JP2012524910A - 免疫調節物質の同定方法及びシステム - Google Patents

免疫調節物質の同定方法及びシステム Download PDF

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JP2012524910A
JP2012524910A JP2012507451A JP2012507451A JP2012524910A JP 2012524910 A JP2012524910 A JP 2012524910A JP 2012507451 A JP2012507451 A JP 2012507451A JP 2012507451 A JP2012507451 A JP 2012507451A JP 2012524910 A JP2012524910 A JP 2012524910A
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エル ラウンド ジュン
シェン ユー
ケイ マズマニアン サーキス
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California Institute of Technology
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics

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  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
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  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
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  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2012507451A 2009-04-23 2010-04-23 免疫調節物質の同定方法及びシステム Pending JP2012524910A (ja)

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US17210109P 2009-04-23 2009-04-23
US61/172,101 2009-04-23
PCT/US2010/032300 WO2010124256A2 (en) 2009-04-23 2010-04-23 Methods and systems for identifying immunomodulatory substances

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US (2) US20100275282A1 (enExample)
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013523838A (ja) * 2010-04-07 2013-06-17 シェン，ユエ 粘膜へ化合物を送るための媒体、それに関連する組成物、方法、及びシステム
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
JP2019054752A (ja) * 2017-09-21 2019-04-11 光博 岡野 口腔細菌叢中の構成叢比を予測する方法
US10857177B2 (en) 2015-08-19 2020-12-08 President And Fellows Of Harvard College Lipidated PSA compositions and methods
US11103566B2 (en) 2010-05-20 2021-08-31 California Institute Of Technology Antigen specific Tregs and related compositions, methods and systems
US11331335B2 (en) 2015-06-10 2022-05-17 California Institute Of Technology Sepsis treatment and related compositions methods and systems
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use
US11622973B2 (en) 2007-11-09 2023-04-11 California Institute Of Technology Immunomodulating compounds and related compositions and methods

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AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
WO2011151941A1 (ja) 2010-06-04 2011-12-08 国立大学法人東京大学 制御性ｔ細胞の増殖または集積を誘導する作用を有する組成物
US20130064859A1 (en) * 2011-01-28 2013-03-14 Sarkis K. Mazmanian Combinatorial vitamin d and probiotic therapy for inflammatory bowel disease
WO2013019896A1 (en) * 2011-08-01 2013-02-07 Symbiotix Biotherapies, Inc. Platform for identifying and/or characterizing immunomodulatory agents
WO2013052099A2 (en) 2011-10-03 2013-04-11 Mazmanian Sarkis K Generation of psa-only producing mutant strain
EP3569690B1 (en) 2011-12-01 2024-08-28 The University of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory t cells
EP2994161B1 (en) 2013-05-10 2020-10-28 California Institute of Technology Probiotic prevention and treatment of colon cancer
US10823699B2 (en) 2016-07-29 2020-11-03 Vital Biosciences, Inc. Gel electrophoresis diagnostic kit and methods of using the same
CA3048210A1 (en) 2016-12-23 2018-06-28 Vital Biosciences, Inc. Electrophoresis diagnostic methods and kits

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JP2003204796A (ja) * 2001-11-08 2003-07-22 Japan Science & Technology Corp 非ヒト遺伝子改変動物およびその利用
WO2003095606A2 (en) * 2002-05-14 2003-11-20 Institut National de la Santé et de la Recherche Médicale A t cell subpopulation regulating gut immunity
WO2005010215A2 (en) * 2003-07-17 2005-02-03 Tolerrx, Inc. Methods for identifying tolerance modulatory compounds and uses therefor
WO2005094571A1 (ja) * 2004-03-31 2005-10-13 Japan Science And Technology Agency 遺伝子改変ヘテロ動物及び該動物を用いたエキソサイトシスの計測方法
JP2007119414A (ja) * 2005-10-31 2007-05-17 Univ Nagoya Ｃｄ８＋ｃｄ１２２＋ｔ細胞の免疫抑制活性を増強させる免疫抑制剤

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US5700787A (en) * 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
SV2003000753A (es) * 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
ATE489968T1 (de) * 2001-03-09 2010-12-15 Id Biomedical Corp Quebec Proteosom-liposaccharid-vakzine-adjuvans
EP1570265A2 (en) * 2002-12-03 2005-09-07 Dartmouth College Method to measure a t cell response and its uses to qualify antigen-presenting cells
AU2004227852B2 (en) * 2003-03-31 2010-01-14 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
US8426146B2 (en) * 2005-06-03 2013-04-23 University of Pittsburgh—of the Commonwealth System of Higher Education Multiparameteric method for assessing immune system status
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JP2003204796A (ja) * 2001-11-08 2003-07-22 Japan Science & Technology Corp 非ヒト遺伝子改変動物およびその利用
WO2003095606A2 (en) * 2002-05-14 2003-11-20 Institut National de la Santé et de la Recherche Médicale A t cell subpopulation regulating gut immunity
WO2005010215A2 (en) * 2003-07-17 2005-02-03 Tolerrx, Inc. Methods for identifying tolerance modulatory compounds and uses therefor
WO2005094571A1 (ja) * 2004-03-31 2005-10-13 Japan Science And Technology Agency 遺伝子改変ヘテロ動物及び該動物を用いたエキソサイトシスの計測方法
JP2007119414A (ja) * 2005-10-31 2007-05-17 Univ Nagoya Ｃｄ８＋ｃｄ１２２＋ｔ細胞の免疫抑制活性を増強させる免疫抑制剤

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JPN6014004504; Ｌｉｓｂｅｔｈ　Ｎ．　Ｆｉｎｋ　ｅｔ　ａｌ．: 'Ｈｕｍａｎ　ａｎｔｉｇｅｎ-ｐｒｅｓｅｎｔｉｎｇ　ｃｅｌｌｓ　ｒｅｓｐｏｎｄ　ｄｉｆｆｅｒｅｎｔｌｙ　ｔｏ　ｇｕｔ-ｄｅｒｉｖｅｄ　ｐｒｏｂｉｏｔｉｃ　ｂａｃｔｅｒｉａ　ｂｕｔｍｅｄｉａｔｅ　ｓｉｍｉ' ＦＥＭＳ　Ｉｍｍｕｎｏｌｏｇｙ　＆　Ｍｅｄｉｃａｌ　Ｍｉｃｒｏｂｉｏｌｏｇｙ Ｖｏｌｕｍｅ　５１，　Ｉｓｓｕｅ　３, 2007, ５３５-５４６ *
JPN6014004505; Ｈｅｒｍｅｌｉｊｎ　Ｈ．　Ｓｍｉｔｓ　ｅｔ　ａｌ．: 'Ｓｅｌｅｃｔｉｖｅ　ｐｒｏｂｉｏｔｉｃ　ｂａｃｔｅｒｉａ　ｉｎｄｕｃｅ　ＩＬ-１０-ｐｒｏｄｕｃｉｎｇ　ｒｅｇｕｌａｔｏｒｙ　Ｔ　ｃｅｌｌｓ　ｉｎ　ｖｉｔｒｏ　ｂｙ　ｍｏｄｕｌａｔｉｎｇ　ｄｅｎｄｒｉ' Ｊｏｕｒｎａｌ　ｏｆ　Ａｌｌｅｒｇｙ　ａｎｄ　Ｃｌｉｎｉｃａｌ　Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌｕｍｅ　１１５，　Ｉｓｓｕｅ　６, 2005, １２６０-１２６７ *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11622973B2 (en) 2007-11-09 2023-04-11 California Institute Of Technology Immunomodulating compounds and related compositions and methods
JP2013523838A (ja) * 2010-04-07 2013-06-17 シェン，ユエ 粘膜へ化合物を送るための媒体、それに関連する組成物、方法、及びシステム
JP2017014201A (ja) * 2010-04-07 2017-01-19 シェン, ユエSHEN, Yue 粘膜へ化合物を送るための媒体、それに関連する組成物、方法、及びシステム
JP2018109016A (ja) * 2010-04-07 2018-07-12 ザ カリフォルニア インスティテュート オブ テクノロジー 粘膜へ化合物を送るための媒体、それに関連する組成物、方法、及びシステム
US11419887B2 (en) 2010-04-07 2022-08-23 California Institute Of Technology Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems
US11103566B2 (en) 2010-05-20 2021-08-31 California Institute Of Technology Antigen specific Tregs and related compositions, methods and systems
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
US11331335B2 (en) 2015-06-10 2022-05-17 California Institute Of Technology Sepsis treatment and related compositions methods and systems
US10857177B2 (en) 2015-08-19 2020-12-08 President And Fellows Of Harvard College Lipidated PSA compositions and methods
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use
JP2019054752A (ja) * 2017-09-21 2019-04-11 光博 岡野 口腔細菌叢中の構成叢比を予測する方法

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EP2422200A4 (en) 2013-02-27
JP2016014660A (ja) 2016-01-28
US20170003274A1 (en) 2017-01-05
EP2422200A2 (en) 2012-02-29
WO2010124256A3 (en) 2011-03-31
WO2010124256A2 (en) 2010-10-28
US20100275282A1 (en) 2010-10-28

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