JP2016504351A5 - - Google Patents
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- JP2016504351A5 JP2016504351A5 JP2015550315A JP2015550315A JP2016504351A5 JP 2016504351 A5 JP2016504351 A5 JP 2016504351A5 JP 2015550315 A JP2015550315 A JP 2015550315A JP 2015550315 A JP2015550315 A JP 2015550315A JP 2016504351 A5 JP2016504351 A5 JP 2016504351A5
- Authority
- JP
- Japan
- Prior art keywords
- diastereomer
- enantiomer
- isomer
- compound according
- racemic mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261746980P | 2012-12-28 | 2012-12-28 | |
| US61/746,980 | 2012-12-28 | ||
| PCT/KR2013/012204 WO2014104757A1 (ko) | 2012-12-28 | 2013-12-26 | Btk 키나아제 억제제로서의 2,3-디하이드로-이소인돌-1-온 유도체 및 이를 함유하는 약학적 조성물 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018076877A Division JP6596537B2 (ja) | 2012-12-28 | 2018-04-12 | Ｂｔｋキナーゼ抑制剤としての２，３−ジヒドロ−イソインドール−１−オン誘導体及びこれを含む薬学的組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016504351A JP2016504351A (ja) | 2016-02-12 |
| JP2016504351A5 true JP2016504351A5 (OSRAM) | 2017-02-16 |
| JP6325573B2 JP6325573B2 (ja) | 2018-05-16 |
Family
ID=51021712
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015550315A Active JP6325573B2 (ja) | 2012-12-28 | 2013-12-26 | Ｂｔｋキナーゼ抑制剤としての２，３−ジヒドロ−イソインドール−１−オン誘導体及びこれを含む薬学的組成物 |
| JP2018076877A Active JP6596537B2 (ja) | 2012-12-28 | 2018-04-12 | Ｂｔｋキナーゼ抑制剤としての２，３−ジヒドロ−イソインドール−１−オン誘導体及びこれを含む薬学的組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018076877A Active JP6596537B2 (ja) | 2012-12-28 | 2018-04-12 | Ｂｔｋキナーゼ抑制剤としての２，３−ジヒドロ−イソインドール−１−オン誘導体及びこれを含む薬学的組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US9758508B2 (OSRAM) |
| EP (2) | EP3428161B1 (OSRAM) |
| JP (2) | JP6325573B2 (OSRAM) |
| KR (1) | KR102009163B1 (OSRAM) |
| CN (1) | CN104995184B (OSRAM) |
| AU (3) | AU2013371146C1 (OSRAM) |
| BR (1) | BR112015015477B1 (OSRAM) |
| CA (1) | CA2896711C (OSRAM) |
| DK (1) | DK2940014T3 (OSRAM) |
| ES (2) | ES2696700T3 (OSRAM) |
| MX (2) | MX2021011563A (OSRAM) |
| PL (1) | PL2940014T3 (OSRAM) |
| PT (1) | PT2940014T (OSRAM) |
| RU (2) | RU2018138028A (OSRAM) |
| WO (1) | WO2014104757A1 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3205654T3 (pl) | 2010-05-20 | 2019-08-30 | Array Biopharma, Inc. | Związki makrocykliczne jako inhibitory kinazy TRK |
| MX2021011563A (es) | 2012-12-28 | 2022-10-10 | Crystalgenomics Inc | Derivados de 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmaceuticas que los incluyen. |
| BR112018000808A2 (pt) | 2015-07-16 | 2018-09-04 | Array Biopharma Inc | compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| WO2018102785A2 (en) | 2016-12-03 | 2018-06-07 | Juno Therapeutics, Inc. | Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| WO2018136661A1 (en) | 2017-01-18 | 2018-07-26 | Andrews Steven W | SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS |
| EP3585778A4 (en) * | 2017-02-21 | 2020-12-02 | Aptose Biosciences Inc. | METHODS OF TREATING PATIENTS WITH HEMATOLOGICAL MALIGNACIES |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TW201932464A (zh) | 2018-01-18 | 2019-08-16 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑基[4,3-c]吡啶化合物 |
| CN111630054B (zh) | 2018-01-18 | 2023-05-09 | 奥瑞生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物 |
| WO2019143977A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| WO2020055672A1 (en) | 2018-09-10 | 2020-03-19 | Array Biopharma Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
| JP2022509257A (ja) * | 2018-11-30 | 2022-01-20 | アプトース バイオサイエンシズ インコーポレイテッド | ２，３－ジヒドロ－イソインドール－１－オン化合物を用いた組合せ療法及び様々な変異を有する患者を治療するための方法 |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| EP4274567A1 (en) * | 2021-01-05 | 2023-11-15 | Sumitomo Pharma Oncology, Inc. | Forms and formulations of a tyrosine kinase non-receptor 1 (tnk1) inhibitor |
| WO2022187856A1 (en) * | 2021-03-05 | 2022-09-09 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
| WO2022213062A1 (en) | 2021-03-29 | 2022-10-06 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
| WO2024245578A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor |
| WO2024245577A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2246012T3 (es) * | 2001-04-12 | 2006-02-01 | F. Hoffmann-La Roche Ag | Derivados de dihidro benzo(b) (1,4)diacepin-2-ona como antagonistas de mglur2 ii. |
| JP2006526648A (ja) * | 2003-06-02 | 2006-11-24 | アボット・ラボラトリーズ | キナーゼ阻害剤としてのイソインドリン−１−オン化合物 |
| PE20061119A1 (es) * | 2005-01-19 | 2006-11-27 | Aventis Pharma Sa | PIRAZOLO PIRIDINAS SUSTITUIDAS COMO INHIBIDORES DE CINASAS FAK, KDR Y Tie |
| KR20080011199A (ko) | 2005-04-19 | 2008-01-31 | 교와 핫꼬 고교 가부시끼가이샤 | 질소 함유 복소환 화합물 |
| WO2007047646A2 (en) * | 2005-10-14 | 2007-04-26 | Janssen Pharmaceutica, N.V. | Substituted dihydro-isoindolones useful in treating kinase disorders |
| CN101405001A (zh) * | 2006-03-20 | 2009-04-08 | 霍夫曼-拉罗奇有限公司 | 抑制btk和syk蛋白质激酶的方法 |
| WO2008047831A1 (en) * | 2006-10-17 | 2008-04-24 | Kyowa Hakko Kirin Co., Ltd. | Jak inhibitor |
| SG185330A1 (en) * | 2007-10-23 | 2012-11-29 | Hoffmann La Roche | Novel kinase inhibitors |
| WO2012014017A1 (en) | 2010-07-30 | 2012-02-02 | Poly Medicure Limited | Catheter introducer |
| WO2012047017A2 (ko) * | 2010-10-05 | 2012-04-12 | 크리스탈지노믹스(주) | 2,3-디히드로-이소인돌-1-온 유도체 및 이를 포함하는 조성물 |
| MX2021011563A (es) | 2012-12-28 | 2022-10-10 | Crystalgenomics Inc | Derivados de 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmaceuticas que los incluyen. |
| US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
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2013
- 2013-12-26 MX MX2021011563A patent/MX2021011563A/es unknown
- 2013-12-26 AU AU2013371146A patent/AU2013371146C1/en active Active
- 2013-12-26 US US14/655,954 patent/US9758508B2/en active Active
- 2013-12-26 CA CA2896711A patent/CA2896711C/en active Active
- 2013-12-26 DK DK13867650.7T patent/DK2940014T3/en active
- 2013-12-26 CN CN201380068623.6A patent/CN104995184B/zh active Active
- 2013-12-26 WO PCT/KR2013/012204 patent/WO2014104757A1/ko not_active Ceased
- 2013-12-26 PL PL13867650T patent/PL2940014T3/pl unknown
- 2013-12-26 RU RU2018138028A patent/RU2018138028A/ru unknown
- 2013-12-26 RU RU2015124381A patent/RU2671847C2/ru active
- 2013-12-26 KR KR1020157018342A patent/KR102009163B1/ko active Active
- 2013-12-26 EP EP18190153.9A patent/EP3428161B1/en active Active
- 2013-12-26 PT PT13867650T patent/PT2940014T/pt unknown
- 2013-12-26 ES ES13867650T patent/ES2696700T3/es active Active
- 2013-12-26 EP EP13867650.7A patent/EP2940014B1/en active Active
- 2013-12-26 BR BR112015015477-8A patent/BR112015015477B1/pt active IP Right Grant
- 2013-12-26 JP JP2015550315A patent/JP6325573B2/ja active Active
- 2013-12-26 MX MX2015008396A patent/MX386542B/es unknown
- 2013-12-26 ES ES18190153T patent/ES2929906T3/es active Active
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2017
- 2017-08-30 US US15/691,432 patent/US10604508B2/en active Active
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2018
- 2018-04-12 JP JP2018076877A patent/JP6596537B2/ja active Active
- 2018-08-10 AU AU2018214134A patent/AU2018214134B2/en active Active
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2020
- 2020-02-14 US US16/791,753 patent/US11230539B2/en active Active
- 2020-02-27 AU AU2020201431A patent/AU2020201431B2/en active Active
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2022
- 2022-07-22 US US17/871,458 patent/US20220380346A1/en not_active Abandoned