JP2015533491A5 - - Google Patents
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- Publication number
- JP2015533491A5 JP2015533491A5 JP2015532125A JP2015532125A JP2015533491A5 JP 2015533491 A5 JP2015533491 A5 JP 2015533491A5 JP 2015532125 A JP2015532125 A JP 2015532125A JP 2015532125 A JP2015532125 A JP 2015532125A JP 2015533491 A5 JP2015533491 A5 JP 2015533491A5
- Authority
- JP
- Japan
- Prior art keywords
- salmonella typhi
- shigella
- antigen
- ty21a
- dna sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 45
- 239000000427 antigen Substances 0.000 claims 31
- 108091007433 antigens Proteins 0.000 claims 30
- 102000036639 antigens Human genes 0.000 claims 30
- 108090000623 proteins and genes Proteins 0.000 claims 19
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
- 231100000331 toxic Toxicity 0.000 claims 16
- 230000002588 toxic effect Effects 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 230000015572 biosynthetic process Effects 0.000 claims 14
- 208000015181 infectious disease Diseases 0.000 claims 12
- 210000000349 chromosome Anatomy 0.000 claims 10
- 241000607760 Shigella sonnei Species 0.000 claims 9
- 229940115939 shigella sonnei Drugs 0.000 claims 9
- 241000147000 Shigella flexneri 2a Species 0.000 claims 7
- 241001353153 Shigella flexneri 3a Species 0.000 claims 7
- 230000000890 antigenic effect Effects 0.000 claims 6
- 239000013612 plasmid Substances 0.000 claims 6
- 241000607764 Shigella dysenteriae Species 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 5
- 229940007046 shigella dysenteriae Drugs 0.000 claims 5
- 241000607768 Shigella Species 0.000 claims 4
- 241000446766 Shigella dysenteriae 1 Species 0.000 claims 4
- 241000607626 Vibrio cholerae Species 0.000 claims 4
- 230000007124 immune defense Effects 0.000 claims 4
- 229940118696 vibrio cholerae Drugs 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 3
- 210000003578 bacterial chromosome Anatomy 0.000 claims 3
- 241000607142 Salmonella Species 0.000 claims 2
- 241000607762 Shigella flexneri Species 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 229930027917 kanamycin Natural products 0.000 claims 2
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 claims 2
- 229960000318 kanamycin Drugs 0.000 claims 2
- 229930182823 kanamycin A Natural products 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000005215 recombination Methods 0.000 claims 2
- 230000006798 recombination Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 241000588921 Enterobacteriaceae Species 0.000 claims 1
- 241000186781 Listeria Species 0.000 claims 1
- 241001138501 Salmonella enterica Species 0.000 claims 1
- 241000607766 Shigella boydii Species 0.000 claims 1
- 241000607734 Yersinia <bacteria> Species 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 229960001212 bacterial vaccine Drugs 0.000 claims 1
- 230000001851 biosynthetic effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 238000012248 genetic selection Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261701939P | 2012-09-17 | 2012-09-17 | |
| US61/701,939 | 2012-09-17 | ||
| PCT/US2013/059980 WO2014043637A1 (en) | 2012-09-17 | 2013-09-16 | Multifunctional oral vaccine based on chromosome recombineering |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015533491A JP2015533491A (ja) | 2015-11-26 |
| JP2015533491A5 true JP2015533491A5 (enExample) | 2016-09-01 |
Family
ID=50278754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532125A Pending JP2015533491A (ja) | 2012-09-17 | 2013-09-16 | 染色体組換え操作に基づく多機能性経口ワクチン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9750793B2 (enExample) |
| EP (1) | EP2895596A4 (enExample) |
| JP (1) | JP2015533491A (enExample) |
| KR (1) | KR20150058435A (enExample) |
| CN (1) | CN104812890A (enExample) |
| HK (1) | HK1211980A1 (enExample) |
| IL (1) | IL237339B (enExample) |
| IN (1) | IN2015KN00516A (enExample) |
| WO (1) | WO2014043637A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2675020T3 (es) * | 2013-04-25 | 2018-07-05 | Vaximm Ag | Vectores basados en Salmonella para inmunoterapia del cáncer dirigida al gen WT1 del tumor de Wilms |
| SG11201604911VA (en) | 2013-12-18 | 2016-07-28 | Vaximm Gmbh | Novel msln targeting dna vaccine for cancer immunotherapy |
| CN105734001B (zh) * | 2014-12-08 | 2020-04-07 | 中国人民解放军军事医学科学院生物工程研究所 | 一种o抗原糖链延长的甲型副伤寒沙门氏菌及其应用 |
| HK1255555A1 (zh) * | 2015-07-06 | 2019-08-23 | Protein Potential, Llc | 抗志贺氏菌病和伤寒的活性减毒口服疫苗 |
| GB201519734D0 (en) * | 2015-11-09 | 2015-12-23 | Univ Swansea | Cancer therapy |
| CN106801029B (zh) * | 2017-01-22 | 2020-05-01 | 山东大学 | 一株重组大肠杆菌及其在制备抗志贺氏菌的糖疫苗中的应用 |
| MY190074A (en) * | 2018-01-09 | 2022-03-24 | Aimst Univ | A monovalent vaccine formulation and a method for preparation thereof |
| US12180487B2 (en) | 2019-02-06 | 2024-12-31 | Fred Hutchinson Cancer Center | Minicircle producing bacteria engineered to differentially methylate nucleic acid molecules therein |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7541043B2 (en) * | 2002-01-16 | 2009-06-02 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine for protection against Shigella sonnei disease |
| US8071113B2 (en) | 2004-05-24 | 2011-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Live, oral vaccine for protection against Shigella dysenteriae serotype 1 |
-
2013
- 2013-09-16 KR KR1020157010066A patent/KR20150058435A/ko not_active Ceased
- 2013-09-16 JP JP2015532125A patent/JP2015533491A/ja active Pending
- 2013-09-16 EP EP13836396.5A patent/EP2895596A4/en not_active Ceased
- 2013-09-16 HK HK15112845.5A patent/HK1211980A1/xx unknown
- 2013-09-16 WO PCT/US2013/059980 patent/WO2014043637A1/en not_active Ceased
- 2013-09-16 CN CN201380059559.5A patent/CN104812890A/zh active Pending
- 2013-09-16 IN IN516KON2015 patent/IN2015KN00516A/en unknown
- 2013-09-16 US US14/428,870 patent/US9750793B2/en active Active
-
2015
- 2015-02-22 IL IL237339A patent/IL237339B/en not_active IP Right Cessation
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