CN104781281A - 包含抗体部分、穿过血脑屏障的多肽和细胞毒素的结合物 - Google Patents

包含抗体部分、穿过血脑屏障的多肽和细胞毒素的结合物 Download PDF

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Publication number
CN104781281A
CN104781281A CN201380043328.5A CN201380043328A CN104781281A CN 104781281 A CN104781281 A CN 104781281A CN 201380043328 A CN201380043328 A CN 201380043328A CN 104781281 A CN104781281 A CN 104781281A
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polypeptide
binding
lys
antibody
antibody moiety
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CN201380043328.5A
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Chinese (zh)
Inventor
让-保罗·卡斯泰恩
杨高强
克里斯蒂安·切
米歇尔·德默勒
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Angiochem Inc
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Angiochem Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/3015—Breast
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380043328.5A 2012-08-14 2013-08-14 包含抗体部分、穿过血脑屏障的多肽和细胞毒素的结合物 Pending CN104781281A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261682991P 2012-08-14 2012-08-14
US61/682,991 2012-08-14
US201361865071P 2013-08-12 2013-08-12
US61/865,071 2013-08-12
PCT/CA2013/050625 WO2014026286A1 (en) 2012-08-14 2013-08-14 Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin

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CN104781281A true CN104781281A (zh) 2015-07-15

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CN201380043328.5A Pending CN104781281A (zh) 2012-08-14 2013-08-14 包含抗体部分、穿过血脑屏障的多肽和细胞毒素的结合物

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US (2) US20160106856A1 (enExample)
EP (1) EP2885321A4 (enExample)
JP (1) JP2015526435A (enExample)
CN (1) CN104781281A (enExample)
AU (1) AU2013302273A1 (enExample)
CA (1) CA2880342A1 (enExample)
WO (1) WO2014026286A1 (enExample)

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CN114502201A (zh) * 2019-08-28 2022-05-13 星药私人有限公司 靶向性树枝状体缀合物
CN114478772A (zh) * 2021-12-31 2022-05-13 苏州大学 工程化免疫细胞、纳米凝胶及其制备方法和应用

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RU2422143C2 (ru) 2005-07-15 2011-06-27 Анджиокем Инк. Усиление действия противораковых агентов
CN102245642A (zh) 2008-10-15 2011-11-16 安吉奥开米公司 Glp-1激动剂的结合物及其用途
BRPI0922689A2 (pt) 2008-12-05 2018-11-06 Angiochem Inc. conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos
CA2881602A1 (en) 2012-08-14 2014-02-20 Angiochem Inc. Peptide-dendrimer conjugates and uses thereof
EP3134125B1 (en) 2014-04-25 2019-10-09 Pierre Fabre Medicament Antibody-drug-conjugate and its use for the treatment of cancer
KR101795984B1 (ko) 2014-04-25 2017-11-10 피에르 파브르 메디카먼트 Igf-1r 항체-약물-결합체 및 암의 치료를 위한 그의 용도
EP3218414A1 (en) * 2014-11-14 2017-09-20 Angiochem Inc. Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
CN107921143B (zh) 2015-06-15 2021-11-19 安吉奥开米公司 用于治疗软脑膜癌病的方法
US20210046189A1 (en) * 2018-03-30 2021-02-18 HANMl PHARM. CO., LTD. Long-acting protein conjugates for brain targeting, a preparation method thereof, and a composition comprising the same
US20210353767A1 (en) * 2018-09-28 2021-11-18 North Carolina State University Compositions and methods for drug delivery
CN115989039A (zh) * 2020-06-03 2023-04-18 星药私人有限公司 治疗缀合物

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