JP2016014660A5 - - Google Patents
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- JP2016014660A5 JP2016014660A5 JP2015116494A JP2015116494A JP2016014660A5 JP 2016014660 A5 JP2016014660 A5 JP 2016014660A5 JP 2015116494 A JP2015116494 A JP 2015116494A JP 2015116494 A JP2015116494 A JP 2015116494A JP 2016014660 A5 JP2016014660 A5 JP 2016014660A5
- Authority
- JP
- Japan
- Prior art keywords
- expression
- detecting
- inflammatory
- inflammatory biomarkers
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 19
- 239000000090 biomarker Substances 0.000 claims 13
- 230000003110 anti-inflammatory effect Effects 0.000 claims 12
- 230000001580 bacterial effect Effects 0.000 claims 12
- 239000000126 substance Substances 0.000 claims 11
- 241000894006 Bacteria Species 0.000 claims 8
- 102100030703 Interleukin-22 Human genes 0.000 claims 8
- 230000002757 inflammatory effect Effects 0.000 claims 7
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 5
- 102000001398 Granzyme Human genes 0.000 claims 4
- 108060005986 Granzyme Proteins 0.000 claims 4
- 102000013691 Interleukin-17 Human genes 0.000 claims 4
- 108050003558 Interleukin-17 Proteins 0.000 claims 4
- 102000013264 Interleukin-23 Human genes 0.000 claims 4
- 108010065637 Interleukin-23 Proteins 0.000 claims 4
- 108090000978 Interleukin-4 Proteins 0.000 claims 4
- 102000004388 Interleukin-4 Human genes 0.000 claims 4
- 108010002616 Interleukin-5 Proteins 0.000 claims 4
- 102000000743 Interleukin-5 Human genes 0.000 claims 4
- 108090001005 Interleukin-6 Proteins 0.000 claims 4
- 102000004889 Interleukin-6 Human genes 0.000 claims 4
- 108090001007 Interleukin-8 Proteins 0.000 claims 4
- 102000004890 Interleukin-8 Human genes 0.000 claims 4
- 108010002335 Interleukin-9 Proteins 0.000 claims 4
- 102000000585 Interleukin-9 Human genes 0.000 claims 4
- KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 108010074108 interleukin-21 Proteins 0.000 claims 4
- 108010074109 interleukin-22 Proteins 0.000 claims 4
- 229930192851 perforin Natural products 0.000 claims 4
- 230000009261 transgenic effect Effects 0.000 claims 4
- 102000003816 Interleukin-13 Human genes 0.000 claims 3
- 108090000176 Interleukin-13 Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 230000002519 immonomodulatory effect Effects 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 239000000463 material Substances 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 238000003304 gavage Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17210109P | 2009-04-23 | 2009-04-23 | |
| US61/172,101 | 2009-04-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012507451A Division JP2012524910A (ja) | 2009-04-23 | 2010-04-23 | 免疫調節物質の同定方法及びシステム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016014660A JP2016014660A (ja) | 2016-01-28 |
| JP2016014660A5 true JP2016014660A5 (enExample) | 2016-04-28 |
Family
ID=42993293
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012507451A Pending JP2012524910A (ja) | 2009-04-23 | 2010-04-23 | 免疫調節物質の同定方法及びシステム |
| JP2015116494A Pending JP2016014660A (ja) | 2009-04-23 | 2015-06-09 | 免疫調節物質の同定方法及びシステム |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012507451A Pending JP2012524910A (ja) | 2009-04-23 | 2010-04-23 | 免疫調節物質の同定方法及びシステム |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20100275282A1 (enExample) |
| EP (1) | EP2422200A4 (enExample) |
| JP (2) | JP2012524910A (enExample) |
| WO (1) | WO2010124256A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| JP2011503104A (ja) | 2007-11-09 | 2011-01-27 | カリフォルニア インスティテュート オブ テクノロジー | 免疫調節化合物ならびに関連組成物および方法 |
| WO2011127302A2 (en) * | 2010-04-07 | 2011-10-13 | Yue Shen | Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems |
| CA2800174A1 (en) | 2010-05-20 | 2011-11-24 | June L. Round | Antigen specific tregs and related compositions, methods and systems |
| WO2011151941A1 (ja) | 2010-06-04 | 2011-12-08 | 国立大学法人東京大学 | 制御性ｔ細胞の増殖または集積を誘導する作用を有する組成物 |
| US20130064859A1 (en) * | 2011-01-28 | 2013-03-14 | Sarkis K. Mazmanian | Combinatorial vitamin d and probiotic therapy for inflammatory bowel disease |
| WO2013009945A1 (en) | 2011-07-12 | 2013-01-17 | The Brigham And Women's Hospital, Inc. | Lipid-containing psa compositions, methods of isolation and methods of use thereof |
| WO2013019896A1 (en) * | 2011-08-01 | 2013-02-07 | Symbiotix Biotherapies, Inc. | Platform for identifying and/or characterizing immunomodulatory agents |
| WO2013052099A2 (en) | 2011-10-03 | 2013-04-11 | Mazmanian Sarkis K | Generation of psa-only producing mutant strain |
| EP3569690B1 (en) | 2011-12-01 | 2024-08-28 | The University of Tokyo | Human-derived bacteria that induce proliferation or accumulation of regulatory t cells |
| EP2994161B1 (en) | 2013-05-10 | 2020-10-28 | California Institute of Technology | Probiotic prevention and treatment of colon cancer |
| WO2016201342A1 (en) | 2015-06-10 | 2016-12-15 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
| CA2997211A1 (en) | 2015-08-19 | 2017-02-23 | President And Fellows Of Harvard College | Lipidated psa compositions and methods |
| CA3030974A1 (en) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
| US10823699B2 (en) | 2016-07-29 | 2020-11-03 | Vital Biosciences, Inc. | Gel electrophoresis diagnostic kit and methods of using the same |
| CA3048210A1 (en) | 2016-12-23 | 2018-06-28 | Vital Biosciences, Inc. | Electrophoresis diagnostic methods and kits |
| JP6836756B2 (ja) * | 2017-09-21 | 2021-03-03 | 光博 岡野 | 口腔細菌叢中の構成叢比を予測する方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5679654A (en) * | 1994-09-02 | 1997-10-21 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| US5700787A (en) * | 1994-09-02 | 1997-12-23 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| US7083777B1 (en) * | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
| SV2003000753A (es) * | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
| ATE489968T1 (de) * | 2001-03-09 | 2010-12-15 | Id Biomedical Corp Quebec | Proteosom-liposaccharid-vakzine-adjuvans |
| JP2003204796A (ja) * | 2001-11-08 | 2003-07-22 | Japan Science & Technology Corp | 非ヒト遺伝子改変動物およびその利用 |
| US7829289B2 (en) * | 2002-05-14 | 2010-11-09 | Institut National De La Sante Et De Recherche Medicale | T cell subpopulation regulating gut immunity |
| EP1570265A2 (en) * | 2002-12-03 | 2005-09-07 | Dartmouth College | Method to measure a t cell response and its uses to qualify antigen-presenting cells |
| AU2004227852B2 (en) * | 2003-03-31 | 2010-01-14 | The Brigham And Women's Hospital, Inc. | Zwitterionic immunomodulators for the treatment of asthma and allergy |
| WO2005010215A2 (en) * | 2003-07-17 | 2005-02-03 | Tolerrx, Inc. | Methods for identifying tolerance modulatory compounds and uses therefor |
| JPWO2005094571A1 (ja) * | 2004-03-31 | 2008-02-14 | 独立行政法人科学技術振興機構 | 遺伝子改変ヘテロ動物及び該動物を用いたエキソサイトシスの計測方法 |
| US8426146B2 (en) * | 2005-06-03 | 2013-04-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multiparameteric method for assessing immune system status |
| JP2007119414A (ja) * | 2005-10-31 | 2007-05-17 | Univ Nagoya | Ｃｄ８＋ｃｄ１２２＋ｔ細胞の免疫抑制活性を増強させる免疫抑制剤 |
| US8206726B2 (en) * | 2006-02-06 | 2012-06-26 | The Brigham And Women's Hospital, Inc. | Zwitterionic polysaccharides for promotion of immune system maturation and health |
| EP2679995A1 (en) * | 2007-05-31 | 2014-01-01 | AbbVie Inc. | Biomarkers predictive of the responsiveness to TNF-alfa inhibitors in autoimmune disorders |
-
2010
- 2010-04-23 US US12/766,787 patent/US20100275282A1/en not_active Abandoned
- 2010-04-23 JP JP2012507451A patent/JP2012524910A/ja active Pending
- 2010-04-23 EP EP10767863A patent/EP2422200A4/en not_active Withdrawn
- 2010-04-23 WO PCT/US2010/032300 patent/WO2010124256A2/en not_active Ceased
-
2015
- 2015-06-09 JP JP2015116494A patent/JP2016014660A/ja active Pending
-
2016
- 2016-01-29 US US15/011,151 patent/US20170003274A1/en not_active Abandoned
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