JP2015522544A5 - - Google Patents
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- Publication number
- JP2015522544A5 JP2015522544A5 JP2015513123A JP2015513123A JP2015522544A5 JP 2015522544 A5 JP2015522544 A5 JP 2015522544A5 JP 2015513123 A JP2015513123 A JP 2015513123A JP 2015513123 A JP2015513123 A JP 2015513123A JP 2015522544 A5 JP2015522544 A5 JP 2015522544A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- group
- aromatic heterocycle
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(*)N(C*CC(*)(NC(N)=NC(c1nc(*)c(N)nc1N)=O)N1)C*1=* Chemical compound *C(*)N(C*CC(*)(NC(N)=NC(c1nc(*)c(N)nc1N)=O)N1)C*1=* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12169577.9 | 2012-05-25 | ||
| EP12169577 | 2012-05-25 | ||
| PCT/EP2013/060282 WO2013174757A1 (en) | 2012-05-25 | 2013-05-17 | Tertiary amines, medicaments containing said amines, use thereof and processes for the preparation thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522544A JP2015522544A (ja) | 2015-08-06 |
| JP2015522544A5 true JP2015522544A5 (https=) | 2016-07-07 |
| JP6204977B2 JP6204977B2 (ja) | 2017-09-27 |
Family
ID=48539098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513123A Active JP6204977B2 (ja) | 2012-05-25 | 2013-05-17 | 三級アミン、前記アミンを含む薬物、その使用及びその調製方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9078909B2 (https=) |
| EP (1) | EP2861577B1 (https=) |
| JP (1) | JP6204977B2 (https=) |
| WO (1) | WO2013174757A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3219705B1 (en) | 2005-12-28 | 2020-03-11 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| EP2991981B1 (en) | 2013-04-30 | 2017-03-01 | Boehringer Ingelheim International GmbH | Diaminopyrazine compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| RU2744460C2 (ru) | 2014-04-15 | 2021-03-09 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
| CN115028661A (zh) * | 2022-05-19 | 2022-09-09 | 上海应用技术大学 | 一种4-氨基哌啶-1-甲基磷酸酯及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6812003A (https=) | 1967-09-07 | 1969-03-11 | ||
| US3953476A (en) | 1971-12-27 | 1976-04-27 | Merck & Co., Inc. | 3-Amino-5-sulfonylbenzoic acids |
| JP2003520042A (ja) | 2000-01-24 | 2003-07-02 | アイシス・ファーマシューティカルス・インコーポレーテッド | 誘導性一酸化窒素シンターゼ発現のアンチセンスモジュレーション |
| JP2007502829A (ja) * | 2003-08-18 | 2007-02-15 | パリオン・サイエンシィズ・インコーポレーテッド | 環状ピラジノイルグアニジンナトリウムチャネルブロッカー |
| GB0526240D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| DE602008005140D1 (de) | 2007-05-07 | 2011-04-07 | Novartis Ag | Organische verbindungen |
| CA2723938A1 (en) | 2008-05-13 | 2009-11-19 | Novartis Ag | 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases |
| CN103687488B (zh) | 2011-06-27 | 2015-06-10 | 帕里昂科学公司 | 化学和代谢稳定的具有钠通道阻滞剂活性的二肽 |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
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2013
- 2013-05-17 EP EP13726129.3A patent/EP2861577B1/en active Active
- 2013-05-17 WO PCT/EP2013/060282 patent/WO2013174757A1/en not_active Ceased
- 2013-05-17 JP JP2015513123A patent/JP6204977B2/ja active Active
- 2013-05-22 US US13/899,762 patent/US9078909B2/en active Active