JP2015526075A5 - - Google Patents
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- Publication number
- JP2015526075A5 JP2015526075A5 JP2015524572A JP2015524572A JP2015526075A5 JP 2015526075 A5 JP2015526075 A5 JP 2015526075A5 JP 2015524572 A JP2015524572 A JP 2015524572A JP 2015524572 A JP2015524572 A JP 2015524572A JP 2015526075 A5 JP2015526075 A5 JP 2015526075A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- seq
- aptamer
- stem cell
- rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091008103 RNA aptamers Proteins 0.000 claims 15
- 210000000130 stem cell Anatomy 0.000 claims 14
- 108091023037 Aptamer Proteins 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 9
- 229940039227 diagnostic agent Drugs 0.000 claims 5
- 239000000032 diagnostic agent Substances 0.000 claims 5
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000463 material Substances 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 229940124447 delivery agent Drugs 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 208000030381 cutaneous melanoma Diseases 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000010562 histological examination Methods 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000012857 radioactive material Substances 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 201000003708 skin melanoma Diseases 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2012903332A AU2012903332A0 (en) | 2012-08-02 | CD133 Aptamers for Detection of Cancer Stem Cells | |
| AU2012903332 | 2012-08-02 | ||
| PCT/AU2013/000850 WO2014019024A1 (en) | 2012-08-02 | 2013-08-02 | Cd133 aptamers for detection of cancer stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015526075A JP2015526075A (ja) | 2015-09-10 |
| JP2015526075A5 true JP2015526075A5 (enExample) | 2016-09-23 |
| JP6279573B2 JP6279573B2 (ja) | 2018-02-14 |
Family
ID=50026987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524572A Expired - Fee Related JP6279573B2 (ja) | 2012-08-02 | 2013-08-02 | 癌幹細胞を検出するためのｃｄ１３３アプタマー |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9840712B2 (enExample) |
| EP (1) | EP2880185B1 (enExample) |
| JP (1) | JP6279573B2 (enExample) |
| KR (1) | KR20150085806A (enExample) |
| CN (1) | CN104781417B (enExample) |
| AU (1) | AU2013299331B2 (enExample) |
| BR (1) | BR112015002289A2 (enExample) |
| CA (1) | CA2880589A1 (enExample) |
| ES (1) | ES2741949T3 (enExample) |
| IL (1) | IL237034A0 (enExample) |
| IN (1) | IN2015DN00634A (enExample) |
| MX (1) | MX2015001433A (enExample) |
| NZ (1) | NZ704719A (enExample) |
| SG (1) | SG11201500666TA (enExample) |
| WO (1) | WO2014019024A1 (enExample) |
| ZA (1) | ZA201501318B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2851924T3 (es) * | 2014-02-05 | 2021-09-09 | Univ Deakin | Estructura artificial de aptámero |
| KR101612272B1 (ko) | 2014-06-20 | 2016-04-15 | 한양대학교 산학협력단 | 신경교종 줄기세포 검출용 펩타이드 |
| JP6978317B2 (ja) | 2015-02-11 | 2021-12-08 | ディーキン・ユニバーシティー | ＥｐＣＡＭアプタマー及びそのコンジュゲート |
| CN104745590A (zh) * | 2015-03-23 | 2015-07-01 | 莱萌科医疗技术有限公司 | 可检测癌症病人血清内enox2蛋白的核酸适配子及其应用 |
| KR101726212B1 (ko) * | 2015-05-08 | 2017-04-13 | 한양대학교 산학협력단 | Cd133 검출용 다중 펩타이드 프로브 |
| CN105602904B (zh) * | 2015-08-24 | 2019-05-31 | 天津市第四中心医院 | Cd133质粒的新用途 |
| KR20190023197A (ko) | 2017-08-28 | 2019-03-08 | 피엠씨씨 주식회사 | 암 줄기세포 검출을 위한 재조합 발현벡터와 이로부터 형질전환된 세포주 그리고 이의 제조방법 |
| WO2019157647A1 (zh) | 2018-02-13 | 2019-08-22 | 深圳麦克韦尔股份有限公司 | 电子烟及其发热组件和发热体 |
| WO2019157648A1 (zh) | 2018-02-13 | 2019-08-22 | 深圳麦克韦尔股份有限公司 | 电子烟及其发热组件 |
| WO2019157645A1 (zh) | 2018-02-13 | 2019-08-22 | 深圳麦克韦尔股份有限公司 | 电子烟及其发热组件 |
| EP3753427B1 (en) | 2018-02-13 | 2024-10-30 | Shenzhen Smoore Technology Limited | Electronic cigarette and heating assembly and heating member thereof |
| CN108866061A (zh) * | 2018-06-21 | 2018-11-23 | 中山大学附属第五医院 | 一种识别肝癌细胞的核酸适配体及其筛选方法与用途 |
| CN108866062A (zh) * | 2018-06-21 | 2018-11-23 | 中山大学附属第五医院 | 一种特异性识别肝癌干细胞的dna适配体及其筛选方法与应用 |
| CA3116767A1 (en) * | 2018-10-26 | 2020-04-30 | North Carolina State University | Compositions and methods related to nucleic acid anticoagulants |
| CN109536503B (zh) * | 2018-12-06 | 2021-03-02 | 浙江省肿瘤医院 | 一种靶向结合cd133蛋白的核酸适配体及其筛选方法和用途 |
| KR102212149B1 (ko) * | 2019-03-28 | 2021-02-04 | 부산대학교 산학협력단 | 암 줄기세포에 특이적으로 결합하는 압타머 및 이의 용도 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6261774B1 (en) | 1990-06-11 | 2001-07-17 | Gilead Sciences, Inc. | Truncation selex method |
| KR970002255B1 (ko) | 1990-06-11 | 1997-02-26 | 넥스스타 파아마슈티컬드, 인크. | 핵산 리간드 |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5637459A (en) * | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| AU2003206865B2 (en) | 2002-02-08 | 2007-10-04 | D. Collen Research Foundation Vzw | A novel target to inhibit angiogenesis |
| US20060263336A1 (en) * | 2003-03-24 | 2006-11-23 | Caplan Arnold I | Cell targeting methods and compositions |
| JP5697297B2 (ja) * | 2004-05-14 | 2015-04-08 | ロゼッタ ジノミクス リミテッド | マイクロｎａｓおよびその使用 |
| CA2629330C (en) | 2004-11-12 | 2018-05-22 | Cambridge University Technical Services Ltd. | Methods and means related to cancer stem cells |
| JP2007319153A (ja) | 2006-06-02 | 2007-12-13 | Takashi Otsu | 核酸リガンドと中和剤との組み合わせ製剤 |
| US20090047295A1 (en) * | 2007-07-12 | 2009-02-19 | Berry David A | Methods and Compositions for Reducing Stemness in Oncogenesis |
| US20110206614A1 (en) * | 2007-11-23 | 2011-08-25 | Whitehead Institute For Biomedical Research | Systemic instigation systems to study tumor growth or metastasis |
-
2013
- 2013-08-02 SG SG11201500666TA patent/SG11201500666TA/en unknown
- 2013-08-02 KR KR1020157005476A patent/KR20150085806A/ko not_active Withdrawn
- 2013-08-02 US US14/418,648 patent/US9840712B2/en not_active Expired - Fee Related
- 2013-08-02 CN CN201380048080.1A patent/CN104781417B/zh not_active Expired - Fee Related
- 2013-08-02 IN IN634DEN2015 patent/IN2015DN00634A/en unknown
- 2013-08-02 CA CA2880589A patent/CA2880589A1/en not_active Abandoned
- 2013-08-02 WO PCT/AU2013/000850 patent/WO2014019024A1/en not_active Ceased
- 2013-08-02 EP EP13825421.4A patent/EP2880185B1/en not_active Not-in-force
- 2013-08-02 MX MX2015001433A patent/MX2015001433A/es unknown
- 2013-08-02 ES ES13825421T patent/ES2741949T3/es active Active
- 2013-08-02 NZ NZ704719A patent/NZ704719A/en not_active IP Right Cessation
- 2013-08-02 AU AU2013299331A patent/AU2013299331B2/en not_active Ceased
- 2013-08-02 BR BR112015002289A patent/BR112015002289A2/pt not_active Application Discontinuation
- 2013-08-02 JP JP2015524572A patent/JP6279573B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-01 IL IL237034A patent/IL237034A0/en unknown
- 2015-02-26 ZA ZA2015/01318A patent/ZA201501318B/en unknown
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