JP2015526435A - 抗体成分と血液脳関門を通過するポリペプチドと細胞毒とを含むコンジュゲート - Google Patents

抗体成分と血液脳関門を通過するポリペプチドと細胞毒とを含むコンジュゲート Download PDF

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JP2015526435A
JP2015526435A JP2015526846A JP2015526846A JP2015526435A JP 2015526435 A JP2015526435 A JP 2015526435A JP 2015526846 A JP2015526846 A JP 2015526846A JP 2015526846 A JP2015526846 A JP 2015526846A JP 2015526435 A JP2015526435 A JP 2015526435A
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polypeptide
conjugate
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antibody
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カステーニュ，ジャン−ポール
ヤン，ガオチアン
シュ，クリスチャン
デミュール，ミシェル
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アンジオケム インコーポレーテッド
アンジオケム インコーポレーテッド
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JP2015526846A 2012-08-14 2013-08-14 抗体成分と血液脳関門を通過するポリペプチドと細胞毒とを含むコンジュゲート Pending JP2015526435A (ja)

Applications Claiming Priority (5)

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US201261682991P 2012-08-14 2012-08-14
US61/682,991 2012-08-14
US201361865071P 2013-08-12 2013-08-12
US61/865,071 2013-08-12
PCT/CA2013/050625 WO2014026286A1 (en) 2012-08-14 2013-08-14 Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin

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JP2015526435A true JP2015526435A (ja) 2015-09-10
JP2015526435A5 JP2015526435A5 (enExample) 2016-03-31

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US (2) US20160106856A1 (enExample)
EP (1) EP2885321A4 (enExample)
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CN (1) CN104781281A (enExample)
AU (1) AU2013302273A1 (enExample)
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WO2010043047A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
WO2010063122A1 (en) 2008-12-05 2010-06-10 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
CN104781276A (zh) 2012-08-14 2015-07-15 安吉奥开米公司 肽-树枝状聚合物结合物及其用途
MA39909B1 (fr) 2014-04-25 2019-05-31 Pf Medicament Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer
MX378281B (es) 2014-04-25 2025-03-10 Pf Medicament Conjugado farmaco-anticuerpo y su uso para el tratamiento contra el cancer.
EP3218414A1 (en) * 2014-11-14 2017-09-20 Angiochem Inc. Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
EP3307326B9 (en) 2015-06-15 2021-02-24 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
WO2019190293A1 (ko) * 2018-03-30 2019-10-03 한미약품 주식회사 뇌 표적 지속성 단백질 결합체, 이의 제조 방법, 및 이를 포함하는 조성물
WO2020069488A1 (en) * 2018-09-28 2020-04-02 North Carolina State University Compositions and methods for drug delivery
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AU2021284918A1 (en) * 2020-06-03 2023-01-05 Starpharma Pty Ltd Therapeutic conjugates
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