JP2016505559A5 - - Google Patents
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- Publication number
- JP2016505559A5 JP2016505559A5 JP2015546121A JP2015546121A JP2016505559A5 JP 2016505559 A5 JP2016505559 A5 JP 2016505559A5 JP 2015546121 A JP2015546121 A JP 2015546121A JP 2015546121 A JP2015546121 A JP 2015546121A JP 2016505559 A5 JP2016505559 A5 JP 2016505559A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- engineered
- amino acid
- linked glycosylation
- monomeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 38
- 102000004196 processed proteins & peptides Human genes 0.000 claims 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims 38
- 230000004988 N-glycosylation Effects 0.000 claims 13
- 150000001413 amino acids Chemical class 0.000 claims 10
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims 8
- 238000006471 dimerization reaction Methods 0.000 claims 7
- 230000004048 modification Effects 0.000 claims 7
- 238000012986 modification Methods 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 238000005215 recombination Methods 0.000 claims 3
- 230000006798 recombination Effects 0.000 claims 3
- 108091035707 Consensus sequence Proteins 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108091006020 Fc-tagged proteins Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261734841P | 2012-12-07 | 2012-12-07 | |
| US61/734,841 | 2012-12-07 | ||
| PCT/IB2013/060384 WO2014087299A1 (en) | 2012-12-07 | 2013-11-25 | Engineered monomeric antibody fragments |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505559A JP2016505559A (ja) | 2016-02-25 |
| JP2016505559A5 true JP2016505559A5 (cg-RX-API-DMAC7.html) | 2017-01-12 |
| JP6396313B2 JP6396313B2 (ja) | 2018-09-26 |
Family
ID=50001048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015546121A Expired - Fee Related JP6396313B2 (ja) | 2012-12-07 | 2013-11-25 | 操作された単量体抗体断片 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10233229B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2928917B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6396313B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2892756C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2664095T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014087299A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015074063A1 (en) * | 2013-11-18 | 2015-05-21 | University Of Maryland, Baltimore | Hyper-glycosylated antibodies with selective fc receptor binding |
| US20160130324A1 (en) | 2014-10-31 | 2016-05-12 | Shire Human Genetic Therapies, Inc. | C1 Inhibitor Fusion Proteins and Uses Thereof |
| MA45473A (fr) | 2016-04-04 | 2019-02-13 | Shire Human Genetic Therapies | Inhibiteur de c1 estérase conjugué et ses utilisations |
| US12054544B2 (en) | 2017-02-24 | 2024-08-06 | Chugai Seiyaku Kabushiki Kaisha | Compositions comprising antigen-binding molecules |
| WO2019023097A1 (en) * | 2017-07-26 | 2019-01-31 | Smet Pharmaceutical Inc | ASYMMETRIC BISPECIFIC ANTIBODIES AND THEIR USE |
| WO2020221450A1 (en) * | 2019-04-30 | 2020-11-05 | Humabs Biomed Sa | Antibodies and methods for treatment of influenza a infection |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| JP2532858B2 (ja) | 1985-04-01 | 1996-09-11 | セルテツク リミテツド | 形質転換したミエロ―マ細胞系 |
| US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| US6517529B1 (en) | 1999-11-24 | 2003-02-11 | Radius International Limited Partnership | Hemodialysis catheter |
| KR100545720B1 (ko) * | 2004-05-31 | 2006-01-24 | 메덱스젠 주식회사 | 당화된 면역글로불린 및 이를 포함하는 면역접합체 |
| US7393662B2 (en) * | 2004-09-03 | 2008-07-01 | Centocor, Inc. | Human EPO mimetic hinge core mimetibodies, compositions, methods and uses |
| WO2006031994A2 (en) * | 2004-09-14 | 2006-03-23 | Xencor, Inc. | Monomeric immunoglobulin fc domains |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| EA016609B1 (ru) | 2005-11-28 | 2012-06-29 | Генмаб А/С | Рекомбинантные моновалентные антитела и способы их получения |
| US20110045007A1 (en) | 2007-05-31 | 2011-02-24 | Genmab A/S | Fusion or linked proteins with extended half life |
| CA2766166A1 (en) * | 2009-07-08 | 2011-01-13 | Amgen Inc. | Design of stable and aggregation free antibody fc molecules through ch3 domain interface engineering |
| WO2011059684A1 (en) * | 2009-10-29 | 2011-05-19 | Centocor Ortho Biotech Inc. | Antibody glycosylation variants |
| ES2688978T3 (es) * | 2009-11-23 | 2018-11-07 | Amgen Inc. | Anticuerpo monomérico Fc |
-
2013
- 2013-11-25 CA CA2892756A patent/CA2892756C/en active Active
- 2013-11-25 WO PCT/IB2013/060384 patent/WO2014087299A1/en not_active Ceased
- 2013-11-25 EP EP13824174.0A patent/EP2928917B1/en not_active Not-in-force
- 2013-11-25 ES ES13824174.0T patent/ES2664095T3/es active Active
- 2013-11-25 US US14/650,188 patent/US10233229B2/en active Active
- 2013-11-25 JP JP2015546121A patent/JP6396313B2/ja not_active Expired - Fee Related