JP2016164165A5 - - Google Patents
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- Publication number
- JP2016164165A5 JP2016164165A5 JP2016049674A JP2016049674A JP2016164165A5 JP 2016164165 A5 JP2016164165 A5 JP 2016164165A5 JP 2016049674 A JP2016049674 A JP 2016049674A JP 2016049674 A JP2016049674 A JP 2016049674A JP 2016164165 A5 JP2016164165 A5 JP 2016164165A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- microparticles
- acid labile
- patient
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 31
- 238000009472 formulation Methods 0.000 description 21
- 239000003814 drug Substances 0.000 description 16
- 229940079593 drug Drugs 0.000 description 15
- 239000002253 acid Substances 0.000 description 14
- 239000007788 liquid Substances 0.000 description 12
- 239000011859 microparticle Substances 0.000 description 12
- 239000002702 enteric coating Substances 0.000 description 8
- 238000009505 enteric coating Methods 0.000 description 8
- 239000000546 pharmaceutical excipient Substances 0.000 description 7
- 208000018522 Gastrointestinal disease Diseases 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 4
- 239000012669 liquid formulation Substances 0.000 description 4
- 239000002775 capsule Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 208000010643 digestive system disease Diseases 0.000 description 2
- 208000018685 gastrointestinal system disease Diseases 0.000 description 2
- 229960003174 lansoprazole Drugs 0.000 description 2
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 description 1
- 206010041235 Snoring Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 201000000052 gastrinoma Diseases 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 229960000381 omeprazole Drugs 0.000 description 1
- 239000006174 pH buffer Substances 0.000 description 1
- 229960005019 pantoprazole Drugs 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 229940126409 proton pump inhibitor Drugs 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/190,242 | 2002-07-03 | ||
| US10/190,242 US20040005362A1 (en) | 2002-07-03 | 2002-07-03 | Liquid dosage forms of acid labile drugs |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015021882A Division JP5997788B2 (ja) | 2002-07-03 | 2015-02-06 | 酸不安定性薬物の液体剤形 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017115697A Division JP2017206525A (ja) | 2002-07-03 | 2017-06-13 | 酸不安定性薬物の液体剤形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016164165A JP2016164165A (ja) | 2016-09-08 |
| JP2016164165A5 true JP2016164165A5 (enExample) | 2017-08-03 |
| JP6209237B2 JP6209237B2 (ja) | 2017-10-04 |
Family
ID=29999830
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004519788A Pending JP2005533832A (ja) | 2002-07-03 | 2003-07-02 | 酸不安定性薬物の液体剤形 |
| JP2011179648A Withdrawn JP2012021008A (ja) | 2002-07-03 | 2011-08-19 | 酸不安定性薬物の液体剤形 |
| JP2015021882A Expired - Fee Related JP5997788B2 (ja) | 2002-07-03 | 2015-02-06 | 酸不安定性薬物の液体剤形 |
| JP2016049674A Expired - Fee Related JP6209237B2 (ja) | 2002-07-03 | 2016-03-14 | 酸不安定性薬物の液体剤形 |
| JP2017115697A Pending JP2017206525A (ja) | 2002-07-03 | 2017-06-13 | 酸不安定性薬物の液体剤形 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004519788A Pending JP2005533832A (ja) | 2002-07-03 | 2003-07-02 | 酸不安定性薬物の液体剤形 |
| JP2011179648A Withdrawn JP2012021008A (ja) | 2002-07-03 | 2011-08-19 | 酸不安定性薬物の液体剤形 |
| JP2015021882A Expired - Fee Related JP5997788B2 (ja) | 2002-07-03 | 2015-02-06 | 酸不安定性薬物の液体剤形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017115697A Pending JP2017206525A (ja) | 2002-07-03 | 2017-06-13 | 酸不安定性薬物の液体剤形 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040005362A1 (enExample) |
| EP (1) | EP1539156B8 (enExample) |
| JP (5) | JP2005533832A (enExample) |
| CA (1) | CA2490145C (enExample) |
| ES (1) | ES2401102T3 (enExample) |
| MX (1) | MXPA05000298A (enExample) |
| WO (1) | WO2004004718A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040082618A1 (en) * | 2002-07-03 | 2004-04-29 | Rajneesh Taneja | Liquid dosage forms of acid labile drugs |
| US20050220870A1 (en) * | 2003-02-20 | 2005-10-06 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
| AU2004257864A1 (en) * | 2003-07-18 | 2005-01-27 | Santarus, Inc. | Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders |
| CA2531564C (en) * | 2003-07-18 | 2016-01-19 | Santarus, Inc. | Pharmaceutical composition for inhibiting acid secretion |
| US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| TWI372066B (en) | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
| US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
| EP1718303A4 (en) * | 2004-02-10 | 2010-09-01 | Santarus Inc | COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND NON-STEROIDAL ANTI-INFLAMMATORY DRUG |
| CA2561700A1 (en) * | 2004-04-16 | 2005-12-15 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and prokinetic agent |
| US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US20060134210A1 (en) * | 2004-12-22 | 2006-06-22 | Astrazeneca Ab | Solid dosage form comprising proton pump inhibitor and suspension made thereof |
| US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
| HUE051635T2 (hu) * | 2013-12-12 | 2021-03-01 | Hollister Inc | Toalettben lehúzható szétmálló katéter |
| JP6122815B2 (ja) * | 2014-02-20 | 2017-04-26 | ライオン株式会社 | 経口製剤及びその製造方法 |
| BE1024339B1 (fr) * | 2016-07-01 | 2018-01-29 | Be Pharbel Mfg Sa | Microparticules multicouches libérant un composé pharmaceutiquement actif dans une forme pharmaceutique liquide |
| US12472149B2 (en) | 2015-07-17 | 2025-11-18 | BE Pharbel Manufacturing | Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form |
| CN108348475B (zh) * | 2015-07-17 | 2022-01-04 | 比利时法贝尔制造股份有限公司 | 处于液体剂型的多层药学活性化合物释放微粒 |
| EP3117824A1 (en) * | 2015-07-17 | 2017-01-18 | BE Pharbel Manufacturing | Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| US4808411A (en) * | 1987-06-05 | 1989-02-28 | Abbott Laboratories | Antibiotic-polymer compositions |
| FR2679451B1 (fr) * | 1991-07-22 | 1994-09-09 | Prographarm Laboratoires | Comprime multiparticulaire a delitement rapide. |
| US5464632C1 (en) * | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
| SE9301489D0 (sv) * | 1993-04-30 | 1993-04-30 | Ab Astra | Veterinary composition |
| JPH06319496A (ja) * | 1993-05-11 | 1994-11-22 | Seiichi Kudo | リンゴジュース |
| US5824339A (en) * | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
| SE512835C2 (sv) * | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
| JP4939680B2 (ja) * | 1997-05-27 | 2012-05-30 | 武田薬品工業株式会社 | 固形製剤 |
| TW580397B (en) * | 1997-05-27 | 2004-03-21 | Takeda Chemical Industries Ltd | Solid preparation |
| CA2318087A1 (en) * | 1998-01-30 | 1999-08-05 | Errol V. Raghubeer | Method for ultra high pressure inactivation of microorganisms in juice products |
| PT1121103E (pt) * | 1998-05-18 | 2007-02-28 | Takeda Pharmaceutical | Comprimidos de desintegração oral compreendendo um benzimidazole |
| EE200100660A (et) * | 1999-06-07 | 2003-04-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Ravimvorm happe suhtes labiilsete toimeainete jaoks, toimeaine üksus, selle valmistamismeetod ja mikrokerake |
| JP5009482B2 (ja) * | 2000-12-07 | 2012-08-22 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 酸に不安定な活性成分を含有する懸濁液の形の製薬製剤 |
-
2002
- 2002-07-03 US US10/190,242 patent/US20040005362A1/en not_active Abandoned
-
2003
- 2003-07-02 EP EP20030763122 patent/EP1539156B8/en not_active Expired - Lifetime
- 2003-07-02 ES ES03763122T patent/ES2401102T3/es not_active Expired - Lifetime
- 2003-07-02 CA CA2490145A patent/CA2490145C/en not_active Expired - Fee Related
- 2003-07-02 JP JP2004519788A patent/JP2005533832A/ja active Pending
- 2003-07-02 MX MXPA05000298A patent/MXPA05000298A/es active IP Right Grant
- 2003-07-02 WO PCT/US2003/020875 patent/WO2004004718A1/en not_active Ceased
-
2011
- 2011-08-19 JP JP2011179648A patent/JP2012021008A/ja not_active Withdrawn
-
2015
- 2015-02-06 JP JP2015021882A patent/JP5997788B2/ja not_active Expired - Fee Related
-
2016
- 2016-03-14 JP JP2016049674A patent/JP6209237B2/ja not_active Expired - Fee Related
-
2017
- 2017-06-13 JP JP2017115697A patent/JP2017206525A/ja active Pending
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