JP2015526506A - アルトカルプス・アルティリスの果実、葉、若しくは幹の抽出物、又はそれらの画分を有効成分として含有するがんの予防又は治療のための組成物 - Google Patents
アルトカルプス・アルティリスの果実、葉、若しくは幹の抽出物、又はそれらの画分を有効成分として含有するがんの予防又は治療のための組成物 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
Description
1)抽出溶媒をアルトカルプス・アルティリスに添加した後、抽出する工程、
2)工程1)で得られた抽出物を冷却し、それを濾過する工程、及び、
3)工程2)で濾過された抽出物を減圧下で濃縮し、それを乾燥する工程。
1)抽出溶媒をアルトカルプス・アルティリスに添加した後、抽出する工程、
2)工程1)で得られた抽出物を冷却し、それを濾過する工程、及び、
3)工程2)で濾過された抽出物を減圧下で濃縮し、それを乾燥する工程。
<1−1>アルトカルプス・アルティリスの果実、葉、又は幹のメタノール抽出物の調製
乾燥アルトカルプス・アルティリスの果実、葉、又は幹(ナイジェリア、イバダン、イバダン大学)1kgを砕き、4Lのメタノールに浸漬した。混合物を室温に5日間置いた。粗抽出物を濾過し、減圧下で濃縮した。その結果、アルトカルプス・アルティリスの果実、葉、又は幹のメタノール抽出物60gを得た。
乾燥アルトカルプス・アルティリスの果実、葉、又は幹1kgを砕き、4Lのエタノールに浸漬した。混合物を室温に5日間置いた。粗抽出物を濾過し、減圧下で濃縮した。その結果、アルトカルプス・アルティリスの果実、葉、又は幹のエタノール抽出物60gを得た。
乾燥アルトカルプス・アルティリスの果実、葉、又は幹1kgを砕き、4Lの水に浸漬した。混合物を100℃に5時間置いた。粗抽出物を濾過し、減圧下で濃縮した。その結果、アルトカルプス・アルティリスの果実、葉、又は幹の熱水抽出物60gを得た。
実施例<1−1>で調製したアルトカルプス・アルティリスの果実、葉、又は幹のメタノール抽出物10gを50mLのメタノールに溶解し、500gのC18に吸収させた。それぞれ1リットルの50%メタノール、70%メタノール、及び100%メタノールをこの順に用いて連続溶出を行った。その結果、70%メタノールから560mgの活性画分を得た。
直腸がん細胞株におけるSTAT3の活性に対する、実施例1及び実施例2で調製されたアルトカルプス・アルティリスの果実、葉、又は幹の抽出物、及びそれらの画分の阻害効果を調べるため、デュアルルシフェラーゼアッセイを行った。
前立腺がん細胞株におけるSTAT3の活性に対する、実施例1及び実施例2で調製されたアルトカルプス・アルティリスの果実、葉、又は幹の抽出物、及びそれらの画分の阻害効果を調べるため、ウェスタンブロッティングを行った。
前立腺がん細胞株における腫瘍成長に対する、実施例1及び実施例2で調製されたアルトカルプス・アルティリスの果実、葉、若しくは幹の抽出物、又はそれらの画分の阻害効果を調べるため、動物実験を行った。
<1−1>散剤の調製
実施例<1−1>のアルトカルプス・アルティリスの果実、葉、又は幹のメタノール抽出物 0.1g
ラクトース 1.5g
タルク 0.5g
実施例<1−1>のアルトカルプス・アルティリスの果実、葉、又は幹のメタノール抽出物 0.1g
ラクトース 7.9g
結晶セルロース 1.5g
ステアリン酸マグネシウム 0.5g
実施例2のアルトカルプス・アルティリスの果実、葉、又は幹の50%メタノール抽出物 0.1g
コーンスターチ 5g
カルボキシセルロース 4.9g
実施例2のアルトカルプス・アルティリスの果実、葉、又は幹の70%メタノール抽出物 0.1g
滅菌注射用DW 適量
pH調整剤 適量
実施例2のアルトカルプス・アルティリスの果実、葉、又は幹の100%メタノール抽出物 0.1g
異性化糖 10g
マンニトール 5g
精製水 適量
<2−1>小麦粉食品の調製
実施例<1−3>のアルトカルプス・アルティリスの果実、葉、又は幹の熱水抽出物0.5重量部〜5.0重量部を小麦粉に添加した。従来法に従い、該小麦粉混合物を用いてパン、ケーキ、クッキー、クラッカー及び麺類等の健康増進用食品を調製した。
実施例<1−3>のアルトカルプス・アルティリスの果実、葉、又は幹の熱水抽出物0.1重量部〜5.0重量部をスープ及びグレービーに添加した。この混合物を用いて従来法により健康増進用の肉製品であるスープ及びグレービーを調製した。
実施例<1−3>のアルトカルプス・アルティリスの果実、葉、又は幹の熱水抽出物10重量部と牛挽肉とを従来法に従って混合し、健康増進用の挽肉を調製した。
実施例<1−3>のアルトカルプス・アルティリスの果実、葉、又は幹の熱水抽出物5重量部〜10重量部を牛乳に添加した。従来法に従い、牛乳混合物を用いてバター及びアイスクリーム等の健康増進用の乳製品を調製した。
従来法に従って玄米、オオムギ、モチ米及びハトムギ(Yulmu:ジュズダマ(Job's tears))を糊化し、乾燥し、粉砕して60メッシュ粉末を得た。
種子(エゴマ:7重量部、黒豆:8重量部、黒ゴマ:7重量部)、
実施例<1−3>のアルトカルプス・アルティリスの葉又は幹の熱水抽出物の乾燥粉末(1重量部)、
ガノデルマ・ルキドゥム(Ganoderma lucidum:レイシ)(0.5重量部)、
リューマニア・グルチノーザ(Rehmannia glutinosa:アカヤジオウ)(0.5重量部)
実施例<1−3>のアルトカルプス・アルティリスの果実、葉、又は幹の熱水抽出物 100mg
複合ビタミン 適量
ビタミンAアセテート 70μg
ビタミンE 1.0mg
ビタミンB1 0.13mg
ビタミンB2 0.15mg
ビタミンB6 0.5mg
ビタミンB12 0.2μg
ビタミンC 10mg
ビオチン 10μg
ニコチン酸アミド 1.7mg
葉酸 50μg
パントテン酸カルシウム 0.5mg
ミネラル 適量
硫酸第一鉄 1.75mg
酸化亜鉛 0.82mg
炭酸マグネシウム 25.3mg
一塩基性リン酸カリウム 15mg
二塩基性リン酸カリウム 55mg
クエン酸カリウム 90mg
炭酸カルシウム 100mg
塩化マグネシウム 24.8mg
実施例<1−3>のアルトカルプス・アルティリスの果実、葉、又は幹の熱水抽出物 100mg
クエン酸 100mg
オリゴ糖 100mg
ウメ(プルヌス・ムメ(Prunus mume))抽出物 2mg
タウリン 100mg
精製水 500mLまで
Claims (19)
- アルトカルプス・アルティリスの果実、葉、又は幹の抽出物を有効成分として含む、がんの予防及び治療のための医薬組成物。
- 前記抽出物が、水、炭素数1〜2の低級アルコール、又はその混合溶媒を溶媒として使用することにより抽出される、請求項1に記載のがんの予防及び治療のための医薬組成物。
- 前記低級アルコールがメタノール又はエタノールである、請求項2に記載のがんの予防及び治療のための医薬組成物。
- 前記抽出物が、STAT3(シグナル伝達兼転写活性化因子3)の活性を抑制することを特徴とする、請求項1に記載のがんの予防及び治療のための医薬組成物。
- 前記がんが、大腸がん、胃がん、前立腺がん、乳がん、腎がん、肝がん、脳腫瘍、肺がん、子宮がん、結腸がん、膀胱がん、及び膵臓がんからなる群から選択される、請求項1に記載のがんの予防及び治療のための医薬組成物。
- 50%〜100%のメタノールを使用することによるアルトカルプス・アルティリスの果実、葉、又は幹の抽出物の更なる精製から得られた活性画分を有効成分として含む、がんの予防及び治療のための医薬組成物。
- 前記画分が、STAT3(シグナル伝達兼転写活性化因子3)の活性を抑制することを特徴とする、請求項6に記載のがんの予防及び治療のための医薬組成物。
- 前記がんが、大腸がん、胃がん、前立腺がん、乳がん、腎がん、肝がん、脳腫瘍、肺がん、子宮がん、結腸がん、膀胱がん、及び膵臓がんからなる群から選択される、請求項6に記載のがんの予防及び治療のための医薬組成物。
- アルトカルプス・アルティリスの果実、葉、又は幹の抽出物を有効成分として含む、がんの予防及び改善のための健康食品組成物。
- アルトカルプス・アルティリスの果実、葉、又は幹の抽出物の画分を有効成分として含む、がんの予防及び改善のための健康食品組成物。
- 前記がんが、大腸がん、胃がん、前立腺がん、乳がん、腎がん、肝がん、脳腫瘍、肺がん、子宮がん、結腸がん、膀胱がん、及び膵臓がんからなる群から選択される、請求項9又は10に記載のがんの予防及び改善のための健康食品組成物。
- アルトカルプス・アルティリスの果実、葉、又は幹の抽出物の薬学的に有効な投与量を、がんを保有する被験体に投与する工程を含む、被験体のがんを治療する方法。
- アルトカルプス・アルティリスの果実、葉、又は幹の抽出物の画分の薬物的に有効な投与量を、がんを保有する被験体に投与する工程を含む、被験体のがんを治療する方法。
- アルトカルプス・アルティリスの果実、葉、又は幹の抽出物の薬学的に有効な投与量を被験体に投与する工程を含む、被験体のがんを予防する方法。
- アルトカルプス・アルティリスの果実、葉、又は幹の抽出物の画分の薬学的に有効な投与量を被験体に投与する工程を含む、被験体のがんを予防する方法。
- がんの予防及び治療のための医薬組成物の有効成分としてのアルトカルプス・アルティリスの果実、葉、又は幹の抽出物の使用。
- がんの予防及び治療のための医薬組成物の有効成分としてのアルトカルプス・アルティリスの果実、葉、又は幹の抽出物の画分の使用。
- がんの予防及び改善のための健康食品組成物の有効成分としてのアルトカルプス・アルティリスの果実、葉、又は幹の抽出物の使用。
- がんの予防及び改善のための健康食品組成物の有効成分としてのアルトカルプス・アルティリスの果実、葉、又は幹の抽出物の画分の使用。
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JP7080813B2 (ja) | 2015-12-10 | 2022-06-06 | シティ・オブ・ホープ | 細胞透過性のシアニド結合抗体 |
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