JP2016505036A5 - - Google Patents
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- Publication number
- JP2016505036A5 JP2016505036A5 JP2015553165A JP2015553165A JP2016505036A5 JP 2016505036 A5 JP2016505036 A5 JP 2016505036A5 JP 2015553165 A JP2015553165 A JP 2015553165A JP 2015553165 A JP2015553165 A JP 2015553165A JP 2016505036 A5 JP2016505036 A5 JP 2016505036A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- ray powder
- crystalline
- form according
- powder diffraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 13
- 208000021642 Muscular disease Diseases 0.000 claims description 13
- 206010010904 Convulsion Diseases 0.000 claims description 12
- 206010044565 Tremor Diseases 0.000 claims description 12
- 230000036461 convulsion Effects 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 10
- 201000009623 Myopathy Diseases 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 230000002265 prevention Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 3
- 208000029578 Muscle disease Diseases 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims 9
- 238000000634 powder X-ray diffraction Methods 0.000 claims 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 239000012458 free base Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 206010012735 Diarrhoea Diseases 0.000 claims 2
- 206010021333 Ileus paralytic Diseases 0.000 claims 2
- 201000005081 Intestinal Pseudo-Obstruction Diseases 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 2
- 208000007107 Stomach Ulcer Diseases 0.000 claims 2
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 2
- 239000002178 crystalline material Substances 0.000 claims 2
- 208000010643 digestive system disease Diseases 0.000 claims 2
- 201000005917 gastric ulcer Diseases 0.000 claims 2
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000018360 neuromuscular disease Diseases 0.000 claims 2
- 201000007620 paralytic ileus Diseases 0.000 claims 2
- 201000009881 secretory diarrhea Diseases 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 206010048994 Bladder spasm Diseases 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003387 muscular Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002390 rotary evaporation Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 238000010792 warming Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1300903.0A GB201300903D0 (en) | 2013-01-18 | 2013-01-18 | Crystalline Form |
| GB1300903.0 | 2013-01-18 | ||
| PCT/GB2014/050127 WO2014111720A1 (en) | 2013-01-18 | 2014-01-17 | Crystalline form of vsn16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016505036A JP2016505036A (ja) | 2016-02-18 |
| JP2016505036A5 true JP2016505036A5 (https=) | 2017-02-23 |
Family
ID=47843537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553165A Pending JP2016505036A (ja) | 2013-01-18 | 2014-01-17 | Ｖｓｎ１６の結晶形態 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9682924B2 (https=) |
| EP (1) | EP2945619B1 (https=) |
| JP (1) | JP2016505036A (https=) |
| CN (1) | CN105142626A (https=) |
| CA (1) | CA2897524A1 (https=) |
| GB (1) | GB201300903D0 (https=) |
| NZ (1) | NZ630795A (https=) |
| RU (1) | RU2015134560A (https=) |
| WO (1) | WO2014111720A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3256112A1 (en) * | 2015-02-13 | 2017-12-20 | Canbex Therapeutics Limited | Compounds for treating disorders associated with bk channel modulation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0403864D0 (en) * | 2004-02-20 | 2004-03-24 | Ucl Ventures | Modulator |
| GB0903956D0 (en) | 2009-03-06 | 2009-04-22 | Ucl Business Plc | Process |
-
2013
- 2013-01-18 GB GBGB1300903.0A patent/GB201300903D0/en not_active Ceased
-
2014
- 2014-01-17 US US14/760,592 patent/US9682924B2/en active Active
- 2014-01-17 CA CA2897524A patent/CA2897524A1/en not_active Abandoned
- 2014-01-17 NZ NZ630795A patent/NZ630795A/en not_active IP Right Cessation
- 2014-01-17 EP EP14702299.0A patent/EP2945619B1/en active Active
- 2014-01-17 RU RU2015134560A patent/RU2015134560A/ru not_active Application Discontinuation
- 2014-01-17 WO PCT/GB2014/050127 patent/WO2014111720A1/en not_active Ceased
- 2014-01-17 CN CN201480013204.7A patent/CN105142626A/zh active Pending
- 2014-01-17 JP JP2015553165A patent/JP2016505036A/ja active Pending
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