JP2023515270A5 - - Google Patents
Info
- Publication number
- JP2023515270A5 JP2023515270A5 JP2022564450A JP2022564450A JP2023515270A5 JP 2023515270 A5 JP2023515270 A5 JP 2023515270A5 JP 2022564450 A JP2022564450 A JP 2022564450A JP 2022564450 A JP2022564450 A JP 2022564450A JP 2023515270 A5 JP2023515270 A5 JP 2023515270A5
- Authority
- JP
- Japan
- Prior art keywords
- tcr
- bcr
- pool
- probes
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063013130P | 2020-04-21 | 2020-04-21 | |
| US63/013,130 | 2020-04-21 | ||
| US202063084459P | 2020-09-28 | 2020-09-28 | |
| US63/084,459 | 2020-09-28 | ||
| US202163201020P | 2021-04-08 | 2021-04-08 | |
| US63/201,020 | 2021-04-08 | ||
| PCT/US2021/070440 WO2021217181A1 (en) | 2020-04-21 | 2021-04-21 | Tcr/bcr profiling |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023515270A JP2023515270A (ja) | 2023-04-12 |
| JP2023515270A5 true JP2023515270A5 (https=) | 2025-08-15 |
Family
ID=78270138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022564450A Pending JP2023515270A (ja) | 2020-04-21 | 2021-04-21 | Ｔｃｒ／ｂｃｒプロファイリング |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11414700B2 (https=) |
| EP (1) | EP4139477A4 (https=) |
| JP (1) | JP2023515270A (https=) |
| AU (1) | AU2021259958A1 (https=) |
| CA (1) | CA3174332A1 (https=) |
| WO (1) | WO2021217181A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4271837A4 (en) | 2020-12-31 | 2025-10-15 | Tempus Ai Inc | SYSTEMS AND METHODS FOR DETECTING MULTIMOLECULAR BIOMARKERS |
| WO2023064309A1 (en) | 2021-10-11 | 2023-04-20 | Tempus Labs, Inc. | Methods and systems for detecting alternative splicing in sequencing data |
| US20250011886A1 (en) * | 2021-11-17 | 2025-01-09 | Ampel Biosolutions, Llc | Systems and Methods for Targeting COVID-19 Therapies |
| WO2023115065A2 (en) * | 2021-12-17 | 2023-06-22 | Allen Institute | Molecular signatures for cell typing and monitoring immune health |
| EP4499877A4 (en) * | 2022-03-25 | 2026-04-08 | Freenome Holdings Inc | TCR/BCR Profiling for Cell-Free Nucleic Acid Cancer Detection |
| BE1031300B1 (fr) | 2023-01-30 | 2024-09-03 | Grand Hopital De Charleroi | Procede pour l'integration ciblée d'identificateurs moleculaires uniques (ium) et la détection de haute précision d'états médicaux ou cosmetiques |
| US20240355485A1 (en) | 2023-04-13 | 2024-10-24 | Tempus Ai, Inc. | Systems and methods for predicting clinical response |
| CN116751280B (zh) * | 2023-05-17 | 2024-01-26 | 复旦大学附属中山医院 | 一种特异性识别SARS-CoV-2新冠病毒S蛋白抗原肽的T细胞受体及制备和应用 |
| EP4550335A1 (en) | 2023-10-31 | 2025-05-07 | Tempus AI, Inc. | T cell receptor screening methods |
| WO2025175065A1 (en) * | 2024-02-13 | 2025-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for assessment of immune response and applications thereof |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635354A (en) | 1991-01-09 | 1997-06-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for describing the repertoires of antibodies (Ab) and of T-cell receptors (TcR) of an individual's immune system |
| US6080840A (en) | 1992-01-17 | 2000-06-27 | Slanetz; Alfred E. | Soluble T cell receptors |
| US6399368B1 (en) | 1992-01-17 | 2002-06-04 | Board Of Regents, The University Of Texas System | Secretion of T cell receptor fragments from recombinant Escherichia coli cells |
| US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
| US20090137416A1 (en) | 2001-01-16 | 2009-05-28 | Regeneron Pharmaceuticals, Inc. | Isolating Cells Expressing Secreted Proteins |
| IL160359A0 (en) | 2001-08-31 | 2004-07-25 | Avidex Ltd | Soluble t cell receptor |
| US9193997B2 (en) * | 2010-12-15 | 2015-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Measuring and monitoring of cell clonality |
| US20170335331A1 (en) | 2014-10-31 | 2017-11-23 | The Trustees Of The University Of Pennsylvania | Altering Gene Expression in CART Cells and Uses Thereof |
| EP3227464B1 (en) | 2014-12-05 | 2022-04-20 | Foundation Medicine, Inc. | Multigene analysis of tumor samples |
| KR20230006929A (ko) * | 2016-01-13 | 2023-01-11 | 리제너론 파마슈티칼스 인코포레이티드 | 조작된 중쇄 다양성 영역을 갖는 설치류 |
| EP3443149B1 (en) * | 2016-04-15 | 2024-08-14 | University Health Network (UHN) | Hybrid-capture sequencing for determining immune cell clonality |
| GB201612242D0 (en) * | 2016-07-14 | 2016-08-31 | Genome Res Ltd And Cambridge Entpr Ltd | Novel kit |
| EP3568508A4 (en) * | 2017-01-12 | 2020-12-16 | Massachusetts Institute Of Technology | METHODS FOR T-LYMPHOCYTE RECEPTOR AND B-LYMPHOCYTE RECEPTOR ANALYSIS |
| EP3631053A4 (en) * | 2017-05-30 | 2021-05-19 | University of Health Network | Hybrid-capture sequencing for determining immune cell clonality |
| WO2018231958A1 (en) * | 2017-06-13 | 2018-12-20 | Adaptive Biotechnologies Corp. | Determining wt-1 specific t cells and wt-1 specific t cell receptors (tcrs) |
| US10957041B2 (en) | 2018-05-14 | 2021-03-23 | Tempus Labs, Inc. | Determining biomarkers from histopathology slide images |
| US10801064B2 (en) * | 2018-05-31 | 2020-10-13 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
| AU2019317440B2 (en) | 2018-08-06 | 2026-01-22 | Tempus Ai, Inc. | A multi-modal approach to predicting immune infiltration based on integrated RNA expression and imaging features |
| EP3853381A4 (en) * | 2018-09-21 | 2022-10-19 | Garvan Institute of Medical Research | Phenotypic and molecular characterisation of single cells |
| AU2019346427A1 (en) | 2018-09-24 | 2021-05-13 | Tempus Ai, Inc. | Methods of normalizing and correcting RNA expression data |
| WO2020081607A1 (en) | 2018-10-15 | 2020-04-23 | Tempus Labs, Inc. | Microsatellite instability determination system and related methods |
| US20200258601A1 (en) | 2018-10-17 | 2020-08-13 | Tempus Labs | Targeted-panel tumor mutational burden calculation systems and methods |
| US20200365232A1 (en) | 2018-10-17 | 2020-11-19 | Tempus Labs | Adaptive order fulfillment and tracking methods and systems |
| EP4198057A1 (en) * | 2018-12-05 | 2023-06-21 | F. Hoffmann-La Roche AG | Diagnostic methods and compositions for cancer immunotherapy |
| AU2019418813A1 (en) | 2018-12-31 | 2021-07-22 | Tempus Ai, Inc. | A method and process for predicting and analyzing patient cohort response, progression, and survival |
| WO2020142563A1 (en) | 2018-12-31 | 2020-07-09 | Tempus Labs, Inc. | Transcriptome deconvolution of metastatic tissue samples |
| US10975445B2 (en) | 2019-02-12 | 2021-04-13 | Tempus Labs, Inc. | Integrated machine-learning framework to estimate homologous recombination deficiency |
| EP3924503A4 (en) | 2019-02-12 | 2023-03-08 | Tempus Labs, Inc. | DETECTION OF LOSS OF HETEROZYGOSIS IN HUMAN LEUKOCYTE ANTIGEN |
| ES3043308T3 (en) | 2019-02-26 | 2025-11-25 | Tempus Ai Inc | Systems and methods for using sequencing data for pathogen detection |
| JP7747524B2 (ja) | 2019-05-14 | 2025-10-01 | テンパス エーアイ，インコーポレイテッド | マルチラベルがん分類のためのシステムおよび方法 |
| US20200395097A1 (en) | 2019-05-30 | 2020-12-17 | Tempus Labs, Inc. | Pan-cancer model to predict the pd-l1 status of a cancer cell sample using rna expression data and other patient data |
| EP3977343A4 (en) | 2019-05-31 | 2023-06-14 | Tempus Labs | CLINICAL TRIAL EVALUATION SYSTEMS AND METHODS |
| US11705226B2 (en) | 2019-09-19 | 2023-07-18 | Tempus Labs, Inc. | Data based cancer research and treatment systems and methods |
| WO2021022225A1 (en) | 2019-08-01 | 2021-02-04 | Tempus Labs, Inc. | Methods and systems for detecting microsatellite instability of a cancer in a liquid biopsy assay |
| AU2020334901A1 (en) | 2019-08-16 | 2022-03-24 | Tempus Ai, Inc. | Systems and methods for detecting cellular pathway dysregulation in cancer specimens |
| US11041200B2 (en) | 2019-10-21 | 2021-06-22 | Tempus Labs, Inc. | Systems and methods for next generation sequencing uniform probe design |
| WO2021080978A1 (en) | 2019-10-21 | 2021-04-29 | Tempus Labs, Inc. | Calculating cell-type rna profiles for diagnosis and treatment |
| WO2021081253A1 (en) | 2019-10-22 | 2021-04-29 | Tempus Labs, Inc. | Systems and methods for predicting therapeutic sensitivity |
| US20210118559A1 (en) | 2019-10-22 | 2021-04-22 | Tempus Labs, Inc. | Artificial intelligence assisted precision medicine enhancements to standardized laboratory diagnostic testing |
| US11629385B2 (en) | 2019-11-22 | 2023-04-18 | Tempus Labs, Inc. | Tumor organoid culture compositions, systems, and methods |
| WO2021113749A1 (en) | 2019-12-04 | 2021-06-10 | Tempus Labs, Inc. | Systems and methods for automating rna expression calls in a cancer prediction pipeline |
| EP4070232A4 (en) | 2019-12-05 | 2024-01-31 | Tempus Labs, Inc. | SYSTEMS AND METHODS FOR HIGH-THROUGHPUT ACTIVE SCREENING |
| US20230197269A1 (en) | 2020-02-18 | 2023-06-22 | Tempus Labs, Inc. | Systems and methods for detecting viral dna from sequencing |
-
2021
- 2021-04-21 CA CA3174332A patent/CA3174332A1/en active Pending
- 2021-04-21 US US17/302,030 patent/US11414700B2/en active Active
- 2021-04-21 AU AU2021259958A patent/AU2021259958A1/en active Pending
- 2021-04-21 JP JP2022564450A patent/JP2023515270A/ja active Pending
- 2021-04-21 EP EP21792956.1A patent/EP4139477A4/en active Pending
- 2021-04-21 WO PCT/US2021/070440 patent/WO2021217181A1/en not_active Ceased
-
2022
- 2022-08-12 US US17/886,769 patent/US12129519B2/en active Active
-
2024
- 2024-10-23 US US18/924,744 patent/US20250115954A1/en active Pending
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