JP2016185166A5 - - Google Patents
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- Publication number
- JP2016185166A5 JP2016185166A5 JP2016148272A JP2016148272A JP2016185166A5 JP 2016185166 A5 JP2016185166 A5 JP 2016185166A5 JP 2016148272 A JP2016148272 A JP 2016148272A JP 2016148272 A JP2016148272 A JP 2016148272A JP 2016185166 A5 JP2016185166 A5 JP 2016185166A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinase
- pair
- nsi
- coin
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25607809P | 2009-10-29 | 2009-10-29 | |
| US61/256,078 | 2009-10-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016017198A Division JP6085696B2 (ja) | 2009-10-29 | 2016-02-01 | 多機能性対立遺伝子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016185166A JP2016185166A (ja) | 2016-10-27 |
| JP2016185166A5 true JP2016185166A5 (enExample) | 2017-03-30 |
| JP6333316B2 JP6333316B2 (ja) | 2018-05-30 |
Family
ID=43244777
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537099A Active JP5908405B2 (ja) | 2009-10-29 | 2010-10-29 | 多機能性対立遺伝子 |
| JP2016017198A Active JP6085696B2 (ja) | 2009-10-29 | 2016-02-01 | 多機能性対立遺伝子 |
| JP2016148272A Active JP6333316B2 (ja) | 2009-10-29 | 2016-07-28 | 多機能性対立遺伝子 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537099A Active JP5908405B2 (ja) | 2009-10-29 | 2010-10-29 | 多機能性対立遺伝子 |
| JP2016017198A Active JP6085696B2 (ja) | 2009-10-29 | 2016-02-01 | 多機能性対立遺伝子 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20110104799A1 (enExample) |
| EP (2) | EP3147362B1 (enExample) |
| JP (3) | JP5908405B2 (enExample) |
| CN (2) | CN102666854B (enExample) |
| AU (1) | AU2010319894B2 (enExample) |
| CA (1) | CA2779858C (enExample) |
| CY (2) | CY1118659T1 (enExample) |
| DK (2) | DK2494047T3 (enExample) |
| ES (2) | ES2613662T3 (enExample) |
| PL (2) | PL2494047T3 (enExample) |
| PT (2) | PT2494047T (enExample) |
| TR (1) | TR201903376T4 (enExample) |
| WO (1) | WO2011059799A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2494047T (pt) | 2009-10-29 | 2017-02-08 | Regeneron Pharma | Alelos multifuncionais |
| RU2645475C2 (ru) | 2012-04-25 | 2018-02-21 | Регенерон Фармасьютикалз, Инк. | Опосредованное нуклеазой нацеливание с большими нацеливающими векторами |
| US9510569B2 (en) | 2013-03-13 | 2016-12-06 | Regeneron Pharmaceuticals, Inc. | Genetically modified mouse with an inducible Acvr1 gene with a mutant R206H exon 5 that has ectopic bone formation |
| DK2986729T3 (en) | 2013-04-16 | 2018-10-29 | Regeneron Pharma | TARGETED MODIFICATION OF ROOT THROUGH |
| EP3178928B1 (en) * | 2013-08-07 | 2020-06-10 | Regeneron Pharmaceuticals, Inc. | Pint knockout mouse exhibiting a premature aging-associated phenotype |
| WO2015088643A1 (en) | 2013-12-11 | 2015-06-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
| PT3080279T (pt) | 2013-12-11 | 2018-12-17 | Regeneron Pharma | Métodos e composições para a modificação direcionada de um genoma |
| RU2704283C9 (ru) | 2014-06-06 | 2020-02-07 | Регенерон Фармасьютикалз, Инк. | Способы и композиции для модификации целевого локуса |
| RS60366B1 (sr) | 2014-06-23 | 2020-07-31 | Regeneron Pharma | Sastavljanje dnk posredovano nukleazom |
| PT3161128T (pt) | 2014-06-26 | 2018-11-21 | Regeneron Pharma | Métodos e composições para modificações genéticas alvejadas e métodos de utilização |
| SG11201702309RA (en) | 2014-10-15 | 2017-04-27 | Regeneron Pharma | Methods and compositions for generating or maintaining pluripotent cells |
| CA2968440A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| BR112017013104A2 (en) | 2014-12-19 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | methods for modifying a target genomic locus in a cell, for enhancing homologous recombination at a target genomic locus in a cell, and for producing an f0 generation from a nonhuman animal. |
| AU2016233250C1 (en) | 2015-03-16 | 2022-08-18 | Regeneron Pharmaceuticals, Inc. | Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception |
| WO2017180669A1 (en) * | 2016-04-11 | 2017-10-19 | Applied Stemcell, Inc. | Site-specific integration of transgenes |
| US20170332610A1 (en) | 2016-05-20 | 2017-11-23 | Regeneron Pharmaceuticals, Inc. | Methods for breaking immunological tolerance using multiple guide rnas |
| KR20190041476A (ko) | 2016-07-29 | 2019-04-22 | 리제너론 파마슈티칼스 인코포레이티드 | C-절단된 피브릴린-1의 발현을 유도하는 돌연변이를 포함하는 마우스 |
| CN107779462B (zh) * | 2016-08-29 | 2021-06-04 | 中国科学院分子细胞科学卓越创新中心 | 双同源重组谱系示踪技术 |
| WO2018096356A1 (en) * | 2016-11-28 | 2018-05-31 | Horizon Discovery Limited | Methods for conditional gene knock-out |
| SG11201906735RA (en) | 2017-01-23 | 2019-08-27 | Regeneron Pharma | Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof |
| EP4484562A3 (en) | 2017-06-27 | 2025-03-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized asgr1 locus |
| JP7139419B2 (ja) | 2017-09-29 | 2022-09-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｔｒ遺伝子座を含む非ヒト動物および使用方法 |
| ES2911249T3 (es) | 2017-11-10 | 2022-05-18 | Regeneron Pharma | Animales no humanos que comprenden una mutación de slc30a8 y métodos de uso |
| IL274740B2 (en) | 2017-11-30 | 2024-06-01 | Regeneron Pharma | Non-human animals comprising a humanized trkb locus |
| US11419319B2 (en) | 2018-06-13 | 2022-08-23 | Regeneran Pharmaceuticals, Inc. | Genetically modified rodent with an inducible ACVR1 mutation in exon 7 that causes ectopic bone formation |
| US11690362B2 (en) | 2018-12-20 | 2023-07-04 | Regeneran Pharmaceuticals, Inc. | Nuclease-mediated repeat expansion |
| JP7524214B2 (ja) | 2019-04-03 | 2024-07-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗体コード配列をセーフハーバー遺伝子座に挿入するための方法および組成物 |
| ES2966625T3 (es) | 2019-04-04 | 2024-04-23 | Regeneron Pharma | Roedores que comprenden un locus del factor de coagulación 12 humanizado |
| US11891618B2 (en) | 2019-06-04 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| CA3137764A1 (en) | 2019-06-07 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized albumin locus |
| BR112021025425A2 (pt) * | 2019-06-19 | 2022-02-01 | Hoffmann La Roche | Método para produzir uma célula de mamífero recombinante e uso de mrna de recombinase cre |
| JP7756639B2 (ja) | 2019-11-08 | 2025-10-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｘ連鎖性若年網膜分離療法のためのｃｒｉｓｐｒおよびａａｖ戦略 |
| WO2021108363A1 (en) | 2019-11-25 | 2021-06-03 | Regeneron Pharmaceuticals, Inc. | Crispr/cas-mediated upregulation of humanized ttr allele |
| CN115175559A (zh) | 2020-01-28 | 2022-10-11 | 瑞泽恩制药公司 | 包含人源化pnpla3基因座的非人动物及其使用方法 |
| WO2021158883A1 (en) | 2020-02-07 | 2021-08-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized klkb1 locus and methods of use |
| EP4125348A1 (en) | 2020-03-23 | 2023-02-08 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use |
| US20230232796A1 (en) | 2020-06-26 | 2023-07-27 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ace2 locus |
| MX2023007012A (es) | 2020-12-14 | 2023-06-27 | Regeneron Pharma | Metodos para tratar los trastornos metabolicos y las enfermedades cardiovasculares con inhibidores de la subunidad beta e de la inhibina (inhbe). |
| EP4422661A1 (en) | 2021-10-26 | 2024-09-04 | Regeneron Pharmaceuticals, Inc. | Overexpression of lemd2, lemd3, or chmp7 as a therapeutic modality for tauopathy |
| JP2024540086A (ja) | 2021-10-28 | 2024-10-31 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｃ５をノックアウトするためのｃｒｉｓｐｒ／ｃａｓ関連方法及び組成物 |
| US12582104B2 (en) | 2021-12-08 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Mutant myocilin disease model and uses thereof |
| EP4451863A1 (en) | 2021-12-20 | 2024-10-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising humanized ace2 and tmprss loci |
| EP4475671A1 (en) | 2022-02-07 | 2024-12-18 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for defining optimal treatment timeframes in lysosomal disease |
| EP4522726A1 (en) | 2022-05-09 | 2025-03-19 | Regeneron Pharmaceuticals, Inc. | Vectors and methods for in vivo antibody production |
| WO2023220697A1 (en) * | 2022-05-12 | 2023-11-16 | Memorial Sloan-Kettering Cancer Center | Inducible recombinase systems |
| WO2023235725A2 (en) | 2022-05-31 | 2023-12-07 | Regeneron Pharmaceuticals, Inc. | Crispr-based therapeutics for c9orf72 repeat expansion disease |
| JP7635182B2 (ja) * | 2022-08-04 | 2025-02-25 | 株式会社豊田中央研究所 | 相同組換え方法 |
| KR20250044256A (ko) | 2022-08-05 | 2025-03-31 | 리제너론 파마슈티칼스 인코포레이티드 | Tdp-43의 응집 저항성 변이체 |
| WO2024163650A1 (en) | 2023-02-01 | 2024-08-08 | Regeneron Pharmaceuticals, Inc. | Animals comprising a modified klhdc7b locus |
| AU2024285988A1 (en) | 2023-06-08 | 2025-11-20 | Regeneron Pharmaceuticals, Inc. | Animal model with rapid onset of alzheimer's amyloid beta plaque pathology |
| WO2025235388A1 (en) | 2024-05-06 | 2025-11-13 | Regeneron Pharmaceuticals, Inc. | Transgene genomic identification by nuclease-mediated long read sequencing |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1092768A1 (en) * | 1999-10-16 | 2001-04-18 | ARTEMIS Pharmaceuticals GmbH | Conditional gene trapping construct for the disruption of genes |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| WO2002040685A2 (en) * | 2000-11-16 | 2002-05-23 | Cornell Research Foundation, Inc. | Vectors for conditional gene inactivation |
| US7074611B2 (en) | 2001-04-27 | 2006-07-11 | Gie-Cerbn, Centre Europeen De Recherche En Biologie Et En Medecine (Gie) | Method for the stable inversion of DNA sequence by site-specific recombination and DNA vectors and transgenic cells thereof |
| US7473557B2 (en) | 2001-06-06 | 2009-01-06 | Regeneron Pharmaceuticals, Inc. | Method for targeting transcriptionally active loci |
| US7205148B2 (en) | 2003-06-11 | 2007-04-17 | Regeneron Pharmaceuticals, Inc. | Genome mutation by intron insertion into an embryonic stem cell genome |
| US7582741B2 (en) * | 2004-07-26 | 2009-09-01 | University Of Massachusetts | Conditional disruption of dicer1 in cell lines and non-human mammals |
| EP1815001B8 (en) | 2004-11-26 | 2011-03-23 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Gene trap cassettes for random and targeted conditional gene inactivation |
| EP1662005A1 (en) * | 2004-11-26 | 2006-05-31 | FrankGen Biotechnologie AG | Enhancer-containing gene trap vectors for random and targeted gene trapping |
| PT2494047T (pt) | 2009-10-29 | 2017-02-08 | Regeneron Pharma | Alelos multifuncionais |
-
2010
- 2010-10-29 PT PT107743916T patent/PT2494047T/pt unknown
- 2010-10-29 CN CN201080056458.9A patent/CN102666854B/zh active Active
- 2010-10-29 PT PT16196614T patent/PT3147362T/pt unknown
- 2010-10-29 JP JP2012537099A patent/JP5908405B2/ja active Active
- 2010-10-29 US US12/915,447 patent/US20110104799A1/en not_active Abandoned
- 2010-10-29 AU AU2010319894A patent/AU2010319894B2/en active Active
- 2010-10-29 CN CN201610565668.XA patent/CN106191126B/zh active Active
- 2010-10-29 CA CA2779858A patent/CA2779858C/en active Active
- 2010-10-29 TR TR2019/03376T patent/TR201903376T4/tr unknown
- 2010-10-29 ES ES10774391.6T patent/ES2613662T3/es active Active
- 2010-10-29 PL PL10774391T patent/PL2494047T3/pl unknown
- 2010-10-29 ES ES16196614T patent/ES2716981T3/es active Active
- 2010-10-29 EP EP16196614.8A patent/EP3147362B1/en active Active
- 2010-10-29 DK DK10774391.6T patent/DK2494047T3/en active
- 2010-10-29 DK DK16196614.8T patent/DK3147362T3/en active
- 2010-10-29 EP EP10774391.6A patent/EP2494047B1/en active Active
- 2010-10-29 PL PL16196614T patent/PL3147362T3/pl unknown
- 2010-10-29 WO PCT/US2010/054654 patent/WO2011059799A1/en not_active Ceased
-
2013
- 2013-07-12 US US13/940,609 patent/US10392633B2/en active Active
-
2016
- 2016-02-01 JP JP2016017198A patent/JP6085696B2/ja active Active
- 2016-07-28 JP JP2016148272A patent/JP6333316B2/ja active Active
-
2017
- 2017-01-26 CY CY20171100118T patent/CY1118659T1/el unknown
-
2019
- 2019-03-26 CY CY20191100345T patent/CY1121457T1/el unknown
- 2019-07-01 US US16/459,236 patent/US11319557B2/en active Active
-
2022
- 2022-04-01 US US17/712,003 patent/US12473574B2/en active Active
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