CA2900776C - Method for evaluating an immunorepertoire - Google Patents

Method for evaluating an immunorepertoire Download PDF

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Publication number
CA2900776C
CA2900776C CA2900776A CA2900776A CA2900776C CA 2900776 C CA2900776 C CA 2900776C CA 2900776 A CA2900776 A CA 2900776A CA 2900776 A CA2900776 A CA 2900776A CA 2900776 C CA2900776 C CA 2900776C
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Prior art keywords
cells
immunoprofile
subject
disease
library
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CA2900776A
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English (en)
French (fr)
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CA2900776A1 (en
Inventor
Chunlin Wang
Jian Han
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Irepertoire Inc
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Irepertoire Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Theoretical Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Library & Information Science (AREA)
  • Computing Systems (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2900776A 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire Active CA2900776C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361763451P 2013-02-11 2013-02-11
US61/763,451 2013-02-11
PCT/US2014/015841 WO2014124451A1 (en) 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire

Publications (2)

Publication Number Publication Date
CA2900776A1 CA2900776A1 (en) 2014-08-14
CA2900776C true CA2900776C (en) 2023-08-15

Family

ID=51300201

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2900776A Active CA2900776C (en) 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire

Country Status (9)

Country Link
US (1) US20160034637A1 (https=)
EP (1) EP2954070B1 (https=)
JP (1) JP6460343B2 (https=)
KR (1) KR102228488B1 (https=)
CN (1) CN105164277B (https=)
CA (1) CA2900776C (https=)
ES (1) ES2798119T3 (https=)
PT (1) PT2954070T (https=)
WO (1) WO2014124451A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115449542A (zh) 2015-03-06 2022-12-09 艾瑞普特公司 用于测量个体的免疫组库的变化的方法
US20160333409A1 (en) * 2015-03-09 2016-11-17 Cb Biotechnologies, Inc. Method for identifying disease-associated cdr3 patterns in an immune repertoire
US11047011B2 (en) * 2015-09-29 2021-06-29 iRepertoire, Inc. Immunorepertoire normality assessment method and its use
WO2017193097A1 (en) 2016-05-06 2017-11-09 Girihlet Inc. Methods and compositions for determining specifc tcr and bcr chain pairings
CN106283201B (zh) * 2016-09-20 2019-08-06 中国医学科学院肿瘤医院 基于高通量测序的tcr多样性检测和文库构建
WO2018209625A1 (zh) * 2017-05-18 2018-11-22 北京吉因加科技有限公司 一种基于外周血无创性检测病灶免疫组库多样性的分析系统及其用途
CN111344416A (zh) * 2017-09-01 2020-06-26 生命技术公司 用于免疫组库测序的组合物和方法
WO2020018836A1 (en) 2018-07-18 2020-01-23 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
CN114424291A (zh) * 2019-05-17 2022-04-29 艾瑞普特公司 免疫组库健康评估系统和方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0910668A4 (en) * 1996-06-03 2003-02-19 Univ Alberta METHOD FOR DETECTING REASSEMBLED DNA
HUE029914T2 (en) 2008-04-03 2017-04-28 Cb Biotechnologies Inc Amplicon-saving multiplex polymerase chain reaction for amplification of multiple targets
US9012148B2 (en) * 2008-04-16 2015-04-21 Jian Han Method for evaluating and comparing immunorepertoires
US8691510B2 (en) * 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
CN104195227B (zh) * 2008-11-07 2017-04-12 适应生物技术公司 通过序列分析监测状况的方法
EP4219759A3 (en) 2010-05-06 2023-09-06 Adaptive Biotechnologies Corporation Monitoring health and disease status using clonotype profiles
WO2011140433A2 (en) * 2010-05-07 2011-11-10 The Board Of Trustees Of The Leland Stanford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
WO2012097374A1 (en) * 2011-01-14 2012-07-19 Cb Biotechnologies, Inc. Immunodiversity assessment method and its use
JP2014528001A (ja) * 2011-09-28 2014-10-23 シービー バイオテクノロジーズ インコーポレイテッド アームｐｃｒおよび高処理シーケンシングを用いた抗原特異的適応免疫応答の同定法
CN106103711A (zh) * 2013-11-21 2016-11-09 组库创世纪株式会社 T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用

Also Published As

Publication number Publication date
JP6460343B2 (ja) 2019-01-30
WO2014124451A1 (en) 2014-08-14
PT2954070T (pt) 2020-06-22
HK1212735A1 (zh) 2016-06-17
CN105164277A (zh) 2015-12-16
JP2016506750A (ja) 2016-03-07
KR20150141939A (ko) 2015-12-21
KR102228488B1 (ko) 2021-03-15
EP2954070A4 (en) 2016-10-26
CN105164277B (zh) 2021-05-28
ES2798119T3 (es) 2020-12-09
US20160034637A1 (en) 2016-02-04
EP2954070A1 (en) 2015-12-16
CA2900776A1 (en) 2014-08-14
EP2954070B1 (en) 2020-04-01

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JP2018506996A (ja) 個体の免疫レパートリーの変化を測定するための方法
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