JP2015533510A5 - - Google Patents

Download PDF

Info

Publication number
JP2015533510A5
JP2015533510A5 JP2015539817A JP2015539817A JP2015533510A5 JP 2015533510 A5 JP2015533510 A5 JP 2015533510A5 JP 2015539817 A JP2015539817 A JP 2015539817A JP 2015539817 A JP2015539817 A JP 2015539817A JP 2015533510 A5 JP2015533510 A5 JP 2015533510A5
Authority
JP
Japan
Prior art keywords
retrovirus
promoter
cancer
pharmaceutical composition
retroviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015539817A
Other languages
English (en)
Japanese (ja)
Other versions
JP6419706B2 (ja
JP2015533510A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/066709 external-priority patent/WO2014066700A1/en
Publication of JP2015533510A publication Critical patent/JP2015533510A/ja
Publication of JP2015533510A5 publication Critical patent/JP2015533510A5/ja
Application granted granted Critical
Publication of JP6419706B2 publication Critical patent/JP6419706B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015539817A 2012-10-25 2013-10-24 ミニプロモーターカセットを含むレトロウイルスベクター Expired - Fee Related JP6419706B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718610P 2012-10-25 2012-10-25
US61/718,610 2012-10-25
PCT/US2013/066709 WO2014066700A1 (en) 2012-10-25 2013-10-24 Retroviral vector with mini-promoter cassette

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018128726A Division JP2018183155A (ja) 2012-10-25 2018-07-06 ミニプロモーターカセットを含むレトロウイルスベクター

Publications (3)

Publication Number Publication Date
JP2015533510A JP2015533510A (ja) 2015-11-26
JP2015533510A5 true JP2015533510A5 (enExample) 2016-11-10
JP6419706B2 JP6419706B2 (ja) 2018-11-07

Family

ID=50545284

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015539817A Expired - Fee Related JP6419706B2 (ja) 2012-10-25 2013-10-24 ミニプロモーターカセットを含むレトロウイルスベクター
JP2018128726A Pending JP2018183155A (ja) 2012-10-25 2018-07-06 ミニプロモーターカセットを含むレトロウイルスベクター
JP2020136906A Pending JP2021006031A (ja) 2012-10-25 2020-08-14 ミニプロモーターカセットを含むレトロウイルスベクター

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2018128726A Pending JP2018183155A (ja) 2012-10-25 2018-07-06 ミニプロモーターカセットを含むレトロウイルスベクター
JP2020136906A Pending JP2021006031A (ja) 2012-10-25 2020-08-14 ミニプロモーターカセットを含むレトロウイルスベクター

Country Status (6)

Country Link
US (1) US11065311B2 (enExample)
EP (2) EP2909324B1 (enExample)
JP (3) JP6419706B2 (enExample)
CN (1) CN104884627A (enExample)
ES (1) ES2786051T3 (enExample)
WO (1) WO2014066700A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3122884B1 (en) * 2014-03-26 2019-12-25 Tocagen Inc. A retroviral vector having immune-stimulating activity
AU2016317936A1 (en) * 2015-09-04 2018-03-08 Tocagen Inc. Recombinant vectors comprising 2A peptide
US10688164B2 (en) * 2015-11-20 2020-06-23 Oregon Health & Science University CMV vectors comprising microRNA recognition elements
FR3044016A1 (fr) * 2015-11-24 2017-05-26 Glaxosmithkline Ip Dev Ltd Lignees cellulaires stables pour la production retrovirale
WO2018101498A1 (ko) 2016-11-29 2018-06-07 충남대학교 산학협력단 유전자치료 벡터시스템 및 전구약물 유전자
CN117821509A (zh) 2017-04-03 2024-04-05 编码治疗公司 组织选择性转基因表达
CA3063464A1 (en) 2017-05-19 2018-11-22 Encoded Therapeutics, Inc. High activity regulatory elements
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
CN118345115A (zh) 2017-12-01 2024-07-16 编码治疗公司 工程化的dna结合蛋白
GB201720948D0 (en) 2017-12-15 2018-01-31 Autolus Ltd Plasmid system
US20220002752A1 (en) * 2018-11-13 2022-01-06 Denovo Biopharma Llc Recombinant vectors comprising genes for binding domains and secretable peptides
CN114127121B (zh) 2019-08-12 2025-04-11 北京恩瑞尼生物科技股份有限公司 用于通过cd39表达细胞的adcc靶向促进和增强t细胞介导的免疫反应的方法和组合物
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
CA3168943A1 (en) * 2020-01-30 2021-08-05 Purdue Research Foundation Ligand-mediated delivery of therapeutic proteins and the uses thereof
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
TW202334196A (zh) 2021-10-07 2023-09-01 英商阿法克塔生命科學有限公司 Pd-l1結合多肽
WO2023057946A1 (en) 2021-10-07 2023-04-13 Avacta Life Sciences Limited Serum half-life extended pd-l1 binding polypeptides
CA3248580A1 (en) 2022-04-29 2023-11-02 Purinomia Biotech, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES AND DISORDERS CAUSED BY EOSINOPHIL ACTIVITY
WO2024102954A1 (en) 2022-11-10 2024-05-16 Massachusetts Institute Of Technology Activation induced clipping system (aics)
CN116334010B (zh) * 2023-05-30 2023-08-29 中义(北京)健康研究院 一种重组单纯疱疹病毒及其制备方法和应用
WO2025235862A1 (en) 2024-05-10 2025-11-13 Inndura Therapeutics Inc. A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937190A (en) 1987-10-15 1990-06-26 Wisconsin Alumni Research Foundation Translation enhancer
US6133029A (en) 1988-03-21 2000-10-17 Chiron Corporation Replication defective viral vectors for infecting human cells
US5997859A (en) 1988-03-21 1999-12-07 Chiron Corporation Method for treating a metastatic carcinoma using a conditionally lethal gene
US5716826A (en) 1988-03-21 1998-02-10 Chiron Viagene, Inc. Recombinant retroviruses
DE68921034D1 (de) 1988-09-27 1995-03-23 Dana Farber Cancer Inst Inc Vektor, der ein replikationskompetentes HIV-I-Provirus und ein heterologes Gen enthält.
US5674486A (en) 1991-06-25 1997-10-07 San Diego Regional Cancer Center Cancer immunotherapy with carrier cells
DK0598029T3 (da) 1991-08-07 2002-05-27 W French Anderson Retrovirale vektorer indeholdende interne ribosome indgangssteder
WO1993010218A1 (en) 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vectors including foreign genes and negative selective markers
CA2148934C (en) 1992-11-09 2005-08-02 French W. Anderson Targetable vector particles
US5770428A (en) 1993-02-17 1998-06-23 Wisconsin Alumni Research Foundation Chimeric retrovial expression vectors and particles containing a simple retroviral long terminal repeat, BLV or HIV coding regions and cis-acting regulatory sequences, and an RNA translational enhancer with internal ribsome entry site
AU680508B2 (en) 1993-04-06 1997-07-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Gibbon ape leukemia virus-based retroviral vectors
FR2716459B1 (fr) 1994-02-22 1996-05-10 Univ Paris Curie Système hôte-vecteur utilisable en thérapie génique.
US5585096A (en) 1994-06-23 1996-12-17 Georgetown University Replication-competent herpes simplex virus mediates destruction of neoplastic cells
JP4046349B2 (ja) 1994-11-07 2008-02-13 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド 腫瘍壊死因子−γ
US20030157070A1 (en) 1994-12-30 2003-08-21 Jolly Douglas J. High efficiency ex vivo transduction of cells by high titer recombinant retroviral preparations
US6117681A (en) 1995-03-29 2000-09-12 Bavarian Nordic Research Inst. A/S Pseudotyped retroviral particles
AU2363695A (en) 1995-04-27 1996-11-18 Human Genome Sciences, Inc. Human tumor necrosis factor receptors
US20030026789A1 (en) 1995-05-03 2003-02-06 Richard J. Gregory Gene therapy using replication competent targeted adenoviral vectors
GB9604354D0 (en) 1996-02-29 1996-05-01 Isis Innovation Targeting adapters
WO1997033904A1 (en) 1996-03-12 1997-09-18 Human Genome Sciences, Inc. Death domain containing receptors
WO1997033899A1 (en) 1996-03-14 1997-09-18 Human Genome Sciences, Inc. Apoptosis inducing molecule i
WO1998007880A1 (en) 1996-08-16 1998-02-26 Human Genome Sciences, Inc. Human endokine alpha
DK0920505T3 (da) 1996-08-16 2008-09-08 Schering Corp Pattedyrcelleoverfladeantigener og tilhörende reagenser
US6025192A (en) 1996-09-20 2000-02-15 Cold Spring Harbor Laboratory Modified retroviral vectors
NZ334309A (en) 1996-10-25 2000-08-25 Human Genome Sciences Inc Neutrokine alpha protein, a member of the TNF family, and its use in treating and/or detecting immune disorders
EP0990031B1 (en) 1997-01-14 2006-03-29 Human Genome Sciences, Inc. Tumor necrosis factor receptor 5
ATE362982T1 (de) 1997-01-28 2007-06-15 Human Genome Sciences Inc ßDEATH-DOMAINß-ENTHALTENDER REZEPTOR 4 (DR4), EIN MITGLIED DER TNF-REZEPTOR SUPERFAMILIE, WELCHER AN TRAIL (APO-2L) BINDET
US6248721B1 (en) 1997-04-09 2001-06-19 Lung-Ji Chang Method of using mouse model for evaluation of HIV vaccines
US6207455B1 (en) 1997-05-01 2001-03-27 Lung-Ji Chang Lentiviral vectors
US6214580B1 (en) 1997-05-30 2001-04-10 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr10
CA2295991A1 (en) 1997-06-11 1998-12-17 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr9
EP1025208A2 (en) 1997-10-20 2000-08-09 Universita' Degli Studi Di Padova A packaging cell line producing siv-pseudotyped mlv
FR2773561A1 (fr) 1998-01-15 1999-07-16 Centre Nat Rech Scient Utilisation d'une sequence riche en proline pour augmenter le caractere fusogenique d'enveloppes de retrovirus
US6451304B1 (en) 1998-03-09 2002-09-17 The Regents Of The University Of California Method for retrovirus vector production by separated gag and pol expression
JP2002512805A (ja) 1998-04-29 2002-05-08 オクラホマ メディカル リサーチ ファウンデーション アデノウイルスベクターおよびレトロウイルスベクターからのレトロウイルスプロデューサー細胞の構築
US6291214B1 (en) 1998-05-11 2001-09-18 Glaxo Wellcome Inc. System for generating recombinant viruses
US7001733B1 (en) 1998-05-12 2006-02-21 Rigel Pharmaceuticals, Inc. Methods and compositions for screening for modulations of IgE synthesis, secretion and switch rearrangement
FR2778670B1 (fr) 1998-05-18 2002-12-13 Rhone Poulenc Rorer Sa Methodes et compositions pour la production de particules virales
GB9810752D0 (en) 1998-05-19 1998-07-15 Glaxo Group Ltd Cystosine deaminase gene
WO1999060110A2 (en) 1998-05-20 1999-11-25 The University Of Tennessee Research Corporation Stable envelope proteins for retroviral, viral and liposome vectors and use in gene and drug therapy
US6264940B1 (en) 1998-08-05 2001-07-24 The Research Foundation Of State University Of New York Recombinant poliovirus for the treatment of cancer
US6899871B2 (en) 1998-10-01 2005-05-31 University Of Southern California Gene delivery system and methods of use
DE69940521D1 (de) 1998-10-01 2009-04-16 Univ Southern California Retrovirales genübertragungssystem und entsprechendes verwendungverfahren
GB0122803D0 (en) * 2001-09-21 2001-11-14 Oxford Biomedica Ltd Vector
US6576463B1 (en) 1999-01-15 2003-06-10 The Regents Of The University Of California Hybrid vectors for gene therapy
EP1173597A1 (en) 1999-04-29 2002-01-23 Aarhus University Expression of heterologous genes from an ires translational cassette in retroviral vectors
EP1059356B1 (en) 1999-06-09 2005-11-02 Universite Pierre Et Marie Curie Paris Vi Replicating retroviral constructs, preparation and uses for gene delivery
EP1059357A1 (en) 1999-06-09 2000-12-13 Universite Pierre Et Marie Curie Paris Vi Replicating or semi-replicating retroviral constructs, preparation and uses for gene delivery
WO2001004266A1 (en) 1999-07-08 2001-01-18 The Regents Of The Universty Of California A lung cancer associated retrovirus, gene delivery vector and methods of use thereof
WO2001040488A1 (en) 1999-11-30 2001-06-07 Novartis Ag Increased transgene expression in retroviral vectors having scaffold attachment region
US6322696B1 (en) 2000-02-25 2001-11-27 Gp Companies, Inc. Inlet filter for high pressure sprayer
US6692736B2 (en) 2000-03-24 2004-02-17 Cell Genesys, Inc. Cell-specific adenovirus vectors comprising an internal ribosome entry site
WO2002022663A2 (en) 2000-09-18 2002-03-21 Maxygen, Inc. Stress resistant retroviruses
GB0024550D0 (enExample) 2000-10-06 2000-11-22 Oxford Biomedica Ltd
WO2002042482A2 (en) 2000-11-27 2002-05-30 Chiron Corporation Functional lentiviral vector from an mlv-based backbone
US7226779B2 (en) 2001-01-30 2007-06-05 The United States Of America As Represented By The Department Of Health And Human Services Hybrid adenoviral vector
DE10111433A1 (de) 2001-03-09 2002-09-19 Bundesrepublik Deutschland Let Replikationskompetente molekulare Klone von porcinem endogenem Retrovirus der Klasse A und Klasse B,abgeleitet von Schweine- und humanen Zellen
EP1379281A4 (en) 2001-03-26 2005-05-18 Univ Leland Stanford Junior HELPER-DEPENDENT ADENOVIRUS VECTOR SYSTEM AND METHOD FOR ITS USE
US7211247B2 (en) 2001-04-09 2007-05-01 University Of Southern California Lentivirus vectors for gene transfer to alveolar epithelial cells
JP2002335965A (ja) 2001-05-14 2002-11-26 Japan Science & Technology Corp 細胞特異的発現複製ベクター
DE10143237A1 (de) 2001-09-04 2003-03-20 Icon Genetics Ag Herstellung künstlicher interner ribosomaler Eingangsstellenelemente (Ires-Elemente)
JP2005510491A (ja) 2001-10-26 2005-04-21 イミュノ−アールエックス, インコーポレイテッド 免疫抑制を逆転させるための免疫治療
FR2832424B1 (fr) 2001-11-20 2004-09-24 Genethon Iii Plasmide chimere comprenant un genome retroviral replicatif et utilisations
US20030121068A1 (en) 2001-11-30 2003-06-26 Paul Orchard Vector encoding suicide and marker constructs
EP1470233A1 (en) 2002-02-01 2004-10-27 Transgene S.A. Adenoviral vectors for modulating the cellular activities associated with pods
US20060147420A1 (en) 2004-03-10 2006-07-06 Juan Fueyo Oncolytic adenovirus armed with therapeutic genes
EP1511767B1 (en) 2002-05-17 2009-07-22 RetroVec ApS A purified polypeptide, isolated nucleic acids encoding said polypeptide, vectors and use thereof
AU2003251931B2 (en) 2002-07-17 2008-03-06 Bristol-Myers Squibb Company Transgenic non-human mammals expressing a reporter nucleic acid under the regulation of androgen response elements
AU2003260769A1 (en) 2002-09-03 2004-03-29 Oxford Biomedica (Uk) Limited Retroviral vector and stable packaging cell lines
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
US8106180B2 (en) 2003-08-07 2012-01-31 Whitehead Institute For Biomedical Research Methods and products for expression of micro RNAs
WO2005118802A2 (en) 2004-06-03 2005-12-15 The Regents Of The University Of California Targeting pseudotyped retroviral vectors
US20070003522A1 (en) 2004-07-08 2007-01-04 Albritton Lorraine M Methods and compositions for improved retroviral gene and drug delivery
AU2005300315A1 (en) 2004-11-04 2006-05-11 Pfizer Products Inc. CTLA-4 antibody and aromatase inhibitor or combination treatment for breast cancer
JP2008521405A (ja) 2004-11-24 2008-06-26 ナノヴェクター・リミテッド ウイルスベクター
US20060147429A1 (en) 2004-12-30 2006-07-06 Paul Diamond Facilitated cellular reconstitution of organs and tissues
WO2006127980A2 (en) 2005-05-25 2006-11-30 The Regents Of The University Of California Optimized core promoters and uses therefor
JP2007054069A (ja) 2005-08-24 2007-03-08 Medizinische Hochschule Hannover 自己不活性化レトロウイルスベクター
AU2006296840A1 (en) 2005-09-30 2007-04-05 Zgene A/S Dekkera/Brettanomyces cytosine deaminases and their use
WO2007041350A2 (en) 2005-10-01 2007-04-12 Charles Stout Regulatable fusion promoters
US8034355B2 (en) 2005-10-07 2011-10-11 Presidents And Fellows Of Harvard College Attenuated nonsegmented negative-sense RNA viruses with reduced mRNA cap methyltransferase activity comprising mutations within conserved domain VI of the large polymerase
EP1795596A1 (en) 2005-12-08 2007-06-13 Ganymed Pharmaceuticals AG Composition and methods for therapy and diagnosis of cancer
EP2484782B1 (en) 2006-01-05 2015-11-18 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
WO2007095201A2 (en) 2006-02-15 2007-08-23 The Regents Of The University Of California Pseudotyped retroviral vectors and methods of use thereof
WO2007107156A2 (en) 2006-03-17 2007-09-27 Aarhus Universitet Chimeric viral envelopes
JP5441685B2 (ja) 2006-05-02 2014-03-12 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ チモシンα1の、単独またはPTX3またはガンシクロビルとの組合せにおける、サイトメガロウイルス感染の処置のための使用
WO2008011636A2 (en) 2006-07-21 2008-01-24 California Institute Of Technology Targeted gene delivery for dendritic cell vaccination
WO2008151633A2 (en) 2007-06-15 2008-12-18 Skau Aps Vectors for vaccines against lentivirus infections
EP2306823A4 (en) 2008-06-30 2012-09-26 Tocagen Inc 5-FLUOROCYTOSINE FORMULATIONS AND USES THEREOF
DK2346995T3 (en) 2008-09-26 2019-02-11 Tocagen Inc GENETERIVE VECTORS AND CYTOSINDEAMINASES
US8829173B2 (en) * 2008-09-26 2014-09-09 Tocagen Inc. Recombinant vectors
EP3546583A1 (en) 2009-06-17 2019-10-02 Tocagen Inc. Producer cells for replication competent retroviral vectors
CA2805941A1 (en) * 2010-08-13 2012-02-16 Pioneer Hi-Bred International, Inc. Methods and compositions for targeting sequences of interest to the chloroplast
US9669049B2 (en) 2010-10-31 2017-06-06 Tocagen Inc. Compositions comprising gamma retrovirus vectors and methods of treating proliferative disorders
KR101888391B1 (ko) 2014-09-01 2018-08-14 삼성전자 주식회사 음성 신호 관리 방법 및 이를 제공하는 전자 장치

Similar Documents

Publication Publication Date Title
ES2779149T3 (es) Vector retroviral que tiene actividad inmunoestimuladora
US11065311B2 (en) Retroviral vector with mini-promoter cassette
JP4663943B2 (ja) 免疫治療組成物調製用のレンチウイルスベクター
CN1058993C (zh) 用于癌症治疗的分子嵌合体的制备方法及应用
JP2012503987A5 (enExample)
JP2016526920A5 (enExample)
JP2012503986A5 (enExample)
ES2911448T3 (es) Vectores combinados y métodos para el tratamiento del cáncer
CN105579581A (zh) 具有优化的a凸出物的重组载体
JP2018526007A (ja) 2aペプチドを含む組換えベクター
JP2010509223A (ja) 癌および他の疾患のための向病巣性標的化遺伝子送達系
AU2011278931A1 (en) Targeted nanoparticles for cancer and other disorders
JP2009112314A (ja) 疾患を処置するための方法および組成物
CN109072253B (zh) 包含GM-CSF基因、Flt3L-TRAIL融合基因、抑制TGF-β表达的shRNA和抑制HSP表达的shRNA的抗肿瘤组合物
ES2744448T5 (es) Vectores para la expresión transgénica
JP4343708B2 (ja) 改良型キメラ糖タンパク質と、類型化されたレンチウイルス
US20240167038A1 (en) RNA Trans-Splicing Molecule
ES2236888T3 (es) Expresion de una proteina modificada de la envoltura del virus espumoso.
Mitrović et al. Gene therapy of cancer