JP2016504165A - 血小板溶解または活性化のためのデバイスおよび方法 - Google Patents

血小板溶解または活性化のためのデバイスおよび方法 Download PDF

Info

Publication number
JP2016504165A
JP2016504165A JP2015555402A JP2015555402A JP2016504165A JP 2016504165 A JP2016504165 A JP 2016504165A JP 2015555402 A JP2015555402 A JP 2015555402A JP 2015555402 A JP2015555402 A JP 2015555402A JP 2016504165 A JP2016504165 A JP 2016504165A
Authority
JP
Japan
Prior art keywords
platelet
lysis
activation
containing solution
activation chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015555402A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016504165A5 (enExample
Inventor
クリストファー ジェイ センテノ，
クリストファー ジェイ センテノ，
ブライアン ジェイ． リーチ，
ブライアン ジェイ． リーチ，
ライアン ドレガラ，
ライアン ドレガラ，
パトリック レイシュリング，
パトリック レイシュリング，
ニコレット ライオンズ，
ニコレット ライオンズ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2016504165A publication Critical patent/JP2016504165A/ja
Publication of JP2016504165A5 publication Critical patent/JP2016504165A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/10—Rotating vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C12N2521/10—Sound, e.g. ultrasounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Mechanical Engineering (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
JP2015555402A 2013-01-28 2014-01-28 血小板溶解または活性化のためのデバイスおよび方法 Pending JP2016504165A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361849444P 2013-01-28 2013-01-28
US61/849,444 2013-01-28
US201361824090P 2013-05-16 2013-05-16
US61/824,090 2013-05-16
PCT/US2014/013351 WO2014117140A1 (en) 2013-01-28 2014-01-28 Device and methods for platelet lysis or activation

Publications (2)

Publication Number Publication Date
JP2016504165A true JP2016504165A (ja) 2016-02-12
JP2016504165A5 JP2016504165A5 (enExample) 2017-02-02

Family

ID=51228130

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015555402A Pending JP2016504165A (ja) 2013-01-28 2014-01-28 血小板溶解または活性化のためのデバイスおよび方法

Country Status (5)

Country Link
US (1) US20160002598A1 (enExample)
EP (1) EP2948210A4 (enExample)
JP (1) JP2016504165A (enExample)
KR (1) KR20150113978A (enExample)
WO (1) WO2014117140A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020513895A (ja) * 2016-12-22 2020-05-21 リジェネックス， エルエルシー 血小板溶解または活性化のためのデバイスおよび方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10905721B2 (en) 2013-01-28 2021-02-02 Regenexx, Llc. Device and methods for platelet lysis or activation
JP6508502B2 (ja) 2017-05-09 2019-05-08 日産化学株式会社 微生物製剤を製造する方法、微生物製剤の投入方法、微生物製剤の自動投入装置及び廃水処理システム
JP6379409B1 (ja) * 2017-05-09 2018-08-29 日産化学株式会社 微生物製剤の投入方法、微生物製剤の自動投入装置及び廃水処理システム
US12310989B2 (en) 2018-11-14 2025-05-27 Onderzoeks- En Ontwikkelingsfonds Rode Kruis-Vlaanderen Methods for preparing platelet releasate
US11253548B1 (en) 2019-03-11 2022-02-22 Napa Medical Research Foundation Method of producing the constituents of a therapeutic product from mammalian cells
US12465378B2 (en) 2021-12-03 2025-11-11 Curative Sound, LLC Platelet-rich plasma activation system and method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4787883A (en) * 1986-03-10 1988-11-29 Kroyer K K K Extracorporal thermo-therapy device and method for curing diseases
JP2008246200A (ja) * 2007-03-07 2008-10-16 Jms Co Ltd 血清調製方法及び血清調製装置
JP2009500352A (ja) * 2005-06-30 2009-01-08 サイトメディックス インコーポレイテッド 濃縮血小板創傷治癒剤により創傷を治療する方法
US20120230967A1 (en) * 2011-03-08 2012-09-13 Howmedica Osteonics Corp. Device and method to activate platelets

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801537D0 (sv) * 1988-04-26 1988-04-26 Ellco Food Ab Cellodlingsmedium samt forfarande for dess framstellning
US5834418A (en) * 1996-03-20 1998-11-10 Theratechnologies, Inc. Process for the preparation of platelet growth factors extract
US20080199513A1 (en) * 1997-06-24 2008-08-21 Cascade Medical Enterprises, Llc Systems and methods for preparing autologous fibrin glue
US7857761B2 (en) * 2003-04-16 2010-12-28 Drexel University Acoustic blood analyzer for assessing blood properties
US7541166B2 (en) * 2003-09-19 2009-06-02 Microfluidic Systems, Inc. Sonication to selectively lyse different cell types
US20060039991A1 (en) * 2004-08-20 2006-02-23 Alberto Gorrochategui Barrueta Biological tissue regenerative agent and method for preparing and using same
SE528214C2 (sv) * 2005-06-23 2006-09-26 Proliff Ab Förfarande för framställning av blodplättslysat
US20110200642A1 (en) * 2007-12-19 2011-08-18 Regenerative Sciences, Llc Compositions and Methods to Promote Implantation and Engrafment of Stem Cells
US20110052533A1 (en) * 2008-03-14 2011-03-03 Regenerative Sciences, Llc Compositions and Methods for Cartilage Repair
WO2010021993A1 (en) * 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
WO2010064267A1 (en) * 2008-12-05 2010-06-10 Universita' Degli Studi Di Pavia Platelets lysate and bioadesive compositions thereof for the treatment of mucositis
US20110091873A1 (en) * 2009-10-21 2011-04-21 Microfluidic Systems, Inc. Integrated sample preparation and amplification for nucleic acid detection from biological samples
US20110295175A1 (en) * 2010-03-16 2011-12-01 Marv Enterprises Llc Sequential Extracoporeal Treatment of Bodily Fluids
EP2619356A4 (en) * 2010-09-22 2014-04-09 Univ Virginia Commonwealth PREPARATION WITH A HIGH SHARE OF FIBER MATRICES ON A GROWTH FACTOR BASIS FOR TISSUE ENGINEERING, GROWTH FACTOR LEAKAGE AND WOUND HEALING
DE102010049477B4 (de) * 2010-10-27 2012-10-04 Ingrid Barbknecht Vorrichtung zur selektiven Kühlung physiologischen Gewebes
CN108671224B (zh) * 2011-06-27 2022-12-13 爱默蕾大学 血小板裂解物的组合物、用途和制备

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4787883A (en) * 1986-03-10 1988-11-29 Kroyer K K K Extracorporal thermo-therapy device and method for curing diseases
JP2009500352A (ja) * 2005-06-30 2009-01-08 サイトメディックス インコーポレイテッド 濃縮血小板創傷治癒剤により創傷を治療する方法
JP2008246200A (ja) * 2007-03-07 2008-10-16 Jms Co Ltd 血清調製方法及び血清調製装置
US20120230967A1 (en) * 2011-03-08 2012-09-13 Howmedica Osteonics Corp. Device and method to activate platelets

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020513895A (ja) * 2016-12-22 2020-05-21 リジェネックス， エルエルシー 血小板溶解または活性化のためのデバイスおよび方法

Also Published As

Publication number Publication date
WO2014117140A1 (en) 2014-07-31
EP2948210A4 (en) 2016-10-19
US20160002598A1 (en) 2016-01-07
EP2948210A1 (en) 2015-12-02
KR20150113978A (ko) 2015-10-08

Similar Documents

Publication Publication Date Title
JP2016504165A (ja) 血小板溶解または活性化のためのデバイスおよび方法
EP2769745B1 (en) A blood component separator and a method for preparing a serum
EP1893253B1 (en) Integrated system for collecting, processing and transplanting cell subsets, including adult stem cells, for regenerative medicine
US8603821B2 (en) Method for preparing serum and serum preparation apparatus
JP2009040784A (ja) 感温性の材料を処理する方法および装置
MX2014006779A (es) Metodo y dispositivo para el procesamiento de muestras.
US10300188B2 (en) Extemporaneous preparation of autologous fibrin
CN105994250A (zh) 一种基于微流控和膜分离技术的细胞低温保护剂添加或去除方法
US12391922B2 (en) Platelet lysate production method, production system, and bag set
RU2017103172A (ru) Устройства и способы получения инъекционных склеропен для сосудов с помощью матрицы-носителя и их применение
US20240245724A1 (en) Device and Methods for Platelet Lysis or Activation
JP2016504165A5 (enExample)
KR102375196B1 (ko) 혈소판 용해 또는 활성화를 위한 장치 및 방법
CN204490875U (zh) 一种去除细胞悬浮液中低温保护剂的装置
EP3003418B1 (en) Extemporaneous preparation of autologous fibrin
RU2547426C1 (ru) Способ криоконсервирования гемопоэтических стволовых клеток пуповинной крови
WO2014194930A1 (en) Extemporaneous preparation of autologous fibrin
HK1135042B (en) Serum preparation method and serum preparation apparatus
BR102013031169B1 (pt) Processo de obtenção de lisado de plaquetas com maior concentração de heparina
CN104611218A (zh) 一种去除细胞悬浮液中低温保护剂的装置及方法
HK1119094B (en) Integrated system for collecting, processing and transplanting cell subsets, including adult stem cells, for regenerative medicine

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20160511

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20160511

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161214

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20161214

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170921

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171214

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180601

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20190213