JP2015528466A5 - - Google Patents
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- Publication number
- JP2015528466A5 JP2015528466A5 JP2015530070A JP2015530070A JP2015528466A5 JP 2015528466 A5 JP2015528466 A5 JP 2015528466A5 JP 2015530070 A JP2015530070 A JP 2015530070A JP 2015530070 A JP2015530070 A JP 2015530070A JP 2015528466 A5 JP2015528466 A5 JP 2015528466A5
- Authority
- JP
- Japan
- Prior art keywords
- urea
- bar
- inclusion body
- high pressure
- inclusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261694968P | 2012-08-30 | 2012-08-30 | |
| US61/694,968 | 2012-08-30 | ||
| US201361830425P | 2013-06-03 | 2013-06-03 | |
| US61/830,425 | 2013-06-03 | ||
| PCT/US2013/057430 WO2014036349A1 (en) | 2012-08-30 | 2013-08-30 | Expression of chimeric ksac protein and method of producing soluble proteins by high pressure |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528466A JP2015528466A (ja) | 2015-09-28 |
| JP2015528466A5 true JP2015528466A5 (https=) | 2016-08-12 |
| JP6405308B2 JP6405308B2 (ja) | 2018-10-17 |
Family
ID=49162270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530070A Expired - Fee Related JP6405308B2 (ja) | 2012-08-30 | 2013-08-30 | キメラｋｓａｃタンパク質の発現及び高圧により可溶性タンパク質を製造する方法 |
| JP2015530066A Active JP6438396B2 (ja) | 2012-08-30 | 2013-08-30 | 不活化ワクチンを作製するための、ならびに組換えタンパク質をリフォールディング／可溶化させるための高圧デバイスおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530066A Active JP6438396B2 (ja) | 2012-08-30 | 2013-08-30 | 不活化ワクチンを作製するための、ならびに組換えタンパク質をリフォールディング／可溶化させるための高圧デバイスおよび方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9169302B2 (https=) |
| EP (2) | EP2890393A2 (https=) |
| JP (2) | JP6405308B2 (https=) |
| KR (1) | KR102208844B1 (https=) |
| CN (3) | CN108578679A (https=) |
| AP (1) | AP2015008331A0 (https=) |
| AU (4) | AU2013308623B2 (https=) |
| BR (1) | BR112015004463B8 (https=) |
| CA (2) | CA2883303A1 (https=) |
| EA (1) | EA031988B1 (https=) |
| ES (1) | ES2744709T3 (https=) |
| HK (1) | HK1211874A1 (https=) |
| MD (1) | MD4608C1 (https=) |
| MX (3) | MX358782B (https=) |
| NZ (3) | NZ705790A (https=) |
| PH (1) | PH12015500700B1 (https=) |
| RU (1) | RU2647568C2 (https=) |
| WO (2) | WO2014036345A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8968749B2 (en) * | 2006-07-21 | 2015-03-03 | Universidade Federal De Minas Gerais—Ufmg | Vaccine composition and immunization method |
| EP2890393A2 (en) * | 2012-08-30 | 2015-07-08 | Merial, Inc. | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
| ZA201501696B (en) | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
| EP2978447B1 (en) * | 2013-03-28 | 2019-05-08 | Infectious Disease Research Institute | Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis |
| CN104758944B (zh) * | 2015-04-02 | 2017-11-28 | 中国科学院过程工程研究所 | 一种疫苗制剂及其制备方法和用途 |
| JP2018082987A (ja) * | 2016-11-25 | 2018-05-31 | 株式会社日立製作所 | ウイルス不活化方法及びウイルス不活化装置 |
| JP2020152644A (ja) * | 2019-03-18 | 2020-09-24 | 国立大学法人愛媛大学 | Ｖｎａｒのリフォールディング方法およびｖｎａｒの製造方法 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US12537071B1 (en) | 2020-07-22 | 2026-01-27 | David Gordon Bermudes | Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins |
| CN112120012B (zh) * | 2020-09-30 | 2022-03-22 | 广东康盾创新产业集团股份公司 | 一种car-t细胞冻存方法 |
| BR102021000794A2 (pt) * | 2021-01-15 | 2022-07-26 | Fundação Oswaldo Cruz | Proteína quimérica, kit, método para diagnóstico de leishmaniose, uso de uma proteína quimérica, composição vacinal contra leishmaniose visceral, e, uso de uma composição vacinal |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| JP2743177B2 (ja) * | 1987-04-24 | 1998-04-22 | 財団法人阪大微生物病研究会 | 百日咳菌の培養方法、及び百日咳トキソイドとその混合ワクチン |
| ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
| US5980912A (en) | 1997-03-25 | 1999-11-09 | Zonagen, Inc. | Chitosan induced immunopotentiation |
| FR2771011B1 (fr) | 1997-11-17 | 2000-01-28 | Hippocampe | Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale |
| FR2775601B1 (fr) | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
| FR2776928B1 (fr) | 1998-04-03 | 2000-06-23 | Merial Sas | Vaccins adn adjuves |
| EP1095056B1 (en) | 1998-07-09 | 2006-12-27 | BaroFold, Inc. | High pressure refolding of protein aggregates and inclusion bodies |
| AU4906200A (en) | 1999-05-28 | 2000-12-18 | Universite Laval | Inactivation of food spoilage and pathogenic microorganisms by dynamic high pressure |
| US6645740B1 (en) | 1999-06-10 | 2003-11-11 | Merial Limited | Nucleic acids encodings equine GM-CSF |
| NZ517929A (en) | 1999-09-25 | 2004-02-27 | Univ Iowa Res Found | Immunostimulatory nucleic acids |
| US7615617B2 (en) | 1999-10-25 | 2009-11-10 | University Of Delaware | Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding |
| WO2002056824A2 (en) | 2000-08-10 | 2002-07-25 | Boston Biomedica, Inc. | Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines |
| US6635223B2 (en) * | 2000-10-25 | 2003-10-21 | Andreas Maerz | Method for inactivating micro-organisms using high pressure processing |
| CA2434045A1 (en) * | 2000-10-31 | 2002-08-15 | The Regents Of The University Of Colorado, A Body Corporate | Improved protein disaggregation and refolding using high pressure |
| AU2003245416A1 (en) | 2002-06-07 | 2004-04-30 | University Of Florida | Endodontic files made using bulk metallic glasses |
| SE525457C2 (sv) * | 2002-06-24 | 2005-02-22 | Flow Holdings Sagl | Förfarande för åstadkommande av en tryckändring mellan två trycktillstånd, högtryckspressanordning samt användning av förfarande eller högtryckspressanordning |
| WO2005044301A2 (en) * | 2003-11-05 | 2005-05-19 | C.B.F. Leti, S.L. Unipersonal | Use of specific histones for the treatment of parasitic diseases |
| US7993580B2 (en) | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
| JP2009519706A (ja) | 2005-11-21 | 2009-05-21 | バロフォールド， インコーポレイテッド | タンパク質の高圧リフォールディングのためのデバイスおよび方法 |
| CN200945252Y (zh) * | 2006-09-01 | 2007-09-12 | 天津市华泰森淼生物工程技术有限公司 | 手动开启式小型超高压生物处理设备 |
| CA2663416A1 (en) * | 2006-09-15 | 2008-03-20 | Barofold, Inc. | High pressure treatment of proteins for reduced immunogenicity |
| WO2008124134A2 (en) | 2007-04-05 | 2008-10-16 | Barofold, Inc. | High-pressure refolding of proteins in the presence of binding partners |
| WO2008124139A1 (en) | 2007-04-05 | 2008-10-16 | Barofold, Inc. | High pressure inclusion body solubilization in the presence of a protease |
| EP2207890A4 (en) | 2007-10-05 | 2010-12-15 | Barofold Inc | HIGH PRESSURE PROCESSING OF AGGREGATED INTERFERONS |
| KR101254848B1 (ko) * | 2007-12-21 | 2013-04-15 | 화이자 인코포레이티드 | 열 처리된 박테린, 및 상기 열 처리된 박테린으로부터 제조된 에멀젼 백신 |
| BRPI0800357A2 (pt) | 2008-03-10 | 2009-10-27 | Fundacao Oswaldo Cruz | método para produção de uma vacina estabilizada |
| MX2010012069A (es) | 2008-05-08 | 2010-12-14 | Merial Ltd | Vacuna de la leishmaniasis con el uso del inmunogeno salival de la mosca de la arena. |
| BRPI0912768A2 (pt) | 2008-05-21 | 2016-05-17 | Infectious Disease Res Inst | vacinas de poliproteínas recombinante para o tratamento e diagnóstico de leishmaniose |
| US8410258B2 (en) * | 2008-05-21 | 2013-04-02 | Infections Disease Research Institute | Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis |
| WO2009155102A2 (en) | 2008-05-30 | 2009-12-23 | Barofold, Inc. | Method for derivatization of proteins using hydrostatic pressure |
| US20110070219A1 (en) | 2009-04-27 | 2011-03-24 | Seefeldt Matthew B | High pressure protein crystallization |
| WO2011091860A1 (en) * | 2010-02-01 | 2011-08-04 | Avure Technologies Ab | High-pressure arrangement with locking element preventing rotation of load basket |
| CN201781934U (zh) * | 2010-04-14 | 2011-04-06 | 中国农业大学 | 一种小型框架自动式超高压设备 |
| EP2600843B9 (en) | 2010-07-19 | 2020-03-11 | Pressure BioSciences, Inc. | Therapeutic protein compositions having reduced immunogenicity and/or improved efficacy |
| ZA201501696B (en) * | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
| EP2890393A2 (en) | 2012-08-30 | 2015-07-08 | Merial, Inc. | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
-
2013
- 2013-08-30 EP EP13766420.7A patent/EP2890393A2/en active Pending
- 2013-08-30 US US14/014,434 patent/US9169302B2/en active Active
- 2013-08-30 AP AP2015008331A patent/AP2015008331A0/xx unknown
- 2013-08-30 WO PCT/US2013/057426 patent/WO2014036345A2/en not_active Ceased
- 2013-08-30 NZ NZ705790A patent/NZ705790A/en unknown
- 2013-08-30 US US14/014,437 patent/US9315553B2/en active Active
- 2013-08-30 MX MX2015002699A patent/MX358782B/es active IP Right Grant
- 2013-08-30 AU AU2013308623A patent/AU2013308623B2/en active Active
- 2013-08-30 ES ES13760212T patent/ES2744709T3/es active Active
- 2013-08-30 CA CA2883303A patent/CA2883303A1/en not_active Abandoned
- 2013-08-30 EA EA201500275A patent/EA031988B1/ru unknown
- 2013-08-30 NZ NZ715459A patent/NZ715459A/en unknown
- 2013-08-30 AU AU2013308627A patent/AU2013308627B2/en not_active Ceased
- 2013-08-30 KR KR1020157008190A patent/KR102208844B1/ko active Active
- 2013-08-30 HK HK16100050.9A patent/HK1211874A1/xx unknown
- 2013-08-30 CN CN201810318137.XA patent/CN108578679A/zh active Pending
- 2013-08-30 JP JP2015530070A patent/JP6405308B2/ja not_active Expired - Fee Related
- 2013-08-30 CN CN201380053720.8A patent/CN104717976A/zh active Pending
- 2013-08-30 CN CN201380054922.4A patent/CN104768577B/zh active Active
- 2013-08-30 RU RU2015111255A patent/RU2647568C2/ru active
- 2013-08-30 WO PCT/US2013/057430 patent/WO2014036349A1/en not_active Ceased
- 2013-08-30 JP JP2015530066A patent/JP6438396B2/ja active Active
- 2013-08-30 MX MX2015002701A patent/MX381717B/es unknown
- 2013-08-30 BR BR112015004463A patent/BR112015004463B8/pt active IP Right Grant
- 2013-08-30 MD MDA20150031A patent/MD4608C1/ro active IP Right Revival
- 2013-08-30 EP EP13760212.4A patent/EP2890392B1/en not_active Not-in-force
- 2013-08-30 NZ NZ706288A patent/NZ706288A/en not_active IP Right Cessation
- 2013-08-30 CA CA2883296A patent/CA2883296A1/en not_active Abandoned
-
2015
- 2015-02-27 MX MX2021004478A patent/MX2021004478A/es unknown
- 2015-03-27 PH PH12015500700A patent/PH12015500700B1/en unknown
-
2016
- 2016-02-05 US US15/017,486 patent/US10364274B2/en active Active
-
2017
- 2017-01-17 AU AU2017200301A patent/AU2017200301A1/en not_active Abandoned
- 2017-03-14 AU AU2017201724A patent/AU2017201724B2/en active Active
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