JP2016506750A5 - - Google Patents
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- JP2016506750A5 JP2016506750A5 JP2015557201A JP2015557201A JP2016506750A5 JP 2016506750 A5 JP2016506750 A5 JP 2016506750A5 JP 2015557201 A JP2015557201 A JP 2015557201A JP 2015557201 A JP2015557201 A JP 2015557201A JP 2016506750 A5 JP2016506750 A5 JP 2016506750A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- shared
- library
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 35
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 20
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 18
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 16
- 230000003321 amplification Effects 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 16
- 210000000265 leukocyte Anatomy 0.000 claims description 14
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 12
- 210000004027 cell Anatomy 0.000 claims description 11
- 108091093088 Amplicon Proteins 0.000 claims description 10
- 230000008707 rearrangement Effects 0.000 claims description 6
- 229960005486 vaccine Drugs 0.000 claims description 6
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 4
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 4
- 210000003519 mature b lymphocyte Anatomy 0.000 claims description 4
- 210000001806 memory b lymphocyte Anatomy 0.000 claims description 4
- 210000003071 memory t lymphocyte Anatomy 0.000 claims description 4
- 238000005070 sampling Methods 0.000 claims description 4
- 238000012163 sequencing technique Methods 0.000 claims description 4
- 108091008874 T cell receptors Proteins 0.000 claims description 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 2
- 230000001186 cumulative effect Effects 0.000 claims description 2
- 238000000684 flow cytometry Methods 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 239000002157 polynucleotide Substances 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 238000003757 reverse transcription PCR Methods 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361763451P | 2013-02-11 | 2013-02-11 | |
| US61/763,451 | 2013-02-11 | ||
| PCT/US2014/015841 WO2014124451A1 (en) | 2013-02-11 | 2014-02-11 | Method for evaluating an immunorepertoire |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506750A JP2016506750A (ja) | 2016-03-07 |
| JP2016506750A5 true JP2016506750A5 (https=) | 2017-03-09 |
| JP6460343B2 JP6460343B2 (ja) | 2019-01-30 |
Family
ID=51300201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015557201A Active JP6460343B2 (ja) | 2013-02-11 | 2014-02-11 | 免疫レパートリーを評価するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20160034637A1 (https=) |
| EP (1) | EP2954070B1 (https=) |
| JP (1) | JP6460343B2 (https=) |
| KR (1) | KR102228488B1 (https=) |
| CN (1) | CN105164277B (https=) |
| CA (1) | CA2900776C (https=) |
| ES (1) | ES2798119T3 (https=) |
| PT (1) | PT2954070T (https=) |
| WO (1) | WO2014124451A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115449542A (zh) | 2015-03-06 | 2022-12-09 | 艾瑞普特公司 | 用于测量个体的免疫组库的变化的方法 |
| US20160333409A1 (en) * | 2015-03-09 | 2016-11-17 | Cb Biotechnologies, Inc. | Method for identifying disease-associated cdr3 patterns in an immune repertoire |
| US11047011B2 (en) * | 2015-09-29 | 2021-06-29 | iRepertoire, Inc. | Immunorepertoire normality assessment method and its use |
| WO2017193097A1 (en) | 2016-05-06 | 2017-11-09 | Girihlet Inc. | Methods and compositions for determining specifc tcr and bcr chain pairings |
| CN106283201B (zh) * | 2016-09-20 | 2019-08-06 | 中国医学科学院肿瘤医院 | 基于高通量测序的tcr多样性检测和文库构建 |
| WO2018209625A1 (zh) * | 2017-05-18 | 2018-11-22 | 北京吉因加科技有限公司 | 一种基于外周血无创性检测病灶免疫组库多样性的分析系统及其用途 |
| CN111344416A (zh) * | 2017-09-01 | 2020-06-26 | 生命技术公司 | 用于免疫组库测序的组合物和方法 |
| WO2020018836A1 (en) | 2018-07-18 | 2020-01-23 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| CN114424291A (zh) * | 2019-05-17 | 2022-04-29 | 艾瑞普特公司 | 免疫组库健康评估系统和方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0910668A4 (en) * | 1996-06-03 | 2003-02-19 | Univ Alberta | METHOD FOR DETECTING REASSEMBLED DNA |
| HUE029914T2 (en) | 2008-04-03 | 2017-04-28 | Cb Biotechnologies Inc | Amplicon-saving multiplex polymerase chain reaction for amplification of multiple targets |
| US9012148B2 (en) * | 2008-04-16 | 2015-04-21 | Jian Han | Method for evaluating and comparing immunorepertoires |
| US8691510B2 (en) * | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| CN104195227B (zh) * | 2008-11-07 | 2017-04-12 | 适应生物技术公司 | 通过序列分析监测状况的方法 |
| EP4219759A3 (en) | 2010-05-06 | 2023-09-06 | Adaptive Biotechnologies Corporation | Monitoring health and disease status using clonotype profiles |
| WO2011140433A2 (en) * | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| WO2012097374A1 (en) * | 2011-01-14 | 2012-07-19 | Cb Biotechnologies, Inc. | Immunodiversity assessment method and its use |
| JP2014528001A (ja) * | 2011-09-28 | 2014-10-23 | シービー バイオテクノロジーズ インコーポレイテッド | アームｐｃｒおよび高処理シーケンシングを用いた抗原特異的適応免疫応答の同定法 |
| CN106103711A (zh) * | 2013-11-21 | 2016-11-09 | 组库创世纪株式会社 | T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用 |
-
2014
- 2014-02-11 ES ES14749095T patent/ES2798119T3/es active Active
- 2014-02-11 CN CN201480020810.1A patent/CN105164277B/zh active Active
- 2014-02-11 WO PCT/US2014/015841 patent/WO2014124451A1/en not_active Ceased
- 2014-02-11 KR KR1020157023530A patent/KR102228488B1/ko active Active
- 2014-02-11 US US14/767,178 patent/US20160034637A1/en not_active Abandoned
- 2014-02-11 EP EP14749095.7A patent/EP2954070B1/en active Active
- 2014-02-11 CA CA2900776A patent/CA2900776C/en active Active
- 2014-02-11 PT PT147490957T patent/PT2954070T/pt unknown
- 2014-02-11 JP JP2015557201A patent/JP6460343B2/ja active Active
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