JP2015524849A - 神経変性疾患に対するエキソソームに基づく治療法 - Google Patents
神経変性疾患に対するエキソソームに基づく治療法 Download PDFInfo
- Publication number
- JP2015524849A JP2015524849A JP2015527641A JP2015527641A JP2015524849A JP 2015524849 A JP2015524849 A JP 2015524849A JP 2015527641 A JP2015527641 A JP 2015527641A JP 2015527641 A JP2015527641 A JP 2015527641A JP 2015524849 A JP2015524849 A JP 2015524849A
- Authority
- JP
- Japan
- Prior art keywords
- exosomes
- mir
- cell
- cells
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Botany (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261683596P | 2012-08-15 | 2012-08-15 | |
| US61/683,596 | 2012-08-15 | ||
| PCT/US2013/055187 WO2014028763A1 (en) | 2012-08-15 | 2013-08-15 | Exosome-based therapeutics against neurodegenerative disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015524849A true JP2015524849A (ja) | 2015-08-27 |
| JP2015524849A5 JP2015524849A5 (https=) | 2016-09-29 |
Family
ID=50101510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527641A Pending JP2015524849A (ja) | 2012-08-15 | 2013-08-15 | 神経変性疾患に対するエキソソームに基づく治療法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10231997B2 (https=) |
| EP (1) | EP2885414B1 (https=) |
| JP (1) | JP2015524849A (https=) |
| AU (1) | AU2013302526B2 (https=) |
| CA (1) | CA2882248A1 (https=) |
| WO (1) | WO2014028763A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018534370A (ja) * | 2015-11-18 | 2018-11-22 | ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド | 神経細胞の細胞外小胞 |
| JP2022534786A (ja) * | 2019-06-04 | 2022-08-03 | トーマス・ジェファーソン・ユニバーシティ | 多発性硬化症療法のためのオリゴデンドロサイト由来細胞外小胞 |
| JP2024086785A (ja) * | 2016-11-23 | 2024-06-28 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 生物学的製剤の粒子媒介送達 |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| JP2015524849A (ja) | 2012-08-15 | 2015-08-27 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | 神経変性疾患に対するエキソソームに基づく治療法 |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| CA2926092A1 (en) * | 2013-10-24 | 2015-04-30 | Nanosomix, Inc. | Biomarkers and diagnostic methods for alzheimer's disease and other neurodegenerative disorders |
| PL4023249T3 (pl) | 2014-04-23 | 2025-03-10 | Modernatx, Inc. | Szczepionki z kwasem nukleinowym |
| DK3145493T3 (da) * | 2014-05-18 | 2022-10-31 | Childrens Medical Center | Fremgangsmåder og sammensætninger vedrørende exosomer |
| US20170184613A1 (en) * | 2014-05-23 | 2017-06-29 | Georgetown University | Exosome and lipid biomarkers for memory loss |
| KR101766373B1 (ko) * | 2015-01-05 | 2017-08-09 | 권영아 | 루테리온을 이용한 암세포의 텔로머라아제 억제방법 |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| WO2017087685A1 (en) | 2015-11-20 | 2017-05-26 | The Regents Of The University Of California | Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery |
| LT3394030T (lt) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| WO2017124000A1 (en) | 2016-01-14 | 2017-07-20 | The Regents Of The University Of California | 3d-exoquant method for the analysis of surface molecules and quantification of tissue-specific exosomes in biological fluids |
| AU2017227790B2 (en) | 2016-03-02 | 2023-03-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Matrix bound nanovesicles and their use |
| WO2017152035A1 (en) * | 2016-03-03 | 2017-09-08 | Henry Ford Health System | 3-d collagen scaffold-generated exosomes and uses thereof |
| WO2018035204A1 (en) * | 2016-08-16 | 2018-02-22 | Henry Ford Health System | Compositions for the treatment of neuropathic pain and sensitization of tumors to chemotherapies |
| US20210290556A1 (en) * | 2016-08-22 | 2021-09-23 | Codiak Biosciences, Inc. | Methods of suppressing delivery of exosomes to liver and spleen |
| WO2018071681A1 (en) | 2016-10-13 | 2018-04-19 | Vbc Holdings Llc | Cancer stem cell exosomes |
| KR20190109389A (ko) | 2016-11-03 | 2019-09-25 | 엑소스템 바이오텍 리미티드 | 간엽 줄기 세포 집단, 이들의 산물 및 이들의 용도 |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| WO2018132728A1 (en) * | 2017-01-12 | 2018-07-19 | Duke University | Compositions and methods for the treatment of demyelinating conditions |
| EP4186888B1 (en) | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Compound and compositions for intracellular delivery of therapeutic agents |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| CA3055653A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
| CA3058782A1 (en) | 2017-04-03 | 2018-10-11 | The Regents Of The University Of California | Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery |
| US11672849B2 (en) * | 2017-05-10 | 2023-06-13 | University Of Louisville Research Foundation, Inc. | Method of inhibiting lung or breast cancer growth with engineered embryonic stem-cell derived exosomes compositions |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| CN108103026B (zh) * | 2017-12-05 | 2020-12-22 | 四川省肿瘤医院 | 用于肿瘤免疫治疗的γδ-T细胞外泌体及其制备方法 |
| CN107988153B (zh) * | 2017-12-15 | 2021-05-18 | 英科博雅生命科技有限公司 | 人脐带血间充质干细胞源分离外泌体的方法和使用的试剂 |
| US12017066B2 (en) | 2018-01-05 | 2024-06-25 | Mayo Foundation For Medical Education And Research | Modulation of extracellular vesicles with electrical stimulation |
| JP7538044B2 (ja) | 2018-04-30 | 2024-08-21 | ザ チルドレンズ メディカル センター コーポレーション | 間葉系間質細胞エキソソームおよびそれらの使用 |
| US11278575B2 (en) | 2018-07-12 | 2022-03-22 | Duke University | Compositions and methods for the treatment of demyelinating conditions |
| WO2020061367A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| WO2020072744A1 (en) * | 2018-10-04 | 2020-04-09 | Synaptec Network, Inc. | Systems and methods for delivering exosomes through the blood-brain barrier |
| US20220133908A1 (en) | 2019-02-08 | 2022-05-05 | Curevac Ag | Coding rna administered into the suprachoroidal space in the treatment of ophthalmic diseases |
| JP7372518B2 (ja) * | 2019-06-27 | 2023-11-01 | 国立大学法人山口大学 | 骨髄由来間葉系幹細胞の培養方法 |
| US20220241325A1 (en) * | 2019-07-26 | 2022-08-04 | Mayo Foundation For Medical Education And Research | Antioxidant and antiviral compositions and methods |
| CN111117964B (zh) * | 2019-07-30 | 2020-12-01 | 段海峰 | 一种肿瘤来源外泌体及其制备方法和用途 |
| TR201911667A2 (tr) | 2019-08-01 | 2021-02-22 | Univ Yeditepe | Hücrelerde oluşan protein birikintilerinden kaynaklanan hastalıkların tedavisi için kullanılan bitki eksozomları. |
| CA3155015A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| WO2021076973A1 (en) * | 2019-10-16 | 2021-04-22 | The Johns Hopkins University | Extracellular vesicle-based agents and methods for the treatment of neuropathic disorders |
| CN112972702A (zh) * | 2019-12-17 | 2021-06-18 | 南京大学 | 用于治疗耐药菌感染的外泌体制剂 |
| PH12022551608A1 (en) * | 2019-12-31 | 2023-10-16 | Chase Therapeutics Corp | Kinases as biomarkers for neurodegenerative conditions |
| WO2021154888A1 (en) * | 2020-01-27 | 2021-08-05 | Mantra Bio. Inc. | Non-naturally occurring vesicles comprising a chimeric vesicle localization moiety, methods of making and uses thereof |
| US20230314412A1 (en) * | 2020-03-21 | 2023-10-05 | Florica Therapeutics, Inc. | Neuronal diencephalon stem cells, preparation and uses for treatment and prevention of hormonal disorders and other diseases |
| CN111876388A (zh) * | 2020-07-24 | 2020-11-03 | 赛瑞诚(苏州)生物科技有限公司 | 一种骨和骨组织靶向外泌体及其制备方法和应用 |
| WO2022023559A1 (en) | 2020-07-31 | 2022-02-03 | Curevac Ag | Nucleic acid encoded antibody mixtures |
| WO2022204045A1 (en) * | 2021-03-22 | 2022-09-29 | Spiritus Therapeutics, Inc. | Diagnostic and therapeutic uses of purified potent exosomes containing disease-based and therapy based signature cargo |
| WO2023283218A2 (en) * | 2021-07-07 | 2023-01-12 | University Of Florida Research Foundation, Incorporated | Light-induced cellular production of immune functional extracellular vesicles |
| CN116440168A (zh) * | 2022-01-06 | 2023-07-18 | 南京大学 | 一种生物制品及其制备方法和其在制备抗衰延寿产品中的应用 |
| CN115006427A (zh) * | 2022-05-31 | 2022-09-06 | 尧舜泽生物医药(南京)有限公司 | 骨髓间充质干细胞外泌体在治疗帕金森病中的应用 |
| CN120712096A (zh) * | 2022-11-23 | 2025-09-26 | ExoMed私人有限公司 | 使用源自幼小哺乳动物的细胞外囊泡预防或治疗年龄相关病状的方法 |
| WO2024186630A1 (en) * | 2023-03-03 | 2024-09-12 | Henry Ford Health System | Use of extracellular vesicles for the treatment of cancer |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011513217A (ja) * | 2008-02-22 | 2011-04-28 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ(エイ・スター) | 間葉系幹細胞粒子 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5888773A (en) | 1994-08-17 | 1999-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Method of producing single-chain Fv molecules |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| FR2788780B1 (fr) | 1999-01-27 | 2001-03-30 | Ap Cells Inc | Procede de preparation de vesicules membranaires |
| US20040241176A1 (en) | 2000-04-27 | 2004-12-02 | Ap Cells. Inc. | Method of producing membrane vesicles |
| US7689196B2 (en) | 2002-06-26 | 2010-03-30 | Qualcomm Incorporated | Timer-based sleep for terminals in wireless communication systems |
| EP1713900A4 (en) * | 2004-01-27 | 2009-06-17 | Compugen Ltd | METHOD AND SYSTEMS FOR COMMENTING BIOMOLECULAR SEQUENCES |
| JP5697297B2 (ja) * | 2004-05-14 | 2015-04-08 | ロゼッタ ジノミクス リミテッド | マイクロnasおよびその使用 |
| CA2676113C (en) * | 2007-07-25 | 2014-07-08 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
| WO2009023517A2 (en) * | 2007-08-10 | 2009-02-19 | Wayne State University | Compositions and methods for detecting and modulating cell death by a translation regulated gene expression system |
| WO2010056337A2 (en) | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
| WO2013016223A2 (en) | 2011-07-22 | 2013-01-31 | The University Of Chicago | Treatments for migraine and related disorders |
| JP2015524849A (ja) | 2012-08-15 | 2015-08-27 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | 神経変性疾患に対するエキソソームに基づく治療法 |
-
2013
- 2013-08-15 JP JP2015527641A patent/JP2015524849A/ja active Pending
- 2013-08-15 EP EP13829748.6A patent/EP2885414B1/en active Active
- 2013-08-15 CA CA2882248A patent/CA2882248A1/en not_active Abandoned
- 2013-08-15 AU AU2013302526A patent/AU2013302526B2/en active Active
- 2013-08-15 WO PCT/US2013/055187 patent/WO2014028763A1/en not_active Ceased
- 2013-08-15 US US14/420,680 patent/US10231997B2/en active Active
-
2019
- 2019-01-28 US US16/259,563 patent/US11369634B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011513217A (ja) * | 2008-02-22 | 2011-04-28 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ(エイ・スター) | 間葉系幹細胞粒子 |
Non-Patent Citations (4)
| Title |
|---|
| FRONTIERS IN NEROSCIENCE, vol. 6(13), JPN6017021495, 6 February 2012 (2012-02-06), pages 1 - 7, ISSN: 0003799122 * |
| GLIA, vol. 45, JPN6017021489, 2004, pages 54 - 8, ISSN: 0003799119 * |
| J. C. SCI., vol. 124, JPN6017021494, 2010, pages 447 - 58, ISSN: 0003799121 * |
| PLOS ONE, vol. 5(12), JPN6017021491, 2010, pages 1 - 8, ISSN: 0003799120 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018534370A (ja) * | 2015-11-18 | 2018-11-22 | ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド | 神経細胞の細胞外小胞 |
| US11111475B2 (en) | 2015-11-18 | 2021-09-07 | University Of Georgia Research Foundation, Inc. | Neural cell extracellular vesicles |
| JP2022009194A (ja) * | 2015-11-18 | 2022-01-14 | ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド | 神経細胞の細胞外小胞 |
| JP7075594B2 (ja) | 2015-11-18 | 2022-05-26 | ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド | 神経細胞の細胞外小胞 |
| US11993787B2 (en) | 2015-11-18 | 2024-05-28 | University Of Georgia Research Foundation, Inc. | Neural cell extracellular vesicles |
| JP7551975B2 (ja) | 2015-11-18 | 2024-09-18 | ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド | 神経細胞の細胞外小胞 |
| US12139723B2 (en) | 2015-11-18 | 2024-11-12 | University Of Georgia Research Foundation, Inc. | Neural cell extracellular vesicles |
| JP2024086785A (ja) * | 2016-11-23 | 2024-06-28 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 生物学的製剤の粒子媒介送達 |
| JP2022534786A (ja) * | 2019-06-04 | 2022-08-03 | トーマス・ジェファーソン・ユニバーシティ | 多発性硬化症療法のためのオリゴデンドロサイト由来細胞外小胞 |
| JP2025081585A (ja) * | 2019-06-04 | 2025-05-27 | トーマス・ジェファーソン・ユニバーシティ | 多発性硬化症療法のためのオリゴデンドロサイト由来細胞外小胞 |
| US12508285B2 (en) | 2019-06-04 | 2025-12-30 | Thomas Jefferson University | Oligodendrocyte-derived extracellular vesicles for therapy of multiple sclerosis |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013302526B2 (en) | 2018-03-22 |
| US11369634B2 (en) | 2022-06-28 |
| EP2885414A1 (en) | 2015-06-24 |
| US20190160097A1 (en) | 2019-05-30 |
| EP2885414A4 (en) | 2016-01-06 |
| EP2885414B1 (en) | 2020-09-23 |
| CA2882248A1 (en) | 2014-02-20 |
| WO2014028763A1 (en) | 2014-02-20 |
| US20150216899A1 (en) | 2015-08-06 |
| US10231997B2 (en) | 2019-03-19 |
| AU2013302526A1 (en) | 2015-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11369634B2 (en) | Exosome-based therapeutics against neurodegenerative disorders | |
| Pusic et al. | Youth and environmental enrichment generate serum exosomes containing miR‐219 that promote CNS myelination | |
| Wang et al. | Mesenchymal stem cell-derived exosomes reduce A1 astrocytes via downregulation of phosphorylated NFκB P65 subunit in spinal cord injury | |
| US8962583B2 (en) | Treatment of inflammatory diseases using miR-124 | |
| JP2021020951A (ja) | セロトニン放出ホルモン、アドレナリン放出ホルモン、ノルアドレナリン放出ホルモン、グルタミン酸放出ホルモンおよび副腎皮質刺激ホルモン放出ホルモン関連の医学的状態の処置および診断のためのマイクロrnaおよび該マイクロrnaを含む組成物 | |
| WO2018029656A2 (en) | Methods for making and using therapeutic exosomes | |
| Wang et al. | Developmental cytoplasmic-to-nuclear translocation of RNA-binding protein HuR is required for adult neurogenesis | |
| Yasuzaki et al. | Localization of exogenous DNA to mitochondria in skeletal muscle following hydrodynamic limb vein injection | |
| Xu et al. | Oligodendrocyte progenitor cell-specific delivery of lipid nanoparticles loaded with Olig2 synthetically modified messenger RNA for ischemic stroke therapy | |
| Jensen et al. | Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis‐linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice | |
| Hu et al. | microRNA‐425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies | |
| Song et al. | Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease | |
| Ionescu et al. | Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models | |
| Gabery et al. | Characterization of a rat model of Huntington’s disease based on targeted expression of mutant huntingtin in the forebrain using adeno‐associated viral vectors | |
| Park et al. | Characterization of the subventricular-thalamo-cortical circuit in the NP-C mouse brain, and new insights regarding treatment | |
| Minamiyama et al. | Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model | |
| CN115414485B (zh) | uN2CpolyG蛋白抑制剂的用途 | |
| Picchiarelli et al. | FUS controls muscle differentiation and structure through LLPS mediated recruitment of MEF2 and ETV5 | |
| Liu et al. | MiR-125a-5p in extracellular vesicles of neural stem cells acts as a crosstalk signal modulating neuroinflammatory microenvironment to alleviate cerebral ischemia-reperfusion injury | |
| Kim et al. | Mesenchymal stem cell derived extracellular vesicles reverses neural aging via OSKM modulation | |
| Chen et al. | Lactylation-driven FTO-mediated m6A modification of CDK2 aggravates diabetic microvascular anomalies | |
| Gautier et al. | Long term AAV2/9-mediated silencing of PMP22 prevents CMT1A disease in rats and validates skin biomarkers as treatment outcome measure | |
| Li et al. | RVG‐Modified BMSCs‐Derived Small Extracellular Vesicles Loaded With miR‐21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/Akt/mTOR Pathway After Cerebral Ischaemia | |
| Wang et al. | Engineered BMSC-derived exosomes deliver miR-17-5p inhibitor to restore sensory conduction via the IL-11/GP130/STAT3/GAP-43 axis in dorsal column lesion | |
| Merheb | Understanding the Pathogenesis of Pol III-related Leukodystrophy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160805 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160805 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170612 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20170912 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20180521 |