JP2015537028A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015537028A5 JP2015537028A5 JP2015542751A JP2015542751A JP2015537028A5 JP 2015537028 A5 JP2015537028 A5 JP 2015537028A5 JP 2015542751 A JP2015542751 A JP 2015542751A JP 2015542751 A JP2015542751 A JP 2015542751A JP 2015537028 A5 JP2015537028 A5 JP 2015537028A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- scar
- independently
- skin wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 28
- 231100000241 scar Toxicity 0.000 claims description 26
- 206010072170 Skin wound Diseases 0.000 claims description 22
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 13
- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
- 208000032544 Cicatrix Diseases 0.000 claims description 5
- 230000037387 scars Effects 0.000 claims description 5
- 239000000443 aerosol Substances 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 235000015110 jellies Nutrition 0.000 claims description 4
- 239000006210 lotion Substances 0.000 claims description 4
- 239000006072 paste Substances 0.000 claims description 4
- 230000036573 scar formation Effects 0.000 claims description 4
- 238000001356 surgical procedure Methods 0.000 claims description 4
- 230000000699 topical effect Effects 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000000499 gel Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 208000009043 Chemical Burns Diseases 0.000 claims description 2
- 208000034693 Laceration Diseases 0.000 claims description 2
- 208000002847 Surgical Wound Diseases 0.000 claims description 2
- 206010053615 Thermal burn Diseases 0.000 claims description 2
- 238000005299 abrasion Methods 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 230000001969 hypertrophic effect Effects 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 208000018380 Chemical injury Diseases 0.000 claims 1
- 206010041899 Stab wound Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 25
- 238000007920 subcutaneous administration Methods 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- ZXRNXIUNEPOVTF-FXYIOBSRSA-N C[C@@H](CCc(nccc1)c1OCc1ccccc1)/C(/C)=C/C=C\C Chemical compound C[C@@H](CCc(nccc1)c1OCc1ccccc1)/C(/C)=C/C=C\C ZXRNXIUNEPOVTF-FXYIOBSRSA-N 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- GOZYDZKZNKSXNG-UHFFFAOYSA-N CC(Cc(cc1)ccc1C(C)=O)C(N(Cc1ccccc1C(F)(F)F)c(cc1)c(C)cc1F)=O Chemical compound CC(Cc(cc1)ccc1C(C)=O)C(N(Cc1ccccc1C(F)(F)F)c(cc1)c(C)cc1F)=O GOZYDZKZNKSXNG-UHFFFAOYSA-N 0.000 description 1
- XZGLNCKSNVGDNX-UHFFFAOYSA-N Cc1nnn[nH]1 Chemical compound Cc1nnn[nH]1 XZGLNCKSNVGDNX-UHFFFAOYSA-N 0.000 description 1
- 208000035874 Excoriation Diseases 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- BXLOSDFUQRTRSZ-UHFFFAOYSA-N OC(c1ccc(CC2Sc(cccc3)c3N(Cc3cc(F)ccc3C(F)(F)F)C2=O)cc1)=O Chemical compound OC(c1ccc(CC2Sc(cccc3)c3N(Cc3cc(F)ccc3C(F)(F)F)C2=O)cc1)=O BXLOSDFUQRTRSZ-UHFFFAOYSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000036575 thermal burns Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000037373 wrinkle formation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261727574P | 2012-11-16 | 2012-11-16 | |
| US61/727,574 | 2012-11-16 | ||
| PCT/US2013/069919 WO2014078434A1 (en) | 2012-11-16 | 2013-11-13 | Compounds and methods for skin repair |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015537028A JP2015537028A (ja) | 2015-12-24 |
| JP2015537028A5 true JP2015537028A5 (enExample) | 2017-01-12 |
Family
ID=49667612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015542751A Pending JP2015537028A (ja) | 2012-11-16 | 2013-11-13 | 皮膚修復のための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20140142092A1 (enExample) |
| EP (1) | EP2919771A1 (enExample) |
| JP (1) | JP2015537028A (enExample) |
| CA (1) | CA2891595A1 (enExample) |
| WO (1) | WO2014078434A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014078446A2 (en) * | 2012-11-16 | 2014-05-22 | Allergan, Inc. | Skin wound healing and scar reduction with prostaglandin ep4 agonist combinations |
| EP3178462A1 (de) | 2015-12-07 | 2017-06-14 | WDT-Wolz-Dental-Technik GmbH | Verfahren zur herstellung eines polychrom und/oder räumlich polychrom oder eines monochrom gefärbten keramischen körpers und vorrichtung hierfür |
| BR112020003022A2 (pt) | 2017-12-26 | 2020-08-25 | Hirotaro Fukuoka | composição farmacêutica para o uso no crescimento de cabelo, modificação do couro cabeludo ou pele, cicatrização de uma ferida, promoção da osteogênese ou modificação do cabelo |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674888A (en) * | 1995-06-07 | 1997-10-07 | University Of California | Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division |
| AU2004216898A1 (en) * | 2003-03-04 | 2004-09-16 | Pfizer Products Inc. | Use of EP2 selective receptor agonists in medical treatment |
| WO2005116010A1 (en) * | 2004-05-26 | 2005-12-08 | Merck Frosst Canada Ltd. | Ep4 receptor agonist, compositions and methods thereof |
| RU2016116516A (ru) * | 2008-12-08 | 2018-12-07 | Мандифарма Интернэшнл Корпорейшн Лимитед | Композиции ингибиторов тирозинкиназных рецепторов белков |
| WO2010116270A1 (en) * | 2009-04-10 | 2010-10-14 | Pfizer Inc. | Ep2/4 agonists |
| CN103068382A (zh) * | 2010-07-30 | 2013-04-24 | 阿勒根公司 | 用于皮肤修复的化合物和方法 |
| US20120142684A1 (en) * | 2010-12-02 | 2012-06-07 | Allergan, Inc. | Compounds and methods for skin repair |
-
2013
- 2013-11-13 CA CA2891595A patent/CA2891595A1/en not_active Abandoned
- 2013-11-13 WO PCT/US2013/069919 patent/WO2014078434A1/en not_active Ceased
- 2013-11-13 JP JP2015542751A patent/JP2015537028A/ja active Pending
- 2013-11-13 EP EP13795958.1A patent/EP2919771A1/en not_active Withdrawn
- 2013-11-13 US US14/078,847 patent/US20140142092A1/en not_active Abandoned
-
2016
- 2016-06-23 US US15/191,262 patent/US20170143733A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2013108394A (ru) | Соединения и способы восстановления кожи | |
| EP3195863A1 (en) | Compounds and methods for skin repair | |
| EA201792559A1 (ru) | Фармацевтические композиции для местного применения | |
| KR20120099454A (ko) | 모발 성장을 촉진하기 위한 조성물 및 방법 | |
| JP2013544842A5 (enExample) | ||
| JP2013536183A5 (enExample) | ||
| RU2015122627A (ru) | Кожные композиции, содержащие неприродные гигроскопические аминокислоты | |
| CN101972225A (zh) | 一种含吡非尼酮的凝胶组合物 | |
| JP2007523832A (ja) | 有効なエンハンサーとしてのサリチル酸誘導体及び方法 | |
| RU2020110783A (ru) | Полутвердая композиция для наружного применения, содержащая антимикробный агент и пирфенидон для лечения хронического повреждения кожи | |
| RU2015146679A (ru) | Тетрапептиды, полученные из с-х-с-хемокинов человека, подходящие для лечения различных состояний кожи | |
| PH12018500910A1 (en) | Novel method of use and compositions | |
| WO2012125941A1 (en) | Lithium treatment for microbial infections | |
| WO2014168228A1 (ja) | 局所用組成物 | |
| JP6487459B2 (ja) | アルテミシニンおよびその誘導体を使用する脂漏性角化症の処置若しくは予防 | |
| EP3049088B1 (en) | Prostaglandin f2alpha and analogues thereof for treating atrophic cutaneous scarring | |
| JP2015537028A (ja) | 皮膚修復のための組成物および方法 | |
| KR101733189B1 (ko) | 손톱 또는 발톱 성장 촉진용 조성물 | |
| EP4267244A1 (en) | Formulation comprising erbium borate for use in prevention and treatment of wound scars | |
| RU2788332C1 (ru) | Мазь для лечения травматического повреждения кожных покровов | |
| RU2005122467A (ru) | Способ химической стабилизации собилизированного ретиноида и водная композиция, полученная этим способом, содержащая по меньшей мере один ретиноид в виде соли | |
| JP6016085B2 (ja) | 抗真菌外用組成物及び抗真菌外用組成物の適用方法 | |
| KR20150066810A (ko) | 여드름 예방 및 개선용 조성물 | |
| MX2008004946A (en) | Treatment and prevention of benign pigmented moles (naevi) using artemisinine and the derivatives thereof | |
| TH4847Y (th) | สารผสมทางเภสัชกรรมสำหรับบำบัดอาการปวด |