cilostazol |
| US20100172989A1 (en) * | 2006-01-21 | 2010-07-08 | Abbott Laboratories | Abuse resistant melt extruded formulation having reduced alcohol interaction |
| JP2007308480A (ja) * | 2006-04-20 | 2007-11-29 | Shin Etsu Chem Co Ltd | 腸溶性固体分散体を含んでなる固形製剤 |
| US20110165236A1 (en) * | 2006-09-22 | 2011-07-07 | Biokey, Inc. | Controlled release hydrogel formulation |
| KR20080076440A (ko) * | 2007-02-16 | 2008-08-20 | (주)아모레퍼시픽 | 실로스타졸의 제어방출 제제 및 그 제조방법 |
| CN101702878B (zh) | 2007-05-11 | 2012-11-28 | 弗·哈夫曼-拉罗切有限公司 | 可溶性差的药物的药物组合物 |
| SI2180882T1 (sl) * | 2007-10-19 | 2013-05-31 | Otsuka Pharmaceutical Co., Ltd. | Trdni matriksni farmacevtski pripravek |
| AR071706A1 (es) | 2008-05-15 | 2010-07-07 | Otsuka Pharma Co Ltd | Una formulacion farmaceutica de cilostazol solida de liberacion sostenida y metodo de preparacion. |
| TW201010743A (en) * | 2008-09-05 | 2010-03-16 | Otsuka Pharma Co Ltd | Pharmaceutical solid preparation |
| WO2011027656A1 (en) | 2009-09-04 | 2011-03-10 | Semiconductor Energy Laboratory Co., Ltd. | Transistor and display device |
| KR101282847B1 (ko) * | 2011-07-27 | 2013-07-05 | 조선대학교산학협력단 | 실로스타졸을 함유하는 고체분산체 및 이를 포함하는 약학 조성물 |
-
2014
- 2014-01-28 TW TW103103097A patent/TWI615157B/zh active
- 2014-02-04 AR ARP140100366A patent/AR095143A1/es unknown
- 2014-02-05 EP EP14706960.3A patent/EP2953615B1/en active Active
- 2014-02-05 WO PCT/JP2014/053232 patent/WO2014123244A1/en active Application Filing
- 2014-02-05 AU AU2014215920A patent/AU2014215920B2/en active Active
- 2014-02-05 CN CN201480018458.8A patent/CN105050586B/zh active Active
- 2014-02-05 CA CA2899389A patent/CA2899389C/en active Active
- 2014-02-05 KR KR1020157023661A patent/KR102205192B1/ko active IP Right Grant
- 2014-02-05 US US14/764,663 patent/US9555026B2/en active Active
- 2014-02-05 JP JP2015555863A patent/JP5980449B2/ja active Active
-
2015
- 2015-08-05 PH PH12015501722A patent/PH12015501722B1/en unknown
-
2016
- 2016-05-24 JP JP2016102975A patent/JP2016193915A/ja active Pending
- 2016-06-08 HK HK16106603.8A patent/HK1218618A1/zh unknown
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