CA2900776C - Method for evaluating an immunorepertoire - Google Patents

Method for evaluating an immunorepertoire Download PDF

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Publication number
CA2900776C
CA2900776C CA2900776A CA2900776A CA2900776C CA 2900776 C CA2900776 C CA 2900776C CA 2900776 A CA2900776 A CA 2900776A CA 2900776 A CA2900776 A CA 2900776A CA 2900776 C CA2900776 C CA 2900776C
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Prior art keywords
cells
immunoprofile
subject
disease
library
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CA2900776A
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English (en)
French (fr)
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CA2900776A1 (en
Inventor
Chunlin Wang
Jian Han
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Irepertoire Inc
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Irepertoire Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Theoretical Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Library & Information Science (AREA)
  • Computing Systems (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2900776A 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire Active CA2900776C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361763451P 2013-02-11 2013-02-11
US61/763,451 2013-02-11
PCT/US2014/015841 WO2014124451A1 (en) 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire

Publications (2)

Publication Number Publication Date
CA2900776A1 CA2900776A1 (en) 2014-08-14
CA2900776C true CA2900776C (en) 2023-08-15

Family

ID=51300201

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2900776A Active CA2900776C (en) 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire

Country Status (9)

Country Link
US (1) US20160034637A1 (https=)
EP (1) EP2954070B1 (https=)
JP (1) JP6460343B2 (https=)
KR (1) KR102228488B1 (https=)
CN (1) CN105164277B (https=)
CA (1) CA2900776C (https=)
ES (1) ES2798119T3 (https=)
PT (1) PT2954070T (https=)
WO (1) WO2014124451A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107429293A (zh) * 2015-03-06 2017-12-01 艾瑞普特公司 用于测量个体的免疫组库的变化的方法
US20160333409A1 (en) * 2015-03-09 2016-11-17 Cb Biotechnologies, Inc. Method for identifying disease-associated cdr3 patterns in an immune repertoire
US11047011B2 (en) * 2015-09-29 2021-06-29 iRepertoire, Inc. Immunorepertoire normality assessment method and its use
WO2017193097A1 (en) * 2016-05-06 2017-11-09 Girihlet Inc. Methods and compositions for determining specifc tcr and bcr chain pairings
CN106283201B (zh) * 2016-09-20 2019-08-06 中国医学科学院肿瘤医院 基于高通量测序的tcr多样性检测和文库构建
WO2018209625A1 (zh) * 2017-05-18 2018-11-22 北京吉因加科技有限公司 一种基于外周血无创性检测病灶免疫组库多样性的分析系统及其用途
WO2019046817A1 (en) 2017-09-01 2019-03-07 Life Technologies Corporation COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING
WO2020018836A1 (en) 2018-07-18 2020-01-23 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
US20220148690A1 (en) * 2019-05-17 2022-05-12 iRepertoire, Inc. Immunorepertoire wellness assessment systems and methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6416948B1 (en) * 1996-06-03 2002-07-09 The Governors Of The University Of Alberta Methods for detection of rearranged DNA
PT2271767T (pt) * 2008-04-03 2016-08-18 Cb Biotechnologies Inc Reação em cadeia de polimerase para captura de amplicões em multiplexo para amplificação de alvos múltiplos
AU2009244634B2 (en) * 2008-04-16 2014-12-18 iRepertoire, Inc. Method for evaluating and comparing immunorepertoires
EP2364368B1 (en) * 2008-11-07 2014-01-15 Sequenta, Inc. Methods of monitoring conditions by sequence analysis
US8691510B2 (en) * 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
EP2567226B1 (en) * 2010-05-06 2016-08-10 Adaptive Biotechnologies Corporation Monitoring health and disease status using clonotype profiles
WO2011140433A2 (en) * 2010-05-07 2011-11-10 The Board Of Trustees Of The Leland Stanford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
EP2663864B8 (en) * 2011-01-14 2019-06-05 iRepertoire, Inc. Immunodiversity assessment method and its use
CN109254143A (zh) * 2011-09-28 2019-01-22 艾瑞普特公司 使用Arm-PCR和高通量测序鉴定抗原特异的适应性免疫应答
US11203783B2 (en) * 2013-11-21 2021-12-21 Repertoire Genesis Incorporation T cell receptor and B cell receptor repertoire analysis system, and use of same in treatment and diagnosis

Also Published As

Publication number Publication date
EP2954070A4 (en) 2016-10-26
JP2016506750A (ja) 2016-03-07
WO2014124451A1 (en) 2014-08-14
ES2798119T3 (es) 2020-12-09
KR20150141939A (ko) 2015-12-21
CA2900776A1 (en) 2014-08-14
HK1212735A1 (zh) 2016-06-17
US20160034637A1 (en) 2016-02-04
EP2954070B1 (en) 2020-04-01
EP2954070A1 (en) 2015-12-16
KR102228488B1 (ko) 2021-03-15
PT2954070T (pt) 2020-06-22
JP6460343B2 (ja) 2019-01-30
CN105164277B (zh) 2021-05-28
CN105164277A (zh) 2015-12-16

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