JP2015523410A5 - - Google Patents
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- JP2015523410A5 JP2015523410A5 JP2015524902A JP2015524902A JP2015523410A5 JP 2015523410 A5 JP2015523410 A5 JP 2015523410A5 JP 2015524902 A JP2015524902 A JP 2015524902A JP 2015524902 A JP2015524902 A JP 2015524902A JP 2015523410 A5 JP2015523410 A5 JP 2015523410A5
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- Japan
- Prior art keywords
- als
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- mnd
- processing
- expression
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261677494P | 2012-07-31 | 2012-07-31 | |
| US61/677,494 | 2012-07-31 | ||
| PCT/IL2013/050655 WO2014020608A1 (en) | 2012-07-31 | 2013-07-31 | Methods of diagnosing and treating motor neuron diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523410A JP2015523410A (ja) | 2015-08-13 |
| JP2015523410A5 true JP2015523410A5 (https=) | 2016-06-23 |
| JP6340366B2 JP6340366B2 (ja) | 2018-06-06 |
Family
ID=49085064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524902A Active JP6340366B2 (ja) | 2012-07-31 | 2013-07-31 | 運動ニューロン疾患を診断および処置する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10159670B2 (https=) |
| EP (1) | EP2879678B1 (https=) |
| JP (1) | JP6340366B2 (https=) |
| CN (1) | CN104684558A (https=) |
| HK (1) | HK1205453A1 (https=) |
| WO (1) | WO2014020608A1 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| JP6340366B2 (ja) | 2012-07-31 | 2018-06-06 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | 運動ニューロン疾患を診断および処置する方法 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| AU2014346559B2 (en) | 2013-11-07 | 2020-07-09 | Editas Medicine,Inc. | CRISPR-related methods and compositions with governing gRNAs |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| SG11201609211VA (en) * | 2014-03-05 | 2016-12-29 | Nat Univ Corp Univ Kobe | Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| WO2016030899A1 (en) * | 2014-08-28 | 2016-03-03 | Yeda Research And Development Co. Ltd. | Methods of treating amyotrophic lateral scleroses |
| US10487324B2 (en) | 2015-02-25 | 2019-11-26 | Washington University | Methods to detect motor neuron disease comprising micro-RNAs |
| WO2016157175A1 (en) | 2015-03-27 | 2016-10-06 | Yeda Research And Development Co. Ltd. | Methods of treating motor neuron diseases |
| JP6666002B2 (ja) * | 2015-10-07 | 2020-03-13 | 国立大学法人京都大学 | Ｔｄｐ−４３プロテノパシーの予防又は治療用組成物 |
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| CN105663129B (zh) * | 2015-12-29 | 2020-05-15 | 山东大学 | 用于治疗肌萎缩侧索硬化和额颞叶痴呆的化合物与应用 |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN106620721B (zh) * | 2016-09-30 | 2020-05-26 | 武汉大风生物科技有限公司 | 单核细胞趋化蛋白-1诱导蛋白1（Mcpip1）在肝缺血再灌注损伤中的应用 |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| CN106377761A (zh) * | 2016-10-27 | 2017-02-08 | 武汉大学 | 单核细胞趋化蛋白‑1诱导蛋白1在治疗脂肪肝和ⅱ型糖尿病中的功能和应用 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US12527768B2 (en) | 2017-06-20 | 2026-01-20 | Neurosense Therapeutics Ltd. | Compositions comprising an anti-inflammatory drug and a dicer activator for use in the treatment of neuronal diseases |
| ES2938895T3 (es) * | 2017-06-20 | 2023-04-17 | Neurosense Therapeutics Ltd | Composiciones que comprenden un fármaco antiinflamatorio y un activador DICER para uso en el tratamiento de enfermedades neuronales |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| EP3820494A4 (en) * | 2018-07-13 | 2022-07-13 | The Trustees of Princeton University | System and method for modulating stress granule assembly |
| WO2020058979A2 (en) * | 2018-09-20 | 2020-03-26 | Yeda Research And Development Co. Ltd. | Methods of treating amyotrophic lateral sclerosis |
| CN113196055B (zh) | 2018-10-15 | 2025-06-27 | 马克斯·普朗克科学促进协会 | 用于治疗疾病的化合物及其筛选方法 |
| EP3870699A4 (en) | 2018-10-26 | 2022-08-03 | The Jackson Laboratory | TREATMENTS FOR CHARCOT-MARIE-TOOTH DISEASE |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CA3127237A1 (en) | 2019-02-08 | 2020-08-13 | Dewpoint Therapeutics, Inc. | Methods of characterizing condensate-associated characteristics of compounds and uses thereof |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| EP3969619A1 (en) | 2019-05-13 | 2022-03-23 | Yeda Research and Development Co. Ltd | Cell-free mirna biomarkers for prognosis and diagnosis of neurodegenerative diseases |
| US11851462B2 (en) * | 2019-07-22 | 2023-12-26 | University Of South Carolina | Targeting G3BP aggregation to prevent neurodegeneration |
| KR20220084047A (ko) | 2019-09-18 | 2022-06-21 | 듀포인트 테라퓨틱스, 인크. | 응축물 관련 특이성에 대한 스크리닝 방법 및 이의 용도 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021178448A1 (en) * | 2020-03-02 | 2021-09-10 | Motor Life Sciences, Llc | Compositions and methods for diagnosing, preventing, and treating amyotrophic lateral sclerosis in patients with hypofunctional anti-trypsin activity |
| EP4114938A4 (en) * | 2020-03-04 | 2025-02-19 | The Trustees of Indiana University | Methods to re-engage a fetal wound healing pathway for adult skin repair |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| CN112043721B (zh) * | 2020-09-04 | 2022-01-28 | 南通大学 | miR-132-5p在制备神经再生药物或材料中的应用 |
| KR20220035693A (ko) * | 2020-09-14 | 2022-03-22 | 주식회사 제너로스 | 표적화된 유전자 전달을 위한 아데노-부속 바이러스 벡터 |
| TW202444389A (zh) * | 2023-01-30 | 2024-11-16 | 中央研究院 | 藉由調節mir34治療脊髓性肌肉萎縮症(sma)以及mir34作為sma的預測生物標記的用途 |
| AU2024288170A1 (en) * | 2023-07-07 | 2026-01-22 | The Board Of Regents Of The University Of Texas System | Targeting heterogeneous nuclear ribonucleoproteins for neuroprotection |
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| US8734759B2 (en) * | 2008-12-05 | 2014-05-27 | Yeda Research And Development Co. Ltd. | Methods of diagnosing and treating motor neuron diseases |
| US9867837B2 (en) * | 2011-03-01 | 2018-01-16 | Pharnext | Compositions for treating neurological disorders |
| WO2012162249A1 (en) | 2011-05-20 | 2012-11-29 | Benjamin Wolozin | Identification of compounds that disperse tdp-43 inclusions |
| WO2013063412A2 (en) | 2011-10-27 | 2013-05-02 | Massachusetts Institute Of Technology | Methods of diagnosis and treatment of endoplasmic reticulum (er) stress-related conditions |
| JP6340366B2 (ja) | 2012-07-31 | 2018-06-06 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | 運動ニューロン疾患を診断および処置する方法 |
-
2013
- 2013-07-31 JP JP2015524902A patent/JP6340366B2/ja active Active
- 2013-07-31 WO PCT/IL2013/050655 patent/WO2014020608A1/en not_active Ceased
- 2013-07-31 EP EP13756208.8A patent/EP2879678B1/en active Active
- 2013-07-31 HK HK15105895.8A patent/HK1205453A1/xx unknown
- 2013-07-31 CN CN201380051051.0A patent/CN104684558A/zh active Pending
-
2015
- 2015-02-02 US US14/612,034 patent/US10159670B2/en active Active
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