JP2016121073A5 - - Google Patents
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- Publication number
- JP2016121073A5 JP2016121073A5 JP2014260006A JP2014260006A JP2016121073A5 JP 2016121073 A5 JP2016121073 A5 JP 2016121073A5 JP 2014260006 A JP2014260006 A JP 2014260006A JP 2014260006 A JP2014260006 A JP 2014260006A JP 2016121073 A5 JP2016121073 A5 JP 2016121073A5
- Authority
- JP
- Japan
- Prior art keywords
- range
- acetic acid
- injection
- added
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000008215 water for injection Substances 0.000 description 4
- 239000002033 PVDF binder Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 3
- 229960003682 rocuronium bromide Drugs 0.000 description 3
- OYTJKRAYGYRUJK-FMCCZJBLSA-M rocuronium bromide Chemical group [Br-].N1([C@@H]2[C@@H](O)C[C@@H]3CC[C@H]4[C@@H]5C[C@@H]([C@@H]([C@]5(CC[C@@H]4[C@@]3(C)C2)C)OC(=O)C)[N+]2(CC=C)CCCC2)CCOCC1 OYTJKRAYGYRUJK-FMCCZJBLSA-M 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- DGPIGKCOQYBCJH-UHFFFAOYSA-M sodium;acetic acid;hydroxide Chemical compound O.[Na+].CC([O-])=O DGPIGKCOQYBCJH-UHFFFAOYSA-M 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- NDDAQHROMJDMKS-XFYXLWKMSA-N [(2s,3s,5s,8r,9s,10s,13s,14s)-2-hydroxy-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]azanium;chloride Chemical compound Cl.C1[C@H](N)[C@@H](O)C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC[C@H]21 NDDAQHROMJDMKS-XFYXLWKMSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014260006A JP2016121073A (ja) | 2014-12-24 | 2014-12-24 | 注射剤用医薬組成物の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014260006A JP2016121073A (ja) | 2014-12-24 | 2014-12-24 | 注射剤用医薬組成物の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016121073A JP2016121073A (ja) | 2016-07-07 |
| JP2016121073A5 true JP2016121073A5 (enrdf_load_stackoverflow) | 2017-10-05 |
Family
ID=56327001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014260006A Pending JP2016121073A (ja) | 2014-12-24 | 2014-12-24 | 注射剤用医薬組成物の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2016121073A (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108670949A (zh) * | 2018-06-21 | 2018-10-19 | 上药东英（江苏）药业有限公司 | 一种低杂质水平的罗库溴铵注射液的制备方法 |
| WO2021200823A1 (ja) * | 2020-03-31 | 2021-10-07 | ニプロ株式会社 | エリブリン含有非経口医薬溶液 |
| KR20230044359A (ko) | 2020-07-30 | 2023-04-04 | 니폰 조키 세야쿠 가부시키가이샤 | 액제 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9302455D0 (en) * | 1993-02-08 | 1993-03-24 | Lab Inpharm N V | Process for preparing a pharmaceutical preparation having neuromuscular blocking activity |
| US20060058275A1 (en) * | 2004-07-15 | 2006-03-16 | Oded Friedman | Processes for preparing stabilized, highly pure rocuronium bromide |
| EP1874319A2 (en) * | 2005-04-15 | 2008-01-09 | Lyotropic Therapeutics, Inc. | Formulations of quaternary ammonium neuromuscular blocking agents |
| EP2107066A3 (en) * | 2005-09-13 | 2009-10-21 | Sicor, Inc. | Processes for the synthesis of rocuronium bromide |
| CN1864667B (zh) * | 2006-06-02 | 2010-10-06 | 重庆医药工业研究院有限责任公司 | 一种稳定的罗库溴铵冻干制剂及其制备方法 |
| GB2445746A (en) * | 2007-01-17 | 2008-07-23 | Texcontor Ets | Use of carbonated water as a solvent for freeze drying, and method of purification comprising dissolution of material in carbonated water and freeze drying |
| CN101653412B (zh) * | 2009-09-15 | 2014-06-25 | 尹双保 | 一种稳定的罗库溴铵注射液 |
| EP2712611A1 (en) * | 2012-09-27 | 2014-04-02 | B. Braun Melsungen AG | Stabilized aqueous compositions of neuromuscular blocking agents |
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2014
- 2014-12-24 JP JP2014260006A patent/JP2016121073A/ja active Pending