JP2015536783A - リアルタイム適応的線量計算による放射線治療 - Google Patents
リアルタイム適応的線量計算による放射線治療 Download PDFInfo
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Abstract
Description
Claims (20)
- ターゲット及び1又は複数のリスク臓器を含む被検体身体領域の少なくとも一部のベースライン及びリアルタイム3D画像を生成するリアルタイム3Dイメージングユニットと、
被検体身体領域の計画画像及び前記ベースライン3D画像を変形可能に位置合わせし、前記計画画像内の組織の放射線吸収特性を前記ベースライン3D画像にマップする位置合わせユニットと、
放射線治療処置の間、前記リアルタイム3D画像に基づいて前記ターゲット及び前記リスク臓器の動きを測定する動きユニットと、
前記ベースライン3D画像又は前記計画画像から前記リアルタイム3D画像にマップされる組織放射線吸収特性に基づいて、前記ターゲット及び前記リスク臓器に供給されるリアルタイム放射線線量を計算するリアルタイム線量計算エンジンと、
を有する放射線治療システム。 - 前記動きユニットは、前記マップされた放射線吸収特性をもつ前記ベースライン3D画像を、前記リアルタイム3D画像と位置合わせする、請求項1に記載のシステム。
- 前記ターゲットボリュームを横切るように被検体身体領域に放射線ビームを供給する放射線源を更に有し、各放射線ビームは、放射線治療計画に基づくサイズ、形状、方向、強度及び持続時間をもつ、請求項1又は2に記載のシステム。
- 被検体身体領域に供給される前記計算されたリアルタイム放射線線量は、前記計画画像の各ボクセルごとに計算された累積線量を含む、請求項1乃至3のいずれか1項に記載のシステム。
- 組織に供給される前記計算されたリアルタイム放射線線量は、前記計画画像の各ボクセルごとに計算された蓄積された線量と、放射線治療処置の残りの部分について放出される計算された累積線量と、を含む、請求項1乃至4のいずれか1項に記載のシステム。
- 放射線供給が、前記計算されたリアルタイム累積線量に基づいて変更される、請求項1乃至5のいずれか1項に記載のシステム。
- 前記リアルタイム3Dイメージングユニットが、
リアルタイム3D超音波画像を生成する超音波手段と、
前記リアルタイム3D超音波画像を生成するために、超音波を送受信する超音波プローブの位置及び/又は向きを制御するロボットと、
を有する、請求項6に記載のシステム。 - 放射線吸収特性が組織の密度を含む、請求項1乃至7のいずれか1項に記載のシステム。
- 前記計算されたリアルタイム累積放射線線量を、前記計画画像上に重ねて表示するディスプレイ装置を更に有する、請求項1乃至8のいずれか1項に記載のシステム。
- 前記計算されたリアルタイム累積放射線線量と計画された放射線線量との間の差を、前記計画画像上に重ねて表示するディスプレイ装置を更に有する、請求項1乃至9のいずれか1項に記載のシステム。
- 放射線治療の方法であって、
ターゲット及び1又は複数のリスク臓器を含む被検体身体領域のベースライン及びリアルタイム3D画像を生成するステップと、
計画画像及び前記ベースライン3D画像を変形可能に位置合わせするステップと、
計画画像からの被検体身体領域の組織の放射線吸収特性を、前記ベースライン3D画像にマップするステップと、
放射線治療処置の間、前記リアルタイム3D画像に基づいて、前記ターゲット及び前記リスク臓器のリアルタイムの動きを測定するステップと、
前記ベースライン3D画像又は前記計画画像から前記リアルタイム3D画像にマップされる組織放射線吸収特性に基づいて、組織に供給されるリアルタイム放射線線量を計算するステップと、
を含む方法。 - 前記マップされた放射線吸収特性を有する前記ベースライン3D画像を、前記リアルタイム3D画像の各々と位置合わせするステップを更に含む、請求項11に記載の方法。
- 被検体身体領域の組織に放射線ビームを供給するステップを更に含み、各放射線ビームは、放射線治療計画に基づくサイズ、形状、方向、強度及び持続時間をもつ、請求項11又は12に記載の方法。
- リアルタイム放射線線量を計算する前記ステップは、前記計画画像の各ボクセルごとに累積線量を計算することを含む、請求項11乃至13のいずれか1項に記載の方法。
- リアルタイム放射線線量を計算する前記ステップは、細分された処置の残りに関して放出される蓄積線量を計算することを含む、請求項11乃至14のいずれか1項に記載の方法。
- 計算された蓄積線量に基づいて放射線供給を変更するステップを更に含む、請求項11乃至15のいずれか1項に記載の方法。
- 前記計算されたリアルタイム放射線線量を、前記計画画像及び/又は前記リアルタイム3D画像上に重ねて表示するステップを更に含む、請求項11乃至16のいずれか1項に記載の方法。
- 1又は複数の電子データ処理装置を制御して、請求項11乃至17のいずれか1項に記載の方法の各ステップを実行させるソフトウェアを保持する非一時的コンピュータ可読記憶媒体。
- 請求項11乃至17のいずれか1項に記載の方法を実施するように構成される電子データ処理装置。
- 被検体身体の少なくとも1つのターゲットボリュームへ向けられる複数の放射線ビームを生成する線形加速器であって、各放射線ビームが、放射線治療計画に基づくサイズ、形状、方向、強度及び持続時間をもつ、線形加速器と、
複数の放射線ビームに曝露される少なくとも1つのターゲットボリューム及び周囲組織を含む被検体身体の領域の3D超音波画像を生成するロボット制御される超音波イメージングユニットと、
コンピュータトモグラフィ(CT)X線計画画像と、処置前に前記超音波イメージングユニットによって生成されたベースライン超音波画像とを変形可能に位置合わせし、3D組織密度マップを生成するために、CT計画画像に基づく組織密度を、ベースライン3D超音波画像にマップする位置合わせユニットと、
ターゲットボリューム及び周囲組織の動きを測定し、前記3D組織密度マップを、前記超音波イメージングユニットによって生成されるリアルタイム3D超音波画像と位置合わせする超音波動きユニットと、
前記3D組織密度マップ、前記リアルタイム3D超音波画像、及び前記測定された動きに基づいて、前記少なくとも1つのターゲットボリューム、リスク臓器及び周囲組織に供給されるリアルタイム放射線線量を計算する線量計算エンジンと、
を有する放射線治療システム。
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PCT/IB2013/058588 WO2014096993A1 (en) | 2012-12-17 | 2013-09-17 | Real-time adaptive dose computation radiation therapy |
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