JP2015525060A - Ａｋｔ３関連病態の予知及び治療方法 - Google Patents

Ａｋｔ３関連病態の予知及び治療方法 Download PDF

Info

Publication number
JP2015525060A
JP2015525060A JP2015509554A JP2015509554A JP2015525060A JP 2015525060 A JP2015525060 A JP 2015525060A JP 2015509554 A JP2015509554 A JP 2015509554A JP 2015509554 A JP2015509554 A JP 2015509554A JP 2015525060 A JP2015525060 A JP 2015525060A
Authority
JP
Japan
Prior art keywords
akt3
subject
cancer
activity
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015509554A
Other languages
English (en)
Japanese (ja)
Inventor
ローレンス，ジム
タイロン，クリーナ
Original Assignee
ベルゲンビオ アーエス
ベルゲンビオ アーエス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ベルゲンビオ アーエス, ベルゲンビオ アーエス filed Critical ベルゲンビオ アーエス
Publication of JP2015525060A publication Critical patent/JP2015525060A/ja
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G01N33/575—
    • G01N33/57595—
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
JP2015509554A 2012-05-02 2013-05-02 Ａｋｔ３関連病態の予知及び治療方法 Pending JP2015525060A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261641512P 2012-05-02 2012-05-02
GB201207722A GB201207722D0 (en) 2012-05-02 2012-05-02 Method
GB1207722.8 2012-05-02
US61/641,512 2012-05-02
PCT/IB2013/053488 WO2013164788A2 (en) 2012-05-02 2013-05-02 Method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017052865A Division JP6738755B2 (ja) 2012-05-02 2017-03-17 Ａｋｔ３関連病態の予知及び治療方法

Publications (1)

Publication Number Publication Date
JP2015525060A true JP2015525060A (ja) 2015-09-03

Family

ID=46330714

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015509554A Pending JP2015525060A (ja) 2012-05-02 2013-05-02 Ａｋｔ３関連病態の予知及び治療方法
JP2017052865A Expired - Fee Related JP6738755B2 (ja) 2012-05-02 2017-03-17 Ａｋｔ３関連病態の予知及び治療方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017052865A Expired - Fee Related JP6738755B2 (ja) 2012-05-02 2017-03-17 Ａｋｔ３関連病態の予知及び治療方法

Country Status (13)

Country Link
US (2) US10317405B2 (enExample)
EP (1) EP2845004A2 (enExample)
JP (2) JP2015525060A (enExample)
KR (1) KR102179389B1 (enExample)
CN (1) CN104335046B (enExample)
AU (1) AU2013255456B2 (enExample)
BR (1) BR112014027219A2 (enExample)
CA (1) CA2871352A1 (enExample)
EA (1) EA201401201A1 (enExample)
GB (1) GB201207722D0 (enExample)
IN (1) IN2014MN02114A (enExample)
SG (1) SG11201407032WA (enExample)
WO (1) WO2013164788A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016011052A1 (en) * 2014-07-14 2016-01-21 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
GB201420239D0 (en) * 2014-11-14 2014-12-31 Bergenbio As Biomarker
GB201512133D0 (en) * 2015-07-10 2015-08-19 Bergenbio As Biomarkers
KR101941054B1 (ko) * 2016-07-20 2019-01-23 연세대학교 산학협력단 암 예후 예측을 위한 조성물 및 이를 포함하는 키트
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
KR102080384B1 (ko) * 2018-02-28 2020-02-21 주식회사 마크로젠 암줄기세포 특이적 바이오마커
WO2020101571A1 (en) * 2018-11-12 2020-05-22 Agency For Science, Technology And Research Methods for manipulating cell state transitions in cancer
IL297596A (en) * 2020-05-08 2022-12-01 Georgiamune Llc Modulators of akt3 and methods of using them

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010115119A2 (en) * 2009-04-02 2010-10-07 Tufts Medical Center, Inc. Compositions and methods for diagnosis and prognosis of cancer and progression, and for screening anti-cancer agents

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6809194B1 (en) 2000-05-10 2004-10-26 Chiron Corporation Akt3 inhibitors
US20040121413A1 (en) 2002-12-20 2004-06-24 Aebersold Rudolf H. Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions
WO2004086038A2 (en) 2003-03-28 2004-10-07 Institut Curie A method for screening compounds having the capacity to control tumor cell invasion or metastasis using constitutively active akt
ATE446752T1 (de) * 2003-04-24 2009-11-15 Merck & Co Inc Hemmer der akt aktivität
WO2008042867A2 (en) * 2006-09-29 2008-04-10 Emiliem Inc. Modulators of multiple kinases
EP2114983B8 (en) 2007-02-07 2015-02-18 The Regents of the University of Colorado, A Body Corporate Axl tyrosine kinase inhibitors and methods of making and using the same
JP5568471B2 (ja) * 2007-07-12 2014-08-06 ユニヴァーシティ オブ サウス フロリダ 抗腫瘍活性を有するａｋｔ／ｐｋｂの阻害剤
AU2008289442A1 (en) * 2007-08-21 2009-02-26 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
US8735064B2 (en) 2007-12-24 2014-05-27 Bergenbio As Methods for creating and identifying functional RNA interference elements
US8067178B2 (en) 2008-03-14 2011-11-29 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
CA2749843C (en) 2009-01-16 2017-09-05 Rigel Pharmaceuticals, Inc. Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer
WO2010091354A2 (en) 2009-02-06 2010-08-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Akt tyrosine 176 phosphorylation cancer biomarker
CA2755341A1 (en) * 2009-03-13 2010-09-16 Bergen Teknologioverforing As Methods using axl as biomarker of epithelial-to-mesnchymal transition
US8673572B2 (en) 2009-10-23 2014-03-18 The Translational Genomics Research Institute Methods used in identifying glioblastoma
US20120213801A1 (en) 2009-10-30 2012-08-23 Ekaterina Gresko Phosphorylated Twist1 and cancer
JP2013532482A (ja) 2010-07-27 2013-08-19 ジェノミック ヘルス， インコーポレイテッド 遺伝子発現を用いた前立腺癌の予後を定量化する方法
US20130171159A1 (en) * 2010-09-10 2013-07-04 Brian Arthur Hemmings Phosphorylated twist1 and metastasis
WO2012061515A2 (en) * 2010-11-03 2012-05-10 Merck Sharp & Dohme Corp. Methods of classifying human subjects with regard to cancer prognosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010115119A2 (en) * 2009-04-02 2010-10-07 Tufts Medical Center, Inc. Compositions and methods for diagnosis and prognosis of cancer and progression, and for screening anti-cancer agents

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANTICANCER RESEARCH, vol. Vol.29, JPN6016048782, 2009, pages 4175 - 4184 *
CANCER RES., vol. Vol.64, JPN6016048780, 2004, pages 7002 - 7010 *
CANCER RES., vol. Vol.74, JPN6016048783, 2014, pages 964 - 973 *
CELLULAR SIGNALLING, vol. Vol.23, JPN6016048778, 2011, pages 1952 - 1960 *
STEM CELLS, vol. Vol.26, JPN6016048781, 2008, pages 3027 - 3036 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 31, JPN6016048779, 1999, pages 21528 - 21532 *

Also Published As

Publication number Publication date
WO2013164788A3 (en) 2014-01-23
GB201207722D0 (en) 2012-06-13
KR102179389B1 (ko) 2020-11-18
WO2013164788A2 (en) 2013-11-07
JP6738755B2 (ja) 2020-08-12
CA2871352A1 (en) 2013-11-07
US20150119475A1 (en) 2015-04-30
BR112014027219A2 (pt) 2017-06-27
CN104335046A (zh) 2015-02-04
AU2013255456B2 (en) 2018-07-26
JP2017136077A (ja) 2017-08-10
EA201401201A1 (ru) 2015-02-27
KR20150016518A (ko) 2015-02-12
US10317405B2 (en) 2019-06-11
AU2013255456A1 (en) 2014-11-13
EP2845004A2 (en) 2015-03-11
SG11201407032WA (en) 2014-11-27
CN104335046B (zh) 2019-10-11
IN2014MN02114A (enExample) 2015-09-04
US20200072839A1 (en) 2020-03-05

Similar Documents

Publication Publication Date Title
JP6738755B2 (ja) Ａｋｔ３関連病態の予知及び治療方法
RU2586493C2 (ru) Способ применения axl в качестве маркера эпителиально-мезенхимального перехода
US11971402B2 (en) Methods and reagents for determination and treatment of organotropic metastasis
JP6599334B2 (ja) 血中循環腫瘍細胞に関する方法およびアッセイ
EP2399129B1 (en) A method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm
CN103975078B (zh) 治疗和诊断膀胱癌的方法和组合物
US20130059903A1 (en) Compositions and Methods for Characterizing Breast Cancer
MX2014014802A (es) Metodo para el diagnostico, pronostico y tratamiento de metastasis de cancer de pulmon.
US11035008B2 (en) Biomarkers for cancer
US20170314077A1 (en) Slfn11 as biomarker for aml
CN111630185A (zh) 包含pmvk作为活性成分的用于诊断耐放射癌症或预测放射疗法预后的生物标志物组合物
US20170258871A1 (en) Combined use of a trka inhibitor and an epha2 inhibitor for using in the treatment of solid cancers, and method for the prognosis of survival of a patient who has a solid cancer
KR101150410B1 (ko) 간암 진단용 마커로서의 ｓ100ｐ의 용도
Mele The role of StAR-D3 in HER2 overexpressing breast cancer

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160307

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161220

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170317

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170711