JP2015535290A5 - - Google Patents
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- Publication number
- JP2015535290A5 JP2015535290A5 JP2015540801A JP2015540801A JP2015535290A5 JP 2015535290 A5 JP2015535290 A5 JP 2015535290A5 JP 2015540801 A JP2015540801 A JP 2015540801A JP 2015540801 A JP2015540801 A JP 2015540801A JP 2015535290 A5 JP2015535290 A5 JP 2015535290A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- alkyl
- carbocyclyl
- carbamoyl
- formyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261722339P | 2012-11-05 | 2012-11-05 | |
| US61/722,339 | 2012-11-05 | ||
| US201361845399P | 2013-07-12 | 2013-07-12 | |
| US61/845,399 | 2013-07-12 | ||
| PCT/US2013/067972 WO2014071134A1 (en) | 2012-11-05 | 2013-11-01 | 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019020153A Division JP2019089817A (ja) | 2012-11-05 | 2019-02-06 | ７，８−ジヒドロキシフラボンおよび７，８−置換フラボン誘導体、組成物、およびそれらに関連する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535290A JP2015535290A (ja) | 2015-12-10 |
| JP2015535290A5 true JP2015535290A5 (https=) | 2016-12-08 |
| JP6479670B2 JP6479670B2 (ja) | 2019-03-06 |
Family
ID=50628080
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540801A Active JP6479670B2 (ja) | 2012-11-05 | 2013-11-01 | ７，８−ジヒドロキシフラボンおよび７，８−置換フラボン誘導体、組成物、およびそれらに関連する方法 |
| JP2019020153A Pending JP2019089817A (ja) | 2012-11-05 | 2019-02-06 | ７，８−ジヒドロキシフラボンおよび７，８−置換フラボン誘導体、組成物、およびそれらに関連する方法 |
| JP2020206038A Pending JP2021050230A (ja) | 2012-11-05 | 2020-12-11 | ７，８−ジヒドロキシフラボンおよび７，８−置換フラボン誘導体、組成物、およびそれらに関連する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019020153A Pending JP2019089817A (ja) | 2012-11-05 | 2019-02-06 | ７，８−ジヒドロキシフラボンおよび７，８−置換フラボン誘導体、組成物、およびそれらに関連する方法 |
| JP2020206038A Pending JP2021050230A (ja) | 2012-11-05 | 2020-12-11 | ７，８−ジヒドロキシフラボンおよび７，８−置換フラボン誘導体、組成物、およびそれらに関連する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9682948B2 (https=) |
| EP (2) | EP2914585B1 (https=) |
| JP (3) | JP6479670B2 (https=) |
| CN (2) | CN107868071B (https=) |
| AU (3) | AU2013337742B2 (https=) |
| CA (1) | CA2890075C (https=) |
| ES (1) | ES2823237T3 (https=) |
| WO (1) | WO2014071134A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11998516B2 (en) | 2011-03-07 | 2024-06-04 | Tonix Pharma Holdings Limited | Methods and compositions for treating depression using cyclobenzaprine |
| WO2014018741A1 (en) | 2012-07-27 | 2014-01-30 | Emory University | Heterocyclic flavone derivatives, compositions, and methods related thereto |
| CN107868071B (zh) * | 2012-11-05 | 2021-07-20 | 爱默蕾大学 | 7,8-二羟黄酮和7,8-取代的黄酮衍生物、组合物及其相关方法 |
| MX2020006140A (es) * | 2017-12-11 | 2020-08-13 | Tonix Pharma Holdings Ltd | Tratamiento con ciclobenzaprina para la agitacion, psicosis y deterioro cognitivo en la demencia y enfermedades neurodegenerativas. |
| CN108299367B (zh) * | 2018-01-26 | 2022-04-12 | 南阳师范学院 | 一种芹菜苷元氨基甲酸酯类化合物、其制备方法及应用 |
| CA3099311A1 (en) * | 2018-05-03 | 2019-11-07 | Georgia State University Research Foundation, Inc. | Inhibitors of rsv replication and applications thereof |
| CN110577532B (zh) * | 2018-06-08 | 2022-06-03 | 江苏威凯尔医药科技有限公司 | 原肌球蛋白受体激酶抑制剂及其制备方法和应用 |
| WO2020024977A1 (zh) * | 2018-08-01 | 2020-02-06 | 陕西麦科奥特科技有限公司 | 用于治疗神经系统疾病的化合物及其应用 |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| EA202191079A1 (ru) | 2018-11-19 | 2021-09-20 | Зодженикс Интернэшнл Лимитед | Способы лечения синдрома ретта с применением фенфлурамина |
| CN109574975B (zh) * | 2019-01-14 | 2023-07-14 | 上海博芮健制药有限公司 | 7,8-二羟基黄酮衍生物的晶型及其制备方法和应用 |
| WO2020154434A1 (en) * | 2019-01-24 | 2020-07-30 | Pharmatrophix, Inc. | Compositions and methods for treating and preventing cognitive dysfunction |
| CN111825649A (zh) * | 2019-04-15 | 2020-10-27 | 上海博芮健制药有限公司 | 7,8-二羟基黄酮衍生物的纯化方法 |
| CN114075162A (zh) * | 2020-08-20 | 2022-02-22 | 上海博芮健制药有限公司 | 7,8-二羟基黄酮衍生物的晶型b及其制备方法、应用 |
| CN112168976B (zh) * | 2020-10-15 | 2022-11-04 | 天津科技大学 | 一种黄酮衍生物前药及合成和作为抗肿瘤药物的应用 |
| WO2023288069A1 (en) * | 2021-07-15 | 2023-01-19 | Emory University | Methods of using substituted flavones for treating bone disorders |
| CN118251415A (zh) * | 2021-10-29 | 2024-06-25 | 清华大学 | 用于治疗或诊断精神分裂症的方法和产品 |
| PT4426434T (pt) | 2021-11-02 | 2025-11-24 | Flare Therapeutics Inc | Agonistas inversos de pparg e suas utilizações |
| JP7712994B2 (ja) * | 2022-11-02 | 2025-07-24 | ペトラ・ファーマ・コーポレイション | 疾患の治療用のホスホイノシチド３－キナーゼ（ｐｉ３ｋ）のアロステリッククロメノン阻害剤 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| AU2001291077A1 (en) * | 2000-09-21 | 2002-04-02 | Teva Pharmaceuticals Industries Ltd. | N-disubstituted carbamoyloxy flavones |
| US20020160983A1 (en) * | 2001-03-16 | 2002-10-31 | Alberto Bargiotti | Substituted benzopyranones as telomerase inhibitors |
| CA2442330A1 (en) | 2001-03-29 | 2002-10-10 | Emory University | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
| US20030125264A1 (en) * | 2001-12-29 | 2003-07-03 | Kimberly-Clark Worldwide, Inc. | Methods For Treating Wounds |
| BRPI0606793A8 (pt) * | 2005-02-04 | 2018-03-13 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitável do mesmo, processo para a preparação e uso do mesmo, métodos para a inibição da atividade de trk, para o tratamento ou profilaxia de câncer e para a produção de um efeito anti-proliferativo em um animal de sangue quente, e, composição farmacêutica |
| JP5498782B2 (ja) | 2006-06-21 | 2014-05-21 | ピラマル エンタープライジーズ リミテッド | 増殖性疾患治療用のエナンチオマー的に純粋なフラボン誘導体の調製方法 |
| CZ300589B6 (cs) | 2006-09-04 | 2009-06-24 | Univerzita Palackého | Deriváty 2-fenyl-3-hydroxychinolin-4(1H)-onu a zpusob jejich prípravy a použití |
| WO2010011836A2 (en) | 2008-07-25 | 2010-01-28 | Emory University | Treating various disorders with 7,8-dihydroxyflavone and derivatives thereof |
| WO2010107866A2 (en) | 2009-03-20 | 2010-09-23 | Emory University | Catecholamine derivatives for obesity and neurological disorders |
| CN101591319B (zh) * | 2009-06-22 | 2011-12-21 | 复旦大学 | 黄酮类衍生物及其在制备药物组合物中的用途 |
| EP2473495A1 (en) * | 2009-09-18 | 2012-07-11 | Almac Discovery Limited | Pharmaceutical compounds |
| EP2579870B1 (en) * | 2010-06-09 | 2018-02-14 | Emory University | Trkb agonists and methods of use |
| CN107868071B (zh) * | 2012-11-05 | 2021-07-20 | 爱默蕾大学 | 7,8-二羟黄酮和7,8-取代的黄酮衍生物、组合物及其相关方法 |
-
2013
- 2013-11-01 CN CN201711170821.XA patent/CN107868071B/zh active Active
- 2013-11-01 WO PCT/US2013/067972 patent/WO2014071134A1/en not_active Ceased
- 2013-11-01 CN CN201380062367.XA patent/CN104812744B/zh active Active
- 2013-11-01 CA CA2890075A patent/CA2890075C/en active Active
- 2013-11-01 AU AU2013337742A patent/AU2013337742B2/en active Active
- 2013-11-01 JP JP2015540801A patent/JP6479670B2/ja active Active
- 2013-11-01 EP EP13851584.6A patent/EP2914585B1/en active Active
- 2013-11-01 ES ES18155705T patent/ES2823237T3/es active Active
- 2013-11-01 EP EP18155705.9A patent/EP3369730B1/en active Active
- 2013-11-01 US US14/437,232 patent/US9682948B2/en active Active
-
2017
- 2017-05-12 US US15/593,654 patent/US9975868B2/en active Active
-
2018
- 2018-02-13 AU AU2018201060A patent/AU2018201060B2/en active Active
- 2018-02-26 US US15/905,179 patent/US10526303B2/en active Active
-
2019
- 2019-02-06 JP JP2019020153A patent/JP2019089817A/ja active Pending
- 2019-08-12 AU AU2019213454A patent/AU2019213454B2/en active Active
-
2020
- 2020-12-11 JP JP2020206038A patent/JP2021050230A/ja active Pending
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