JP2015528698A5 - - Google Patents
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- JP2015528698A5 JP2015528698A5 JP2015521016A JP2015521016A JP2015528698A5 JP 2015528698 A5 JP2015528698 A5 JP 2015528698A5 JP 2015521016 A JP2015521016 A JP 2015521016A JP 2015521016 A JP2015521016 A JP 2015521016A JP 2015528698 A5 JP2015528698 A5 JP 2015528698A5
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- 230000014509 gene expression Effects 0.000 claims 90
- 238000000034 method Methods 0.000 claims 25
- 238000004393 prognosis Methods 0.000 claims 24
- 206010028980 Neoplasm Diseases 0.000 claims 23
- 102100038395 Granzyme K Human genes 0.000 claims 18
- 101001033007 Homo sapiens Granzyme K Proteins 0.000 claims 18
- 101000598002 Homo sapiens Interferon regulatory factor 1 Proteins 0.000 claims 18
- 102100036981 Interferon regulatory factor 1 Human genes 0.000 claims 18
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims 17
- 102100030386 Granzyme A Human genes 0.000 claims 17
- 102100030385 Granzyme B Human genes 0.000 claims 17
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims 17
- 101001009599 Homo sapiens Granzyme A Proteins 0.000 claims 17
- 101001009603 Homo sapiens Granzyme B Proteins 0.000 claims 17
- 101000987581 Homo sapiens Perforin-1 Proteins 0.000 claims 17
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 17
- 101000738413 Homo sapiens T-cell surface glycoprotein CD3 gamma chain Proteins 0.000 claims 17
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 17
- -1 ICOS Proteins 0.000 claims 17
- 102100028467 Perforin-1 Human genes 0.000 claims 17
- 102000005886 STAT4 Transcription Factor Human genes 0.000 claims 17
- 108010019992 STAT4 Transcription Factor Proteins 0.000 claims 17
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 17
- 102100037911 T-cell surface glycoprotein CD3 gamma chain Human genes 0.000 claims 17
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 17
- 102100025279 C-X-C motif chemokine 11 Human genes 0.000 claims 16
- 102100022087 Granzyme M Human genes 0.000 claims 16
- 101000858060 Homo sapiens C-X-C motif chemokine 11 Proteins 0.000 claims 16
- 101000900697 Homo sapiens Granzyme M Proteins 0.000 claims 16
- 101000713602 Homo sapiens T-box transcription factor TBX21 Proteins 0.000 claims 16
- 102000006381 STAT1 Transcription Factor Human genes 0.000 claims 16
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims 16
- 102100036840 T-box transcription factor TBX21 Human genes 0.000 claims 16
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 15
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 15
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims 15
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 15
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims 15
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 15
- 101000946863 Homo sapiens T-cell surface glycoprotein CD3 delta chain Proteins 0.000 claims 15
- 102000003812 Interleukin-15 Human genes 0.000 claims 15
- 108090000172 Interleukin-15 Proteins 0.000 claims 15
- 102100035891 T-cell surface glycoprotein CD3 delta chain Human genes 0.000 claims 15
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 14
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 claims 14
- 230000004083 survival effect Effects 0.000 claims 11
- 238000010837 poor prognosis Methods 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 238000009169 immunotherapy Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010052358 Colorectal cancer metastatic Diseases 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 230000000683 nonmetastatic effect Effects 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 206010050017 Lung cancer metastatic Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 241000287463 Phalacrocorax Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000009098 adjuvant therapy Methods 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940047122 interleukins Drugs 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 238000009099 neoadjuvant therapy Methods 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019099354A JP6936277B2 (ja) | 2012-07-12 | 2019-05-28 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305836.4 | 2012-07-12 | ||
| EP12305836 | 2012-07-12 | ||
| PCT/EP2013/064808 WO2014009535A2 (en) | 2012-07-12 | 2013-07-12 | Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019099354A Division JP6936277B2 (ja) | 2012-07-12 | 2019-05-28 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528698A JP2015528698A (ja) | 2015-10-01 |
| JP2015528698A5 true JP2015528698A5 (enExample) | 2016-08-25 |
| JP6923291B2 JP6923291B2 (ja) | 2021-08-18 |
Family
ID=48782367
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521016A Active JP6923291B2 (ja) | 2012-07-12 | 2013-07-12 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
| JP2019099354A Active JP6936277B2 (ja) | 2012-07-12 | 2019-05-28 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
| JP2021112781A Active JP7378443B2 (ja) | 2012-07-12 | 2021-07-07 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019099354A Active JP6936277B2 (ja) | 2012-07-12 | 2019-05-28 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
| JP2021112781A Active JP7378443B2 (ja) | 2012-07-12 | 2021-07-07 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11242564B2 (enExample) |
| EP (1) | EP2872646B1 (enExample) |
| JP (3) | JP6923291B2 (enExample) |
| DK (1) | DK2872646T3 (enExample) |
| ES (1) | ES2648176T3 (enExample) |
| NO (1) | NO2872646T3 (enExample) |
| PL (1) | PL2872646T3 (enExample) |
| WO (1) | WO2014009535A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11242564B2 (en) * | 2012-07-12 | 2022-02-08 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes |
| WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
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| WO2015094992A1 (en) | 2013-12-17 | 2015-06-25 | Merck Sharp & Dohme Corp. | Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists |
| EP3084001A4 (en) * | 2013-12-17 | 2017-07-12 | Merck Sharp & Dohme Corp. | Gene signature biomarkers of tumor response to pd-1 antagonists |
| EP3082853A2 (en) | 2013-12-20 | 2016-10-26 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
| EP3232199B1 (en) * | 2014-08-19 | 2022-05-04 | National University Corporation Okayama University | Combination of immunosuppressive factor blocking agent and biguanide antidiabetic drug for use in a method of preventing progression of, treating and/or preventing cancer |
| US20170298443A1 (en) * | 2014-09-25 | 2017-10-19 | Moffitt Genetics Corporation | Prognostic tumor biomarkers |
| CA2966507A1 (en) | 2014-11-03 | 2016-05-12 | Genentech, Inc. | Methods and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment |
| MX2017005750A (es) | 2014-11-03 | 2017-12-15 | Genentech Inc | Ensayos para detectar subgrupos inmunes de células t y sus métodos de uso. |
| EP3230498B1 (en) | 2014-12-09 | 2023-01-18 | Merck Sharp & Dohme LLC | System and methods for deriving gene signature biomarkers of response to pd-1 antagonists |
| WO2016100975A1 (en) * | 2014-12-19 | 2016-06-23 | Massachsetts Institute Ot Technology | Molecular biomarkers for cancer immunotherapy |
| WO2016100977A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute Inc. | Methods for profiling the t-cel- receptor repertoire |
| RS60614B1 (sr) | 2015-03-23 | 2020-08-31 | Jounce Therapeutics Inc | Antitela za icos |
| EP3073268A1 (en) * | 2015-03-27 | 2016-09-28 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Biomarker panel for diagnosing cancer |
| WO2016168133A1 (en) | 2015-04-17 | 2016-10-20 | Merck Sharp & Dohme Corp. | Blood-based biomarkers of tumor sensitivity to pd-1 antagonists |
| CR20200476A (es) | 2015-05-20 | 2020-12-02 | Dana Farber Cancer Inst Inc | ANTÍGENOS COMPARTIDOS (Divisional 2017-0584) |
| WO2017065000A1 (ja) * | 2015-10-15 | 2017-04-20 | 国立大学法人京都大学 | Ｐｄ－１経路阻害薬の著効例を予測するためのバイオマーカー |
| US10968277B2 (en) | 2015-10-22 | 2021-04-06 | Jounce Therapeutics, Inc. | Gene signatures for determining ICOS expression |
| WO2017096458A1 (en) * | 2015-12-07 | 2017-06-15 | Ontario Institute For Cancer Research (Oicr) | Immune gene signature predictive of anthracycline benefit |
| AU2017250029C1 (en) * | 2016-04-15 | 2022-03-24 | Pfizer Inc. | Macrophage stimulation in CD47 blockade therapy |
| CN109690314B (zh) * | 2016-05-09 | 2022-08-02 | 法国国家卫生及研究医学协会 | 患有实体癌症的患者的分类方法 |
| EP3487522A4 (en) | 2016-07-19 | 2020-04-01 | Teva Pharmaceuticals Australia Pty Ltd | Anti-cd47 combination therapy |
| WO2018045346A1 (en) * | 2016-09-01 | 2018-03-08 | Autotelic Llc | Methods for treating cancer and determining efficacy of treatment |
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| CN110546277B (zh) | 2017-03-01 | 2024-06-11 | 豪夫迈·罗氏有限公司 | 用于癌症的诊断和治疗方法 |
| JP2020523022A (ja) * | 2017-06-14 | 2020-08-06 | アイカーン スクール オブ メディシン アット マウント サイナイ | 免疫療法に反応する肝細胞癌のクラスの検出および治療方法 |
| JP2020523991A (ja) * | 2017-06-16 | 2020-08-13 | ナントミクス，エルエルシー | Ｐｒａｅｇｎａｎｔ転移性乳癌コホートにおける不良アウトカムの予後指標因子 |
| WO2020245155A1 (en) | 2019-06-03 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for modulating a treatment regimen |
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| GB202007099D0 (en) | 2020-05-14 | 2020-07-01 | Kymab Ltd | Tumour biomarkers for immunotherapy |
| CN116209773A (zh) * | 2020-06-18 | 2023-06-02 | 宏观基因有限公司 | 双特异性CD123 x CD3双抗体用于治疗血液系统恶性肿瘤的用途 |
| WO2022002873A1 (en) | 2020-06-30 | 2022-01-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
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-
2013
- 2013-07-12 US US14/413,856 patent/US11242564B2/en active Active
- 2013-07-12 PL PL13735334T patent/PL2872646T3/pl unknown
- 2013-07-12 NO NO13735334A patent/NO2872646T3/no unknown
- 2013-07-12 WO PCT/EP2013/064808 patent/WO2014009535A2/en not_active Ceased
- 2013-07-12 ES ES13735334.8T patent/ES2648176T3/es active Active
- 2013-07-12 EP EP13735334.8A patent/EP2872646B1/en active Active
- 2013-07-12 DK DK13735334.8T patent/DK2872646T3/en active
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