CN105164277B - 用于评估免疫组库的方法 - Google Patents

用于评估免疫组库的方法 Download PDF

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CN105164277B
CN105164277B CN201480020810.1A CN201480020810A CN105164277B CN 105164277 B CN105164277 B CN 105164277B CN 201480020810 A CN201480020810 A CN 201480020810A CN 105164277 B CN105164277 B CN 105164277B
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cdr3
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CN105164277A (zh
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王春林
韩建
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CB BIOTECHNOLOGIES Inc
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR

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CN201480020810.1A 2013-02-11 2014-02-11 用于评估免疫组库的方法 Active CN105164277B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361763451P 2013-02-11 2013-02-11
US61/763,451 2013-02-11
PCT/US2014/015841 WO2014124451A1 (en) 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire

Publications (2)

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CN105164277A CN105164277A (zh) 2015-12-16
CN105164277B true CN105164277B (zh) 2021-05-28

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US (1) US20160034637A1 (https=)
EP (1) EP2954070B1 (https=)
JP (1) JP6460343B2 (https=)
KR (1) KR102228488B1 (https=)
CN (1) CN105164277B (https=)
CA (1) CA2900776C (https=)
ES (1) ES2798119T3 (https=)
PT (1) PT2954070T (https=)
WO (1) WO2014124451A1 (https=)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
CN115449542A (zh) 2015-03-06 2022-12-09 艾瑞普特公司 用于测量个体的免疫组库的变化的方法
US20160333409A1 (en) * 2015-03-09 2016-11-17 Cb Biotechnologies, Inc. Method for identifying disease-associated cdr3 patterns in an immune repertoire
US11047011B2 (en) * 2015-09-29 2021-06-29 iRepertoire, Inc. Immunorepertoire normality assessment method and its use
WO2017193097A1 (en) 2016-05-06 2017-11-09 Girihlet Inc. Methods and compositions for determining specifc tcr and bcr chain pairings
CN106283201B (zh) * 2016-09-20 2019-08-06 中国医学科学院肿瘤医院 基于高通量测序的tcr多样性检测和文库构建
WO2018209625A1 (zh) * 2017-05-18 2018-11-22 北京吉因加科技有限公司 一种基于外周血无创性检测病灶免疫组库多样性的分析系统及其用途
CN111344416A (zh) * 2017-09-01 2020-06-26 生命技术公司 用于免疫组库测序的组合物和方法
WO2020018836A1 (en) 2018-07-18 2020-01-23 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
CN114424291A (zh) * 2019-05-17 2022-04-29 艾瑞普特公司 免疫组库健康评估系统和方法

Citations (2)

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WO2011139371A1 (en) * 2010-05-06 2011-11-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
WO2012097374A1 (en) * 2011-01-14 2012-07-19 Cb Biotechnologies, Inc. Immunodiversity assessment method and its use

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EP0910668A4 (en) * 1996-06-03 2003-02-19 Univ Alberta METHOD FOR DETECTING REASSEMBLED DNA
HUE029914T2 (en) 2008-04-03 2017-04-28 Cb Biotechnologies Inc Amplicon-saving multiplex polymerase chain reaction for amplification of multiple targets
US9012148B2 (en) * 2008-04-16 2015-04-21 Jian Han Method for evaluating and comparing immunorepertoires
US8691510B2 (en) * 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
CN104195227B (zh) * 2008-11-07 2017-04-12 适应生物技术公司 通过序列分析监测状况的方法
WO2011140433A2 (en) * 2010-05-07 2011-11-10 The Board Of Trustees Of The Leland Stanford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
JP2014528001A (ja) * 2011-09-28 2014-10-23 シービー バイオテクノロジーズ インコーポレイテッド アームｐｃｒおよび高処理シーケンシングを用いた抗原特異的適応免疫応答の同定法
CN106103711A (zh) * 2013-11-21 2016-11-09 组库创世纪株式会社 T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011139371A1 (en) * 2010-05-06 2011-11-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
WO2012097374A1 (en) * 2011-01-14 2012-07-19 Cb Biotechnologies, Inc. Immunodiversity assessment method and its use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
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High Throughput Sequencing Reveals A Complex Pattem Of Dynamic Interrelationships Among Human T Cell Subsets;WANG，C ET AL.;《PNAS》;20100126;第107卷(第4期);1518-1523 *

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Publication number Publication date
CA2900776C (en) 2023-08-15
JP6460343B2 (ja) 2019-01-30
WO2014124451A1 (en) 2014-08-14
PT2954070T (pt) 2020-06-22
HK1212735A1 (zh) 2016-06-17
CN105164277A (zh) 2015-12-16
JP2016506750A (ja) 2016-03-07
KR20150141939A (ko) 2015-12-21
KR102228488B1 (ko) 2021-03-15
EP2954070A4 (en) 2016-10-26
ES2798119T3 (es) 2020-12-09
US20160034637A1 (en) 2016-02-04
EP2954070A1 (en) 2015-12-16
CA2900776A1 (en) 2014-08-14
EP2954070B1 (en) 2020-04-01

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