JP2016050198A - Sleep disorder improver - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition (agent) for improving sleep.SOLUTION: The present invention provides a composition (agent) having at least glycine blended with inositol, offering an unconventional good feeling of sound sleep.SELECTED DRAWING: None

Description

  The present invention relates to compositions such as foods and supplements (hereinafter referred to as agents) for improving so-called sleep disorders such as insomnia and deep sleep disorders and obtaining deep sleep.

  In the recent stress society, many people suffer from various symptoms resulting from stress. In particular, insomnia and sleep disturbance have a great influence on concentration during daytime work, learning, etc., and may cause obesity, high blood pressure, rough skin, and the like.

  Glycine, a kind of amino acid, is known to have an inhibitory neurotransmitter function in the brain (Non-patent Document 1).

  It has been reported that this glycine prevents insomnia and promotes REM sleep (Non-patent Documents 2 and 3).

  Furthermore, as described in the following Patent Document 1, it has also been reported that ingestion of glycine improves a deep sleep disorder (Japanese Patent No. 4913410).

  Inositol has been studied by various institutions in Japan and overseas, and effects on mental disorders such as depression and panic disorder have been reported so far (Non-patent Document 4).

Japanese Patent No. 4913410

The American Physiological Society, 3417-3422 (1999). Qian Jin Lun Tan Forum, Paradoxic Sleep and Proliferating Life, 9, p25 December 31, 2002 (Chinese) Eric R. Braverman, The Healing Nutrients Within 3rd edition, 2003 revised publication Fux M, Levine J, Aviv A, Belmaker RH, American Journal of Psychiatry 153 (9) 1219-1221 (1996)

  As a current product, there is a product containing about 3 g of glycine per sachet as a product for improving sleep disorder, and it is sold as a supplement for sleep disorder.

  However, since glycine is a food, it is not as effective as a pharmaceutical product, and even if glycine is ingested, there are not a few people who cannot feel the effect.

  As a means for solving such a problem, the present inventor has found that, as a result of intensive studies, at least an agent containing inositol in glycine has a stronger sleep promoting effect than glycine alone. The blending ratio of glycine and inositol is preferably in the range of 1: 1 to 1: 0.1, particularly in the range of 1: 0.1 to 1: 0.5, and the blending amount of inositol is at least It was found that 0.3 g or more is desirable.

  Furthermore, it has been found that the above-mentioned agent is more effective by adding the neurosuppressive amino acids GABA, theanine, tryptophan, sedative effect, vitamin B group, which is considered to have antistress action, and niacin. The present invention is characterized by these.

  In addition, when taking the above-mentioned agent, it is equipped with a measuring device such as a spoon that can make the above-mentioned agent into a tablet, put it in a capsule, put it in a sachet, and measure the amount of intake per meal so that it can be easily taken per meal. It is useful for the user to make it possible to measure and ingest an appropriate amount from a large sachet, or to dissolve it in a liquid to make a drink.

  As described above, according to the present invention, by adding inositol to at least glycine, it is possible to obtain unprecedented relief of sleep disorders and a feeling of deep sleep. In addition, it was confirmed that the inhibitory amino acid GABA and / or tryptophan and theanine were added to further enhance the effect. It is also effective to add vitamin B group and niacin.

  By using a combination of glycine and inositol, it can be applied to foods that have a refreshing sweet taste and give a feeling of deep sleep.

  Seven subjects who are aware of insomnia take glycine 3g (group A), inositol 0.5g (group B), and glycine 3g + inositol 0.5g (group C) before sleep and before intake 1 The sleep state after a week was evaluated by the Pittsburgh Sleep Questionnaire (PSQI). Each test was conducted at intervals of 2 weeks.

Table 1 shows the results of the PSQI survey of the questionnaire. Compared to before intake, the average score of glycine 3g alone (Group A) decreased by 1 and the average score of Group B decreased by 0.4, whereas the average score of Group C decreased by 2.3. This result shows a synergistic effect by simultaneously taking glycine and inositol.

  Seven subjects who are aware of insomnia take glycine 3g (group A), inositol 0.5g (group B), and glycine 3g + inositol 0.5g (group C) before sleep and before intake 1 The sleep state after a week was evaluated using the OSA sleep questionnaire MA version. Each test was conducted at intervals of 2 weeks.

Table 2 shows the results of the OSA sleep questionnaire of the questionnaire. Before ingestion and Group A, sleepiness and recovery from fatigue improved by 6 and 5.2 points, respectively. On the other hand, the remarkable improvement tendency was not seen in the B group. In Group C, sleepiness when waking up (6 points), falling asleep and maintaining sleep (4.8 points), dreaming (3.3 points), recovery from fatigue (7.7 points), sleep time (2.1 points) There was an improvement trend in all items.

  Table 3 shows the results of having subjects unsatisfied with sleep taking glycine 3g + inositol 0.5g capsule daily before bedtime and evaluating the ingestion start and sleep state one week later by polysomnography (PSG) overnight.

Ingestion of 3 g glycine + 0.5 g inositol capsules showed an increase in total sleep time and a decrease in sleep latency. Both REM sleep time and non-REM time were extended.

  The amount of glycine 3g and inositol was examined. Subjects who are dissatisfied with sleep take inositol 0.1g, 0.3g, 0.5g, 1g, 2g added to 3g glycine before sleep, and sleep state before intake and 1 week after intake Table 4 shows the results of evaluation using the Pittsburgh Sleep Questionnaire (PSQI).

By adding 0.3 g or more of inositol to 3 g of glycine, the average score was reduced by 0.5 points compared to 0 g of inositol. Moreover, although what mix | blended 1.0g and 2.0g each decreased by 1.4 points, the big change was not seen with what mixed 0.5g. As a result, the inositol compounding shows that the effect starts to become remarkable from 0.3 g, and that the effect does not change (becomes saturated) even if the amount is increased after 0.5 g. From the above results, it is shown that the blending amount of inositol is best from 0.3 g to 1.0 g with respect to 3 g of glycine. That is, the blending ratio of glycine and inositol is best from 1: 1 to 1: 0.1.

  Addition of GABA 400mg (formulation 1) or tryptophan 50mg (formulation 2) or theanine 50mg (formulation 3) or GABA 400mg, tryptophan 50mg and theanine 50mg to glycine 3g + inositol 0.5g (basic formulation) (Formulation 4) was prepared and taken by 7 subjects who were dissatisfied with sleep before sleep, and the sleep state one week after intake was evaluated by the Pittsburgh Sleep Questionnaire (PSQI). The numerical value shows the average score value of seven people, and the results are shown in Table 5.

By adding GABA 400 mg (Formulation 1), Tryptophan 50 mg (Formulation 2), Theanine 50 mg (Formulation 3), GABA 400 mg, Tryptophan 50 mg and Theanine 50 mg (Formulation 4) to the basic formulation of glycine 3 g + inositol 0.5 g, the average value of PSQI score Decreased by 0.3, 0.2, 0.1, and 0.6 points, respectively, compared to the basic formulation. This result shows that the sleep state is further improved by adding an inhibitory amino acid to the basic formulation of 3 g of glycine + 0.5 g of inositol.

  A sample prepared by adding 1 mg vitamin B1, 1.1 mg vitamin B2, 1.0 mg vitamin B6, 0.002 mg vitamin B12, 11 mg niacin (basic formulation + vitamin) to 3 g of glycine + 0.5 g of inositol (basic formulation) Seven subjects who were dissatisfied with sleep were each ingested before sleep, and the sleep state one week after ingestion was evaluated by the Pittsburgh Sleep Questionnaire (PSQI). The numerical value shows the average score value of 7 people, and the result is shown in Table 6.

By adding vitamins to the base formulation, the average PSQI score was reduced by 0.7 points. This result shows that the sleep state is further improved by adding vitamins such as vitamin B1, vitamin B2, vitamin B6, vitamin B12, and niacin to the basic formulation of 3 g of glycine + 0.5 g of inositol.

  In addition, adding calcium and magnesium having a sedative effect, pantothenic acid having a stress-removing effect, zinc having stress-repairing action, vitamin C, and zinc to the agent of the present invention also improves sleep disorders. It was found to be effective.

Claims (5)

A sleep disorder improving agent containing glycine and inositol. The sleep disorder improving agent according to claim 1, wherein the blending ratio of glycine and inositol is from 1: 1 to 1: 0.1. The sleep disorder improving agent according to claim 1 or 2, wherein GABA and / or tryptophan and theanine are added. The sleep disorder improving agent according to claims 1 to 3, wherein a vitamin B group and / or niacin is added. The sleep disorder improving agent according to claims 1 to 4, comprising 0.3 g or more of inositol as a single intake.