JP2016505006A5 - - Google Patents
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- Publication number
- JP2016505006A5 JP2016505006A5 JP2015550784A JP2015550784A JP2016505006A5 JP 2016505006 A5 JP2016505006 A5 JP 2016505006A5 JP 2015550784 A JP2015550784 A JP 2015550784A JP 2015550784 A JP2015550784 A JP 2015550784A JP 2016505006 A5 JP2016505006 A5 JP 2016505006A5
- Authority
- JP
- Japan
- Prior art keywords
- levonorgestrel
- drug delivery
- delivery system
- days
- transdermal drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000013271 transdermal drug delivery Methods 0.000 claims description 30
- ORKBYCQJWQBPFG-WOMZHKBXSA-N (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 ORKBYCQJWQBPFG-WOMZHKBXSA-N 0.000 claims description 22
- 239000011159 matrix material Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- 229920000642 polymer Polymers 0.000 claims description 17
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 16
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 16
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 16
- 229960002826 levonorgestrel and ethinylestradiol Drugs 0.000 claims description 14
- 229920000058 polyacrylate Polymers 0.000 claims description 14
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 13
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 13
- 229960002568 ethinylestradiol Drugs 0.000 claims description 13
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims description 10
- 229960004400 levonorgestrel Drugs 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 8
- 230000002459 sustained effect Effects 0.000 claims description 8
- 230000037317 transdermal delivery Effects 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000003961 penetration enhancing agent Substances 0.000 claims description 6
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 4
- 230000000699 topical effect Effects 0.000 claims description 4
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 claims description 2
- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims description 2
- 210000004877 mucosa Anatomy 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 claims 2
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 230000004907 flux Effects 0.000 description 3
- KBFRRZPPJPKFHQ-WOMZHKBXSA-N (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.ON=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 KBFRRZPPJPKFHQ-WOMZHKBXSA-N 0.000 description 2
- 229940071844 ortho evra Drugs 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261747013P | 2012-12-28 | 2012-12-28 | |
| US61/747,013 | 2012-12-28 | ||
| PCT/US2013/077932 WO2014106014A1 (en) | 2012-12-28 | 2013-12-27 | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016505006A JP2016505006A (ja) | 2016-02-18 |
| JP2016505006A5 true JP2016505006A5 (https=) | 2017-02-09 |
Family
ID=49956517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015550784A Pending JP2016505006A (ja) | 2012-12-28 | 2013-12-27 | レボノルゲストレル及びエチニルエストラジオール用の経皮薬物送達システム |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9314470B2 (https=) |
| JP (1) | JP2016505006A (https=) |
| AR (1) | AR094289A1 (https=) |
| TW (1) | TW201431554A (https=) |
| WO (1) | WO2014106014A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9314470B2 (en) | 2012-12-28 | 2016-04-19 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
| MX366230B (es) | 2012-12-28 | 2019-07-03 | Noven Pharma | Composiciones multipolimericas para liberación transdermica de farmaco. |
| WO2014159582A1 (en) | 2013-03-14 | 2014-10-02 | Noven Pharmaceuticals, Inc | Amphetamine transdermal compositions with acrylic block copolymer |
| AR095259A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria |
| AR095260A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones de anfetaminas transdérmicas estables y métodos de fabricación |
| AU2016215180B2 (en) | 2015-02-06 | 2020-01-02 | Noven Pharmaceuticals, Inc. | Pressure-sensitive adhesives for transdermal drug delivery |
| US10406116B2 (en) | 2015-02-06 | 2019-09-10 | Noven Pharmaceuticals, Inc. | Pressure-sensitive adhesives for transdermal drug delivery |
| US20170000745A1 (en) * | 2015-07-02 | 2017-01-05 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
| JP7220473B2 (ja) * | 2017-10-30 | 2023-02-10 | 帝國製薬株式会社 | 経皮投与製剤 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863738A (en) * | 1987-11-23 | 1989-09-05 | Alza Corporation | Skin permeation enhancer compositions using glycerol monooleate |
| US5474783A (en) | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5719197A (en) | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5446070A (en) | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5234957A (en) | 1991-02-27 | 1993-08-10 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5053227A (en) | 1989-03-22 | 1991-10-01 | Cygnus Therapeutic Systems | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith |
| US5332576A (en) | 1991-02-27 | 1994-07-26 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US6024974A (en) | 1995-01-06 | 2000-02-15 | Noven Pharmaceuticals, Inc. | Composition and methods for transdermal delivery of acid labile drugs |
| US6316022B1 (en) | 1995-06-07 | 2001-11-13 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
| IL122484A0 (en) | 1995-06-07 | 1998-06-15 | Noven Pharma | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
| US6210705B1 (en) | 1997-12-15 | 2001-04-03 | Noven Pharmaceuticals, Nc. | Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
| US20020102291A1 (en) | 1997-12-15 | 2002-08-01 | Noven Pharmaceuticals, Inc. | Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
| ATE288256T1 (de) | 1999-01-14 | 2005-02-15 | Noven Pharma | Dermale zusammensetzungen |
| US20030170195A1 (en) | 2000-01-10 | 2003-09-11 | Noven Pharmaceuticals, Inc. | Compositions and methods for drug delivery |
| US7045145B1 (en) * | 1999-11-24 | 2006-05-16 | Agile Therapeutics, Inc. | Transdermal contraceptive delivery system and process |
| US7384650B2 (en) | 1999-11-24 | 2008-06-10 | Agile Therapeutics, Inc. | Skin permeation enhancement composition for transdermal hormone delivery system |
| KR100758757B1 (ko) | 1999-11-24 | 2007-09-14 | 애자일 쎄라퓨틱스, 인크. | 개량된 경피적 피임제 송달시스템 및 송달방법 |
| WO2001052823A2 (en) * | 2000-01-20 | 2001-07-26 | Noven Pharmaceuticals, Inc. | Compositions to effect the release profile in the transdermal administration of drugs |
| IL159415A0 (en) | 2001-06-18 | 2004-06-01 | Noven Pharma | Enhanced drug delivery in transdermal systems |
| US20050019385A1 (en) | 2003-07-21 | 2005-01-27 | Noven Pharmaceuticals, Inc. | Composition and method for controlling drug delivery from silicone adhesive blends |
| EP1682102A2 (en) | 2003-09-10 | 2006-07-26 | Noven Pharmaceuticals, Inc. | Multi-layer transdermal drug delivery device |
| MEP23508A (en) | 2003-10-28 | 2010-06-10 | Noven Pharma | Compositions and methods for comtrolling drug loss and delivery in transdermal drug delivery systems |
| US8246976B2 (en) | 2004-10-08 | 2012-08-21 | Noven Pharmaceuticals, Inc. | Transdermal delivery of drugs based on crystal size |
| WO2006041911A2 (en) | 2004-10-08 | 2006-04-20 | Noven Pharmaceuticals, Inc. | Device transdermal administration of drugs including acrylic polymers |
| US8343538B2 (en) | 2004-10-08 | 2013-01-01 | Noven Pharmaceuticals, Inc. | Compositions and methods for controlling the flux of a drug from a transdermal drug delivery systems |
| JP4950510B2 (ja) * | 2006-02-16 | 2012-06-13 | 久光製薬株式会社 | 経皮吸収製剤 |
| JP2009528357A (ja) | 2006-02-27 | 2009-08-06 | ノーヴェン ファーマシューティカルズ インコーポレイテッド | アミノ官能性薬剤の投与のための組成物及び方法 |
| NZ576992A (en) | 2006-10-27 | 2011-02-25 | Noven Pharma | Transdermal delivery of ketoprofen polar derivatives |
| EA020208B1 (ru) | 2007-07-10 | 2014-09-30 | Эджайл Терапьютикс, Инк. | Устройство доставки в кожу с изолирующим слоем in situ |
| US20090098191A1 (en) * | 2007-10-16 | 2009-04-16 | Anderson Christopher G | Use of bases to stabilize transdermal formulations |
| US8231906B2 (en) | 2008-07-10 | 2012-07-31 | Noven Pharmaceuticals, Inc. | Transdermal estrogen device and delivery |
| US8852628B1 (en) | 2009-07-13 | 2014-10-07 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery system for diclofenac |
| EP2506838A1 (en) | 2009-12-01 | 2012-10-10 | Noven Pharmaceuticals, INC. | Transdermal testosterone device and delivery |
| WO2011118683A1 (ja) * | 2010-03-25 | 2011-09-29 | 東洋化学株式会社 | 医用貼付剤 |
| WO2012092165A1 (en) | 2010-12-29 | 2012-07-05 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery system comprising levonorgestrel acetate |
| CA2891467A1 (en) | 2012-10-15 | 2014-04-24 | Noven Pharmaceuticals, Inc. | Compositions and methods for the transdermal delivery of methylphenidate |
| ES2621915T3 (es) | 2012-10-25 | 2017-07-05 | Noven Pharmaceuticals, Inc. | Composiciones y métodos para la administración transdérmica de anfetamina |
| EA030797B1 (ru) | 2012-12-21 | 2018-09-28 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Система трансдермальной доставки гормонов (варианты) и способы ее применения |
| US9314470B2 (en) | 2012-12-28 | 2016-04-19 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
| MX2015008284A (es) | 2012-12-28 | 2015-12-03 | Noven Pharma | Composiciones y metodos para suministro transdermico de agentes no esteroidales anti-inflamatorios. |
| MX366230B (es) | 2012-12-28 | 2019-07-03 | Noven Pharma | Composiciones multipolimericas para liberación transdermica de farmaco. |
| WO2014159582A1 (en) | 2013-03-14 | 2014-10-02 | Noven Pharmaceuticals, Inc | Amphetamine transdermal compositions with acrylic block copolymer |
| US20140271792A1 (en) | 2013-03-14 | 2014-09-18 | Noven Pharmaceuticals, Inc. | Methylphenidate transdermal compositions with rubber-based adhesives |
| US20140276479A1 (en) | 2013-03-14 | 2014-09-18 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery system with overlay |
| US20140276483A1 (en) | 2013-03-14 | 2014-09-18 | Noven Pharmaceuticals, Inc. | Transdermal methylphenidate compositions with acrylic block copolymers |
| AR095259A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria |
| AR095260A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones de anfetaminas transdérmicas estables y métodos de fabricación |
| US20170000745A1 (en) | 2015-07-02 | 2017-01-05 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
-
2013
- 2013-12-27 US US14/141,935 patent/US9314470B2/en active Active
- 2013-12-27 JP JP2015550784A patent/JP2016505006A/ja active Pending
- 2013-12-27 WO PCT/US2013/077932 patent/WO2014106014A1/en not_active Ceased
- 2013-12-27 AR ARP130105039A patent/AR094289A1/es unknown
- 2013-12-27 TW TW102148839A patent/TW201431554A/zh unknown
-
2016
- 2016-03-14 US US15/069,425 patent/US10231977B2/en active Active
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