CN111712522A - 抗pd-1/抗vegf天然抗体结构样异源二聚体形式双特异抗体及其制备 - Google Patents
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Abstract
抗PD‑1/抗VEGF天然抗体结构样异源二聚体形式双特异抗体及其制备。提供了一种具有天然IgG特点、并且没有重轻链错配的高度稳定的异源二聚体形式的抗PD‑1/抗VEGF双特异抗体及其制备方法。该双特异抗体能同时结合两种靶分子并且在治疗复杂疾病方面会更有效。
Description
PCT国内申请，说明书已公开。
Claims (28)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810141323 | 2018-02-11 | ||
| CN2018101413230 | 2018-02-11 | ||
| PCT/CN2019/074541 WO2019154349A1 (zh) | 2018-02-11 | 2019-02-02 | 抗pd-1/抗vegf天然抗体结构样异源二聚体形式双特异抗体及其制备 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111712522A true CN111712522A (zh) | 2020-09-25 |
Family
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Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11827697B2 (zh) |
| EP (1) | EP3750920A4 (zh) |
| JP (1) | JP2021512624A (zh) |
| KR (1) | KR20200120927A (zh) |
| CN (1) | CN111712522A (zh) |
| AU (1) | AU2019218433A1 (zh) |
| CA (1) | CA3090878A1 (zh) |
| WO (1) | WO2019154349A1 (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113827731A (zh) * | 2021-09-22 | 2021-12-24 | 北京远胜达生物科技发展有限公司 | Crispr基因编辑联合pd-1抗体在治疗癌症中的应用 |
| WO2023246247A1 (zh) * | 2022-06-22 | 2023-12-28 | 中山康方生物医药有限公司 | 药物组合物及其用途 |
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| IL290457B1 (en) | 2015-12-30 | 2024-10-01 | Kodiak Sciences Inc | Antibodies and their conjugates |
| CA3035681A1 (en) * | 2016-09-29 | 2018-04-05 | Beijing Hanmi Pharmaceutical Co., Ltd. | Heterodimeric immunoglobulin constructs and preparation methods thereof |
| PE20191080A1 (es) | 2016-11-18 | 2019-08-20 | Beijing Hanmi Pharmaceutical Co Ltd | Anticuerpo biespecifico heterodimerico estructural de anticuerpo natural anti-pd-1/anti-her2 y metodo para preparar el mismo |
| WO2019153200A1 (zh) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CA3162748A1 (en) * | 2019-11-25 | 2021-06-03 | Akeso Biopharma, Inc. | Anti-pd-1-anti-vegfa bispecific antibody, pharmaceutical composition and use thereof |
| CN113121697B (zh) * | 2019-12-31 | 2023-06-09 | 周易 | Ch3结构域改造诱导形成的异源二聚体及其制备方法和应用 |
| BR112022014487A2 (pt) * | 2020-01-21 | 2022-09-27 | Wuxi Biologics Shanghai Co Ltd | Anticorpo bispecífico anti-pd-l1/vegf e usos do mesmo |
| CN113214400B (zh) * | 2020-01-21 | 2022-11-08 | 甫康（上海）健康科技有限责任公司 | 一种双特异性抗pd-l1/vegf抗体及其用途 |
| CN113563473A (zh) * | 2020-04-29 | 2021-10-29 | 三生国健药业（上海）股份有限公司 | 四价双特异性抗体、其制备方法和用途 |
| WO2022188832A1 (zh) * | 2021-03-12 | 2022-09-15 | 中山康方生物医药有限公司 | 含有抗pd-1-抗vegfa双特异性抗体的药物组合及其用途 |
| WO2024017281A1 (zh) * | 2022-07-20 | 2024-01-25 | 明慧医药（杭州）有限公司 | 多特异性抗体及其用途 |
| TW202413427A (zh) * | 2022-08-09 | 2024-04-01 | 大陸商上海濟煜醫藥科技有限公司 | 一種靶向ｐｄ－１和ｖｅｇｆ的抗體及其應用 |
| AU2023387779A1 (en) * | 2022-12-30 | 2024-08-22 | Remegen (Shanghai) Co., Ltd. | Bispecific antibody and application thereof |
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| WO2023246247A1 (zh) * | 2022-06-22 | 2023-12-28 | 中山康方生物医药有限公司 | 药物组合物及其用途 |
Also Published As
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| US20210040193A1 (en) | 2021-02-11 |
| AU2019218433A1 (en) | 2020-09-03 |
| KR20200120927A (ko) | 2020-10-22 |
| CA3090878A1 (en) | 2019-08-15 |
| JP2021512624A (ja) | 2021-05-20 |
| US11827697B2 (en) | 2023-11-28 |
| EP3750920A4 (en) | 2021-11-10 |
| EP3750920A1 (en) | 2020-12-16 |
| WO2019154349A1 (zh) | 2019-08-15 |
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