JP2015526435A - 抗体成分と血液脳関門を通過するポリペプチドと細胞毒とを含むコンジュゲート - Google Patents

抗体成分と血液脳関門を通過するポリペプチドと細胞毒とを含むコンジュゲート Download PDF

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JP2015526435A
JP2015526435A JP2015526846A JP2015526846A JP2015526435A JP 2015526435 A JP2015526435 A JP 2015526435A JP 2015526846 A JP2015526846 A JP 2015526846A JP 2015526846 A JP2015526846 A JP 2015526846A JP 2015526435 A JP2015526435 A JP 2015526435A
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polypeptide
conjugate
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antibody
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カステーニュ，ジャン−ポール
ヤン，ガオチアン
シュ，クリスチャン
デミュール，ミシェル
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アンジオケム インコーポレーテッド
アンジオケム インコーポレーテッド
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JP2015526846A 2012-08-14 2013-08-14 抗体成分と血液脳関門を通過するポリペプチドと細胞毒とを含むコンジュゲート Pending JP2015526435A (ja)

Applications Claiming Priority (5)

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US201261682991P 2012-08-14 2012-08-14
US61/682,991 2012-08-14
US201361865071P 2013-08-12 2013-08-12
US61/865,071 2013-08-12
PCT/CA2013/050625 WO2014026286A1 (en) 2012-08-14 2013-08-14 Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin

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JP2015526435A true JP2015526435A (ja) 2015-09-10
JP2015526435A5 JP2015526435A5 (enExample) 2016-03-31

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US (2) US20160106856A1 (enExample)
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CN (1) CN104781281A (enExample)
AU (1) AU2013302273A1 (enExample)
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JP5436856B2 (ja) 2005-07-15 2014-03-05 アンジオケム インコーポレーティッド 薬学的複合体における担体としてのアプロチニンポリペプチドの使用
US8921314B2 (en) 2008-10-15 2014-12-30 Angiochem, Inc. Conjugates of GLP-1 agonists and uses thereof
MX2011005963A (es) 2008-12-05 2011-09-01 Angiochem Inc Conjugados de neurotensina o analogos de neurotensina y sus usos.
WO2014026283A1 (en) 2012-08-14 2014-02-20 Angiochem Inc. Peptide-dendrimer conjugates and uses thereof
CN106470708B (zh) 2014-04-25 2019-12-31 皮埃尔法布雷医药公司 抗体-药物-缀合物和其用于治疗癌症的用途
EP3134124B1 (en) 2014-04-25 2019-02-20 Pierre Fabre Medicament Igf-1r antibody-drug-conjugate and its use for the treatment of cancer
EP3218414A1 (en) * 2014-11-14 2017-09-20 Angiochem Inc. Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
US10980892B2 (en) 2015-06-15 2021-04-20 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
US20210046189A1 (en) * 2018-03-30 2021-02-18 HANMl PHARM. CO., LTD. Long-acting protein conjugates for brain targeting, a preparation method thereof, and a composition comprising the same
US20210353767A1 (en) * 2018-09-28 2021-11-18 North Carolina State University Compositions and methods for drug delivery
BR112022003628A2 (pt) * 2019-08-28 2022-05-24 Starpharma Pty Ltd Conjugados de dendrímero direcionado
AU2021284918A1 (en) * 2020-06-03 2023-01-05 Starpharma Pty Ltd Therapeutic conjugates
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