JP2015523410A5 - - Google Patents
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- JP2015523410A5 JP2015523410A5 JP2015524902A JP2015524902A JP2015523410A5 JP 2015523410 A5 JP2015523410 A5 JP 2015523410A5 JP 2015524902 A JP2015524902 A JP 2015524902A JP 2015524902 A JP2015524902 A JP 2015524902A JP 2015523410 A5 JP2015523410 A5 JP 2015523410A5
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- JP
- Japan
- Prior art keywords
- als
- agent
- mnd
- processing
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261677494P | 2012-07-31 | 2012-07-31 | |
| US61/677,494 | 2012-07-31 | ||
| PCT/IL2013/050655 WO2014020608A1 (en) | 2012-07-31 | 2013-07-31 | Methods of diagnosing and treating motor neuron diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523410A JP2015523410A (ja) | 2015-08-13 |
| JP2015523410A5 true JP2015523410A5 (https=) | 2016-06-23 |
| JP6340366B2 JP6340366B2 (ja) | 2018-06-06 |
Family
ID=49085064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524902A Active JP6340366B2 (ja) | 2012-07-31 | 2013-07-31 | 運動ニューロン疾患を診断および処置する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10159670B2 (https=) |
| EP (1) | EP2879678B1 (https=) |
| JP (1) | JP6340366B2 (https=) |
| CN (1) | CN104684558A (https=) |
| HK (1) | HK1205453A1 (https=) |
| WO (1) | WO2014020608A1 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| JP6340366B2 (ja) | 2012-07-31 | 2018-06-06 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | 運動ニューロン疾患を診断および処置する方法 |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| EP3115457B1 (en) * | 2014-03-05 | 2019-10-02 | National University Corporation Kobe University | Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| WO2016030899A1 (en) * | 2014-08-28 | 2016-03-03 | Yeda Research And Development Co. Ltd. | Methods of treating amyotrophic lateral scleroses |
| WO2016138287A1 (en) | 2015-02-25 | 2016-09-01 | Washington University | METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs |
| US20180064748A1 (en) | 2015-03-27 | 2018-03-08 | Yeda Research And Development Co. Ltd. | Methods of treating motor neuron diseases |
| JP6666002B2 (ja) * | 2015-10-07 | 2020-03-13 | 国立大学法人京都大学 | Ｔｄｐ−４３プロテノパシーの予防又は治療用組成物 |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CN105663129B (zh) * | 2015-12-29 | 2020-05-15 | 山东大学 | 用于治疗肌萎缩侧索硬化和额颞叶痴呆的化合物与应用 |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN106620721B (zh) * | 2016-09-30 | 2020-05-26 | 武汉大风生物科技有限公司 | 单核细胞趋化蛋白-1诱导蛋白1（Mcpip1）在肝缺血再灌注损伤中的应用 |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| CN106377761A (zh) * | 2016-10-27 | 2017-02-08 | 武汉大学 | 单核细胞趋化蛋白‑1诱导蛋白1在治疗脂肪肝和ⅱ型糖尿病中的功能和应用 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| JP7270255B2 (ja) * | 2017-06-20 | 2023-05-10 | ニューロセンス セラピューティックス リミテッド | 抗炎症剤及びダイサー活性化剤を含む神経疾患治療用組成物 |
| US12527768B2 (en) | 2017-06-20 | 2026-01-20 | Neurosense Therapeutics Ltd. | Compositions comprising an anti-inflammatory drug and a dicer activator for use in the treatment of neuronal diseases |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| JP2021531038A (ja) * | 2018-07-13 | 2021-11-18 | ザ、トラスティーズ オブ プリンストン ユニバーシティ | ストレス顆粒集合を調節するためのシステム及び方法 |
| CA3112135A1 (en) * | 2018-09-20 | 2020-03-26 | Yeda Research And Development Co. Ltd. | Methods of treating amyotrophic lateral sclerosis |
| CN113196055B (zh) * | 2018-10-15 | 2025-06-27 | 马克斯·普朗克科学促进协会 | 用于治疗疾病的化合物及其筛选方法 |
| WO2020086954A2 (en) * | 2018-10-26 | 2020-04-30 | The Jackson Laboratory | Treatments for charcot-marie-tooth disease |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| EP3921650A1 (en) | 2019-02-08 | 2021-12-15 | Dewpoint Therapeutics, Inc. | Methods of characterizing condensate-associated characteristics of compounds and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2020230133A1 (en) | 2019-05-13 | 2020-11-19 | Yeda Research And Development Co. Ltd. | Cell-free mirna biomarkers for prognosis and diagnosis of neurodegenerative diseases |
| US11851462B2 (en) * | 2019-07-22 | 2023-12-26 | University Of South Carolina | Targeting G3BP aggregation to prevent neurodegeneration |
| CN114729941A (zh) | 2019-09-18 | 2022-07-08 | 露点治疗公司 | 筛选凝聚物相关特异性的方法及其用途 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021178448A1 (en) * | 2020-03-02 | 2021-09-10 | Motor Life Sciences, Llc | Compositions and methods for diagnosing, preventing, and treating amyotrophic lateral sclerosis in patients with hypofunctional anti-trypsin activity |
| WO2021178344A1 (en) * | 2020-03-04 | 2021-09-10 | The Trustees Of Indiana University | Methods to re-engage a fetal wound healing pathway for adult skin repair |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CN112043721B (zh) * | 2020-09-04 | 2022-01-28 | 南通大学 | miR-132-5p在制备神经再生药物或材料中的应用 |
| KR20220035693A (ko) * | 2020-09-14 | 2022-03-22 | 주식회사 제너로스 | 표적화된 유전자 전달을 위한 아데노-부속 바이러스 벡터 |
| WO2024163383A2 (en) * | 2023-01-30 | 2024-08-08 | Academia Sinica | Treating spinal muscular atrophy (sma) by modulating mir34 and use of mir34 as a predictive biomarker of sma |
| AU2024288170A1 (en) * | 2023-07-07 | 2026-01-22 | The Board Of Regents Of The University Of Texas System | Targeting heterogeneous nuclear ribonucleoproteins for neuroprotection |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US6756369B2 (en) | 1997-05-06 | 2004-06-29 | Vanderbilt University | Diagnosis and management of infection caused by Chlamydia |
| FR2801217B1 (fr) * | 1999-11-24 | 2002-12-06 | Aventis Pharma Sa | Association de riluzole et de gabapentine et son utilisation comme medicament |
| JP2006519008A (ja) | 2003-02-10 | 2006-08-24 | 独立行政法人産業技術総合研究所 | 哺乳動物細胞の調節 |
| CN1475215A (zh) * | 2003-05-16 | 2004-02-18 | 海口康力元制药有限公司 | 注射用依诺沙星及其制作方法 |
| EP2302055B1 (en) | 2004-11-12 | 2014-08-27 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| EP1962861A2 (en) | 2005-08-26 | 2008-09-03 | Emory University | Compounds and methods for modulating the silencing of a polynucleotide of interest |
| US20070197548A1 (en) * | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V S | Fluoroquinolone compositions |
| WO2008073961A2 (en) | 2006-12-12 | 2008-06-19 | Emory University | Compounds and methods for modulating the silencing of a polynucleotide of interest |
| CN101390854A (zh) * | 2007-09-21 | 2009-03-25 | 北京德众万全药物技术开发有限公司 | 一种含有利鲁唑的药用组合物 |
| EP2265291B1 (en) | 2008-03-17 | 2016-10-19 | The Board of Regents of The University of Texas System | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
| WO2010006425A1 (en) | 2008-07-14 | 2010-01-21 | Delaney Technologies Inc. | Deployment mechanism for a retractable roof system for a large building structure |
| ES2554765T3 (es) * | 2008-12-05 | 2015-12-23 | Yeda Research And Development Co. Ltd. | miRNA-9 o miRNA-9* para uso en el tratamiento de ELA |
| US9867837B2 (en) * | 2011-03-01 | 2018-01-16 | Pharnext | Compositions for treating neurological disorders |
| WO2012162249A1 (en) | 2011-05-20 | 2012-11-29 | Benjamin Wolozin | Identification of compounds that disperse tdp-43 inclusions |
| US20140348857A1 (en) | 2011-10-27 | 2014-11-27 | Massachusetts Institute Of Technology | Methods of diagnosis and treatment of endoplasmic reticulum (er) stress-related conditions |
| JP6340366B2 (ja) | 2012-07-31 | 2018-06-06 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | 運動ニューロン疾患を診断および処置する方法 |
-
2013
- 2013-07-31 JP JP2015524902A patent/JP6340366B2/ja active Active
- 2013-07-31 WO PCT/IL2013/050655 patent/WO2014020608A1/en not_active Ceased
- 2013-07-31 HK HK15105895.8A patent/HK1205453A1/xx unknown
- 2013-07-31 CN CN201380051051.0A patent/CN104684558A/zh active Pending
- 2013-07-31 EP EP13756208.8A patent/EP2879678B1/en active Active
-
2015
- 2015-02-02 US US14/612,034 patent/US10159670B2/en active Active
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