JP2015530087A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015530087A5 JP2015530087A5 JP2015529031A JP2015529031A JP2015530087A5 JP 2015530087 A5 JP2015530087 A5 JP 2015530087A5 JP 2015529031 A JP2015529031 A JP 2015529031A JP 2015529031 A JP2015529031 A JP 2015529031A JP 2015530087 A5 JP2015530087 A5 JP 2015530087A5
- Authority
- JP
- Japan
- Prior art keywords
- species
- human
- immune library
- target antigen
- antibody molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 230000009260 cross reactivity Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 241000894007 species Species 0.000 claims 22
- 238000000034 method Methods 0.000 claims 14
- 241001465754 Metazoa Species 0.000 claims 2
- 241000283984 Rodentia Species 0.000 claims 2
- 235000002198 Annona diversifolia Nutrition 0.000 claims 1
- 101001044883 Homo sapiens Interleukin-22 receptor subunit alpha-1 Proteins 0.000 claims 1
- 102100022723 Interleukin-22 receptor subunit alpha-1 Human genes 0.000 claims 1
- 241000282842 Lama glama Species 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261695664P | 2012-08-31 | 2012-08-31 | |
| US61/695,664 | 2012-08-31 | ||
| PCT/EP2013/067979 WO2014033252A1 (en) | 2012-08-31 | 2013-08-30 | Method for producing antibody molecules having inter-species, intra-target cross-reactivity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015530087A JP2015530087A (ja) | 2015-10-15 |
| JP2015530087A5 true JP2015530087A5 (cg-RX-API-DMAC7.html) | 2017-09-21 |
| JP6391574B2 JP6391574B2 (ja) | 2018-09-26 |
Family
ID=49080903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529031A Active JP6391574B2 (ja) | 2012-08-31 | 2013-08-30 | 種間標的内交差反応性を有する抗体分子を産生する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20150203840A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2890711B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6391574B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN104583238A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2013310924B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2878712A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2890711T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL236523B (cg-RX-API-DMAC7.html) |
| IN (1) | IN2015DN00140A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014033252A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012228194B2 (en) | 2011-03-16 | 2017-06-01 | Argenx Bvba | Antibodies to CD70 |
| JP2016529892A (ja) | 2013-08-01 | 2016-09-29 | ユニベルシテ カソリク デ ロウバイン | 抗ｇａｒｐタンパク質及びその使用 |
| US10391168B1 (en) | 2014-08-22 | 2019-08-27 | University Of Bern | Anti-CD70 combination therapy |
| CA3030099A1 (en) | 2016-07-08 | 2018-01-11 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
| GB201612337D0 (en) | 2016-07-15 | 2016-08-31 | Argen-X N V | Ant-il-22r antibodies |
| WO2018193427A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
| GB201707561D0 (en) | 2017-05-11 | 2017-06-28 | Argenx Bvba | GARP-TGF-beta antibodies |
| US10538583B2 (en) | 2017-10-31 | 2020-01-21 | Staten Biotechnology B.V. | Anti-APOC3 antibodies and compositions thereof |
| CN111315772A (zh) | 2017-10-31 | 2020-06-19 | 斯塔顿生物技术有限公司 | 抗apoc3抗体及其使用方法 |
| EP3723803A4 (en) | 2017-12-12 | 2021-09-15 | Pionyr Immunotherapeutics, Inc. | ANTI-TREM2 ANTIBODIES AND RELATED PROCEDURES |
| GB201800649D0 (en) | 2018-01-16 | 2018-02-28 | Argenx Bvba | CD70 Combination Therapy |
| CN112004826B (zh) | 2018-02-05 | 2024-06-14 | 自由大学基金会 | 反向激动性抗us28抗体 |
| WO2020080941A1 (en) | 2018-10-16 | 2020-04-23 | Umc Utrecht Holding B.V. | Anti- low-density lipoprotein receptor-related protein 5/6 antibodies |
| TW202200623A (zh) * | 2020-05-29 | 2022-01-01 | 日商第一三共股份有限公司 | 對炎症性腸病之治療用抗體 |
| EP4277706A1 (en) | 2021-01-15 | 2023-11-22 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Inducers of senescence, in combination with a selective death receptor 5 (dr5) agonist, for use in a method of treating cancer |
| WO2024096735A1 (en) | 2022-10-31 | 2024-05-10 | Stichting Amsterdam UMC | Single domain anti-cd169 antibodies |
| WO2024101989A1 (en) | 2022-11-08 | 2024-05-16 | Stichting Amsterdam UMC | Activation inducible antigen receptors for adoptive immunotherapy |
| EP4631501A1 (en) | 2024-04-09 | 2025-10-15 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Combinations of a calcium homeostasis disruptor with a death receptor 5 agonist for treating cancer |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU760562B2 (en) * | 1997-12-05 | 2003-05-15 | Scripps Research Institute, The | Humanization of murine antibody |
| CN1735629B (zh) * | 2002-11-08 | 2012-05-09 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子-α的单结构域抗体及其用途 |
| CA2505326A1 (en) * | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders |
| UA93179C2 (ru) * | 2003-03-24 | 2011-01-25 | Займоджинетикс, Инк. | Антитело, kotopoe специфически связывается c il-22ra, и способы его применения |
| EP1606316A2 (en) * | 2003-03-24 | 2005-12-21 | ZymoGenetics, Inc. | Anti-il-20 antibodies and binding partners and methods of using in inflammation |
| PL2163562T3 (pl) * | 2005-06-21 | 2014-03-31 | Xoma Us Llc | Przeciwciała wiążące IL-1 beta i ich fragmenty |
| TWI417301B (zh) * | 2006-02-21 | 2013-12-01 | Wyeth Corp | 對抗人類介白素-２２（ｉｌ-２２）之抗體及其用途 |
| GB2461546B (en) * | 2008-07-02 | 2010-07-07 | Argen X Bv | Antigen binding polypeptides |
| US8444976B2 (en) | 2008-07-02 | 2013-05-21 | Argen-X B.V. | Antigen binding polypeptides |
| CN107337734A (zh) * | 2009-12-04 | 2017-11-10 | 弗·哈夫曼-拉罗切有限公司 | 多特异性抗体、抗体类似物、组合物和方法 |
| GB2476681B (en) | 2010-01-04 | 2012-04-04 | Argen X Bv | Humanized camelid VH, VK and VL immunoglobulin domains |
| GB201002238D0 (en) * | 2010-02-10 | 2010-03-31 | Affitech As | Antibodies |
| KR20180069083A (ko) * | 2010-11-24 | 2018-06-22 | 렉시컨 파마슈티컬스 인코퍼레이티드 | 노텀 펙틴아세틸에스터라제에 대한 항체 |
-
2013
- 2013-08-30 IN IN140DEN2015 patent/IN2015DN00140A/en unknown
- 2013-08-30 CN CN201380044710.8A patent/CN104583238A/zh active Pending
- 2013-08-30 DK DK13753659.5T patent/DK2890711T3/en active
- 2013-08-30 EP EP13753659.5A patent/EP2890711B1/en active Active
- 2013-08-30 WO PCT/EP2013/067979 patent/WO2014033252A1/en not_active Ceased
- 2013-08-30 JP JP2015529031A patent/JP6391574B2/ja active Active
- 2013-08-30 AU AU2013310924A patent/AU2013310924B2/en active Active
- 2013-08-30 US US14/420,039 patent/US20150203840A1/en not_active Abandoned
- 2013-08-30 EP EP15181968.7A patent/EP2977386A1/en not_active Withdrawn
- 2013-08-30 CA CA2878712A patent/CA2878712A1/en not_active Abandoned
-
2014
- 2014-12-31 IL IL236523A patent/IL236523B/en active IP Right Grant
-
2017
- 2017-06-21 AU AU2017204188A patent/AU2017204188A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015530087A5 (cg-RX-API-DMAC7.html) | ||
| CN103562403A8 (zh) | 识别肿瘤起始细胞的抗体和抗原及其应用 | |
| MX2024003651A (es) | Purificacion de anticuerpos multiespecificos. | |
| CO2018005932A2 (es) | Moléculas biespecíficas que tienen inmunorreactividad con pd-1 y ctla-4, y métodos de uso de las mismas | |
| CY1122840T1 (el) | Ανθρωποποιημενα ή χιμαιρικα αντισωματα cd3 | |
| MX395317B (es) | Anticuerpos de grupo de diferenciacion 3 (cd3) humanizados o quimericos. | |
| EA201400875A1 (ru) | Антитела к cd47 и способы их применения | |
| BR112016013347A2 (pt) | anticorpo monoclonal humano neutralizante anti-il-33 | |
| MX2016003593A (es) | Anticuerpos de cadena ligera variable comun intercambiada de dominio multiespecifico. | |
| HK1252827A1 (zh) | 结合lag-3的分子和其使用方法 | |
| EA201791393A2 (ru) | АНТИТЕЛА К ErbB3 И ИХ ПРИМЕНЕНИЕ | |
| EA201690182A1 (ru) | АНТИТЕЛА ПРОТИВ ФАКТОРА КОМПЛЕМЕНТА C1q И ИХ ПРИМЕНЕНИЯ | |
| EA201492137A1 (ru) | Антитела к cd33 и их применение в лечении рака | |
| AU2013310924A8 (en) | Method for producing antibody molecules having inter-species, intra-target cross-reactivity | |
| WO2016201389A3 (en) | Anti-cd33 antibodies and methods of use thereof | |
| MX369220B (es) | Moleculas que enlazan cd3 capaces de enlazar a cd3 humano y no humano. | |
| EA201790438A1 (ru) | Антигенсвязывающие белки, которые связываются с cxcr5 | |
| WO2015127134A3 (en) | Complement component c5 antibodies | |
| HK1218550A1 (zh) | 常見輕鏈小鼠 | |
| GT201300149A (es) | Proteinas de union al tnf-a | |
| MX353278B (es) | Raton con cadena ligera comun. | |
| WO2015028454A3 (en) | Method for the treatment of fibrotic disease | |
| EA201691473A1 (ru) | Биспецифические анти-il-13/il-17 антитела и их применение | |
| EA201691321A1 (ru) | Антитела и способы их применения | |
| EA201990894A1 (ru) | Анти-pd-1/анти-her2 гетеродимерное биспецифическое антитело со структурой природного антитела и способ его получения |