AU2013302526B2 - Exosome-based therapeutics against neurodegenerative disorders - Google Patents
Exosome-based therapeutics against neurodegenerative disorders Download PDFInfo
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- AU2013302526B2 AU2013302526B2 AU2013302526A AU2013302526A AU2013302526B2 AU 2013302526 B2 AU2013302526 B2 AU 2013302526B2 AU 2013302526 A AU2013302526 A AU 2013302526A AU 2013302526 A AU2013302526 A AU 2013302526A AU 2013302526 B2 AU2013302526 B2 AU 2013302526B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/141—MicroRNAs, miRNAs
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- Developmental Biology & Embryology (AREA)
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- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261683596P | 2012-08-15 | 2012-08-15 | |
| US61/683,596 | 2012-08-15 | ||
| PCT/US2013/055187 WO2014028763A1 (en) | 2012-08-15 | 2013-08-15 | Exosome-based therapeutics against neurodegenerative disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013302526A1 AU2013302526A1 (en) | 2015-04-02 |
| AU2013302526B2 true AU2013302526B2 (en) | 2018-03-22 |
Family
ID=50101510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013302526A Active AU2013302526B2 (en) | 2012-08-15 | 2013-08-15 | Exosome-based therapeutics against neurodegenerative disorders |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10231997B2 (https=) |
| EP (1) | EP2885414B1 (https=) |
| JP (1) | JP2015524849A (https=) |
| AU (1) | AU2013302526B2 (https=) |
| CA (1) | CA2882248A1 (https=) |
| WO (1) | WO2014028763A1 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| JP2015524849A (ja) | 2012-08-15 | 2015-08-27 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | 神経変性疾患に対するエキソソームに基づく治療法 |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| CA2926092A1 (en) * | 2013-10-24 | 2015-04-30 | Nanosomix, Inc. | Biomarkers and diagnostic methods for alzheimer's disease and other neurodegenerative disorders |
| PL4023249T3 (pl) | 2014-04-23 | 2025-03-10 | Modernatx, Inc. | Szczepionki z kwasem nukleinowym |
| DK3145493T3 (da) * | 2014-05-18 | 2022-10-31 | Childrens Medical Center | Fremgangsmåder og sammensætninger vedrørende exosomer |
| US20170184613A1 (en) * | 2014-05-23 | 2017-06-29 | Georgetown University | Exosome and lipid biomarkers for memory loss |
| KR101766373B1 (ko) * | 2015-01-05 | 2017-08-09 | 권영아 | 루테리온을 이용한 암세포의 텔로머라아제 억제방법 |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| JP7075594B2 (ja) * | 2015-11-18 | 2022-05-26 | ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド | 神経細胞の細胞外小胞 |
| WO2017087685A1 (en) | 2015-11-20 | 2017-05-26 | The Regents Of The University Of California | Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery |
| LT3394030T (lt) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| WO2017124000A1 (en) | 2016-01-14 | 2017-07-20 | The Regents Of The University Of California | 3d-exoquant method for the analysis of surface molecules and quantification of tissue-specific exosomes in biological fluids |
| AU2017227790B2 (en) | 2016-03-02 | 2023-03-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Matrix bound nanovesicles and their use |
| WO2017152035A1 (en) * | 2016-03-03 | 2017-09-08 | Henry Ford Health System | 3-d collagen scaffold-generated exosomes and uses thereof |
| WO2018035204A1 (en) * | 2016-08-16 | 2018-02-22 | Henry Ford Health System | Compositions for the treatment of neuropathic pain and sensitization of tumors to chemotherapies |
| US20210290556A1 (en) * | 2016-08-22 | 2021-09-23 | Codiak Biosciences, Inc. | Methods of suppressing delivery of exosomes to liver and spleen |
| WO2018071681A1 (en) | 2016-10-13 | 2018-04-19 | Vbc Holdings Llc | Cancer stem cell exosomes |
| KR20190109389A (ko) | 2016-11-03 | 2019-09-25 | 엑소스템 바이오텍 리미티드 | 간엽 줄기 세포 집단, 이들의 산물 및 이들의 용도 |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| ES2912270T3 (es) * | 2016-11-23 | 2022-05-25 | Mayo Found Medical Education & Res | Transporte de productos biológicos por medio de partículas |
| WO2018132728A1 (en) * | 2017-01-12 | 2018-07-19 | Duke University | Compositions and methods for the treatment of demyelinating conditions |
| EP4186888B1 (en) | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Compound and compositions for intracellular delivery of therapeutic agents |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| CA3055653A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
| CA3058782A1 (en) | 2017-04-03 | 2018-10-11 | The Regents Of The University Of California | Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery |
| US11672849B2 (en) * | 2017-05-10 | 2023-06-13 | University Of Louisville Research Foundation, Inc. | Method of inhibiting lung or breast cancer growth with engineered embryonic stem-cell derived exosomes compositions |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| CN108103026B (zh) * | 2017-12-05 | 2020-12-22 | 四川省肿瘤医院 | 用于肿瘤免疫治疗的γδ-T细胞外泌体及其制备方法 |
| CN107988153B (zh) * | 2017-12-15 | 2021-05-18 | 英科博雅生命科技有限公司 | 人脐带血间充质干细胞源分离外泌体的方法和使用的试剂 |
| US12017066B2 (en) | 2018-01-05 | 2024-06-25 | Mayo Foundation For Medical Education And Research | Modulation of extracellular vesicles with electrical stimulation |
| JP7538044B2 (ja) | 2018-04-30 | 2024-08-21 | ザ チルドレンズ メディカル センター コーポレーション | 間葉系間質細胞エキソソームおよびそれらの使用 |
| US11278575B2 (en) | 2018-07-12 | 2022-03-22 | Duke University | Compositions and methods for the treatment of demyelinating conditions |
| WO2020061367A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| WO2020072744A1 (en) * | 2018-10-04 | 2020-04-09 | Synaptec Network, Inc. | Systems and methods for delivering exosomes through the blood-brain barrier |
| US20220133908A1 (en) | 2019-02-08 | 2022-05-05 | Curevac Ag | Coding rna administered into the suprachoroidal space in the treatment of ophthalmic diseases |
| CA3142487A1 (en) * | 2019-06-04 | 2020-12-10 | Thomas Jefferson University | Oligodendrocyte-derived extracellular vesicles for therapy of multiple sclerosis |
| JP7372518B2 (ja) * | 2019-06-27 | 2023-11-01 | 国立大学法人山口大学 | 骨髄由来間葉系幹細胞の培養方法 |
| US20220241325A1 (en) * | 2019-07-26 | 2022-08-04 | Mayo Foundation For Medical Education And Research | Antioxidant and antiviral compositions and methods |
| CN111117964B (zh) * | 2019-07-30 | 2020-12-01 | 段海峰 | 一种肿瘤来源外泌体及其制备方法和用途 |
| TR201911667A2 (tr) | 2019-08-01 | 2021-02-22 | Univ Yeditepe | Hücrelerde oluşan protein birikintilerinden kaynaklanan hastalıkların tedavisi için kullanılan bitki eksozomları. |
| CA3155015A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| WO2021076973A1 (en) * | 2019-10-16 | 2021-04-22 | The Johns Hopkins University | Extracellular vesicle-based agents and methods for the treatment of neuropathic disorders |
| CN112972702A (zh) * | 2019-12-17 | 2021-06-18 | 南京大学 | 用于治疗耐药菌感染的外泌体制剂 |
| PH12022551608A1 (en) * | 2019-12-31 | 2023-10-16 | Chase Therapeutics Corp | Kinases as biomarkers for neurodegenerative conditions |
| WO2021154888A1 (en) * | 2020-01-27 | 2021-08-05 | Mantra Bio. Inc. | Non-naturally occurring vesicles comprising a chimeric vesicle localization moiety, methods of making and uses thereof |
| US20230314412A1 (en) * | 2020-03-21 | 2023-10-05 | Florica Therapeutics, Inc. | Neuronal diencephalon stem cells, preparation and uses for treatment and prevention of hormonal disorders and other diseases |
| CN111876388A (zh) * | 2020-07-24 | 2020-11-03 | 赛瑞诚(苏州)生物科技有限公司 | 一种骨和骨组织靶向外泌体及其制备方法和应用 |
| WO2022023559A1 (en) | 2020-07-31 | 2022-02-03 | Curevac Ag | Nucleic acid encoded antibody mixtures |
| WO2022204045A1 (en) * | 2021-03-22 | 2022-09-29 | Spiritus Therapeutics, Inc. | Diagnostic and therapeutic uses of purified potent exosomes containing disease-based and therapy based signature cargo |
| WO2023283218A2 (en) * | 2021-07-07 | 2023-01-12 | University Of Florida Research Foundation, Incorporated | Light-induced cellular production of immune functional extracellular vesicles |
| CN116440168A (zh) * | 2022-01-06 | 2023-07-18 | 南京大学 | 一种生物制品及其制备方法和其在制备抗衰延寿产品中的应用 |
| CN115006427A (zh) * | 2022-05-31 | 2022-09-06 | 尧舜泽生物医药(南京)有限公司 | 骨髓间充质干细胞外泌体在治疗帕金森病中的应用 |
| CN120712096A (zh) * | 2022-11-23 | 2025-09-26 | ExoMed私人有限公司 | 使用源自幼小哺乳动物的细胞外囊泡预防或治疗年龄相关病状的方法 |
| WO2024186630A1 (en) * | 2023-03-03 | 2024-09-12 | Henry Ford Health System | Use of extracellular vesicles for the treatment of cancer |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110003008A1 (en) * | 2008-02-22 | 2011-01-06 | Agency For Science, Technology And Research (A*Star) | Mesenchymal stem cell particles |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5888773A (en) | 1994-08-17 | 1999-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Method of producing single-chain Fv molecules |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| FR2788780B1 (fr) | 1999-01-27 | 2001-03-30 | Ap Cells Inc | Procede de preparation de vesicules membranaires |
| US20040241176A1 (en) | 2000-04-27 | 2004-12-02 | Ap Cells. Inc. | Method of producing membrane vesicles |
| US7689196B2 (en) | 2002-06-26 | 2010-03-30 | Qualcomm Incorporated | Timer-based sleep for terminals in wireless communication systems |
| EP1713900A4 (en) * | 2004-01-27 | 2009-06-17 | Compugen Ltd | METHOD AND SYSTEMS FOR COMMENTING BIOMOLECULAR SEQUENCES |
| JP5697297B2 (ja) * | 2004-05-14 | 2015-04-08 | ロゼッタ ジノミクス リミテッド | マイクロnasおよびその使用 |
| CA2676113C (en) * | 2007-07-25 | 2014-07-08 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
| WO2009023517A2 (en) * | 2007-08-10 | 2009-02-19 | Wayne State University | Compositions and methods for detecting and modulating cell death by a translation regulated gene expression system |
| WO2010056337A2 (en) | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
| WO2013016223A2 (en) | 2011-07-22 | 2013-01-31 | The University Of Chicago | Treatments for migraine and related disorders |
| JP2015524849A (ja) | 2012-08-15 | 2015-08-27 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | 神経変性疾患に対するエキソソームに基づく治療法 |
-
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- 2013-08-15 EP EP13829748.6A patent/EP2885414B1/en active Active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110003008A1 (en) * | 2008-02-22 | 2011-01-06 | Agency For Science, Technology And Research (A*Star) | Mesenchymal stem cell particles |
Non-Patent Citations (4)
| Title |
|---|
| D. FITZNER ET AL, "Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis", JOURNAL OF CELL SCIENCE, GB, (20110201), vol. 124, no. 3, doi:10.1242/jcs.074088, ISSN 0021-9533, pages 447 - 458 * |
| FRUHBEIS, C ET AL., "Emerging Roles Of Exosomes In Neuron-Glia Communication", FRONTIERS IN PHYSIOLOGY., (2012), vol. 3, pages 1 - 5 * |
| MARIA ELDH ET AL, "Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA", PLOS ONE, (20101217), vol. 5, no. 12, doi:10.1371/journal.pone.0015353, page e15353 * |
| OLGA BARCA-MAYO ET AL, "Fine-Tuning Oligodendrocyte Development by microRNAs", FRONTIERS IN NEUROSCIENCE, (20120101), vol. 6, doi:10.3389/fnins.2012.00013 * |
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| US10231997B2 (en) | 2019-03-19 |
| AU2013302526A1 (en) | 2015-04-02 |
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