JP2023515270A - Tcr/bcrプロファイリング - Google Patents

Tcr/bcrプロファイリング Download PDF

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JP2023515270A
JP2023515270A JP2022564450A JP2022564450A JP2023515270A JP 2023515270 A JP2023515270 A JP 2023515270A JP 2022564450 A JP2022564450 A JP 2022564450A JP 2022564450 A JP2022564450 A JP 2022564450A JP 2023515270 A JP2023515270 A JP 2023515270A
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tcr
bcr
layer
probes
sequencing
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ジェイソン・ペレラ
テイラー・ハーディング
ブリタニー・ミネオ
アリー・エー・カーン
リチャード・ブリドナー
ジェンナ・エル・マリナウスカス
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テンパス・ラボズ・インコーポレイテッド
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JP2022564450A 2020-04-21 2021-04-21 Tcr/bcrプロファイリング Pending JP2023515270A (ja)

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US202063013130P 2020-04-21 2020-04-21
US63/013,130 2020-04-21
US202063084459P 2020-09-28 2020-09-28
US63/084,459 2020-09-28
US202163201020P 2021-04-08 2021-04-08
US63/201,020 2021-04-08
PCT/US2021/070440 WO2021217181A1 (en) 2020-04-21 2021-04-21 Tcr/bcr profiling

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JP2023515270A5 JP2023515270A5 (https=) 2025-08-15

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EP (1) EP4139477A4 (https=)
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AU (1) AU2021259958A1 (https=)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4271837A4 (en) 2020-12-31 2025-10-15 Tempus Ai Inc SYSTEMS AND METHODS FOR DETECTING MULTIMOLECULAR BIOMARKERS
WO2023064309A1 (en) 2021-10-11 2023-04-20 Tempus Labs, Inc. Methods and systems for detecting alternative splicing in sequencing data
US20250011886A1 (en) * 2021-11-17 2025-01-09 Ampel Biosolutions, Llc Systems and Methods for Targeting COVID-19 Therapies
WO2023115065A2 (en) * 2021-12-17 2023-06-22 Allen Institute Molecular signatures for cell typing and monitoring immune health
EP4499877A4 (en) * 2022-03-25 2026-04-08 Freenome Holdings Inc TCR/BCR Profiling for Cell-Free Nucleic Acid Cancer Detection
BE1031300B1 (fr) 2023-01-30 2024-09-03 Grand Hopital De Charleroi Procede pour l'integration ciblée d'identificateurs moleculaires uniques (ium) et la détection de haute précision d'états médicaux ou cosmetiques
US20240355485A1 (en) 2023-04-13 2024-10-24 Tempus Ai, Inc. Systems and methods for predicting clinical response
CN116751280B (zh) * 2023-05-17 2024-01-26 复旦大学附属中山医院 一种特异性识别SARS-CoV-2新冠病毒S蛋白抗原肽的T细胞受体及制备和应用
EP4550335A1 (en) 2023-10-31 2025-05-07 Tempus AI, Inc. T cell receptor screening methods
WO2025175065A1 (en) * 2024-02-13 2025-08-21 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for assessment of immune response and applications thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020056451A1 (en) * 2018-09-21 2020-03-26 Garvan Institute Of Medical Research Phenotypic and molecular characterisation of single cells

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635354A (en) 1991-01-09 1997-06-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for describing the repertoires of antibodies (Ab) and of T-cell receptors (TcR) of an individual's immune system
US6080840A (en) 1992-01-17 2000-06-27 Slanetz; Alfred E. Soluble T cell receptors
US6399368B1 (en) 1992-01-17 2002-06-04 Board Of Regents, The University Of Texas System Secretion of T cell receptor fragments from recombinant Escherichia coli cells
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
IL160359A0 (en) 2001-08-31 2004-07-25 Avidex Ltd Soluble t cell receptor
US9193997B2 (en) * 2010-12-15 2015-11-24 The Board Of Trustees Of The Leland Stanford Junior University Measuring and monitoring of cell clonality
US20170335331A1 (en) 2014-10-31 2017-11-23 The Trustees Of The University Of Pennsylvania Altering Gene Expression in CART Cells and Uses Thereof
EP3227464B1 (en) 2014-12-05 2022-04-20 Foundation Medicine, Inc. Multigene analysis of tumor samples
KR20230006929A (ko) * 2016-01-13 2023-01-11 리제너론 파마슈티칼스 인코포레이티드 조작된 중쇄 다양성 영역을 갖는 설치류
EP3443149B1 (en) * 2016-04-15 2024-08-14 University Health Network (UHN) Hybrid-capture sequencing for determining immune cell clonality
GB201612242D0 (en) * 2016-07-14 2016-08-31 Genome Res Ltd And Cambridge Entpr Ltd Novel kit
EP3568508A4 (en) * 2017-01-12 2020-12-16 Massachusetts Institute Of Technology METHODS FOR T-LYMPHOCYTE RECEPTOR AND B-LYMPHOCYTE RECEPTOR ANALYSIS
EP3631053A4 (en) * 2017-05-30 2021-05-19 University of Health Network Hybrid-capture sequencing for determining immune cell clonality
WO2018231958A1 (en) * 2017-06-13 2018-12-20 Adaptive Biotechnologies Corp. Determining wt-1 specific t cells and wt-1 specific t cell receptors (tcrs)
US10957041B2 (en) 2018-05-14 2021-03-23 Tempus Labs, Inc. Determining biomarkers from histopathology slide images
US10801064B2 (en) * 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
AU2019317440B2 (en) 2018-08-06 2026-01-22 Tempus Ai, Inc. A multi-modal approach to predicting immune infiltration based on integrated RNA expression and imaging features
AU2019346427A1 (en) 2018-09-24 2021-05-13 Tempus Ai, Inc. Methods of normalizing and correcting RNA expression data
WO2020081607A1 (en) 2018-10-15 2020-04-23 Tempus Labs, Inc. Microsatellite instability determination system and related methods
US20200258601A1 (en) 2018-10-17 2020-08-13 Tempus Labs Targeted-panel tumor mutational burden calculation systems and methods
US20200365232A1 (en) 2018-10-17 2020-11-19 Tempus Labs Adaptive order fulfillment and tracking methods and systems
EP4198057A1 (en) * 2018-12-05 2023-06-21 F. Hoffmann-La Roche AG Diagnostic methods and compositions for cancer immunotherapy
AU2019418813A1 (en) 2018-12-31 2021-07-22 Tempus Ai, Inc. A method and process for predicting and analyzing patient cohort response, progression, and survival
WO2020142563A1 (en) 2018-12-31 2020-07-09 Tempus Labs, Inc. Transcriptome deconvolution of metastatic tissue samples
US10975445B2 (en) 2019-02-12 2021-04-13 Tempus Labs, Inc. Integrated machine-learning framework to estimate homologous recombination deficiency
EP3924503A4 (en) 2019-02-12 2023-03-08 Tempus Labs, Inc. DETECTION OF LOSS OF HETEROZYGOSIS IN HUMAN LEUKOCYTE ANTIGEN
ES3043308T3 (en) 2019-02-26 2025-11-25 Tempus Ai Inc Systems and methods for using sequencing data for pathogen detection
JP7747524B2 (ja) 2019-05-14 2025-10-01 テンパス エーアイ,インコーポレイテッド マルチラベルがん分類のためのシステムおよび方法
US20200395097A1 (en) 2019-05-30 2020-12-17 Tempus Labs, Inc. Pan-cancer model to predict the pd-l1 status of a cancer cell sample using rna expression data and other patient data
EP3977343A4 (en) 2019-05-31 2023-06-14 Tempus Labs CLINICAL TRIAL EVALUATION SYSTEMS AND METHODS
US11705226B2 (en) 2019-09-19 2023-07-18 Tempus Labs, Inc. Data based cancer research and treatment systems and methods
WO2021022225A1 (en) 2019-08-01 2021-02-04 Tempus Labs, Inc. Methods and systems for detecting microsatellite instability of a cancer in a liquid biopsy assay
AU2020334901A1 (en) 2019-08-16 2022-03-24 Tempus Ai, Inc. Systems and methods for detecting cellular pathway dysregulation in cancer specimens
US11041200B2 (en) 2019-10-21 2021-06-22 Tempus Labs, Inc. Systems and methods for next generation sequencing uniform probe design
WO2021080978A1 (en) 2019-10-21 2021-04-29 Tempus Labs, Inc. Calculating cell-type rna profiles for diagnosis and treatment
WO2021081253A1 (en) 2019-10-22 2021-04-29 Tempus Labs, Inc. Systems and methods for predicting therapeutic sensitivity
US20210118559A1 (en) 2019-10-22 2021-04-22 Tempus Labs, Inc. Artificial intelligence assisted precision medicine enhancements to standardized laboratory diagnostic testing
US11629385B2 (en) 2019-11-22 2023-04-18 Tempus Labs, Inc. Tumor organoid culture compositions, systems, and methods
WO2021113749A1 (en) 2019-12-04 2021-06-10 Tempus Labs, Inc. Systems and methods for automating rna expression calls in a cancer prediction pipeline
EP4070232A4 (en) 2019-12-05 2024-01-31 Tempus Labs, Inc. SYSTEMS AND METHODS FOR HIGH-THROUGHPUT ACTIVE SCREENING
US20230197269A1 (en) 2020-02-18 2023-06-22 Tempus Labs, Inc. Systems and methods for detecting viral dna from sequencing

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020056451A1 (en) * 2018-09-21 2020-03-26 Garvan Institute Of Medical Research Phenotypic and molecular characterisation of single cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NAT BIOTECHNOL, vol. 36(1), JPN6025018216, 2018, pages 60 - 10, ISSN: 0005732719 *

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US11414700B2 (en) 2022-08-16
CA3174332A1 (en) 2021-10-28
US20250115954A1 (en) 2025-04-10
WO2021217181A1 (en) 2021-10-28
EP4139477A1 (en) 2023-03-01
US12129519B2 (en) 2024-10-29
AU2021259958A1 (en) 2022-11-17
EP4139477A4 (en) 2024-05-22
US20210355533A1 (en) 2021-11-18

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