JP2016503030A - 医薬組成物 - Google Patents

医薬組成物 Download PDF

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Publication number
JP2016503030A
JP2016503030A JP2015548025A JP2015548025A JP2016503030A JP 2016503030 A JP2016503030 A JP 2016503030A JP 2015548025 A JP2015548025 A JP 2015548025A JP 2015548025 A JP2015548025 A JP 2015548025A JP 2016503030 A JP2016503030 A JP 2016503030A
Authority
JP
Japan
Prior art keywords
compound
isopropyl
cyclopenta
pentamethyl
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015548025A
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English (en)
Japanese (ja)
Other versions
JP2016503030A5 (cg-RX-API-DMAC7.html
Inventor
カイ，シェンシェン
ジョーンズ，ブライアン，アルヴィン
スパルテンステイン，アンドリュー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Publication of JP2016503030A publication Critical patent/JP2016503030A/ja
Publication of JP2016503030A5 publication Critical patent/JP2016503030A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2015548025A 2012-12-14 2013-12-14 医薬組成物 Pending JP2016503030A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261737177P 2012-12-14 2012-12-14
US61/737,177 2012-12-14
PCT/US2013/075196 WO2014093941A1 (en) 2012-12-14 2013-12-14 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
JP2016503030A true JP2016503030A (ja) 2016-02-01
JP2016503030A5 JP2016503030A5 (cg-RX-API-DMAC7.html) 2017-02-02

Family

ID=50935020

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015548025A Pending JP2016503030A (ja) 2012-12-14 2013-12-14 医薬組成物

Country Status (20)

Country Link
US (2) US9795619B2 (cg-RX-API-DMAC7.html)
EP (1) EP2931285A4 (cg-RX-API-DMAC7.html)
JP (1) JP2016503030A (cg-RX-API-DMAC7.html)
KR (1) KR20150093819A (cg-RX-API-DMAC7.html)
CN (1) CN104902905A (cg-RX-API-DMAC7.html)
AU (1) AU2013358897B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015013695A2 (cg-RX-API-DMAC7.html)
CA (1) CA2893959A1 (cg-RX-API-DMAC7.html)
CL (1) CL2015001660A1 (cg-RX-API-DMAC7.html)
CR (1) CR20150313A (cg-RX-API-DMAC7.html)
EA (1) EA201590862A1 (cg-RX-API-DMAC7.html)
HK (1) HK1209638A1 (cg-RX-API-DMAC7.html)
IL (1) IL238807A0 (cg-RX-API-DMAC7.html)
MA (1) MA38182A1 (cg-RX-API-DMAC7.html)
MX (1) MX2015007563A (cg-RX-API-DMAC7.html)
PE (1) PE20151326A1 (cg-RX-API-DMAC7.html)
PH (1) PH12015501156A1 (cg-RX-API-DMAC7.html)
SG (2) SG10201704467SA (cg-RX-API-DMAC7.html)
WO (1) WO2014093941A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201503594B (cg-RX-API-DMAC7.html)

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JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
US9795619B2 (en) * 2012-12-14 2017-10-24 Glaxosmithkline Llc Pharmaceutical compositions
AU2013361401C1 (en) 2012-12-21 2018-08-09 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
NO2865735T3 (cg-RX-API-DMAC7.html) 2013-07-12 2018-07-21
EP3019503B1 (en) 2013-07-12 2017-09-06 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their use for the treatment of hiv infections
NO2717902T3 (cg-RX-API-DMAC7.html) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
KR20170056702A (ko) * 2014-09-26 2017-05-23 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 지효성 약제학적 조성물
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
PT3466490T (pt) 2015-04-02 2020-12-24 Gilead Sciences Inc Compostos de carbamoilpiridona policíclicos e sua utilização farmacêutica
WO2018042331A1 (en) * 2016-08-31 2018-03-08 Glaxosmithkline Intellectual Property (No.2) Limited Combinations and uses and treatments thereof
WO2018042332A1 (en) * 2016-08-31 2018-03-08 Glaxosmithkline Intellectual Property (No.2) Limited Combinations and uses and treatments thereof
EP3654980A1 (en) 2017-07-21 2020-05-27 VIIV Healthcare Company Regimens for treating hib infections and aids

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JP2010533148A (ja) * 2007-07-12 2010-10-21 テイボテク・フアーマシユーチカルズ （ｅ）４−［［４−［［４−（２−シアノエテニル）−２，６−ジメチルフェニル］アミノ］−２−ピリミジニル］アミノ］ベンゾニトリルの結晶形
JP2011508747A (ja) * 2008-01-03 2011-03-17 バイロケム ファーマ インコーポレイテッド 新規のｃ−２１ケトルパン誘導体、それらの調製および使用
WO2011100308A1 (en) * 2010-02-11 2011-08-18 Glaxosmithkline Llc Derivatives of betulin
WO2012037320A2 (en) * 2010-09-16 2012-03-22 Glaxosmithkline Llc Pharmaceutical compositions
WO2013090664A1 (en) * 2011-12-16 2013-06-20 Glaxosmithkline Llc Derivatives of betulin

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WO2008057420A2 (en) * 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
JP2010533148A (ja) * 2007-07-12 2010-10-21 テイボテク・フアーマシユーチカルズ （ｅ）４−［［４−［［４−（２−シアノエテニル）−２，６−ジメチルフェニル］アミノ］−２−ピリミジニル］アミノ］ベンゾニトリルの結晶形
JP2011508747A (ja) * 2008-01-03 2011-03-17 バイロケム ファーマ インコーポレイテッド 新規のｃ−２１ケトルパン誘導体、それらの調製および使用
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Title
MED. CHEM. RES., vol. 20, JPN6017035715, 2011, pages 1247 - 1259, ISSN: 0003644120 *

Also Published As

Publication number Publication date
IL238807A0 (en) 2015-06-30
EP2931285A4 (en) 2016-06-01
PH12015501156A1 (en) 2015-08-10
WO2014093941A1 (en) 2014-06-19
AU2013358897A1 (en) 2015-07-02
AU2013358897B2 (en) 2017-01-05
CL2015001660A1 (es) 2015-10-02
CN104902905A (zh) 2015-09-09
HK1209638A1 (en) 2016-04-08
EA201590862A1 (ru) 2016-05-31
BR112015013695A2 (pt) 2017-07-11
CA2893959A1 (en) 2014-06-19
MA38182A1 (fr) 2018-04-30
US20150313917A1 (en) 2015-11-05
EP2931285A1 (en) 2015-10-21
CR20150313A (es) 2015-10-19
US9795619B2 (en) 2017-10-24
MX2015007563A (es) 2015-10-14
KR20150093819A (ko) 2015-08-18
US20180042944A1 (en) 2018-02-15
SG10201704467SA (en) 2017-06-29
SG11201503807TA (en) 2015-06-29
PE20151326A1 (es) 2015-10-12
ZA201503594B (en) 2018-11-28

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