JP2008150352A - Sleep-improving agent composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sleep-improving agent composition in which persons suffering from insomnia can be safely used on a daily basis without risk of side effect. <P>SOLUTION: The sleep-improving agent composition comprises glycine, γ-aminobutyric acid and theanine. According to the present invention, sleep improvement effects such as improvement of hypnagogic retardation, decrease of arousal during sleep and improvement of sleep efficiency can be expected. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a sleep-improving agent composition containing glycine and γ-aminobutyric acid and theanine, a food or drink or pharmaceutical containing the composition, and glycine and γ-aminobutyric acid for producing the food or drink or pharmaceutical, and It relates to the use of a mixture of theanine.

Unlike the sleep pattern in which a short sleep of an infant is repeated throughout the day, human adults are awake during the day and repeat the lifestyle of sleeping intensively at night. Such life rhythm is regulated by various substances in the body.
In the daily life of human beings, the three desires of appetite, libido and sleep are important for maintaining health. In recent years, with the advent of civilized society, it has been said that there is more than one in five people who are experiencing sleep problems, and their interest in sleep is increasing day by day to maintain quality of life and health. Is growing.

Recently, there have been reports using amino acids as an attempt to improve sleep by food. For example, in Patent Document 1 and Patent Document 2, glycine, which is an amino acid synthesized in the living body and having the simplest chemical structure, has an effect of preventing or alleviating breathing disorders during snoring or sleep. Foods with a label indicating that they are used to prevent or mitigate disabilities have been reported. Further, in Patent Document 3, a sleep improving composition mainly composed of theanine which is a glutamic acid derivative contained in tea leaves, a food or drink or pharmaceutical containing the composition, a sleep improving method using theanine, and The food or beverage or medicine has been reported. Similarly, Patent Document 4 also reports on mental fatigue improvement using γ-aminobutyric acid (GABA), which is one type of amino acid. Patent Document 5 describes that vitamin C having a sleep improving effect is blended with vitamin C as a stabilizer and glycine. Furthermore, Patent Document 6 uses a combination of a valerian extract, a hop having a sedative action, and a rice germ extract highly containing γ-aminobutyric acid (GABA) as an “insomnia composition”. It is said that theanine can be added to this. However, a combination of amino acid alone or vitamins as described above has a poor sleep improvement effect and a more effective sleep improvement composition is desired, and glycine, γ-aminobutyric acid, and theanine of the present invention are desired. No sleep improver composition containing three components has been reported.
JP 2006-191933 A International Publication WO2004 / 10098 JP-A-2005-289948 JP 2006-273733 A JP 2006-169221 A JP 2003-183174 A

Problems to be solved by the invention and means for solving the problems

  In order to solve the above-mentioned problems, the present inventors have conducted extensive research. As a result, a mixture of glycine, γ-aminobutyric acid, and theanine is far more effective in improving sleep than glycine, γ-aminobutyric acid, and theanine alone. Yes, among many causes of sleep disorders, the sleep improvement effect reduces fatigue and extends sleep time when waking up. As a result, the present invention has been completed.

The invention's effect

  The sleep-improving agent composition of the present invention (hereinafter, composition) can be used on a daily basis for the purpose of alleviating or improving various sleep disorders caused by various causes. According to the composition of the present invention, at least one symptom in sleep disorder can be improved. In particular, it effectively improves at least one symptom selected from the group consisting of “improving falling asleep”, “reducing mid-wakefulness”, “reducing mid-wakefulness in the latter half of sleep”, and “improving sleep efficiency” in sleep disorders. be able to. The expression of the desired effect of the action of the composition of the present invention is based on the sleep improvement effect first found for the synergistic effect of the composition containing glycine, γ-aminobutyric acid, and theanine.

BEST MODE FOR CARRYING OUT THE INVENTION

Glycine used in the present invention is one of amino acids that has been used for a long time as food and cosmetics. This glycine is the simplest non-essential amino acid that is relatively abundant in animal proteins and has antibacterial and antioxidant properties, chelating action, buffering action, etc., so it can be used as a food additive. Used in cosmetics.
Glycine was known to be an inhibitory neurotransmitter in the brainstem and spinal cord, but in 2004, it was revealed that it affects the quality of sleep. It is said that you can sleep well even in a short time. Recently, research on the function of glycine to improve sleep has been actively carried out, and it has been clarified that it plays an important role in the central and peripheral nervous system as a neurotransmitter. It has not yet been elucidated.

Theanine is a glutamic acid derivative contained in tea leaves, which is an amino acid that is the main ingredient of the umami of tea and is used as a food additive for the purpose of taste.
Research on the relationship between theanine and relaxation, and theanine and sleep has been shown to increase the alpha wave of the brain rapidly in recent years and act on the brain and nerve function to suppress excitement and relax the mind and body Has been. In addition, when theanine is ingested, the effect of improving the quality of sleep by reducing the awakening time during sleep is recognized, and is also attracting attention from the viewpoint of physiological activity.

Further, γ-aminobutyric acid (GABA) in the present invention is not particularly limited, but γ-aminobutyric acid extracted from vegetables, fruits, cereals, etc., γ-aminobutyric acid produced by fermentation method, produced from organic synthesis Refers to γ-aminobutyric acid produced.
GABA is known to be widely distributed in vivo, particularly in the brain, and is known as an inhibitory neurotransmitter. However, it is said that GABA does not cross the blood-brain barrier, and therefore GABA release in the brain central nervous system is not normally affected by GABA taken orally, and recently GABA effectively enhanced alpha waves. At the same time, it has been reported that a “healing state” is brought about by actively reducing beta waves. However, the use of this GABA as a sleep improving agent has not been studied.

  As described above, although each of glycine, γ-aminobutyric acid, and theanine has been reported to have a sleep-improving effect and a healing effect, glycine, γ-aminobutyric acid, and theanine are used in two or three types as in the present invention. It was not known at all about the sleep improvement effect of the mixed composition of various kinds.

The safety of glycine, γ-aminobutyric acid, and theanine used in the present invention is high. For example, in an acute toxicity test using mice, each composition has no death in oral administration of 5 g / kg and no abnormality is observed. . Moreover, it is used also as a food additive for the purpose of taste, and there is no restriction | limiting in the addition amount on Food Sanitation Law. Moreover, unlike conventional drugs, no side effects due to glycine, γ-aminobutyric acid, and theanine are observed, and therefore the composition of the present invention can be used safely and effectively as a sleep improving agent composition.
The blending amounts of glycine, γ-aminobutyric acid, and theanine in the sleep-improving agent of the present invention vary depending on the type of the sleep-improving agent. Therefore, it cannot be generally stated, but the dose per adult for enhancing the hypnotic effect is approximately Since it is the range of 0.1 microgram-3.0g, what is necessary is just to set it as the quantity corresponding to this.

Specifically, for example, the dose per adult is usually in the range of 5 to 3000 mg, preferably 25 to 2000 mg, and more preferably 50 to 500 mg. What is necessary is just to mix | blend with an agent.
The intake of glycine that exerts the sleep improving effect in the present invention is preferably 2 to 3 g for a human having an average body weight of 60 kg, and in the case of theanine, 0.01 mg / kg, preferably 1 mg / kg to 50 mg / kg body weight. Furthermore, GABA is preferably 100 to 500 mg / day for a human having an average weight of 60 kg.

  In order to ingest the sleep-improving agent composition of the present invention as a food, a mixture of glycine and γ-aminobutyric acid and theanine is used as it is, or a dried food or supplement containing glycine, γ-aminobutyric acid and theanine mixture, or It can be used in various dosage forms such as liquid foods such as soft drinks, mineral water, taste drinks, alcoholic drinks, tablets, capsules, powders, granules, drinks and the like.

  In addition to the components described above, the sleep-improving agent composition of the present invention includes excipients, emulsifiers, stabilizers, sweeteners, pH adjusters, thickeners, proteins, peptides, amino acids, lipids, polysaccharides, oligosaccharides. Ingredients commonly used in foods such as

  The sleep-improving agent composition of the present invention comprises three components of glycine and γ-aminobutyric acid and theanine, or two components of glycine and γ-aminobutyric acid, or two components of glycine and theanine. Therefore, the main component is glycine, and γ-aminobutyric acid and theanine are mixed therewith and their synergistic effect is exhibited.

  Although glycine has a sleep-sustaining effect, it lacks a sleep-sleeping effect. On the other hand, γ-aminobutyric acid and theanine have a sleep-sleeping effect but lack a sleep-sustaining effect.

  The ratio of the mixture of glycine, γ-aminobutyric acid, and theanine in the sleep-improving agent composition of the present invention is not particularly limited, but glycine is 90-99.9% by weight, γ-aminobutyric acid is 5-0.01% by weight, The theanine content is preferably 5 to 0.01% by weight.

  The formulation additives used in the above formulation include excipients, bases, binders, disintegrants, disintegration aids, lubricants, fluidizing agents, coating agents, plasticizers, antifoaming agents, sugar coatings Agent, skin, brightener, foaming agent, moisture proofing agent, surfactant, solubilizer, buffer, solubilizer, solubilizer, solvent, stabilizer, emulsifier, suspending agent, dispersant, antioxidant Agents, fillers, thickeners, thickeners, pH adjusters, preservatives, preservatives, sweeteners, flavoring agents, cooling agents, flavoring agents / fragrances, fragrances, colorants, and the like.

  The sleep-improving agent of the present invention can be taken in several times a day, but it is preferably in a form that is taken once a day before going to bed.

Hereinafter, although an example and a test example explain the present invention in detail, the present invention is not limited to the example and a test example concerned.
In the present invention, “Grina” manufactured by Ajinomoto Co., Inc. was used as glycine. As theanine, "Suntheanine" manufactured by Taiyo Kagaku Co., Ltd. was used. In addition, γ-aminobutyric acid used was “Pharmaca 20-D” manufactured by Pharma Foods.

  A granule preparation was produced by using a sleep improving agent composition containing glycine, γ-aminobutyric acid, and theanine at a composition ratio shown in Table 1.

  A granule preparation was produced in the proportion of the composition shown in Table 2 for the sleep improving agent composition containing glycine, γ-aminobutyric acid, and theanine.

  A granule preparation was produced at a ratio of the composition shown in Table 3 to the sleep improving agent composition containing glycine, γ-aminobutyric acid, and theanine.

Comparative Example 1

  As a comparative example of the sleep-improving agent composition containing glycine, γ-aminobutyric acid, and theanine, a single glycine preparation containing only glycine and not containing γ-aminobutyric acid and theanine was used.

Test example 1

  The test subjects were 10 male and female volunteers (average age 42 years old) who had problems with normal sleep, and received sufficient explanations regarding the research content.

Test example 2

During the experiment period, subjects were asked to keep their normal lifestyle, and the holidays were requested to have the same bedtime and wake-up time as work days.
The experimental schedule is 3 days as a life adjustment period, glycine and γ-aminobutyric acid and theanine mixed granule of Example 1 as a dosing period, glycine and γ-aminobutyric acid of Example 2, mixed granule, glycine of Example 3 The theanine mixed granule and the control glycine granule of Comparative Example 1 each 6 days, between the glycine and γ-aminobutyric acid of Examples 1 and 2 and Example 3, and the theanine mixed granule and the control tablet of Comparative Example 1 There was a one-day effect elimination period.

  Table 4 shows the test results.

With the present invention, an adult who suffers from lack of sleep on a daily basis and feels tired and weak during the day and is dissatisfied not only with his work but also with his daily life, feels a good sleep when he gets up. A composition for improving sleep is provided that will greet and have healthy days. Therefore, this composition can be applied as various foods and beverages and pharmaceuticals.

Claims (4)

A sleep improving agent composition comprising glycine, γ-aminobutyric acid, and theanine. The sleep-improving agent composition according to claim 1, wherein the sleep-improving effect is improved sleep delay, decreased arousal during sleep, and improved sleep efficiency. The composition is composed of three components of glycine and γ-aminobutyric acid and theanine, or two components of glycine and γ-aminobutyric acid, or two components of glycine and theanine, that is, blending two or three of the above compounds The sleep-improving agent composition according to claim 1. The mixing ratio of glycine, γ-aminobutyric acid, and theanine is characterized in that glycine is 90-99.9% by weight, γ-aminobutyric acid is 5-0.01% by weight, and theanine is 5-0.01% by weight. The sleep improving agent composition according to claim 1.